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The map label for this gene is czcD [H]

Identifier: 110835331

GI number: 110835331

Start: 2798266

End: 2799222

Strand: Direct

Name: czcD [H]

Synonym: ABO_2470

Alternate gene names: 110835331

Gene position: 2798266-2799222 (Clockwise)

Preceding gene: 110835330

Following gene: 110835337

Centisome position: 89.68

GC content: 55.59

Gene sequence:

>957_bases
ATGCATGGTCACAGGCTCGAAGAATGGCAACACAATCATGTTTTTGGTCAAGATCGTAAAAAATCCGGTGAAATACGCTC
ACTGATCGTCGTCGCTCTAACTGTCGTCATGATGGTTTGGGAAATTCTGGCCGGTGTCTTATACGGTTCGATGGCCCTCC
TGGCCGATGGCCTTCATATGGGCTCTCATGCTGTCGCTCTGGGTATTGCAGCCTTCGCCTATGCATACGCTCGCCGCAAC
GCAGGCAATACACAGTTCTCATTTGGCACCGGGAAGGTCAATGCGCTAGGCGGGTTCACCGGCGCGGTCCTGCTGGCAGG
CTTCGCCCTGTATATGGTGATCGAAAGCATCGACCGCTTCATCCACCCGGTAGAAATTTCGTTCAATGGAGCTATTTTCG
TCGCCGTCATCGGCTTGATCGTCAATGGAGTATCGGCCTGGATACTGGGCGGGGAAGACCACGACCACGGGCATGGGCAT
GGGCATGGGCATGGGCATGGGCATCATGATCATAACCGTCGAGCTGCCTACTTCCACGTACTCGCCGATGCCTTAACTTC
TGTATTGGCGATTGCTGCCTTGCTGGCCGGAAAGTATGCGGGCTGGGACTGGATGGACCCGATCATGGGTATCGTCGGCG
CGTTACTTATCACTCGCTGGTCATGGCATCTGTTGAAAGACACCTCCCGCGTGCTGCTTGATCAACAGCGCAGTGACTTG
GAGCACGACGTCAGACATGCCATTGAGAGTGACGATGCACGAATCAGCGATCTGCACCTCTGGGCCATTGGTCCGAATAT
TCACGCCGCCATCGTCTCGGTCGTGTCGCATGACCCGGAGGCGCCTGCCGTCTACAAGCAGCGTATCCAGGCTCAGTGCC
CGTCATTAGTACACATTACAGTCGAGCCACAGCGCTGTCTCACTGGTCCGGAGAATACCGGCTCCAGGATACGATGA

Upstream 100 bases:

>100_bases
TCTTGCGGAACCGGAGCTGTTAGCAGGGCTTCGCCATCAATCGCCACCACTTTCATTGGTCTTGCTGACCATAATTTTTA
TCAACTCGGAGTATTACAGT

Downstream 100 bases:

>100_bases
GCTGATTGAGCGGGCTGGGCCGAAATAGTCGGTTTTGGTACGGGCGAGGGAGTTGCTCTGCATTCAGCTTGGCCTCGCCC
TCTCTCCAAGCCATGTAAGT

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGVLYGSMALLADGLHMGSHAVALGIAAFAYAYARRN
AGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRFIHPVEISFNGAIFVAVIGLIVNGVSAWILGGEDHDHGHGH
GHGHGHGHHDHNRRAAYFHVLADALTSVLAIAALLAGKYAGWDWMDPIMGIVGALLITRWSWHLLKDTSRVLLDQQRSDL
EHDVRHAIESDDARISDLHLWAIGPNIHAAIVSVVSHDPEAPAVYKQRIQAQCPSLVHITVEPQRCLTGPENTGSRIR

Sequences:

>Translated_318_residues
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGVLYGSMALLADGLHMGSHAVALGIAAFAYAYARRN
AGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRFIHPVEISFNGAIFVAVIGLIVNGVSAWILGGEDHDHGHGH
GHGHGHGHHDHNRRAAYFHVLADALTSVLAIAALLAGKYAGWDWMDPIMGIVGALLITRWSWHLLKDTSRVLLDQQRSDL
EHDVRHAIESDDARISDLHLWAIGPNIHAAIVSVVSHDPEAPAVYKQRIQAQCPSLVHITVEPQRCLTGPENTGSRIR
>Mature_318_residues
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGVLYGSMALLADGLHMGSHAVALGIAAFAYAYARRN
AGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRFIHPVEISFNGAIFVAVIGLIVNGVSAWILGGEDHDHGHGH
GHGHGHGHHDHNRRAAYFHVLADALTSVLAIAALLAGKYAGWDWMDPIMGIVGALLITRWSWHLLKDTSRVLLDQQRSDL
EHDVRHAIESDDARISDLHLWAIGPNIHAAIVSVVSHDPEAPAVYKQRIQAQCPSLVHITVEPQRCLTGPENTGSRIR

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=311, Percent_Identity=28.2958199356913, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI222080086, Length=335, Percent_Identity=21.7910447761194, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40255009, Length=335, Percent_Identity=21.7910447761194, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI21359890, Length=273, Percent_Identity=26.3736263736264, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI52352805, Length=292, Percent_Identity=25.6849315068493, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI52352803, Length=118, Percent_Identity=34.7457627118644, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=261, Percent_Identity=32.9501915708812, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI32564488, Length=281, Percent_Identity=28.8256227758007, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17555794, Length=312, Percent_Identity=27.5641025641026, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17555796, Length=291, Percent_Identity=28.5223367697594, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193210990, Length=245, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17550440, Length=190, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17550442, Length=190, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=145, Percent_Identity=31.7241379310345, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=191, Percent_Identity=31.413612565445, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324892, Length=135, Percent_Identity=28.1481481481481, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24645863, Length=279, Percent_Identity=23.6559139784946, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656728, Length=296, Percent_Identity=26.0135135135135, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656724, Length=296, Percent_Identity=26.0135135135135, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656720, Length=296, Percent_Identity=26.0135135135135, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656715, Length=296, Percent_Identity=26.0135135135135, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357035, Length=296, Percent_Identity=26.0135135135135, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34685; Mature: 34685

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGVLYGSMALLADGLHM
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSHAVALGIAAFAYAYARRNAGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRF
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHH
IHPVEISFNGAIFVAVIGLIVNGVSAWILGGEDHDHGHGHGHGHGHGHHDHNRRAAYFHV
HCCEEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
LADALTSVLAIAALLAGKYAGWDWMDPIMGIVGALLITRWSWHLLKDTSRVLLDQQRSDL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHDVRHAIESDDARISDLHLWAIGPNIHAAIVSVVSHDPEAPAVYKQRIQAQCPSLVHIT
HHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEE
VEPQRCLTGPENTGSRIR
ECHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHGHRLEEWQHNHVFGQDRKKSGEIRSLIVVALTVVMMVWEILAGVLYGSMALLADGLHM
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSHAVALGIAAFAYAYARRNAGNTQFSFGTGKVNALGGFTGAVLLAGFALYMVIESIDRF
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHH
IHPVEISFNGAIFVAVIGLIVNGVSAWILGGEDHDHGHGHGHGHGHGHHDHNRRAAYFHV
HCCEEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
LADALTSVLAIAALLAGKYAGWDWMDPIMGIVGALLITRWSWHLLKDTSRVLLDQQRSDL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHDVRHAIESDDARISDLHLWAIGPNIHAAIVSVVSHDPEAPAVYKQRIQAQCPSLVHIT
HHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEE
VEPQRCLTGPENTGSRIR
ECHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA