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The map label for this gene is livH [H]

Identifier: 110835371

GI number: 110835371

Start: 2846513

End: 2848189

Strand: Direct

Name: livH [H]

Synonym: ABO_2510

Alternate gene names: 110835371

Gene position: 2846513-2848189 (Clockwise)

Preceding gene: 110835370

Following gene: 110835372

Centisome position: 91.23

GC content: 55.22

Gene sequence:

>1677_bases
ATGGGTCGTAAATTTAGCCGAATACTGATAGCGCTGCTAATAGCACTGCAGGTCAGTGTGAGCTGGGCAGAAGAGCCACT
GCAAGAACAAACAACACCAACCCAGCCAATCACGGAGAACAGCGAGGGCGCCACTGGCATACCCACCCCTACCCTCCAAA
ACATTCTTGACCGGTTGACCAGTCGTAGCTTTGATGAAAAAGAAGCGGCTATTCGTGAACTGGCAAACCAAGACAACCCC
CGTGTTATTGCGCTACTCAACGCCTTGATGAATCGCGAACTGGTGCATAATCGAAAAGATAACAGCATCGTCTTAGGCAG
CAAGAAAGACGGTCAATGGGAACTACGCGATCCAGAAACCACCCAGCTTATTGGCCAAGTAGATAGCCGCGCTGCACGGC
CAGTGATCATCAACAACCGCTTGCGTACCGTGATCAATAACCAGCTGGCACTGGCTGCTCTGAACGACCCGGACAGCGAT
GTTCGCTATCGGGCCGCCAACCAACTGATCGGCAATGATGATCCGGAAATGCTAACAGCGCTGGCAAGCCGCCGCGCCCA
GGAAGCGGATCCTCGTGTTGCCGTACAAATTGACACCGCTCTGAATATTGCCGCCCTGCGCAGTGACGATTTGAGTACAC
GACTCAGCGCCATTGACACCCTCGCTGGCAACCTGCACCCAGACGTTAAGAATGCGTTCAATGAGCGCCTGCGTGTAACC
CAACACCCAACAGAAAAAAAGGCACTGGAAAAAGCCATCGCCCGCATCGAAGCACGTATTGAAAGGTTCCAAACCGCCGA
CACCGTGTTCTTCGGTCTGAGCCTGGGCTCGGTATTGTTACTGGCCGCCATCGGCCTGGCCATTACGTTCGGGGTGATGG
GCGTCATCAACATGGCCCATGGCGAACTGATCATGCTGGGCGCCTACACGACCTATGTAGTGCAACAACTGTTGCCCACC
AGTCACGAATGGTCACTGCTGATTGCCATTCCCGCTGCTTTTCTTGTGTCCGCCTTTGTCGGCATACTTATCGAACGCTT
TGTCATTCGCTTTCTGTATGGCCGACCACTGGAAACCCTGCTAGCGACCTTTGGGGTCAGCCTCATTTTGCAACAGGCAG
TACGGGTCATTTTCTCCCCACTGAACCGCACCGTAATTACCCCGGAATGGATGAGTGGTGCATTGGAAATCAACCCCGTG
TTCTCGCTGACCTACAACCGGCTGTACATTATCTTCTTTGCCTTGGCGGTTTTTCTAGCCCTTCTCACTTTGCTCAAGAA
AACCCGACTGGGCCTGCAAGTCCGTGCGGTCAGCCAAAATCGCGCCACCGCCCGCAGCCTCGGTATTCGCAGTGAACGGG
TCAACGCTCTCACCTTCGGGCTGGGCTCAGGCATCGCCGGAGTGGCCGGCGTCGCATTGGCACAGCTAACCAACGTGGGG
CCAAACCTGGGCCAGAGCTACATCATCGACTCCTTCATGGTTGTAGTGTTCGGCGGAGTCGGCAATCTGTGGGGCACTCT
CACTGCGGCCTTCAGCCTCGGCATTGCCAACAAATTACTGGAACCCATGGCCGGCGCGGTACTGGCCAAGATTGTGGTGC
TGGTCTTCATCATTCTGTTTATACAGCGCAAACCGCGGGGTCTGTTCCCGCAACGTGGCCGGGCGGCGGAGGAATAA

Upstream 100 bases:

>100_bases
ACATGAAGCCAGCACCAGAACAGTGGCCATCGCCTTTCACAGGCGCGCCCTCCAACGTATTGATCTGGCTTTCATTTTGA
CGCCCTGTAAGGAGCCCGTC

Downstream 100 bases:

>100_bases
CATGCGAGATTCAACATTCAAAAGCGCCTTCAGCGACCGCGCAGCAAAAACCTTTATGGGCGTGCTGTTTGGTGCCACCC
TGCTGGTGACCATACTCAAC

Product: branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MGRKFSRILIALLIALQVSVSWAEEPLQEQTTPTQPITENSEGATGIPTPTLQNILDRLTSRSFDEKEAAIRELANQDNP
RVIALLNALMNRELVHNRKDNSIVLGSKKDGQWELRDPETTQLIGQVDSRAARPVIINNRLRTVINNQLALAALNDPDSD
VRYRAANQLIGNDDPEMLTALASRRAQEADPRVAVQIDTALNIAALRSDDLSTRLSAIDTLAGNLHPDVKNAFNERLRVT
QHPTEKKALEKAIARIEARIERFQTADTVFFGLSLGSVLLLAAIGLAITFGVMGVINMAHGELIMLGAYTTYVVQQLLPT
SHEWSLLIAIPAAFLVSAFVGILIERFVIRFLYGRPLETLLATFGVSLILQQAVRVIFSPLNRTVITPEWMSGALEINPV
FSLTYNRLYIIFFALAVFLALLTLLKKTRLGLQVRAVSQNRATARSLGIRSERVNALTFGLGSGIAGVAGVALAQLTNVG
PNLGQSYIIDSFMVVVFGGVGNLWGTLTAAFSLGIANKLLEPMAGAVLAKIVVLVFIILFIQRKPRGLFPQRGRAAEE

Sequences:

>Translated_558_residues
MGRKFSRILIALLIALQVSVSWAEEPLQEQTTPTQPITENSEGATGIPTPTLQNILDRLTSRSFDEKEAAIRELANQDNP
RVIALLNALMNRELVHNRKDNSIVLGSKKDGQWELRDPETTQLIGQVDSRAARPVIINNRLRTVINNQLALAALNDPDSD
VRYRAANQLIGNDDPEMLTALASRRAQEADPRVAVQIDTALNIAALRSDDLSTRLSAIDTLAGNLHPDVKNAFNERLRVT
QHPTEKKALEKAIARIEARIERFQTADTVFFGLSLGSVLLLAAIGLAITFGVMGVINMAHGELIMLGAYTTYVVQQLLPT
SHEWSLLIAIPAAFLVSAFVGILIERFVIRFLYGRPLETLLATFGVSLILQQAVRVIFSPLNRTVITPEWMSGALEINPV
FSLTYNRLYIIFFALAVFLALLTLLKKTRLGLQVRAVSQNRATARSLGIRSERVNALTFGLGSGIAGVAGVALAQLTNVG
PNLGQSYIIDSFMVVVFGGVGNLWGTLTAAFSLGIANKLLEPMAGAVLAKIVVLVFIILFIQRKPRGLFPQRGRAAEE
>Mature_557_residues
GRKFSRILIALLIALQVSVSWAEEPLQEQTTPTQPITENSEGATGIPTPTLQNILDRLTSRSFDEKEAAIRELANQDNPR
VIALLNALMNRELVHNRKDNSIVLGSKKDGQWELRDPETTQLIGQVDSRAARPVIINNRLRTVINNQLALAALNDPDSDV
RYRAANQLIGNDDPEMLTALASRRAQEADPRVAVQIDTALNIAALRSDDLSTRLSAIDTLAGNLHPDVKNAFNERLRVTQ
HPTEKKALEKAIARIEARIERFQTADTVFFGLSLGSVLLLAAIGLAITFGVMGVINMAHGELIMLGAYTTYVVQQLLPTS
HEWSLLIAIPAAFLVSAFVGILIERFVIRFLYGRPLETLLATFGVSLILQQAVRVIFSPLNRTVITPEWMSGALEINPVF
SLTYNRLYIIFFALAVFLALLTLLKKTRLGLQVRAVSQNRATARSLGIRSERVNALTFGLGSGIAGVAGVALAQLTNVGP
NLGQSYIIDSFMVVVFGGVGNLWGTLTAAFSLGIANKLLEPMAGAVLAKIVVLVFIILFIQRKPRGLFPQRGRAAEE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=291, Percent_Identity=30.9278350515464, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 61004; Mature: 60873

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRKFSRILIALLIALQVSVSWAEEPLQEQTTPTQPITENSEGATGIPTPTLQNILDRLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SRSFDEKEAAIRELANQDNPRVIALLNALMNRELVHNRKDNSIVLGSKKDGQWELRDPET
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCHH
TQLIGQVDSRAARPVIINNRLRTVINNQLALAALNDPDSDVRYRAANQLIGNDDPEMLTA
HHHHHHHHHHCCCCEEECCHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHH
LASRRAQEADPRVAVQIDTALNIAALRSDDLSTRLSAIDTLAGNLHPDVKNAFNERLRVT
HHHHHHHCCCCCEEEEECCHHEEHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
QHPTEKKALEKAIARIEARIERFQTADTVFFGLSLGSVLLLAAIGLAITFGVMGVINMAH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GELIMLGAYTTYVVQQLLPTSHEWSLLIAIPAAFLVSAFVGILIERFVIRFLYGRPLETL
CCEEEEHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LATFGVSLILQQAVRVIFSPLNRTVITPEWMSGALEINPVFSLTYNRLYIIFFALAVFLA
HHHHHHHHHHHHHHHHHHHHHCCCEECHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHH
LLTLLKKTRLGLQVRAVSQNRATARSLGIRSERVNALTFGLGSGIAGVAGVALAQLTNVG
HHHHHHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHEEECCCCHHHHHHHHHHHHHHCC
PNLGQSYIIDSFMVVVFGGVGNLWGTLTAAFSLGIANKLLEPMAGAVLAKIVVLVFIILF
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQRKPRGLFPQRGRAAEE
HHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GRKFSRILIALLIALQVSVSWAEEPLQEQTTPTQPITENSEGATGIPTPTLQNILDRLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SRSFDEKEAAIRELANQDNPRVIALLNALMNRELVHNRKDNSIVLGSKKDGQWELRDPET
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCHH
TQLIGQVDSRAARPVIINNRLRTVINNQLALAALNDPDSDVRYRAANQLIGNDDPEMLTA
HHHHHHHHHHCCCCEEECCHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHH
LASRRAQEADPRVAVQIDTALNIAALRSDDLSTRLSAIDTLAGNLHPDVKNAFNERLRVT
HHHHHHHCCCCCEEEEECCHHEEHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
QHPTEKKALEKAIARIEARIERFQTADTVFFGLSLGSVLLLAAIGLAITFGVMGVINMAH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GELIMLGAYTTYVVQQLLPTSHEWSLLIAIPAAFLVSAFVGILIERFVIRFLYGRPLETL
CCEEEEHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LATFGVSLILQQAVRVIFSPLNRTVITPEWMSGALEINPVFSLTYNRLYIIFFALAVFLA
HHHHHHHHHHHHHHHHHHHHHCCCEECHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHH
LLTLLKKTRLGLQVRAVSQNRATARSLGIRSERVNALTFGLGSGIAGVAGVALAQLTNVG
HHHHHHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHEEECCCCHHHHHHHHHHHHHHCC
PNLGQSYIIDSFMVVVFGGVGNLWGTLTAAFSLGIANKLLEPMAGAVLAKIVVLVFIILF
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQRKPRGLFPQRGRAAEE
HHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]