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The map label for this gene is mtnC [H]

Identifier: 110834308

GI number: 110834308

Start: 1649607

End: 1650302

Strand: Direct

Name: mtnC [H]

Synonym: ABO_1447

Alternate gene names: 110834308

Gene position: 1649607-1650302 (Clockwise)

Preceding gene: 110834307

Following gene: 110834311

Centisome position: 52.87

GC content: 52.87

Gene sequence:

>696_bases
ATGGAAGGAAACGGCATGATCAACGCCATCATCACAGATATCGAAGGCACCACCAGCAGCATTGCATTTGTGAAGGAGGT
GCTGTTCCCCTATGCCGCCAAGCGGTTTCCCGATTTTCTCGCGGATCACTGGGATCATCCTTGCGTTCAAGAGCAAATAA
AAGCCGCCGAAAAGGAAAGTGGAGAAACGCTGGGCTCCGCTGATAAAGCCGCCGCGCTTTTCCTGCGCTGGATAGAGGAA
GACCGCAAGGCTACCCCGCTGAAAACCCTGCAAGGCATGATCTGGAAAGCCGGTTACGAAAATGGCGACTATACCGCCCA
TATGTATCCGGACACTGCGCCGGCTCTGAAAAAATGGCATCAGAAAGGCATCGCTCTGTACGTGTATTCCTCCGGGTCCA
TCACCGCACAGAAGTTATTCTTTGGCTACAGCGATGCCGGTGATCTCACCGGGCTGTTATCTGGTTATTTCGATACCACC
ACTGGCCCCAAACAGGAGACAGACAGCTATCGGAAGATCCAGCAGGCGATTGATAAACCCGCCAACACCTTACTGTTTCT
GTCCGATATCGAAGCGGAATTGGATGCTGCTGCTGAAGCAGGGTTTAACACCTGCCTACTGGACCGGCAACAGGCAGGGT
TGGAAAGCCGTCACCCGGTGGCCAGCAATTTTAACCACATCAATCTAGCGGATTAG

Upstream 100 bases:

>100_bases
CAGTTTAACCGGCTCGCTTAAACCCGATACTTGCTAAGGCGTTTAGCCTAGCCGTTCTTGTGCAGCCACACACTCACGTC
ATCGGTCCCGACACTCAAGC

Downstream 100 bases:

>100_bases
ACGCCGACGGGGTCGGGCCCTGGCAGCGCCACACCACAAACTTGGCATTACTGGCCAACACGGTCACCGACGTAAAACGA
CGTGCCAACACCTTGTGGTA

Product: enolase/hydrolase

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MEGNGMINAIITDIEGTTSSIAFVKEVLFPYAAKRFPDFLADHWDHPCVQEQIKAAEKESGETLGSADKAAALFLRWIEE
DRKATPLKTLQGMIWKAGYENGDYTAHMYPDTAPALKKWHQKGIALYVYSSGSITAQKLFFGYSDAGDLTGLLSGYFDTT
TGPKQETDSYRKIQQAIDKPANTLLFLSDIEAELDAAAEAGFNTCLLDRQQAGLESRHPVASNFNHINLAD

Sequences:

>Translated_231_residues
MEGNGMINAIITDIEGTTSSIAFVKEVLFPYAAKRFPDFLADHWDHPCVQEQIKAAEKESGETLGSADKAAALFLRWIEE
DRKATPLKTLQGMIWKAGYENGDYTAHMYPDTAPALKKWHQKGIALYVYSSGSITAQKLFFGYSDAGDLTGLLSGYFDTT
TGPKQETDSYRKIQQAIDKPANTLLFLSDIEAELDAAAEAGFNTCLLDRQQAGLESRHPVASNFNHINLAD
>Mature_231_residues
MEGNGMINAIITDIEGTTSSIAFVKEVLFPYAAKRFPDFLADHWDHPCVQEQIKAAEKESGETLGSADKAAALFLRWIEE
DRKATPLKTLQGMIWKAGYENGDYTAHMYPDTAPALKKWHQKGIALYVYSSGSITAQKLFFGYSDAGDLTGLLSGYFDTT
TGPKQETDSYRKIQQAIDKPANTLLFLSDIEAELDAAAEAGFNTCLLDRQQAGLESRHPVASNFNHINLAD

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family [H]

Homologues:

Organism=Homo sapiens, GI10864017, Length=229, Percent_Identity=37.9912663755458, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI115533232, Length=227, Percent_Identity=42.2907488986784, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320797, Length=211, Percent_Identity=39.3364928909953, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281360080, Length=217, Percent_Identity=41.9354838709677, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24644163, Length=217, Percent_Identity=41.9354838709677, Blast_Score=166, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR010041
- InterPro:   IPR023214
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.77 [H]

Molecular weight: Translated: 25463; Mature: 25463

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGNGMINAIITDIEGTTSSIAFVKEVLFPYAAKRFPDFLADHWDHPCVQEQIKAAEKES
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GETLGSADKAAALFLRWIEEDRKATPLKTLQGMIWKAGYENGDYTAHMYPDTAPALKKWH
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHH
QKGIALYVYSSGSITAQKLFFGYSDAGDLTGLLSGYFDTTTGPKQETDSYRKIQQAIDKP
HCCEEEEEEECCCEEEHHHEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
ANTLLFLSDIEAELDAAAEAGFNTCLLDRQQAGLESRHPVASNFNHINLAD
CCEEEEEEHHHHHHHHHHHCCCHHHHHCHHHCCCCCCCCCCCCCCEEECCC
>Mature Secondary Structure
MEGNGMINAIITDIEGTTSSIAFVKEVLFPYAAKRFPDFLADHWDHPCVQEQIKAAEKES
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GETLGSADKAAALFLRWIEEDRKATPLKTLQGMIWKAGYENGDYTAHMYPDTAPALKKWH
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHH
QKGIALYVYSSGSITAQKLFFGYSDAGDLTGLLSGYFDTTTGPKQETDSYRKIQQAIDKP
HCCEEEEEEECCCEEEHHHEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
ANTLLFLSDIEAELDAAAEAGFNTCLLDRQQAGLESRHPVASNFNHINLAD
CCEEEEEEHHHHHHHHHHHCCCHHHHHCHHHCCCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA