Click here to switch to the map view.

The map label for this gene is uvrC

Identifier: 110834166

GI number: 110834166

Start: 1479132

End: 1480955

Strand: Direct

Name: uvrC

Synonym: ABO_1305

Alternate gene names: 110834166

Gene position: 1479132-1480955 (Clockwise)

Preceding gene: 110834165

Following gene: 110834167

Centisome position: 47.41

GC content: 55.92

Gene sequence:

>1824_bases
TTGTCTAATTTCGACCCCAAACACTTCCTTCTCCACTGTGCCCGCAAACCCGGTGTTTATCGCATGCTGGACGCAGAGGG
TGGCGTTTTGTATGTGGGTAAAGCACGTAATCTGCAGGCACGCCTAAACAGTTACTTTCAGAAGAATGTGGCGAGCGTGA
AAACCCGCGCTCTAGTAGGGCGGATTCGCGATATCCAGACCACAGTGACAGGCAGTGAGGTCGAAGCGCTGCTGCTTGAG
CAGTCACTCATCAAGGAGCTTAAGCCGCCGTACAACATTTTGCTTCGCGACGACAAATCCTATCCTTATATACGCATCAC
CCGTTCTGATCGTTTTCCCCGCGTCACCTTTCACCGGGGAACCCGCCGGGCGGGGAGCCAGTATTTTGGCCCTTACCCCA
GCGGCAGTGCGGTGCGAGAAGCGCTATCGTTAATCGAGAAGATTTTCCAGGTTCGCAATTGCAGTGACAGCTACTTTCGA
AATCGCACTCGTCCGTGCTTGCAGCATCAGATTAATCGCTGCACAGCGCCATGTGTGGGCTTAGTGAGCGAAGAGGATTA
TGCCCGTCAGGTAACAATGGCGGCAGACTTTCTGGATGGGCGGAGTCGAGAGGTGGCCGACCAGCTCAGCACTGATATGG
AAGCCGCCGCTGCGGCGCTGGAATTTGAGAAAGCCGCCCTGCTACGCGATCAGCTGGCGGCGATTCAGGCAGTTCAGCAG
AAGCAGTACGCAGAAACCGGGCAAGGCGATCTGGATGTGGTGGCCATCGAAACCCGTCATGGCCTTGCCATAATCGAGGT
GCTGATGATCCGCGATGGCCGAATTCTTGGCCATCGCACCTTCCGACCTGATACCCGAGGAGAGGACGATCGCAGCGAAA
TCCTCGAGGCGTTCCTCTCTCAGTATTACCTTGGTGACAGAGAAGACCCGGTCAAGCCGCAGGAAATATTGCTGTGTATG
GAGATTCCCGGCGCTGAGGCTTTGCAGCAAGCGCTGGAGGAGCAGTGGGCTAAGAAAGTTCGGTTGGCTTGGCGCGTGCG
CAGCGACCGGGCCGCCTGGATTAGCATGGCGCAGACCAATGCCCAGCAATCCATGGCCACGGAAATGGCGGCAAGGGAAC
ACATGGAGGCTCGCTTTCTGGCCCTGGAAACGCTGCTTGAAAGCAGTGAGCCGATTCGCCGCATCGAGTGTTTCGATATT
AGCCATACGCAAGGTGAAAAAGCGGTGGCCTCCTGTGTGGTGTTCGATCAGCAGGGGGCACGCAAACAGGATTACCGGTA
TTTTAATGTAAATCCTGCAGCGGGTGGGGATGATTATGAAGCCTTGGAAGAAGCAATTCGGCGGCGCTATCAGCGTGTTT
TGAAAGAGCAAGGGCGCATGCCCGACTTACTGCTGATCGATGGCGGCAAGGGTCAAATGCAGCGTGGCTGGAAAGTTGTT
CAAGAATTGGATCTGCACGCCAGCATACGAGTGATGGGGATCGGTAAGGGGCCTAGCCGGCGGCCGGGGTTCGAAGCATT
ATACTTGCCTTGCGGGAAAGAAATGATTCCTGGCCCGGCAGACTCCGCGCTGCATCTTTTGCAGCAGGTGCGCGATGAGG
CTCACCGGTTTGCCCTGACAGGACACCGTGCAAGGCGCGGCAAAGCCCGCAAGCAATCGACGCTCGATGAAATTCCCGGT
ATTGGCCCTAAGCGTCGAAAGGCTTTACTTACTCATTTTGGCGGGCTCAAGCAGATGCGAAATGCATCCGCCAGCGAGTT
TGCTCGGGTGCCTGGCATCAATTCGCAAATGGCGCAAACGCTTTATGATTGGTTCCACCGCTAG

