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The map label for this gene is ahcy [H]

Identifier: 110835479

GI number: 110835479

Start: 2962561

End: 2963949

Strand: Direct

Name: ahcy [H]

Synonym: ABO_2618

Alternate gene names: 110835479

Gene position: 2962561-2963949 (Clockwise)

Preceding gene: 110835478

Following gene: 110835480

Centisome position: 94.95

GC content: 53.71

Gene sequence:

>1389_bases
ATGAACGCGAAAGTAGGCACCTTTACTGATTATAAAGTCGCGGATATTTCCCTAGCGAATTATGGCCGCTCAGAAATCCA
TATTGCCGAAACCGAAATGCCGGCACTCATCGCTATTCGTGAAAAATACCGTGCCGAGCAGCCGCTGAAAGGCGCCAAAA
TTATTGGCTGCATTCACATGACCATTCAGACCGCCGTACTGATCGAAACCCTGATTGCCCTGGGCGCAGAAGTACGCTGG
TCCAGCTGTAATATCTTCTCCACCCAGGACCACGCCGCTGCCGCTATCGCTGCTGCCGGTGTTCCCGTGTTTGCCTGGAA
AGGCGAAACCGAAGAAGAGTACATGTGGTGCATCGAGCAGACCTGTCGCGACGGCAACGGTGAACTGTGGGAAGCTAACA
TGATTCTCGATGATGGCGGCGACCTGACCGGCTACATCCACGAAACCTACCCGGCCATGCTCGACAACATTCACGGCATT
ACCGAAGAAACCACCACCGGTGTACACCGTCTCTACGAGATGCTGAACAAAGGCACATTGAAAGTGCCCGCAGTGAACGT
GAATGATTCTGTCACCAAGAGCAAAAACGACAACAAATATGGTTGCCGTCATTCCCTGAACGATGCCATCAAGCGCGGTA
CCGACCACCTGTTGTCTGGCAAGAAAGCCCTGGTTATCGGTTACGGTGACGTGGGCAAGGGCTCCGCCCAGTCCCTGCGT
CAGGAAGGCATGATTGTGAAAGTCACCGAAGCCGATCCAATCTGCGCTATGCAGGCCTGCATGGACGGCTTTGAAGTGGT
CAGCCAATACAAAGGTGGCATTAACGATGGCAGCGAAGCCTCCATCAACACCGATCTGCTAGGCAACACGGATCTGCTGG
TTACCACCACCGGCAATTTCAATGTGTGCGACGCCAACATGCTCAAGGCGATCAAGAAAGGCGCCGTGGTCTGTAACATC
GGTCACTTCGACAACGAAGTGGATACCGCCTTCATGCGCGAAACCTGGGAATGGGAAGAAGTAAAACCCCAAGTCCACAA
AGTATGGCGCAATAAAGCTGAAGGCGATTTCCTGCTGCTGCTTTCCGAAGGCCGCCTGGTCAACCTGGGCAACGCCACCG
GGCACCCCAGCCGCATCATGGATGGCTCCTTCGCCAACCAGGTACTGGCGCAGATGTATCTGTTCGACCAGGGCTACGCC
AACCACTCTGATGCCGTGAAAGAAAAAATGCTCAAGGTAGAAGTGCTGCCCAAAAAGCTGGATGAAGAAGTGGCCCGCTA
CATGGTGGAAGGCTTTGGTGGTGTGATCACCAAGCTCAGCAAAGAGCAAGCCGACTACATCGGCGTAGACGTGAACGGCC
CCTACAAGCCCGAACATTATAAGTACTAA

Upstream 100 bases:

>100_bases
CCGCAGGCAGGCATACCTAACACCTTGGGGCTCGCCACACAGCGAGCCGACTAGCACCACGTAATGCGTTTAGCATGTTA
CGTGCAAGCGGAGAAACAGA

Downstream 100 bases:

>100_bases
ACACTGGTACGCCCCACGCATCATGCAACACGCGTGGGGCGTGAGGTGTGCAGCATGAAGCGAGTTCCCAATGAAACGAA
TCAGTTTTGAATTCTTTCCG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MNAKVGTFTDYKVADISLANYGRSEIHIAETEMPALIAIREKYRAEQPLKGAKIIGCIHMTIQTAVLIETLIALGAEVRW
SSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYMWCIEQTCRDGNGELWEANMILDDGGDLTGYIHETYPAMLDNIHGI
TEETTTGVHRLYEMLNKGTLKVPAVNVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKKALVIGYGDVGKGSAQSLR
QEGMIVKVTEADPICAMQACMDGFEVVSQYKGGINDGSEASINTDLLGNTDLLVTTTGNFNVCDANMLKAIKKGAVVCNI
GHFDNEVDTAFMRETWEWEEVKPQVHKVWRNKAEGDFLLLLSEGRLVNLGNATGHPSRIMDGSFANQVLAQMYLFDQGYA
NHSDAVKEKMLKVEVLPKKLDEEVARYMVEGFGGVITKLSKEQADYIGVDVNGPYKPEHYKY

Sequences:

>Translated_462_residues
MNAKVGTFTDYKVADISLANYGRSEIHIAETEMPALIAIREKYRAEQPLKGAKIIGCIHMTIQTAVLIETLIALGAEVRW
SSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYMWCIEQTCRDGNGELWEANMILDDGGDLTGYIHETYPAMLDNIHGI
TEETTTGVHRLYEMLNKGTLKVPAVNVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKKALVIGYGDVGKGSAQSLR
QEGMIVKVTEADPICAMQACMDGFEVVSQYKGGINDGSEASINTDLLGNTDLLVTTTGNFNVCDANMLKAIKKGAVVCNI
GHFDNEVDTAFMRETWEWEEVKPQVHKVWRNKAEGDFLLLLSEGRLVNLGNATGHPSRIMDGSFANQVLAQMYLFDQGYA
NHSDAVKEKMLKVEVLPKKLDEEVARYMVEGFGGVITKLSKEQADYIGVDVNGPYKPEHYKY
>Mature_462_residues
MNAKVGTFTDYKVADISLANYGRSEIHIAETEMPALIAIREKYRAEQPLKGAKIIGCIHMTIQTAVLIETLIALGAEVRW
SSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYMWCIEQTCRDGNGELWEANMILDDGGDLTGYIHETYPAMLDNIHGI
TEETTTGVHRLYEMLNKGTLKVPAVNVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKKALVIGYGDVGKGSAQSLR
QEGMIVKVTEADPICAMQACMDGFEVVSQYKGGINDGSEASINTDLLGNTDLLVTTTGNFNVCDANMLKAIKKGAVVCNI
GHFDNEVDTAFMRETWEWEEVKPQVHKVWRNKAEGDFLLLLSEGRLVNLGNATGHPSRIMDGSFANQVLAQMYLFDQGYA
NHSDAVKEKMLKVEVLPKKLDEEVARYMVEGFGGVITKLSKEQADYIGVDVNGPYKPEHYKY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=453, Percent_Identity=56.0706401766004, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI239937451, Length=431, Percent_Identity=54.7563805104408, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI298286489, Length=456, Percent_Identity=47.1491228070175, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI24308043, Length=456, Percent_Identity=47.1491228070175, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI195539337, Length=456, Percent_Identity=47.1491228070175, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI195539349, Length=456, Percent_Identity=47.1491228070175, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI21361647, Length=456, Percent_Identity=46.4912280701754, Blast_Score=400, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17506425, Length=453, Percent_Identity=56.953642384106, Blast_Score=484, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6320882, Length=466, Percent_Identity=54.7210300429184, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24642172, Length=453, Percent_Identity=56.5121412803532, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24656245, Length=457, Percent_Identity=47.0459518599562, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45553387, Length=457, Percent_Identity=45.7330415754923, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI45553385, Length=456, Percent_Identity=45.6140350877193, Blast_Score=384, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50892; Mature: 50892

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAKVGTFTDYKVADISLANYGRSEIHIAETEMPALIAIREKYRAEQPLKGAKIIGCIHM
CCCCCCCCCCCEEEEEEHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHH
TIQTAVLIETLIALGAEVRWSSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYMWCIEQ
HHHHHHHHHHHHHCCCCEEECCCCEECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
TCRDGNGELWEANMILDDGGDLTGYIHETYPAMLDNIHGITEETTTGVHRLYEMLNKGTL
HHCCCCCCEEEEEEEEECCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCE
KVPAVNVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKKALVIGYGDVGKGSAQSLR
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCEEEEEECCCCCCCHHHHHH
QEGMIVKVTEADPICAMQACMDGFEVVSQYKGGINDGSEASINTDLLGNTDLLVTTTGNF
HCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCEEEEECCCC
NVCDANMLKAIKKGAVVCNIGHFDNEVDTAFMRETWEWEEVKPQVHKVWRNKAEGDFLLL
CCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCHHHHCHHHHHHHHCCCCCCEEEE
LSEGRLVNLGNATGHPSRIMDGSFANQVLAQMYLFDQGYANHSDAVKEKMLKVEVLPKKL
EECCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
DEEVARYMVEGFGGVITKLSKEQADYIGVDVNGPYKPEHYKY
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNAKVGTFTDYKVADISLANYGRSEIHIAETEMPALIAIREKYRAEQPLKGAKIIGCIHM
CCCCCCCCCCCEEEEEEHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHH
TIQTAVLIETLIALGAEVRWSSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYMWCIEQ
HHHHHHHHHHHHHCCCCEEECCCCEECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
TCRDGNGELWEANMILDDGGDLTGYIHETYPAMLDNIHGITEETTTGVHRLYEMLNKGTL
HHCCCCCCEEEEEEEEECCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCE
KVPAVNVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKKALVIGYGDVGKGSAQSLR
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCEEEEEECCCCCCCHHHHHH
QEGMIVKVTEADPICAMQACMDGFEVVSQYKGGINDGSEASINTDLLGNTDLLVTTTGNF
HCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCEEEEECCCC
NVCDANMLKAIKKGAVVCNIGHFDNEVDTAFMRETWEWEEVKPQVHKVWRNKAEGDFLLL
CCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCHHHHCHHHHHHHHCCCCCCEEEE
LSEGRLVNLGNATGHPSRIMDGSFANQVLAQMYLFDQGYANHSDAVKEKMLKVEVLPKKL
EECCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
DEEVARYMVEGFGGVITKLSKEQADYIGVDVNGPYKPEHYKY
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA