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The map label for this gene is msrA [H]

Identifier: 110835564

GI number: 110835564

Start: 3056820

End: 3057881

Strand: Direct

Name: msrA [H]

Synonym: ABO_2703

Alternate gene names: 110835564

Gene position: 3056820-3057881 (Clockwise)

Preceding gene: 110835562

Following gene: 110835568

Centisome position: 97.97

GC content: 50.09

Gene sequence:

>1062_bases
ATGCGAATGATTACATTACTGGGGTTGCTGATAATCAGCGCACCATCCCTAGCCGCCGAAGCCTATTTCGCCGGTGGCTG
TTTCTGGTGTACCGAGTCCGATTTTGAGCAACTGAACGGCGTTAGCGACGTTATCAGCGGGTATGCGGGTGGCGACGTCG
CCAATCCCAGCTATCAACAAGTAGCCGCTGGCAGCACCGGGCACACCGAAGCCGTAAAGGTCATCTATGACCCCAAAGTG
GTTAGCTACGACAACCTACTGACCTGGTTGTGGCGCCATATCGACCCCACCGACGCCAACGGACAATTCGTGGACCGGGG
CACCCAGTATCGCAGCGAAATTTTTTATCAAACCGATGAAGAAAAAGAGGCTGCTAAAGCATCAAGGATGGAACTGGAAG
AACGTGGCCCCTTTAAAAAACCCATCGTCACAGCAATCACCAAGCTAGATAGCTTTTATCCCGCGGAAGATTACCATCAG
GATTACTACAAAACCCACTCGCTCAAGTACAAGTATTACCGCTATCGATCCGGTCGCGACCAGTTTCTAAAAGAGCACTG
GGATGATCCAGATCACCGCCCTTGGCTTGTAAAAGACGTAACACAATCCTGGCAGGGAGCAGATAAATTTGAGCGCCCAA
GTGATTCGGATTTACAAAAAACGTTACCAAAACTGACCTATAAGGTGACCCGTGAAGACGCCACCGAACGCGCTTTTCAC
AATCCCTATTGGGATAACAAAGAAAAAGGCATTTATGTGGATGTGATCAGTGGCGAGCCACTCTTCTCTTCAACAGACAA
GTACCAATCTGGCACAGGCTGGCCGAGCTTTACCCAACCTATAGATGAGGCCTTTATCACCGCTCATGAAGACAATACAC
TGTTCACCACTCGTACCGAAGTGCGCAGCCGCTACGCAGACTCGCATCTGGGCCATGTCTTTGATGACGGCCCAGCACCT
ACAGGCAAGCGATGGTGCATGAACTCTGCCGCAATGCGATTTGTTCCTCTGGAGGAAATGACCCAAAAGGGTTACGGAAA
ATATCTTTCCTATTTTCAATAG

Upstream 100 bases:

>100_bases
GCTCCGCTCCCTGTCCGTTTACACATACCGGTGATGTAAGCCATAACGGTTTGCAACAAATCACGACCGGCTGCATCCAA
CAGGCAGGAGGTAAGCACTT

Downstream 100 bases:

>100_bases
CGCACATGAAAAGCGAGAATTTTTTCTCGCTTTTCCAATTTTTTCTTATTTTTGTCTCAAAAAATTAACGCCCTTTACTG
CAAACAAAACAATGCTGCCA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MRMITLLGLLIISAPSLAAEAYFAGGCFWCTESDFEQLNGVSDVISGYAGGDVANPSYQQVAAGSTGHTEAVKVIYDPKV
VSYDNLLTWLWRHIDPTDANGQFVDRGTQYRSEIFYQTDEEKEAAKASRMELEERGPFKKPIVTAITKLDSFYPAEDYHQ
DYYKTHSLKYKYYRYRSGRDQFLKEHWDDPDHRPWLVKDVTQSWQGADKFERPSDSDLQKTLPKLTYKVTREDATERAFH
NPYWDNKEKGIYVDVISGEPLFSSTDKYQSGTGWPSFTQPIDEAFITAHEDNTLFTTRTEVRSRYADSHLGHVFDDGPAP
TGKRWCMNSAAMRFVPLEEMTQKGYGKYLSYFQ

Sequences:

