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The map label for this gene is nadB [H]

Identifier: 110834502

GI number: 110834502

Start: 1876484

End: 1878091

Strand: Direct

Name: nadB [H]

Synonym: ABO_1641

Alternate gene names: 110834502

Gene position: 1876484-1878091 (Clockwise)

Preceding gene: 110834488

Following gene: 110834505

Centisome position: 60.14

GC content: 57.15

Gene sequence:

>1608_bases
ATGGCTACCTATCGACACGATGTACTCATTATCGGCTCCGGCGCCGCAGGCCTTACGGCCGCACTTCGCCTGCCTGATGA
GTGTCAGGTTGCCCTGCTCTCCAAAGGAGAGCTCACCAGCGCTAGCACCTACTACGCCCAGGGCGGAGTGGCCGCGGTGC
TAGACCAAGAAGACTCACTGGAAAGTCATGTGGCCGATACCCATGTGGCTGGCGCCGGGCTATGCCAGGATGATGCGGTA
CGCTTTACCGTGGAAAATGGCCCCGACGCCATTCGCTGGTTGATTGATCTAGGCGTGGACTTCACCCGTTTCGATAGCGG
TGATGGCAGTAAATTGCCCTACCACTTAACCCGTGAAGGCGGGCATAGCCATCGGCGCATCATTCACGCCGCCGATGCCA
CCGGCAAAGCCATCTCCGGCACACTGATCGAACAAGTCTGCAAAAAAGAAAACGTGATCCGCTTTGAGCACCGGGTGGCG
GTGGACCTGATCGTACAGGAACACGACGGACCGCAAGGCAAAGAAAAACGTTGCTGTGGCGCCTACGTACACAACATTCA
AACCGGCGAAACCGACGTTATTCTCGCCCGCTCCGTGGTACTGGCCACCGGCGGGGCCTCCAAAGTGTACCTCTACACAT
CCAACCCGGATGTGGCCACCGGCGATGGCATTGCCATGGCCTGGCGAGCCGGCTGTCGGGTCGCGAATATGGAATTCATG
CAGTTCCACCCCACCTGCCTCTATCACCCCAAGGCAAAAAGCTTCCTCGTCACCGAGGCCATCCGCGGCGAAGGCGGGCA
CCTGCTACTCCCCAATGGCGAACGCTTCATGAACCGCTTTGATGAGCGCGGCGAGTTAGCCCCCCGGGATGTGGTTGCCC
GCGCCATTGACCATGAAATGAAACGGCTGGGCGCGGATTGTCTCTACCTTGATATCAGCCACAAACCCGCAGACTTCATT
ATCGAGCACTTCCCCACCGTATACGCCAAATGCCTGCAGCTGGGGCTGGATATCACCCGCGACCCCATTCCGGTGGTCCC
TGCGGCTCATTACACCTGCGGCGGCGTGATGATTAACAAGCATGGACAAACCGATGTGCCTGGCCTCTATGCCATTGGCG
AAACCAGTTTTACCGGTTTACACGGAGCCAACCGCATGGCTAGCAATTCATTGCTGGAGTGCTTTGTGTACGGCAAAGCC
ACCGCCGACCATATTCGCGCCCACCTGGATAAAATTCCCACGCCAAGAGACGACAACGAATGGGATGAATCGCAGGTTAC
CGACTCGGATGAAGACGTGGTGATCAGCCACAACTGGGACGAGCTGCGTCGCTTCATGTGGGACTACGTGGGCATCGTGA
GAACGGAAAAACGGTTGGAGAGAGCCCTGCACCGCGCCGAGCTACTAAAGAGCGAAATCGCCGAGTATTACAGCAACTAC
CACATCAGCAACGACCTACTGGAGCTACGTAATCTGGTGGTCATCGCCGAACTGATTATTCGCTCTGCCATGCAACGCAA
AGAGAGCCGCGGCTTGCATTACATGCGCGATTTCCCAGCAACGAATGAAGAAACCGGAAATACGATCCTAACACCGGGGA
CGTTTTGA

Upstream 100 bases:

>100_bases
AAAAACGTCATTAGCAGGGGGAGCAATCGCCGCTATACTGGCCGCCTGAGACCCCTAAGCCTGCGAAATCGACCAGCTGC
TAACGAATAAAGGATGCTCC

Downstream 100 bases:

>100_bases
CTGGCATAGAATCAAGCCGGGTTACGGGTAAAGGACGGAGCCACACGATGACCGTCCTGCACGAGCGATTCAATTGAACG
TTCAACGTTGAAAAAAAAGC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MATYRHDVLIIGSGAAGLTAALRLPDECQVALLSKGELTSASTYYAQGGVAAVLDQEDSLESHVADTHVAGAGLCQDDAV
RFTVENGPDAIRWLIDLGVDFTRFDSGDGSKLPYHLTREGGHSHRRIIHAADATGKAISGTLIEQVCKKENVIRFEHRVA
VDLIVQEHDGPQGKEKRCCGAYVHNIQTGETDVILARSVVLATGGASKVYLYTSNPDVATGDGIAMAWRAGCRVANMEFM
QFHPTCLYHPKAKSFLVTEAIRGEGGHLLLPNGERFMNRFDERGELAPRDVVARAIDHEMKRLGADCLYLDISHKPADFI
IEHFPTVYAKCLQLGLDITRDPIPVVPAAHYTCGGVMINKHGQTDVPGLYAIGETSFTGLHGANRMASNSLLECFVYGKA
TADHIRAHLDKIPTPRDDNEWDESQVTDSDEDVVISHNWDELRRFMWDYVGIVRTEKRLERALHRAELLKSEIAEYYSNY
HISNDLLELRNLVVIAELIIRSAMQRKESRGLHYMRDFPATNEETGNTILTPGTF

Sequences:

>Translated_535_residues
MATYRHDVLIIGSGAAGLTAALRLPDECQVALLSKGELTSASTYYAQGGVAAVLDQEDSLESHVADTHVAGAGLCQDDAV
RFTVENGPDAIRWLIDLGVDFTRFDSGDGSKLPYHLTREGGHSHRRIIHAADATGKAISGTLIEQVCKKENVIRFEHRVA
VDLIVQEHDGPQGKEKRCCGAYVHNIQTGETDVILARSVVLATGGASKVYLYTSNPDVATGDGIAMAWRAGCRVANMEFM
QFHPTCLYHPKAKSFLVTEAIRGEGGHLLLPNGERFMNRFDERGELAPRDVVARAIDHEMKRLGADCLYLDISHKPADFI
IEHFPTVYAKCLQLGLDITRDPIPVVPAAHYTCGGVMINKHGQTDVPGLYAIGETSFTGLHGANRMASNSLLECFVYGKA
TADHIRAHLDKIPTPRDDNEWDESQVTDSDEDVVISHNWDELRRFMWDYVGIVRTEKRLERALHRAELLKSEIAEYYSNY
HISNDLLELRNLVVIAELIIRSAMQRKESRGLHYMRDFPATNEETGNTILTPGTF
>Mature_534_residues
ATYRHDVLIIGSGAAGLTAALRLPDECQVALLSKGELTSASTYYAQGGVAAVLDQEDSLESHVADTHVAGAGLCQDDAVR
FTVENGPDAIRWLIDLGVDFTRFDSGDGSKLPYHLTREGGHSHRRIIHAADATGKAISGTLIEQVCKKENVIRFEHRVAV
DLIVQEHDGPQGKEKRCCGAYVHNIQTGETDVILARSVVLATGGASKVYLYTSNPDVATGDGIAMAWRAGCRVANMEFMQ
FHPTCLYHPKAKSFLVTEAIRGEGGHLLLPNGERFMNRFDERGELAPRDVVARAIDHEMKRLGADCLYLDISHKPADFII
EHFPTVYAKCLQLGLDITRDPIPVVPAAHYTCGGVMINKHGQTDVPGLYAIGETSFTGLHGANRMASNSLLECFVYGKAT
ADHIRAHLDKIPTPRDDNEWDESQVTDSDEDVVISHNWDELRRFMWDYVGIVRTEKRLERALHRAELLKSEIAEYYSNYH
ISNDLLELRNLVVIAELIIRSAMQRKESRGLHYMRDFPATNEETGNTILTPGTF

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=536, Percent_Identity=31.7164179104478, Blast_Score=222, Evalue=8e-58,
Organism=Escherichia coli, GI1788928, Length=531, Percent_Identity=62.1468926553672, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=542, Percent_Identity=33.3948339483395, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786942, Length=556, Percent_Identity=34.1726618705036, Blast_Score=227, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17505833, Length=538, Percent_Identity=31.0408921933086, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17550100, Length=527, Percent_Identity=30.7400379506641, Blast_Score=208, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI71986328, Length=426, Percent_Identity=27.6995305164319, Blast_Score=110, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322701, Length=533, Percent_Identity=31.5196998123827, Blast_Score=218, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6322416, Length=531, Percent_Identity=32.015065913371, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6320788, Length=492, Percent_Identity=27.2357723577236, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322511, Length=330, Percent_Identity=26.3636363636364, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137288, Length=540, Percent_Identity=32.5925925925926, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24655642, Length=540, Percent_Identity=32.5925925925926, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24655647, Length=540, Percent_Identity=32.5925925925926, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24663005, Length=536, Percent_Identity=31.9029850746269, Blast_Score=205, Evalue=7e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 59249; Mature: 59117

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATYRHDVLIIGSGAAGLTAALRLPDECQVALLSKGELTSASTYYAQGGVAAVLDQEDSL
CCCEECCEEEEECCCCCHHEEECCCCHHEEEEECCCCCCCCCEEEECCCEEEEECCCHHH
ESHVADTHVAGAGLCQDDAVRFTVENGPDAIRWLIDLGVDFTRFDSGDGSKLPYHLTREG
HHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCEEEECCCCCCCCCEEEECCC
GHSHRRIIHAADATGKAISGTLIEQVCKKENVIRFEHRVAVDLIVQEHDGPQGKEKRCCG
CCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEHHEEEEEEEECCCCCCCCHHHHHH
AYVHNIQTGETDVILARSVVLATGGASKVYLYTSNPDVATGDGIAMAWRAGCRVANMEFM
HHHHCCCCCCCEEEEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEHHHCCCEEECCHHE
QFHPTCLYHPKAKSFLVTEAIRGEGGHLLLPNGERFMNRFDERGELAPRDVVARAIDHEM
EECCCEEECCCCCCEEEEHHHCCCCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
KRLGADCLYLDISHKPADFIIEHFPTVYAKCLQLGLDITRDPIPVVPAAHYTCGGVMINK
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCEEEEC
HGQTDVPGLYAIGETSFTGLHGANRMASNSLLECFVYGKATADHIRAHLDKIPTPRDDNE
CCCCCCCCEEEECCCCCCCCCCCCHHHHHHHEEEEEECCCCHHHHHHHHHHCCCCCCCCC
WDESQVTDSDEDVVISHNWDELRRFMWDYVGIVRTEKRLERALHRAELLKSEIAEYYSNY
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HISNDLLELRNLVVIAELIIRSAMQRKESRGLHYMRDFPATNEETGNTILTPGTF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCEEECCCCC
>Mature Secondary Structure 
ATYRHDVLIIGSGAAGLTAALRLPDECQVALLSKGELTSASTYYAQGGVAAVLDQEDSL
CCEECCEEEEECCCCCHHEEECCCCHHEEEEECCCCCCCCCEEEECCCEEEEECCCHHH
ESHVADTHVAGAGLCQDDAVRFTVENGPDAIRWLIDLGVDFTRFDSGDGSKLPYHLTREG
HHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCEEEECCCCCCCCCEEEECCC
GHSHRRIIHAADATGKAISGTLIEQVCKKENVIRFEHRVAVDLIVQEHDGPQGKEKRCCG
CCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEHHEEEEEEEECCCCCCCCHHHHHH
AYVHNIQTGETDVILARSVVLATGGASKVYLYTSNPDVATGDGIAMAWRAGCRVANMEFM
HHHHCCCCCCCEEEEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEHHHCCCEEECCHHE
QFHPTCLYHPKAKSFLVTEAIRGEGGHLLLPNGERFMNRFDERGELAPRDVVARAIDHEM
EECCCEEECCCCCCEEEEHHHCCCCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
KRLGADCLYLDISHKPADFIIEHFPTVYAKCLQLGLDITRDPIPVVPAAHYTCGGVMINK
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCEEEEC
HGQTDVPGLYAIGETSFTGLHGANRMASNSLLECFVYGKATADHIRAHLDKIPTPRDDNE
CCCCCCCCEEEECCCCCCCCCCCCHHHHHHHEEEEEECCCCHHHHHHHHHHCCCCCCCCC
WDESQVTDSDEDVVISHNWDELRRFMWDYVGIVRTEKRLERALHRAELLKSEIAEYYSNY
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HISNDLLELRNLVVIAELIIRSAMQRKESRGLHYMRDFPATNEETGNTILTPGTF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737518; 10984043; 7961421 [H]