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The map label for this gene is maeB [H]

Identifier: 110835100

GI number: 110835100

Start: 2558154

End: 2559428

Strand: Reverse

Name: maeB [H]

Synonym: ABO_2239

Alternate gene names: 110835100

Gene position: 2559428-2558154 (Counterclockwise)

Preceding gene: 110835101

Following gene: 110835098

Centisome position: 82.03

GC content: 54.98

Gene sequence:

>1275_bases
ATGTCCGAGGATTTAAAAACGGCGGCCCTGGAATACCACGCCAAACCGCGGCCGGGGAAAATTAGCGTCGAGGTAACCAA
GCCGGCGGCGACCAGTCGAGATCTGAGCCTGGCCTATAGCCCAGGTGTAGCTGAACCGGTGCGAGAAATCGCGCGGGAGC
CGGAGCTGGCCTACCGTTTTACTTCCAAGGGCAACCTGGTAGCCGTAATTAGTGATGGCACGGCGATTCTTGGTCTTGGC
AATCTGGGCGCGCTAGCCTCCAAGCCGGTGATGGAAGGTAAGGGCATTCTGTTCAAGTTGTTTGCGGGTATCGATGTGTT
CGATATCGAAGTGGACTCTGAGGATTCCCAGGCTTTTATTGATACGGTAATGCGTATTCATCGCACCTTCGGTGGCATCA
ATCTGGAAGATATCCGTGCGCCGGAGTGTTTCGAGATTGAGCGTATTCTCAAAGAACAGTGCGAAGTTCCCGTATTCCAT
GATGACCAGCACGGCACCGCTATTGTGGTGGGGGCAGGTTTGATTAATGCGCTGGAAATTCAAAACAAGCGTATCGAAGA
CATCAAGGTAGTGTGTGTCGGGGCTGGTGCGGCGGGTATCGCATCTGTGCGGTTGTTGATCGAGATGGGCGCGCGCAAGG
AAAATATTCTGGTGTTGGATCGTAAGGGGGTGATTCATAGCCGCCGTGATGATCTGAACCAGTACAAGGCTGCGCTGGCC
AACGATACGGATAAGCGCACATTGAACGATGCTGTGGAAGACGCGGATGTGTTCATCGGCGTTTCCGGGCCGGATATGTT
GACCCCAGAAATGGTCAAGAAGATGGCTCCCAAGCCGATCATCTTCGCGTTGGCTAACCCGGATCCGGAAATTCGTCCGG
AAGTGGCCAAGGCGGCACGTCCGGATGCGATTGTGGCGACGGGTCGTTCGGATTTCCCGAACCAAGTAAACAATGTGCTG
TGTTTCCCGTACATGTTTCGTGGGGCTTTGGATGTGCGCTCCACGTCCATCACTGAAGAAATGAAGATCGCCGCAGTGCA
TGCTATTGCCGGGCTGGTGCGAACGGCGCCCCCGCAGGAAGTGCTGGATGCCTACGGTGGTGAGCCGTTGACCTTCGGGC
CGGAATATATCATTCCCAAGCCGAATGATCCGCGTTTGTTGGGCAAGGTTTCTGCTGCTGTGGCCCAGGCAGCGGTGGAT
TGTGGTGTGGCCCGTAAGGGATACCCATCACACTACCCGCTAAACTCGCTGGACGAGATTTTCCCAGAACTTTAA

Upstream 100 bases:

>100_bases
CGTTACAGCGCCTATTGTAAAAAGCACCCAACTGGGTGCTTTTTACGTTAAGTACTTGCGTACACAGTGTATATCCCAAA
AAAGGGAAGCGGAGACCAGC

Downstream 100 bases:

>100_bases
GGGAGCAGTGCCAGCCATAAAAAAACCGCCTTTCGGCGGTTTTTTTATGGCTGCTCATTTCTGTTTCAGCACAGCACAGC
ACAGCAGAGCAGAGTTGTAC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSEDLKTAALEYHAKPRPGKISVEVTKPAATSRDLSLAYSPGVAEPVREIAREPELAYRFTSKGNLVAVISDGTAILGLG
NLGALASKPVMEGKGILFKLFAGIDVFDIEVDSEDSQAFIDTVMRIHRTFGGINLEDIRAPECFEIERILKEQCEVPVFH
DDQHGTAIVVGAGLINALEIQNKRIEDIKVVCVGAGAAGIASVRLLIEMGARKENILVLDRKGVIHSRRDDLNQYKAALA
NDTDKRTLNDAVEDADVFIGVSGPDMLTPEMVKKMAPKPIIFALANPDPEIRPEVAKAARPDAIVATGRSDFPNQVNNVL
CFPYMFRGALDVRSTSITEEMKIAAVHAIAGLVRTAPPQEVLDAYGGEPLTFGPEYIIPKPNDPRLLGKVSAAVAQAAVD
CGVARKGYPSHYPLNSLDEIFPEL

Sequences:

>Translated_424_residues
MSEDLKTAALEYHAKPRPGKISVEVTKPAATSRDLSLAYSPGVAEPVREIAREPELAYRFTSKGNLVAVISDGTAILGLG
NLGALASKPVMEGKGILFKLFAGIDVFDIEVDSEDSQAFIDTVMRIHRTFGGINLEDIRAPECFEIERILKEQCEVPVFH
DDQHGTAIVVGAGLINALEIQNKRIEDIKVVCVGAGAAGIASVRLLIEMGARKENILVLDRKGVIHSRRDDLNQYKAALA
NDTDKRTLNDAVEDADVFIGVSGPDMLTPEMVKKMAPKPIIFALANPDPEIRPEVAKAARPDAIVATGRSDFPNQVNNVL
CFPYMFRGALDVRSTSITEEMKIAAVHAIAGLVRTAPPQEVLDAYGGEPLTFGPEYIIPKPNDPRLLGKVSAAVAQAAVD
CGVARKGYPSHYPLNSLDEIFPEL
>Mature_423_residues
SEDLKTAALEYHAKPRPGKISVEVTKPAATSRDLSLAYSPGVAEPVREIAREPELAYRFTSKGNLVAVISDGTAILGLGN
LGALASKPVMEGKGILFKLFAGIDVFDIEVDSEDSQAFIDTVMRIHRTFGGINLEDIRAPECFEIERILKEQCEVPVFHD
DQHGTAIVVGAGLINALEIQNKRIEDIKVVCVGAGAAGIASVRLLIEMGARKENILVLDRKGVIHSRRDDLNQYKAALAN
DTDKRTLNDAVEDADVFIGVSGPDMLTPEMVKKMAPKPIIFALANPDPEIRPEVAKAARPDAIVATGRSDFPNQVNNVLC
FPYMFRGALDVRSTSITEEMKIAAVHAIAGLVRTAPPQEVLDAYGGEPLTFGPEYIIPKPNDPRLLGKVSAAVAQAAVDC
GVARKGYPSHYPLNSLDEIFPEL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=346, Percent_Identity=26.5895953757225, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI62420882, Length=343, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI62420880, Length=343, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI239049447, Length=343, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4505145, Length=346, Percent_Identity=26.878612716763, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788806, Length=408, Percent_Identity=61.0294117647059, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI87081919, Length=291, Percent_Identity=26.4604810996564, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17537199, Length=343, Percent_Identity=28.8629737609329, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=33.0543933054393, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI78707242, Length=341, Percent_Identity=26.9794721407625, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI78707238, Length=341, Percent_Identity=26.9794721407625, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI78707240, Length=341, Percent_Identity=26.9794721407625, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646388, Length=346, Percent_Identity=28.9017341040462, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646386, Length=346, Percent_Identity=28.9017341040462, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281362674, Length=349, Percent_Identity=27.2206303724928, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356279, Length=349, Percent_Identity=27.2206303724928, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362672, Length=349, Percent_Identity=27.2206303724928, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 45799; Mature: 45668

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDLKTAALEYHAKPRPGKISVEVTKPAATSRDLSLAYSPGVAEPVREIAREPELAYRF
CCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHCCCCEEEEE
TSKGNLVAVISDGTAILGLGNLGALASKPVMEGKGILFKLFAGIDVFDIEVDSEDSQAFI
ECCCCEEEEEECCEEEEEECCCCCHHCCCCCCCCCCEEEHCCCCEEEEEEECCCCHHHHH
DTVMRIHRTFGGINLEDIRAPECFEIERILKEQCEVPVFHDDQHGTAIVVGAGLINALEI
HHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCEEEEECCHHHHHHH
QNKRIEDIKVVCVGAGAAGIASVRLLIEMGARKENILVLDRKGVIHSRRDDLNQYKAALA
CCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHC
NDTDKRTLNDAVEDADVFIGVSGPDMLTPEMVKKMAPKPIIFALANPDPEIRPEVAKAAR
CCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCC
PDAIVATGRSDFPNQVNNVLCFPYMFRGALDVRSTSITEEMKIAAVHAIAGLVRTAPPQE
CCEEEECCCCCCCHHHHCEEEEHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
VLDAYGGEPLTFGPEYIIPKPNDPRLLGKVSAAVAQAAVDCGVARKGYPSHYPLNSLDEI
HHHHHCCCCEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
FPEL
HCCC
>Mature Secondary Structure 
SEDLKTAALEYHAKPRPGKISVEVTKPAATSRDLSLAYSPGVAEPVREIAREPELAYRF
CCCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHCCCCEEEEE
TSKGNLVAVISDGTAILGLGNLGALASKPVMEGKGILFKLFAGIDVFDIEVDSEDSQAFI
ECCCCEEEEEECCEEEEEECCCCCHHCCCCCCCCCCEEEHCCCCEEEEEEECCCCHHHHH
DTVMRIHRTFGGINLEDIRAPECFEIERILKEQCEVPVFHDDQHGTAIVVGAGLINALEI
HHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCEEEEECCHHHHHHH
QNKRIEDIKVVCVGAGAAGIASVRLLIEMGARKENILVLDRKGVIHSRRDDLNQYKAALA
CCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHC
NDTDKRTLNDAVEDADVFIGVSGPDMLTPEMVKKMAPKPIIFALANPDPEIRPEVAKAAR
CCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCC
PDAIVATGRSDFPNQVNNVLCFPYMFRGALDVRSTSITEEMKIAAVHAIAGLVRTAPPQE
CCEEEECCCCCCCHHHHCEEEEHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
VLDAYGGEPLTFGPEYIIPKPNDPRLLGKVSAAVAQAAVDCGVARKGYPSHYPLNSLDEI
HHHHHCCCCEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
FPEL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]