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The map label for this gene is prs [H]

Identifier: 113474453

GI number: 113474453

Start: 959820

End: 960812

Strand: Direct

Name: prs [H]

Synonym: Tery_0597

Alternate gene names: 113474453

Gene position: 959820-960812 (Clockwise)

Preceding gene: 113474449

Following gene: 113474454

Centisome position: 12.38

GC content: 38.87

Gene sequence:

>993_bases
GTGATCCATGCGACTTTACCAATACAGGCTCCTATACCTGCTATTGTTAACGATCATAATCGACTAAGACTGTTTTCAGG
TTCTGCTAACGTTCCTCTCTCTACAGAAGTAGCTAGATACCTAGGTTTAGATCTAGGCCCAATGGTACGTAAGCACTTTG
CTGATGGAGAGCTATACATTCAAATTCAGGAATCAATTAGAGGTTGTGATGTTTATCTAATTCAACCTAGTTGTCACCCA
GTTAATGATAACCTGATGGAATTGTTGATAATGATAGATGCTTGTCATCGTGCTTCTGCCAGACAAATTACCGCAGTAAT
TCCTTACTATGGTTATGCTAGGGCAGACCGTAAAACTGCTGGAAGAGAATCAATTACAGCGAAATTAGTGGCCAATTTAA
TTACTGAGGCGGGAGCTAGTCGTATTCTAGCAATGGATTTACATTCAGCTCAGATTCAGGGTTATTTTGATATTCCCTTC
GATCATGTTTATGGCTTACCAGTAATTTTAGATTACTTATTAAGTAAAAACTTATCTGATATTGTTGTTGTTTCTCCCGA
TGTAGGTGGAGTAGCAAGAGCTAGAGCTTTTGCAAAAAAGCTAAATGATGCTCCTTTGGCAATTATTGATAAGCGTCGCC
AAGCTCATAATGTAGCAGAAGTTTTCAATGTGATAGGGGATGTTAAGGACAAAACTGCTGTTTTAGTAGATGATATGATT
GATACAGCTGGGACTATTTGTGAAGGTGGGCGACTATTACGGGAAAAAGGGGCACGACAAGTTTATGCCTGTGCTACTCA
TGCTGTATTTTCCGGTACAGCTATTGAGCGCCTTTCAAATGGAATATTTGAAGAGGTAATTGTTACTAATACTATCCCAT
TCAATCAGGAAAATTCTTTTCCTCAGCTAATAGTTCTTTCAGCAGCAAATTTATTGGGTGAGACTATTTGGCGTATTCAC
GAAGACACTTCAGTTAGTAGTATGTTTCGCTAG

Upstream 100 bases:

>100_bases
TTGAAGATTAAATCATGTTTTTATCAACAAAAACACGGAGAGATATTTTGCTTTTAAGATGATAAGATCACCATGAATAA
AGGTTCTACAAGGGGTTGCC

Downstream 100 bases:

>100_bases
AATTAGCTATGTTTACCGCAAAATTGGGTCTCTATTCCCTCGCCCATAAGCAAGCAAAACCTGAGTTTATAGTGGGAAGA
CATAAACTATAGTATTATAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MIHATLPIQAPIPAIVNDHNRLRLFSGSANVPLSTEVARYLGLDLGPMVRKHFADGELYIQIQESIRGCDVYLIQPSCHP
VNDNLMELLIMIDACHRASARQITAVIPYYGYARADRKTAGRESITAKLVANLITEAGASRILAMDLHSAQIQGYFDIPF
DHVYGLPVILDYLLSKNLSDIVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQAHNVAEVFNVIGDVKDKTAVLVDDMI
DTAGTICEGGRLLREKGARQVYACATHAVFSGTAIERLSNGIFEEVIVTNTIPFNQENSFPQLIVLSAANLLGETIWRIH
EDTSVSSMFR

Sequences:

>Translated_330_residues
MIHATLPIQAPIPAIVNDHNRLRLFSGSANVPLSTEVARYLGLDLGPMVRKHFADGELYIQIQESIRGCDVYLIQPSCHP
VNDNLMELLIMIDACHRASARQITAVIPYYGYARADRKTAGRESITAKLVANLITEAGASRILAMDLHSAQIQGYFDIPF
DHVYGLPVILDYLLSKNLSDIVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQAHNVAEVFNVIGDVKDKTAVLVDDMI
DTAGTICEGGRLLREKGARQVYACATHAVFSGTAIERLSNGIFEEVIVTNTIPFNQENSFPQLIVLSAANLLGETIWRIH
EDTSVSSMFR
>Mature_330_residues
MIHATLPIQAPIPAIVNDHNRLRLFSGSANVPLSTEVARYLGLDLGPMVRKHFADGELYIQIQESIRGCDVYLIQPSCHP
VNDNLMELLIMIDACHRASARQITAVIPYYGYARADRKTAGRESITAKLVANLITEAGASRILAMDLHSAQIQGYFDIPF
DHVYGLPVILDYLLSKNLSDIVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQAHNVAEVFNVIGDVKDKTAVLVDDMI
DTAGTICEGGRLLREKGARQVYACATHAVFSGTAIERLSNGIFEEVIVTNTIPFNQENSFPQLIVLSAANLLGETIWRIH
EDTSVSSMFR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=47.7707006369427, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=48.2315112540193, Blast_Score=288, Evalue=3e-78,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=48.0891719745223, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=45.6591639871383, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=33.6231884057971, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=32.8488372093023, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=50, Blast_Score=327, Evalue=9e-91,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=45.016077170418, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=45.016077170418, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=45.016077170418, Blast_Score=263, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=45.3074433656958, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17570245, Length=336, Percent_Identity=29.7619047619048, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319403, Length=339, Percent_Identity=40.117994100295, Blast_Score=245, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=41.4012738853503, Blast_Score=244, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=41.2140575079872, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=39.2857142857143, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=36.3636363636364, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21355239, Length=317, Percent_Identity=45.1104100946372, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI45551540, Length=340, Percent_Identity=42.6470588235294, Blast_Score=264, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24651458, Length=353, Percent_Identity=30.3116147308782, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651456, Length=353, Percent_Identity=30.3116147308782, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281362873, Length=353, Percent_Identity=30.3116147308782, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651454, Length=353, Percent_Identity=30.3116147308782, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651462, Length=200, Percent_Identity=34.5, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24651464, Length=200, Percent_Identity=34.5, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45552010, Length=200, Percent_Identity=34.5, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36220; Mature: 36220

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHATLPIQAPIPAIVNDHNRLRLFSGSANVPLSTEVARYLGLDLGPMVRKHFADGELYI
CEEEECCCCCCCCHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHCCCCEEEE
QIQESIRGCDVYLIQPSCHPVNDNLMELLIMIDACHRASARQITAVIPYYGYARADRKTA
EEEHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHC
GRESITAKLVANLITEAGASRILAMDLHSAQIQGYFDIPFDHVYGLPVILDYLLSKNLSD
CHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCEEEECCHHHHCCHHHHHHHHHHCCCCC
IVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQAHNVAEVFNVIGDVKDKTAVLVDDMI
EEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DTAGTICEGGRLLREKGARQVYACATHAVFSGTAIERLSNGIFEEVIVTNTIPFNQENSF
HHHHHHHCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PQLIVLSAANLLGETIWRIHEDTSVSSMFR
CHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure
MIHATLPIQAPIPAIVNDHNRLRLFSGSANVPLSTEVARYLGLDLGPMVRKHFADGELYI
CEEEECCCCCCCCHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHCCCCEEEE
QIQESIRGCDVYLIQPSCHPVNDNLMELLIMIDACHRASARQITAVIPYYGYARADRKTA
EEEHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHC
GRESITAKLVANLITEAGASRILAMDLHSAQIQGYFDIPFDHVYGLPVILDYLLSKNLSD
CHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCEEEECCHHHHCCHHHHHHHHHHCCCCC
IVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQAHNVAEVFNVIGDVKDKTAVLVDDMI
EEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DTAGTICEGGRLLREKGARQVYACATHAVFSGTAIERLSNGIFEEVIVTNTIPFNQENSF
HHHHHHHCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PQLIVLSAANLLGETIWRIHEDTSVSSMFR
CHHHHHHHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7764342 [H]