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The map label for this gene is folK [H]

Identifier: 113474537

GI number: 113474537

Start: 1124315

End: 1124830

Strand: Direct

Name: folK [H]

Synonym: Tery_0688

Alternate gene names: 113474537

Gene position: 1124315-1124830 (Clockwise)

Preceding gene: 113474534

Following gene: 113474538

Centisome position: 14.51

GC content: 34.3

Gene sequence:

>516_bases
ATGTCTAATCCTACTAACTTAAAGAACTCCCCAAAAAATCAAGGCCATGTAGCTATTGGTATGGGTAGCAATTTGGGAGA
ATCCCTTGATACTCTCAAGAATGCCATTCAAACTTTAGATGAAATTGCTGGTATTAAATTAATTACTTATTCTAGTTGGT
ATAGAACTAAACCTATAGGTCCACCACAACCAGATTATATTAATGGTTGTGCATTATTAAAAGTAGAATTAACCCCTCAT
AAATTATTAGAAGTTCTGTTAGATGTTGAACAAAAATTTAAACGGGTACGTTTAGAACATTGGGGACCTAGAACTTTAGA
TTTAGATTTAATTTTATATGATGATTTAATATTAGATACTCCTAATCTGCAAATACCCCATCCTCGAATGAAAGAAAGAG
CTTTTGTACTTGTCCCACTAGCAGAAATAGCTCCTAATTGGATCGACCCAGTTTCGGGAAAAGCGATCGCTCTTCTTCAA
GAAGAGGTAGAATGTTCTGGAATATCTAAGCTGTAA

Upstream 100 bases:

>100_bases
TGTACTTTAAGAGTATAGAAATTACTATAAAATTGAGGATTATTGATAAAATAATATCAACCAATCACGAACCAGTAAAT
TATAAGCGATCGCTCTAAAA

Downstream 100 bases:

>100_bases
AATAGAAAATATTAACTTGATTTTCTGGTCACGGAACGTAAATTCAATAATACTGGAAATTTGTAGTTGATACTAAGGAA
ATCTCTTGAGGGTAATTAAT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MSNPTNLKNSPKNQGHVAIGMGSNLGESLDTLKNAIQTLDEIAGIKLITYSSWYRTKPIGPPQPDYINGCALLKVELTPH
KLLEVLLDVEQKFKRVRLEHWGPRTLDLDLILYDDLILDTPNLQIPHPRMKERAFVLVPLAEIAPNWIDPVSGKAIALLQ
EEVECSGISKL

Sequences:

>Translated_171_residues
MSNPTNLKNSPKNQGHVAIGMGSNLGESLDTLKNAIQTLDEIAGIKLITYSSWYRTKPIGPPQPDYINGCALLKVELTPH
KLLEVLLDVEQKFKRVRLEHWGPRTLDLDLILYDDLILDTPNLQIPHPRMKERAFVLVPLAEIAPNWIDPVSGKAIALLQ
EEVECSGISKL
>Mature_170_residues
SNPTNLKNSPKNQGHVAIGMGSNLGESLDTLKNAIQTLDEIAGIKLITYSSWYRTKPIGPPQPDYINGCALLKVELTPHK
LLEVLLDVEQKFKRVRLEHWGPRTLDLDLILYDDLILDTPNLQIPHPRMKERAFVLVPLAEIAPNWIDPVSGKAIALLQE
EVECSGISKL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=134, Percent_Identity=44.0298507462687, Blast_Score=111, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324073, Length=147, Percent_Identity=36.734693877551, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19095; Mature: 18964

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPTNLKNSPKNQGHVAIGMGSNLGESLDTLKNAIQTLDEIAGIKLITYSSWYRTKPIG
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCC
PPQPDYINGCALLKVELTPHKLLEVLLDVEQKFKRVRLEHWGPRTLDLDLILYDDLILDT
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEECC
PNLQIPHPRMKERAFVLVPLAEIAPNWIDPVSGKAIALLQEEVECSGISKL
CCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCEEEEEHHHHHCCCCCCC
>Mature Secondary Structure 
SNPTNLKNSPKNQGHVAIGMGSNLGESLDTLKNAIQTLDEIAGIKLITYSSWYRTKPIG
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCC
PPQPDYINGCALLKVELTPHKLLEVLLDVEQKFKRVRLEHWGPRTLDLDLILYDDLILDT
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEECC
PNLQIPHPRMKERAFVLVPLAEIAPNWIDPVSGKAIALLQEEVECSGISKL
CCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCEEEEEHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]