>Translated_353_residues
MRMITLLGLLIISAPSLAAEAYFAGGCFWCTESDFEQLNGVSDVISGYAGGDVANPSYQQVAAGSTGHTEAVKVIYDPKV
VSYDNLLTWLWRHIDPTDANGQFVDRGTQYRSEIFYQTDEEKEAAKASRMELEERGPFKKPIVTAITKLDSFYPAEDYHQ
DYYKTHSLKYKYYRYRSGRDQFLKEHWDDPDHRPWLVKDVTQSWQGADKFERPSDSDLQKTLPKLTYKVTREDATERAFH
NPYWDNKEKGIYVDVISGEPLFSSTDKYQSGTGWPSFTQPIDEAFITAHEDNTLFTTRTEVRSRYADSHLGHVFDDGPAP
TGKRWCMNSAAMRFVPLEEMTQKGYGKYLSYFQ
>Mature_353_residues
MRMITLLGLLIISAPSLAAEAYFAGGCFWCTESDFEQLNGVSDVISGYAGGDVANPSYQQVAAGSTGHTEAVKVIYDPKV
VSYDNLLTWLWRHIDPTDANGQFVDRGTQYRSEIFYQTDEEKEAAKASRMELEERGPFKKPIVTAITKLDSFYPAEDYHQ
DYYKTHSLKYKYYRYRSGRDQFLKEHWDDPDHRPWLVKDVTQSWQGADKFERPSDSDLQKTLPKLTYKVTREDATERAFH
NPYWDNKEKGIYVDVISGEPLFSSTDKYQSGTGWPSFTQPIDEAFITAHEDNTLFTTRTEVRSRYADSHLGHVFDDGPAP
TGKRWCMNSAAMRFVPLEEMTQKGYGKYLSYFQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=125, Percent_Identity=47.2, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI301336162, Length=125, Percent_Identity=47.2, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI73089054, Length=125, Percent_Identity=47.2, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI37620216, Length=125, Percent_Identity=47.2, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI6912516, Length=152, Percent_Identity=42.1052631578947, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI117606353, Length=130, Percent_Identity=46.9230769230769, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI208609995, Length=152, Percent_Identity=42.1052631578947, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI208609993, Length=101, Percent_Identity=43.5643564356436, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790665, Length=158, Percent_Identity=42.4050632911392, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=44.3548387096774, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI115532676, Length=121, Percent_Identity=41.3223140495868, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=121, Percent_Identity=41.3223140495868, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17533973, Length=144, Percent_Identity=38.1944444444444, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=169, Percent_Identity=36.094674556213, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319816, Length=142, Percent_Identity=33.0985915492958, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45553335, Length=120, Percent_Identity=45.8333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21356369, Length=120, Percent_Identity=45.8333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24645799, Length=162, Percent_Identity=39.5061728395062, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221378662, Length=127, Percent_Identity=44.0944881889764, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI221378664, Length=120, Percent_Identity=45, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24645804, Length=131, Percent_Identity=43.5114503816794, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645801, Length=173, Percent_Identity=38.150289017341, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=38.3561643835616, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=38.1294964028777, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=38.7755102040816, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 40578; Mature: 40578

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMITLLGLLIISAPSLAAEAYFAGGCFWCTESDFEQLNGVSDVISGYAGGDVANPSYQQ
CHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCHHHHHHCCHHHHHHCCCCCCCCCCCHHH
VAAGSTGHTEAVKVIYDPKVVSYDNLLTWLWRHIDPTDANGQFVDRGTQYRSEIFYQTDE
HHCCCCCCCCEEEEEECCCEECHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHCCCCC
EKEAAKASRMELEERGPFKKPIVTAITKLDSFYPAEDYHQDYYKTHSLKYKYYRYRSGRD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEEECCCHH
QFLKEHWDDPDHRPWLVKDVTQSWQGADKFERPSDSDLQKTLPKLTYKVTREDATERAFH
HHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NPYWDNKEKGIYVDVISGEPLFSSTDKYQSGTGWPSFTQPIDEAFITAHEDNTLFTTRTE
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEEHHH
VRSRYADSHLGHVFDDGPAPTGKRWCMNSAAMRFVPLEEMTQKGYGKYLSYFQ
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRMITLLGLLIISAPSLAAEAYFAGGCFWCTESDFEQLNGVSDVISGYAGGDVANPSYQQ
CHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCHHHHHHCCHHHHHHCCCCCCCCCCCHHH
VAAGSTGHTEAVKVIYDPKVVSYDNLLTWLWRHIDPTDANGQFVDRGTQYRSEIFYQTDE
HHCCCCCCCCEEEEEECCCEECHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHCCCCC
EKEAAKASRMELEERGPFKKPIVTAITKLDSFYPAEDYHQDYYKTHSLKYKYYRYRSGRD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEEECCCHH
QFLKEHWDDPDHRPWLVKDVTQSWQGADKFERPSDSDLQKTLPKLTYKVTREDATERAFH
HHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NPYWDNKEKGIYVDVISGEPLFSSTDKYQSGTGWPSFTQPIDEAFITAHEDNTLFTTRTE
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEEHHH
VRSRYADSHLGHVFDDGPAPTGKRWCMNSAAMRFVPLEEMTQKGYGKYLSYFQ
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]