Upstream 100 bases:

>100_bases
GTGGAAAACTCGGTATTCTGACCGCTGCGCCTTACACAGGGGGAAATCGCTAGGGCAGTGCTGATACAATTACCTCGCCA
CACTGTGTTGAGATGCCCCC

Downstream 100 bases:

>100_bases
GAGGGGGCGTTTATTGATCTAAAAATCGGAAATGAGTCACGGCTGCCTTTGCGCTATACTGATAGCCTATTTCTTCTAGT
CGGTAGTCCCTCCCTATGCA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MSNFDPKHFLLHCARKPGVYRMLDAEGGVLYVGKARNLQARLNSYFQKNVASVKTRALVGRIRDIQTTVTGSEVEALLLE
QSLIKELKPPYNILLRDDKSYPYIRITRSDRFPRVTFHRGTRRAGSQYFGPYPSGSAVREALSLIEKIFQVRNCSDSYFR
NRTRPCLQHQINRCTAPCVGLVSEEDYARQVTMAADFLDGRSREVADQLSTDMEAAAAALEFEKAALLRDQLAAIQAVQQ
KQYAETGQGDLDVVAIETRHGLAIIEVLMIRDGRILGHRTFRPDTRGEDDRSEILEAFLSQYYLGDREDPVKPQEILLCM
EIPGAEALQQALEEQWAKKVRLAWRVRSDRAAWISMAQTNAQQSMATEMAAREHMEARFLALETLLESSEPIRRIECFDI
SHTQGEKAVASCVVFDQQGARKQDYRYFNVNPAAGGDDYEALEEAIRRRYQRVLKEQGRMPDLLLIDGGKGQMQRGWKVV
QELDLHASIRVMGIGKGPSRRPGFEALYLPCGKEMIPGPADSALHLLQQVRDEAHRFALTGHRARRGKARKQSTLDEIPG
IGPKRRKALLTHFGGLKQMRNASASEFARVPGINSQMAQTLYDWFHR

Sequences:

>Translated_607_residues
MSNFDPKHFLLHCARKPGVYRMLDAEGGVLYVGKARNLQARLNSYFQKNVASVKTRALVGRIRDIQTTVTGSEVEALLLE
QSLIKELKPPYNILLRDDKSYPYIRITRSDRFPRVTFHRGTRRAGSQYFGPYPSGSAVREALSLIEKIFQVRNCSDSYFR
NRTRPCLQHQINRCTAPCVGLVSEEDYARQVTMAADFLDGRSREVADQLSTDMEAAAAALEFEKAALLRDQLAAIQAVQQ
KQYAETGQGDLDVVAIETRHGLAIIEVLMIRDGRILGHRTFRPDTRGEDDRSEILEAFLSQYYLGDREDPVKPQEILLCM
EIPGAEALQQALEEQWAKKVRLAWRVRSDRAAWISMAQTNAQQSMATEMAAREHMEARFLALETLLESSEPIRRIECFDI
SHTQGEKAVASCVVFDQQGARKQDYRYFNVNPAAGGDDYEALEEAIRRRYQRVLKEQGRMPDLLLIDGGKGQMQRGWKVV
QELDLHASIRVMGIGKGPSRRPGFEALYLPCGKEMIPGPADSALHLLQQVRDEAHRFALTGHRARRGKARKQSTLDEIPG
IGPKRRKALLTHFGGLKQMRNASASEFARVPGINSQMAQTLYDWFHR
>Mature_606_residues
SNFDPKHFLLHCARKPGVYRMLDAEGGVLYVGKARNLQARLNSYFQKNVASVKTRALVGRIRDIQTTVTGSEVEALLLEQ
SLIKELKPPYNILLRDDKSYPYIRITRSDRFPRVTFHRGTRRAGSQYFGPYPSGSAVREALSLIEKIFQVRNCSDSYFRN
RTRPCLQHQINRCTAPCVGLVSEEDYARQVTMAADFLDGRSREVADQLSTDMEAAAAALEFEKAALLRDQLAAIQAVQQK
QYAETGQGDLDVVAIETRHGLAIIEVLMIRDGRILGHRTFRPDTRGEDDRSEILEAFLSQYYLGDREDPVKPQEILLCME
IPGAEALQQALEEQWAKKVRLAWRVRSDRAAWISMAQTNAQQSMATEMAAREHMEARFLALETLLESSEPIRRIECFDIS
HTQGEKAVASCVVFDQQGARKQDYRYFNVNPAAGGDDYEALEEAIRRRYQRVLKEQGRMPDLLLIDGGKGQMQRGWKVVQ
ELDLHASIRVMGIGKGPSRRPGFEALYLPCGKEMIPGPADSALHLLQQVRDEAHRFALTGHRARRGKARKQSTLDEIPGI
GPKRRKALLTHFGGLKQMRNASASEFARVPGINSQMAQTLYDWFHR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=606, Percent_Identity=45.3795379537954, Blast_Score=554, Evalue=1e-159,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_ALCBS (Q0VPZ5)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693025.1
- ProteinModelPortal:   Q0VPZ5
- STRING:   Q0VPZ5
- GeneID:   4211955
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1305
- NMPDR:   fig|393595.12.peg.1317
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q0VPZ5
- BioCyc:   ABOR393595:ABO_1305-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68750; Mature: 68619

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFDPKHFLLHCARKPGVYRMLDAEGGVLYVGKARNLQARLNSYFQKNVASVKTRALVG
CCCCCHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
RIRDIQTTVTGSEVEALLLEQSLIKELKPPYNILLRDDKSYPYIRITRSDRFPRVTFHRG
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCEEEEECC
TRRAGSQYFGPYPSGSAVREALSLIEKIFQVRNCSDSYFRNRTRPCLQHQINRCTAPCVG
CHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHH
LVSEEDYARQVTMAADFLDGRSREVADQLSTDMEAAAAALEFEKAALLRDQLAAIQAVQQ
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQYAETGQGDLDVVAIETRHGLAIIEVLMIRDGRILGHRTFRPDTRGEDDRSEILEAFLS
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHH
QYYLGDREDPVKPQEILLCMEIPGAEALQQALEEQWAKKVRLAWRVRSDRAAWISMAQTN
HHHCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AQQSMATEMAAREHMEARFLALETLLESSEPIRRIECFDISHTQGEKAVASCVVFDQQGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHEECCCCC
RKQDYRYFNVNPAAGGDDYEALEEAIRRRYQRVLKEQGRMPDLLLIDGGKGQMQRGWKVV
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHH
QELDLHASIRVMGIGKGPSRRPGFEALYLPCGKEMIPGPADSALHLLQQVRDEAHRFALT
HHHCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GHRARRGKARKQSTLDEIPGIGPKRRKALLTHFGGLKQMRNASASEFARVPGINSQMAQT
CCHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHH
LYDWFHR
HHHHHCC
>Mature Secondary Structure 
SNFDPKHFLLHCARKPGVYRMLDAEGGVLYVGKARNLQARLNSYFQKNVASVKTRALVG
CCCCHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
RIRDIQTTVTGSEVEALLLEQSLIKELKPPYNILLRDDKSYPYIRITRSDRFPRVTFHRG
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCEEEEECC
TRRAGSQYFGPYPSGSAVREALSLIEKIFQVRNCSDSYFRNRTRPCLQHQINRCTAPCVG
CHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHH
LVSEEDYARQVTMAADFLDGRSREVADQLSTDMEAAAAALEFEKAALLRDQLAAIQAVQQ
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQYAETGQGDLDVVAIETRHGLAIIEVLMIRDGRILGHRTFRPDTRGEDDRSEILEAFLS
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHH
QYYLGDREDPVKPQEILLCMEIPGAEALQQALEEQWAKKVRLAWRVRSDRAAWISMAQTN
HHHCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AQQSMATEMAAREHMEARFLALETLLESSEPIRRIECFDISHTQGEKAVASCVVFDQQGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHEECCCCC
RKQDYRYFNVNPAAGGDDYEALEEAIRRRYQRVLKEQGRMPDLLLIDGGKGQMQRGWKVV
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHH
QELDLHASIRVMGIGKGPSRRPGFEALYLPCGKEMIPGPADSALHLLQQVRDEAHRFALT
HHHCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GHRARRGKARKQSTLDEIPGIGPKRRKALLTHFGGLKQMRNASASEFARVPGINSQMAQT
CCHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHH
LYDWFHR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA