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The map label for this gene is czcD2 [H]

Identifier: 110835338

GI number: 110835338

Start: 2807936

End: 2808880

Strand: Direct

Name: czcD2 [H]

Synonym: ABO_2477

Alternate gene names: 110835338

Gene position: 2807936-2808880 (Clockwise)

Preceding gene: 110835337

Following gene: 110835340

Centisome position: 89.99

GC content: 53.44

Gene sequence:

>945_bases
ATGCATGGTCACAGGCTCGAAGAATGGCAACACAATCATGTTTTTGGTCAAGATCGTAAAAAATCCGGTGAAATACGCTC
ACTGATCGTCGTCGCTCTAACTGTCGTAATGATGGTGTGGGAAATTCTGGCAGGCATTATTTATGGCTCGATGGCCCTCC
TGGCCGACGGCCTTCATATGGGCTCTCATGCTGTCGCTCTCGGTATTGCAGCCTTCGCCTATGCATACGCTCGCCGCAAC
GCAGGCAATACACAGTTTTCATTTGGCACCGGGAAGGTCAATGCGCTGGGCGGGTTCACCGGCGCGGTCCTACTGGCAGG
CTTCGCCCTGTATATGGTCATTGAAAGCATCGACCGTTTCATTCATCCGGTCGAAATTTCGTTCAATGGAGCCATTTTTG
TCGCCATCATCGGCTTGATCGTCAATGGAGTATCGGCCTGGATCCTGGGCGGGGAAGACCACGACCATGGGCATGGGCAT
GGGCATGGGCATGGGCACCATGATCATAACCGTCGAGCGGCCTACTTCCACGTACTCGCCGATGCCTTAACTTCGGTATT
GGCGATTGCTGCCTTGCTGGCCGGAAAGTATGCGGGCTGGAACTGGATGGACCCAATCATGGGTATCGTCGGTGCGTTAC
TTATTACCCGCTGGTCATGGCATCTATTGAAGGACACTTCCTGCGTGCTGCTTGATAAACAGCGCAGCGACTTGGAGCAC
GACGTCAGGCAATCCATCGAGAATGGCGATGCCCGAATTAGCGATCTGCACCTCTGGGCCATTGGACCAAATATTCACGC
CGCCATTGTCTCGATCGTTTCGCATGCTCCTGATTCGCCTGCCGTTTATAGGCAACGCATTCAGGCTAGGTGCCCGTCAT
TAGTACACGTTACTGTCGAGCCCCAGCGTTGTATTAATGAAACGAGGGAAACCAACGCCGGATAA

Upstream 100 bases:

>100_bases
TCTTGCGGAACCGGATCTGTTAGCAGGACTACGCCATCAATCGCCACCACTTTCATTGGCCTTGCTGACCATAATTTTTA
TCAACTCGGAGTATTACAGT

Downstream 100 bases:

>100_bases
AGAGATTTCGTGGCTCCAGCCCATTGTGGAGCCTCGAAAAAAAACTTACAGTTGACCGTATAAAATCCATGCGCCCACTG
CAATCAGCGTTAGTCCGCCA

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGIIYGSMALLADGLHMGSHAVALGIAAFAYAYARRN
AGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRFIHPVEISFNGAIFVAIIGLIVNGVSAWILGGEDHDHGHGH
GHGHGHHDHNRRAAYFHVLADALTSVLAIAALLAGKYAGWNWMDPIMGIVGALLITRWSWHLLKDTSCVLLDKQRSDLEH
DVRQSIENGDARISDLHLWAIGPNIHAAIVSIVSHAPDSPAVYRQRIQARCPSLVHVTVEPQRCINETRETNAG

Sequences:

>Translated_314_residues
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGIIYGSMALLADGLHMGSHAVALGIAAFAYAYARRN
AGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRFIHPVEISFNGAIFVAIIGLIVNGVSAWILGGEDHDHGHGH
GHGHGHHDHNRRAAYFHVLADALTSVLAIAALLAGKYAGWNWMDPIMGIVGALLITRWSWHLLKDTSCVLLDKQRSDLEH
DVRQSIENGDARISDLHLWAIGPNIHAAIVSIVSHAPDSPAVYRQRIQARCPSLVHVTVEPQRCINETRETNAG
>Mature_314_residues
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGIIYGSMALLADGLHMGSHAVALGIAAFAYAYARRN
AGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRFIHPVEISFNGAIFVAIIGLIVNGVSAWILGGEDHDHGHGH
GHGHGHHDHNRRAAYFHVLADALTSVLAIAALLAGKYAGWNWMDPIMGIVGALLITRWSWHLLKDTSCVLLDKQRSDLEH
DVRQSIENGDARISDLHLWAIGPNIHAAIVSIVSHAPDSPAVYRQRIQARCPSLVHVTVEPQRCINETRETNAG

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=308, Percent_Identity=26.2987012987013, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI222080086, Length=330, Percent_Identity=22.1212121212121, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI40255009, Length=330, Percent_Identity=22.1212121212121, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI21359890, Length=307, Percent_Identity=25.4071661237785, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI52352805, Length=292, Percent_Identity=25, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI52352803, Length=118, Percent_Identity=33.8983050847458, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786966, Length=267, Percent_Identity=31.4606741573034, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32564488, Length=281, Percent_Identity=28.4697508896797, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17555794, Length=308, Percent_Identity=27.5974025974026, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555796, Length=301, Percent_Identity=27.906976744186, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193210990, Length=245, Percent_Identity=26.530612244898, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=144, Percent_Identity=30.5555555555556, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=188, Percent_Identity=30.8510638297872, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24645863, Length=280, Percent_Identity=23.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656728, Length=296, Percent_Identity=26.3513513513513, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24656724, Length=296, Percent_Identity=26.3513513513513, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24656720, Length=296, Percent_Identity=26.3513513513513, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24656715, Length=296, Percent_Identity=26.3513513513513, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357035, Length=296, Percent_Identity=26.3513513513513, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34259; Mature: 34259

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGIIYGSMALLADGLHM
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSHAVALGIAAFAYAYARRNAGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRF
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHH
IHPVEISFNGAIFVAIIGLIVNGVSAWILGGEDHDHGHGHGHGHGHHDHNRRAAYFHVLA
HCCEEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
DALTSVLAIAALLAGKYAGWNWMDPIMGIVGALLITRWSWHLLKDTSCVLLDKQRSDLEH
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHH
DVRQSIENGDARISDLHLWAIGPNIHAAIVSIVSHAPDSPAVYRQRIQARCPSLVHVTVE
HHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEC
PQRCINETRETNAG
HHHHHHHHHCCCCC
>Mature Secondary Structure
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGIIYGSMALLADGLHM
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSHAVALGIAAFAYAYARRNAGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRF
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHH
IHPVEISFNGAIFVAIIGLIVNGVSAWILGGEDHDHGHGHGHGHGHHDHNRRAAYFHVLA
HCCEEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
DALTSVLAIAALLAGKYAGWNWMDPIMGIVGALLITRWSWHLLKDTSCVLLDKQRSDLEH
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHH
DVRQSIENGDARISDLHLWAIGPNIHAAIVSIVSHAPDSPAVYRQRIQARCPSLVHVTVE
HHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEC
PQRCINETRETNAG
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA