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The map label for this gene is coxA [H]

Identifier: 110834760

GI number: 110834760

Start: 2176026

End: 2177633

Strand: Reverse

Name: coxA [H]

Synonym: ABO_1899

Alternate gene names: 110834760

Gene position: 2177633-2176026 (Counterclockwise)

Preceding gene: 110834761

Following gene: 110834759

Centisome position: 69.79

GC content: 54.54

Gene sequence:

>1608_bases
ATGTCTACTGCAGCTGCAACCCATGATGATCATCACGATCACCACCACGCCCCGACCGGCCTGAAACGTTGGCTGTTCAG
CACCAACCACAAAGATATCGGTACCTTGTACCTGTGGTTCAGCTTCGCCATGTTCCTGTCCGGCGGTTTCTTGGCCATGG
TGATTCGTGCCGAGCTACTCGAGCCCGGCATGCAGTTCGTGGATCCGGAGTTCTTCAATCAGCTGACCACCGTGCACGGC
TTGGCCATGGTATTTGGCGCGGTGATGCCTGCCACTGTTGGCTTAGCTAACTGGATGATTCCCTTGATGATTGGTGCGCC
AGATATGGCGCTACCGCGGATGAATAACTGGTCTTTCTGGATTCTGCCTTTCGCTTTCACCATTCTGATTGGTTCAGTGG
TGTTGAGTGCGTTCGGTGCCGGCAATCCTAGCGCTCCGAACTTTGGCTGGACCTTCTACGCGCCGTTGTCCACCAAGTAC
GGGCCGGCGTCCACCGATTTGTTCATTCTGTCGGTTCACATGATGGGTATCTCCTCCATCATGGGTGCTATCAACGTGGT
GGTAACGGTCTTCAATATGCGTGCCCCTGGCATGACATTGATGAAGATGCCGCTGTTCGTATGGACTTGGCTAATCACTG
CCTTCCTGCTGATCGCGGTCATTCCAGTTCTGGCCGGTGCGGTAACCATGATGCTGACGGACCGTCATTTCGGAACCAGC
TTCTTCGATGCTGCCGGTGGTGGTGATCCAGTATTATTCCAGCACGTGTTTTGGTTCTTCGGGCATCCTGAAGTGTACAT
CATGATCCTGCCGAGCTTCGGTATCGTGTCAGCGATCATTCCGGCGTTTGCTCGCAAGCCGTTGTTCGGTTACGCCTCCA
TGGTGTACGCCACCGCGTCCATTGCCCTGTTGTCCTTCGTGGTATGGGCCCACCACATGTTCACTGTAGGTATGCCGTTG
GCGGGCACCTTATTCTTCATGTACATGACCATGTTGATCTCTGTGCCTACCGGCGTGAAGGTGTTCAACTGGGTGGCCAC
CATGTGGCGCGGATCTATGACCTTCGAACTGCCAATGAAGTGGGCGATTGCCTTTGTGGTGTTGTTTACCTGCGGCGGTC
TGTCCGGTTTGATGCTGGCGATTACCCCGGTAGACTTCCAGTATCATGATACCTATTTCGTGGTGGCGCATTTCCACTAC
GTATTGGTGACTGGCGCGATCTTCTCCATTTACGCTGCTGCCTATTATTGGCTGCCGAAGTGGTCTGGCATCATGCCTAA
CAAAACCCTGGGTGAACTACACTTTTGGAACTCCTTGATTTCCGCCAACCTGCTGTTCTTCCCCATGCACTTTGTGGGCT
TGGCGGGTATGCCGCGTCGTTACGCTGACTACGCGCTGCAGTTTGCGGACTACAACTTCTGGATTTCCATTGGTGGCTTC
TGGTTCGGCTTGTCGCAGCTGTTTTTCTTGGCGGTGGCTGTGCTGTGTGCCCTGAAGAAAGGCGAGAAAGCCCCGGCTAA
ACCATGGGAAGGTGCGGAAGGTCTGGAATGGGAAGTGCCGTCTCCGGCGCCGTTCCATACCTTTGAGACCCCGCCGGTGG
TGAAGTAA

Upstream 100 bases:

>100_bases
CGGCGGTGATCACCTATGAGCGTAACGCTTTCGGCAACGATACCGGCGATCTGATTCAGCCCGCCGACGTTAACGACCAC
GAATAAGGGAGGGGATAGCA

Downstream 100 bases:

>100_bases
CAGAAACTGACGGAGGAGCACCATGGGCGACGAGCAGCTCAGTGTTGAACAGCGCAATAAGCGCACGCTGAAAAAGCTGT
TGATCTGGGCGGTGGCCATG

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSTAAATHDDHHDHHHAPTGLKRWLFSTNHKDIGTLYLWFSFAMFLSGGFLAMVIRAELLEPGMQFVDPEFFNQLTTVHG
LAMVFGAVMPATVGLANWMIPLMIGAPDMALPRMNNWSFWILPFAFTILIGSVVLSAFGAGNPSAPNFGWTFYAPLSTKY
GPASTDLFILSVHMMGISSIMGAINVVVTVFNMRAPGMTLMKMPLFVWTWLITAFLLIAVIPVLAGAVTMMLTDRHFGTS
FFDAAGGGDPVLFQHVFWFFGHPEVYIMILPSFGIVSAIIPAFARKPLFGYASMVYATASIALLSFVVWAHHMFTVGMPL
AGTLFFMYMTMLISVPTGVKVFNWVATMWRGSMTFELPMKWAIAFVVLFTCGGLSGLMLAITPVDFQYHDTYFVVAHFHY
VLVTGAIFSIYAAAYYWLPKWSGIMPNKTLGELHFWNSLISANLLFFPMHFVGLAGMPRRYADYALQFADYNFWISIGGF
WFGLSQLFFLAVAVLCALKKGEKAPAKPWEGAEGLEWEVPSPAPFHTFETPPVVK

Sequences:

>Translated_535_residues
MSTAAATHDDHHDHHHAPTGLKRWLFSTNHKDIGTLYLWFSFAMFLSGGFLAMVIRAELLEPGMQFVDPEFFNQLTTVHG
LAMVFGAVMPATVGLANWMIPLMIGAPDMALPRMNNWSFWILPFAFTILIGSVVLSAFGAGNPSAPNFGWTFYAPLSTKY
GPASTDLFILSVHMMGISSIMGAINVVVTVFNMRAPGMTLMKMPLFVWTWLITAFLLIAVIPVLAGAVTMMLTDRHFGTS
FFDAAGGGDPVLFQHVFWFFGHPEVYIMILPSFGIVSAIIPAFARKPLFGYASMVYATASIALLSFVVWAHHMFTVGMPL
AGTLFFMYMTMLISVPTGVKVFNWVATMWRGSMTFELPMKWAIAFVVLFTCGGLSGLMLAITPVDFQYHDTYFVVAHFHY
VLVTGAIFSIYAAAYYWLPKWSGIMPNKTLGELHFWNSLISANLLFFPMHFVGLAGMPRRYADYALQFADYNFWISIGGF
WFGLSQLFFLAVAVLCALKKGEKAPAKPWEGAEGLEWEVPSPAPFHTFETPPVVK
>Mature_534_residues
STAAATHDDHHDHHHAPTGLKRWLFSTNHKDIGTLYLWFSFAMFLSGGFLAMVIRAELLEPGMQFVDPEFFNQLTTVHGL
AMVFGAVMPATVGLANWMIPLMIGAPDMALPRMNNWSFWILPFAFTILIGSVVLSAFGAGNPSAPNFGWTFYAPLSTKYG
PASTDLFILSVHMMGISSIMGAINVVVTVFNMRAPGMTLMKMPLFVWTWLITAFLLIAVIPVLAGAVTMMLTDRHFGTSF
FDAAGGGDPVLFQHVFWFFGHPEVYIMILPSFGIVSAIIPAFARKPLFGYASMVYATASIALLSFVVWAHHMFTVGMPLA
GTLFFMYMTMLISVPTGVKVFNWVATMWRGSMTFELPMKWAIAFVVLFTCGGLSGLMLAITPVDFQYHDTYFVVAHFHYV
LVTGAIFSIYAAAYYWLPKWSGIMPNKTLGELHFWNSLISANLLFFPMHFVGLAGMPRRYADYALQFADYNFWISIGGFW
FGLSQLFFLAVAVLCALKKGEKAPAKPWEGAEGLEWEVPSPAPFHTFETPPVVK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=518, Percent_Identity=49.034749034749, Blast_Score=451, Evalue=1e-127,
Organism=Escherichia coli, GI1786634, Length=528, Percent_Identity=38.8257575757576, Blast_Score=352, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6226519, Length=539, Percent_Identity=45.6400742115028, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6226524, Length=331, Percent_Identity=48.9425981873112, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6226523, Length=255, Percent_Identity=45.8823529411765, Blast_Score=209, Evalue=8e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59481; Mature: 59350

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAAATHDDHHDHHHAPTGLKRWLFSTNHKDIGTLYLWFSFAMFLSGGFLAMVIRAELL
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EPGMQFVDPEFFNQLTTVHGLAMVFGAVMPATVGLANWMIPLMIGAPDMALPRMNNWSFW
HCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
ILPFAFTILIGSVVLSAFGAGNPSAPNFGWTFYAPLSTKYGPASTDLFILSVHMMGISSI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHH
MGAINVVVTVFNMRAPGMTLMKMPLFVWTWLITAFLLIAVIPVLAGAVTMMLTDRHFGTS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FFDAAGGGDPVLFQHVFWFFGHPEVYIMILPSFGIVSAIIPAFARKPLFGYASMVYATAS
HHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IALLSFVVWAHHMFTVGMPLAGTLFFMYMTMLISVPTGVKVFNWVATMWRGSMTFELPMK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECHHH
WAIAFVVLFTCGGLSGLMLAITPVDFQYHDTYFVVAHFHYVLVTGAIFSIYAAAYYWLPK
HHHHHHHHHHHCCCCCEEEEEEECCEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
WSGIMPNKTLGELHFWNSLISANLLFFPMHFVGLAGMPRRYADYALQFADYNFWISIGGF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCEEEEEECHH
WFGLSQLFFLAVAVLCALKKGEKAPAKPWEGAEGLEWEVPSPAPFHTFETPPVVK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STAAATHDDHHDHHHAPTGLKRWLFSTNHKDIGTLYLWFSFAMFLSGGFLAMVIRAELL
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EPGMQFVDPEFFNQLTTVHGLAMVFGAVMPATVGLANWMIPLMIGAPDMALPRMNNWSFW
HCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
ILPFAFTILIGSVVLSAFGAGNPSAPNFGWTFYAPLSTKYGPASTDLFILSVHMMGISSI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHH
MGAINVVVTVFNMRAPGMTLMKMPLFVWTWLITAFLLIAVIPVLAGAVTMMLTDRHFGTS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FFDAAGGGDPVLFQHVFWFFGHPEVYIMILPSFGIVSAIIPAFARKPLFGYASMVYATAS
HHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IALLSFVVWAHHMFTVGMPLAGTLFFMYMTMLISVPTGVKVFNWVATMWRGSMTFELPMK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECHHH
WAIAFVVLFTCGGLSGLMLAITPVDFQYHDTYFVVAHFHYVLVTGAIFSIYAAAYYWLPK
HHHHHHHHHHHCCCCCEEEEEEECCEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
WSGIMPNKTLGELHFWNSLISANLLFFPMHFVGLAGMPRRYADYALQFADYNFWISIGGF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCEEEEEECHH
WFGLSQLFFLAVAVLCALKKGEKAPAKPWEGAEGLEWEVPSPAPFHTFETPPVVK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]