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The map label for this gene is fadA

Identifier: 110834514

GI number: 110834514

Start: 1890966

End: 1892141

Strand: Direct

Name: fadA

Synonym: ABO_1653

Alternate gene names: 110834514

Gene position: 1890966-1892141 (Clockwise)

Preceding gene: 110834513

Following gene: 110834515

Centisome position: 60.61

GC content: 58.84

Gene sequence:

>1176_bases
ATGAGTTTGAATCCAAAAGACGTTGTCATCGTCGATGCGGTCCGTACCCCCATGGGCAAGAGCCGTAATGGCCAGTTCCG
TCACGTGCGTGCCGAAAAGCTGTCAGCTCAGCTGATCCAGGCGCTGATGGCCCGTAACCCGAACTGGGACATCCAGCTCA
CTGAAGACGTGATTTGGGGCTGTGTAAACCAGACCAAAGAACAGGGCATGAACATCGCCCGTAACATCTCCATGCTGGCC
GGCCTGCCGCGCACCAGCGCTGCACAAACCGTGAACCGTCTGTGTGGTTCTTCCATGCAGGCACTGCACAGCGCCTCACA
AAGCATCATGACCGGCAACGGCGATGTCTTTGTTATCGGTGGTGTAGAGCACATGGGCCACGTGGCCATGGATCACGGCA
TCGACCTGAACCCGGAAATGTCCAAAGTGACCGCCAAGGCGTCCAACATGATGGGCCTGACCGCGGAAATGCTGGGCAAG
ATGCACGGCATCACCCGTGAACAACAAGACGCCTTCGGCGTTCGTTCACACAAGCTGGCGTGGGAAGCCACCCAGCAAGG
CCGTTGGGACAACGAAATCGTACCCATCGAAGGTCACGATCAGAACGGCCACAAAGTGCTGTGCGAAATCGACGAAGTGA
TCCGCCCGGGTGCCAGCATCGAAGACATGCAGAAACTGCGTCCGGTATTCGATCCGGCCAACGGTACCGTGACTGCCGGT
ACGTCATCTGCCCTGTCTGACGGTGCCTCCGCCATGCTGGTCATGAGCGCCGAGCGTGCCCAAGCCCTGGGCCTGAAGCC
CCGTGCCAAAATCCGCTCCATGGCCGTAGCCGGTTGCGACGCCGCCATCATGGGTTACGGCCCTGTACCGGCCACCCAGA
AAGCGCTAGCACGTGCTGGCCTAACCATCGACGACATCGACTATGTAGAGCTGAACGAAGCGTTCGCTGCACAGTCCCTG
CCGGTGGCCAAGGACCTGAAGCTGCTGGACAAAATGGAAGAGAAAGTAAACCTGAACGGCGGCGCTATCGCCCTGGGCCA
CCCGCTGGGTTGCTCCGGTGCGCGTATCACCGGCACCCTGCTGAACGTCATGGAATGGAAAGACGGCCAAATCGGTCTTG
CCACCATGTGTATCGGCCTGGGTCAGGGTATCGCTACCATTATTGAACGGGTTTAA

Upstream 100 bases:

>100_bases
CACCTGGGTGGCATCTACGAAGCACCGCAGATGCTCAAAGACATGGCCTCCAAGGGCGAGTCTTTCTTCGCCTAAGCCAC
GGACAAGCAGGAGTAATGAA

Downstream 100 bases:

>100_bases
CCAACACCTGATGCCCAAAACCTGACGCCGGAGACACTTCGGCGCTCAGGCCCGGCACCCTATTTCCGGCCCCGCCTCAC
AAGGGCAGGGCTGGAAACAA

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSLNPKDVVIVDAVRTPMGKSRNGQFRHVRAEKLSAQLIQALMARNPNWDIQLTEDVIWGCVNQTKEQGMNIARNISMLA
GLPRTSAAQTVNRLCGSSMQALHSASQSIMTGNGDVFVIGGVEHMGHVAMDHGIDLNPEMSKVTAKASNMMGLTAEMLGK
MHGITREQQDAFGVRSHKLAWEATQQGRWDNEIVPIEGHDQNGHKVLCEIDEVIRPGASIEDMQKLRPVFDPANGTVTAG
TSSALSDGASAMLVMSAERAQALGLKPRAKIRSMAVAGCDAAIMGYGPVPATQKALARAGLTIDDIDYVELNEAFAAQSL
PVAKDLKLLDKMEEKVNLNGGAIALGHPLGCSGARITGTLLNVMEWKDGQIGLATMCIGLGQGIATIIERV

Sequences:

>Translated_391_residues
MSLNPKDVVIVDAVRTPMGKSRNGQFRHVRAEKLSAQLIQALMARNPNWDIQLTEDVIWGCVNQTKEQGMNIARNISMLA
GLPRTSAAQTVNRLCGSSMQALHSASQSIMTGNGDVFVIGGVEHMGHVAMDHGIDLNPEMSKVTAKASNMMGLTAEMLGK
MHGITREQQDAFGVRSHKLAWEATQQGRWDNEIVPIEGHDQNGHKVLCEIDEVIRPGASIEDMQKLRPVFDPANGTVTAG
TSSALSDGASAMLVMSAERAQALGLKPRAKIRSMAVAGCDAAIMGYGPVPATQKALARAGLTIDDIDYVELNEAFAAQSL
PVAKDLKLLDKMEEKVNLNGGAIALGHPLGCSGARITGTLLNVMEWKDGQIGLATMCIGLGQGIATIIERV
>Mature_390_residues
SLNPKDVVIVDAVRTPMGKSRNGQFRHVRAEKLSAQLIQALMARNPNWDIQLTEDVIWGCVNQTKEQGMNIARNISMLAG
LPRTSAAQTVNRLCGSSMQALHSASQSIMTGNGDVFVIGGVEHMGHVAMDHGIDLNPEMSKVTAKASNMMGLTAEMLGKM
HGITREQQDAFGVRSHKLAWEATQQGRWDNEIVPIEGHDQNGHKVLCEIDEVIRPGASIEDMQKLRPVFDPANGTVTAGT
SSALSDGASAMLVMSAERAQALGLKPRAKIRSMAVAGCDAAIMGYGPVPATQKALARAGLTIDDIDYVELNEAFAAQSLP
VAKDLKLLDKMEEKVNLNGGAIALGHPLGCSGARITGTLLNVMEWKDGQIGLATMCIGLGQGIATIIERV

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family

Homologues:

Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=37.27959697733, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=38.4810126582278, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI148539872, Length=403, Percent_Identity=37.9652605459057, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=36.3861386138614, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4504327, Length=435, Percent_Identity=34.0229885057471, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI194353979, Length=385, Percent_Identity=27.2727272727273, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI48994986, Length=386, Percent_Identity=64.5077720207254, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1787663, Length=405, Percent_Identity=42.2222222222222, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI87082165, Length=400, Percent_Identity=41.25, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1788554, Length=400, Percent_Identity=43.75, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI1788683, Length=417, Percent_Identity=33.0935251798561, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=38.0952380952381, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=35.6608478802993, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=31.3953488372093, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=32.4189526184539, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=28.8607594936709, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325229, Length=409, Percent_Identity=35.6968215158924, Blast_Score=212, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=34.8484848484849, Blast_Score=210, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=41.3098236775819, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=36.5196078431373, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI17137578, Length=436, Percent_Identity=33.0275229357798, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=35.6608478802993, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FADA_ALCBS (Q0VNZ7)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693373.1
- ProteinModelPortal:   Q0VNZ7
- SMR:   Q0VNZ7
- STRING:   Q0VNZ7
- GeneID:   4211856
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1653
- NMPDR:   fig|393595.12.peg.1656
- eggNOG:   COG0183
- HOGENOM:   HBG370930
- OMA:   KMEEKVN
- PhylomeDB:   Q0VNZ7
- ProtClustDB:   PRK08947
- BioCyc:   ABOR393595:ABO_1653-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01620
- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR18919
- PIRSF:   PIRSF000429
- TIGRFAMs:   TIGR01930
- TIGRFAMs:   TIGR02445

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N; SSF53901 Thiolase-like

EC number: =2.3.1.16

Molecular weight: Translated: 41752; Mature: 41621

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00098 THIOLASE_1; PS00737 THIOLASE_2; PS00099 THIOLASE_3; PS00178 AA_TRNA_LIGASE_I

Important sites: ACT_SITE 95-95 ACT_SITE 347-347 ACT_SITE 377-377

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNPKDVVIVDAVRTPMGKSRNGQFRHVRAEKLSAQLIQALMARNPNWDIQLTEDVIWG
CCCCCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHH
CVNQTKEQGMNIARNISMLAGLPRTSAAQTVNRLCGSSMQALHSASQSIMTGNGDVFVIG
HHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHEEECCCCEEEEE
GVEHMGHVAMDHGIDLNPEMSKVTAKASNMMGLTAEMLGKMHGITREQQDAFGVRSHKLA
CHHHHCHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCHHHEE
WEATQQGRWDNEIVPIEGHDQNGHKVLCEIDEVIRPGASIEDMQKLRPVFDPANGTVTAG
EHHHHCCCCCCCEEEECCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCCEEECC
TSSALSDGASAMLVMSAERAQALGLKPRAKIRSMAVAGCDAAIMGYGPVPATQKALARAG
CCHHHHCCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCC
LTIDDIDYVELNEAFAAQSLPVAKDLKLLDKMEEKVNLNGGAIALGHPLGCSGARITGTL
CCCCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHH
LNVMEWKDGQIGLATMCIGLGQGIATIIERV
HHHHHCCCCCCHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure 
SLNPKDVVIVDAVRTPMGKSRNGQFRHVRAEKLSAQLIQALMARNPNWDIQLTEDVIWG
CCCCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHH
CVNQTKEQGMNIARNISMLAGLPRTSAAQTVNRLCGSSMQALHSASQSIMTGNGDVFVIG
HHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHEEECCCCEEEEE
GVEHMGHVAMDHGIDLNPEMSKVTAKASNMMGLTAEMLGKMHGITREQQDAFGVRSHKLA
CHHHHCHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCHHHEE
WEATQQGRWDNEIVPIEGHDQNGHKVLCEIDEVIRPGASIEDMQKLRPVFDPANGTVTAG
EHHHHCCCCCCCEEEECCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCCEEECC
TSSALSDGASAMLVMSAERAQALGLKPRAKIRSMAVAGCDAAIMGYGPVPATQKALARAG
CCHHHHCCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCC
LTIDDIDYVELNEAFAAQSLPVAKDLKLLDKMEEKVNLNGGAIALGHPLGCSGARITGTL
CCCCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHH
LNVMEWKDGQIGLATMCIGLGQGIATIIERV
HHHHHCCCCCCHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA