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The map label for this gene is msrA [H]

Identifier: 110834391

GI number: 110834391

Start: 1751583

End: 1752209

Strand: Direct

Name: msrA [H]

Synonym: ABO_1530

Alternate gene names: 110834391

Gene position: 1751583-1752209 (Clockwise)

Preceding gene: 110834390

Following gene: 110834392

Centisome position: 56.14

GC content: 52.79

Gene sequence:

>627_bases
ATGAACGCAGTAATTCCCGGCACATCCCTGGCCATTCGCCCTGAAAACTTCCCTGACCCTATCGAAGATCTGCCCGTCAA
TGGCACCGCCAAAGCGGTATTCGCTGGCGGCTGCTTCTGGTGTGTTGAAGCGGTCTATCTAAATCTGGAAGGAGTCAATG
CGGTGGTATCTGGTTATGCAGGAGGCCATGCGGCTCAGGCCAATTACGAAGCCGTTTGCACCGGTACCACCGGCCATGCG
GAAGTCATTGAAGTGGAATACAACAGCGCCGTCATAAGCTTTGGCGAGTTACTGAAAGTGTTTTTTTCTGTGGCCCACGA
TCCTACCCACAAAGACCGCCAGGGCAACGATCGAGGCACCCAGTATCGCTCCGCGGTTTTTTATCATGATAACGCCGAGA
AAACCGTAGCCACGGCCTATATCGAACAGCTAAACAATGCCGGCGCTTTTATTGCGCCCATCGCCACCACCGTGGAGCCT
CTGGAAACATTCTTTCCCGCCGAGGACTACCATCAGAATTTCGCCCGCCGAAACCCAACCCAAGGCTACGTTACGCATGT
AGCCAAACCCAAAGTAGAAAAGCTGATTCATGCTTTCCCCGACAAACTGAAAACACGAACACCTTAA

Upstream 100 bases:

>100_bases
ATCCCTGTCGCCGCTCCTCTAGTTGCACTGATAGTCGCACTGATAGCATGCCAGCCGGTCCACAAGCCCGGCTGGCGTGA
CACTCCCTACTGGAGGGACC

Downstream 100 bases:

>100_bases
CGAGACCAATCTAAGGGAGTGCCTGATGACCCAAGCACTGTCCGCCAGCGGCTTTGATCTGACGCCCCTGAGCGAAGAAG
AGAAGCAGGCCCGCGCACAA

Product: methionine sulfoxide peptide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNAVIPGTSLAIRPENFPDPIEDLPVNGTAKAVFAGGCFWCVEAVYLNLEGVNAVVSGYAGGHAAQANYEAVCTGTTGHA
EVIEVEYNSAVISFGELLKVFFSVAHDPTHKDRQGNDRGTQYRSAVFYHDNAEKTVATAYIEQLNNAGAFIAPIATTVEP
LETFFPAEDYHQNFARRNPTQGYVTHVAKPKVEKLIHAFPDKLKTRTP

Sequences:

>Translated_208_residues
MNAVIPGTSLAIRPENFPDPIEDLPVNGTAKAVFAGGCFWCVEAVYLNLEGVNAVVSGYAGGHAAQANYEAVCTGTTGHA
EVIEVEYNSAVISFGELLKVFFSVAHDPTHKDRQGNDRGTQYRSAVFYHDNAEKTVATAYIEQLNNAGAFIAPIATTVEP
LETFFPAEDYHQNFARRNPTQGYVTHVAKPKVEKLIHAFPDKLKTRTP
>Mature_208_residues
MNAVIPGTSLAIRPENFPDPIEDLPVNGTAKAVFAGGCFWCVEAVYLNLEGVNAVVSGYAGGHAAQANYEAVCTGTTGHA
EVIEVEYNSAVISFGELLKVFFSVAHDPTHKDRQGNDRGTQYRSAVFYHDNAEKTVATAYIEQLNNAGAFIAPIATTVEP
LETFFPAEDYHQNFARRNPTQGYVTHVAKPKVEKLIHAFPDKLKTRTP

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=192, Percent_Identity=40.625, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=43.558282208589, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=45.945945945946, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1790665, Length=158, Percent_Identity=40.5063291139241, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=33.7837837837838, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=42.2360248447205, Blast_Score=110, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24664627, Length=156, Percent_Identity=35.8974358974359, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664631, Length=156, Percent_Identity=35.8974358974359, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=35.9712230215827, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 22643; Mature: 22643

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVIPGTSLAIRPENFPDPIEDLPVNGTAKAVFAGGCFWCVEAVYLNLEGVNAVVSGYA
CCCCCCCCEEEECCCCCCCHHHHCCCCCCCCEEECCHHHHHHHHHHHCCCCHHHHHHCCC
GGHAAQANYEAVCTGTTGHAEVIEVEYNSAVISFGELLKVFFSVAHDPTHKDRQGNDRGT
CCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QYRSAVFYHDNAEKTVATAYIEQLNNAGAFIAPIATTVEPLETFFPAEDYHQNFARRNPT
CEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCC
QGYVTHVAKPKVEKLIHAFPDKLKTRTP
CCHHHHCCCHHHHHHHHHCCHHHCCCCC
>Mature Secondary Structure
MNAVIPGTSLAIRPENFPDPIEDLPVNGTAKAVFAGGCFWCVEAVYLNLEGVNAVVSGYA
CCCCCCCCEEEECCCCCCCHHHHCCCCCCCCEEECCHHHHHHHHHHHCCCCHHHHHHCCC
GGHAAQANYEAVCTGTTGHAEVIEVEYNSAVISFGELLKVFFSVAHDPTHKDRQGNDRGT
CCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QYRSAVFYHDNAEKTVATAYIEQLNNAGAFIAPIATTVEPLETFFPAEDYHQNFARRNPT
CEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCC
QGYVTHVAKPKVEKLIHAFPDKLKTRTP
CCHHHHCCCHHHHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]