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The map label for this gene is qor [C]

Identifier: 110835344

GI number: 110835344

Start: 2816365

End: 2817375

Strand: Direct

Name: qor [C]

Synonym: ABO_2483

Alternate gene names: 110835344

Gene position: 2816365-2817375 (Clockwise)

Preceding gene: 110835341

Following gene: 110835347

Centisome position: 90.26

GC content: 59.55

Gene sequence:

>1011_bases
ATGAAAGCCATTGGATTCAATCGGCCCAGAGCCATAGAAGATGTACACGCCCTGGAGGACATCCAGCTGGACCTTCCCTC
GCCCGCCCCCCGGGACCTACTGGTGGCCGTACACGCTATCTCGGTCAACCCCATTGATACCAAGCTTCGCCAACGCCCCC
TGGAGCAGCCCGGTTACCGGGTACTGGGGTTTGATGCTGCCGGCGTGGTGGAAGCGGTGGGCGAGGAAGTGGAAAACTTC
AACGTCGGCGACCGGGTCTGGTATGCCGGCGCCGTGCAACGCCAGGGCAGCAATGCCCAGTACCAGTGTGTTGATGAACG
GCTAGTGGCAAAAAAACCGAATAGCCTGGGCATGCAAGAAGCGGCTGCACTCCCCCTCACCACACTAACCGCCTGGGAGG
CCCTGGAAGATCAGCTCGGTTTTCAAGCCGGAGAGTGTGAGGGGAAAAGTGTGCTGGTGATCGGTGGCGCAGGAGGAGTG
GGGTCCATCGCTATCCAGCTAGCCGCCCACTATTTTGGTCTTAAGGTGATCACCACTGCGGGTCGCGAAACCTCTGCCAA
CTGGTGTCAAAGCCTCGGCGCTCATCATATCGTGGACTACCGCAAGCCATTACTAGCACAGCTGGACGCCATTGGTTGCC
CGCAGATTGACGGCATCTTCATTACCCAAAATCTGGACGACTATTGGGCCACTGCCTGCCAAGCCGTCGCACCGCTGGGA
GGCATCTGCGCTATCGTCGACGCCCGTGCGCCTCTCGACCTGAACCCCCTTAAGGCCAAGAGCGCGCGCTTCAGCTGGGA
ATTCATGTTCACCCGCGCCATGTTCGCTACCGACATGCAGCATCAAGGCGACATCCTTACCCGGCTCAGCGAACTAGTGG
ATCAAGGCACAGTCCAGACCACCGTCAGCGAAGGCCTGGGCACCATTAATGCCGCCAACCTGAAAGAAGCCCACCGGCGG
CTGGAGTCTGGCAACACAGTGGGGAAACTGGTTCTTGCTGGCTGGGACTAA

Upstream 100 bases:

>100_bases
CGATCAATCCATACTGTGGCATAGTCTGCGCAGCCAAGTATGCTTAATCATTGTGAACAGCATTTGAAAGAATACGTTAG
CGATCCACGAGGGAGCCAGA

Downstream 100 bases:

>100_bases
CCCCGATAATGCCCGGGTTGAATGGCTCTGCCACCATCACCAGCGACGAAAGAAACCGTTACAGCCGCATCCATGAGCGC
CTTTACTGTGGGATTAACGG

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKAIGFNRPRAIEDVHALEDIQLDLPSPAPRDLLVAVHAISVNPIDTKLRQRPLEQPGYRVLGFDAAGVVEAVGEEVENF
NVGDRVWYAGAVQRQGSNAQYQCVDERLVAKKPNSLGMQEAAALPLTTLTAWEALEDQLGFQAGECEGKSVLVIGGAGGV
GSIAIQLAAHYFGLKVITTAGRETSANWCQSLGAHHIVDYRKPLLAQLDAIGCPQIDGIFITQNLDDYWATACQAVAPLG
GICAIVDARAPLDLNPLKAKSARFSWEFMFTRAMFATDMQHQGDILTRLSELVDQGTVQTTVSEGLGTINAANLKEAHRR
LESGNTVGKLVLAGWD

Sequences:

>Translated_336_residues
MKAIGFNRPRAIEDVHALEDIQLDLPSPAPRDLLVAVHAISVNPIDTKLRQRPLEQPGYRVLGFDAAGVVEAVGEEVENF
NVGDRVWYAGAVQRQGSNAQYQCVDERLVAKKPNSLGMQEAAALPLTTLTAWEALEDQLGFQAGECEGKSVLVIGGAGGV
GSIAIQLAAHYFGLKVITTAGRETSANWCQSLGAHHIVDYRKPLLAQLDAIGCPQIDGIFITQNLDDYWATACQAVAPLG
GICAIVDARAPLDLNPLKAKSARFSWEFMFTRAMFATDMQHQGDILTRLSELVDQGTVQTTVSEGLGTINAANLKEAHRR
LESGNTVGKLVLAGWD
>Mature_336_residues
MKAIGFNRPRAIEDVHALEDIQLDLPSPAPRDLLVAVHAISVNPIDTKLRQRPLEQPGYRVLGFDAAGVVEAVGEEVENF
NVGDRVWYAGAVQRQGSNAQYQCVDERLVAKKPNSLGMQEAAALPLTTLTAWEALEDQLGFQAGECEGKSVLVIGGAGGV
GSIAIQLAAHYFGLKVITTAGRETSANWCQSLGAHHIVDYRKPLLAQLDAIGCPQIDGIFITQNLDDYWATACQAVAPLG
GICAIVDARAPLDLNPLKAKSARFSWEFMFTRAMFATDMQHQGDILTRLSELVDQGTVQTTVSEGLGTINAANLKEAHRR
LESGNTVGKLVLAGWD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=339, Percent_Identity=29.7935103244838, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI194239674, Length=249, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13236495, Length=249, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI194239676, Length=190, Percent_Identity=36.3157894736842, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI22538446, Length=344, Percent_Identity=26.7441860465116, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI22538444, Length=344, Percent_Identity=26.7441860465116, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI24308257, Length=218, Percent_Identity=28.8990825688073, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790485, Length=334, Percent_Identity=26.9461077844311, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=186, Percent_Identity=36.0215053763441, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71987554, Length=178, Percent_Identity=33.1460674157303, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36184; Mature: 36184

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIGFNRPRAIEDVHALEDIQLDLPSPAPRDLLVAVHAISVNPIDTKLRQRPLEQPGYR
CCCCCCCCCCHHHHHHHHHHCEEECCCCCCHHHEEEEEEEECCCHHHHHHHCCCCCCCCE
VLGFDAAGVVEAVGEEVENFNVGDRVWYAGAVQRQGSNAQYQCVDERLVAKKPNSLGMQE
EEECCHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCEEEHHHHHHHCCCCCCCCHH
AAALPLTTLTAWEALEDQLGFQAGECEGKSVLVIGGAGGVGSIAIQLAAHYFGLKVITTA
HHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCEEEEEEC
GRETSANWCQSLGAHHIVDYRKPLLAQLDAIGCPQIDGIFITQNLDDYWATACQAVAPLG
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCC
GICAIVDARAPLDLNPLKAKSARFSWEFMFTRAMFATDMQHQGDILTRLSELVDQGTVQT
CEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCHHCCHHHHHHHHHHHCCCHHH
TVSEGLGTINAANLKEAHRRLESGNTVGKLVLAGWD
HHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MKAIGFNRPRAIEDVHALEDIQLDLPSPAPRDLLVAVHAISVNPIDTKLRQRPLEQPGYR
CCCCCCCCCCHHHHHHHHHHCEEECCCCCCHHHEEEEEEEECCCHHHHHHHCCCCCCCCE
VLGFDAAGVVEAVGEEVENFNVGDRVWYAGAVQRQGSNAQYQCVDERLVAKKPNSLGMQE
EEECCHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCEEEHHHHHHHCCCCCCCCHH
AAALPLTTLTAWEALEDQLGFQAGECEGKSVLVIGGAGGVGSIAIQLAAHYFGLKVITTA
HHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCEEEEEEC
GRETSANWCQSLGAHHIVDYRKPLLAQLDAIGCPQIDGIFITQNLDDYWATACQAVAPLG
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCC
GICAIVDARAPLDLNPLKAKSARFSWEFMFTRAMFATDMQHQGDILTRLSELVDQGTVQT
CEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCHHCCHHHHHHHHHHHCCCHHH
TVSEGLGTINAANLKEAHRRLESGNTVGKLVLAGWD
HHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA