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The map label for this gene is bcd [H]

Identifier: 110834125

GI number: 110834125

Start: 1438862

End: 1440058

Strand: Direct

Name: bcd [H]

Synonym: ABO_1264

Alternate gene names: 110834125

Gene position: 1438862-1440058 (Clockwise)

Preceding gene: 110834124

Following gene: 110834126

Centisome position: 46.12

GC content: 53.63

Gene sequence:

>1197_bases
ATGATTAATTTAGAATTGCCCGAGAAGCTTAAACAAACCCAGCAGATGGCCCAGCAACTGGCCAGCGGTGTTTTTCGCCC
GATTTCACGCAAATACGACGCCATTGAACACTGCGAGACTCCGGAAGAGCTGAAACCCGTGGCGCAGATGATGGCGGCTA
TGCCCCGTGGGGGCGGAAAAAAAGGTGGCAGTAGCGAGTCAATTAAGAATGGCATCAACATGATGGGCATTCTAGGTGTT
GAGGCCATGTGCTGGGGTGATGTGGGCCTGATGTTGTCCATTCCCGGTTCCGGGTTAGGTAATGCGGCCATTATGGCCGT
GGGTACACCGGAGCAGAAAGAGAAGTATGGCAAGCTTTACTGTGCCATGGCGATTACGGAACCTGGTGCTGGTTCCGATT
CTGCCGCGGTCGCTACTACAGCGGTAGCAGAGGGTGATGAATGGGTGCTCAACGGTGAGAAGATTTACTGCACCGCTGGC
CAGCGCTGCGATGCTATTGTGGTTTGGGCCACGCTGGACAAGTCACTTGGCAAGGCCGCGATTAAGTCGTTTATCGTTCC
CCGTGATAACCCTGGCGTAGAGCTAGTGCGTGTGGAAGATAAGATGGGCTTACGGGTATCCGATACCGCCGCGTTAGCGT
TTAACAATTGCCGGATACCCAAAGACCATATTCTCGGTTCTGCCGAGGTGGGTGATACGGAAGAGGCACGCAAAAAATCC
TTCGGCGGGGTGATGCAGACCTTCGATAATACCCGTCCACAAGTGGCCGCCATGGCGTTGGGTGTGGCGCGTGCAGCCCT
GGAGATAACTTGCGATATTCTTGAAAAAGAAGGGGTTGCGGCTGATTACTCTAAACAGCCTTACAATTCAACCGCTCGAG
AGTTGGAGGTGTATCGGTTGGAGGCCGACTTGGAAGCGGCGCGGTTGATGACTCTCAAGGCTGCCTGGATGGCAGACAAT
GGCCAGCCCAATTCCCGTGAGGCTTCCATGTGTAAAGCCAAAGCCGGACGTATGGGCAACGACGTCACATTAAAGTGCGT
GGCGCTATGCGGTGAGCTGGGCTACTCCGAGCGCACCTTGTTGGAAAAACTGGCTCGAGATTCGAAAATCATCGATATCT
TCGAGGGCACCCAGCAGATCCAGCAGCTAATTGTGGCAAGGCATCTGCTTGGATTGTCATCGAAAGAACTGAAATAA

Upstream 100 bases:

>100_bases
TGGAGCGGGCTTTGTTCGCGACTACCCACTAGAGATGTGGTACCGGAACTTGCGCAGCATTGCCGTGCTTCACGGCAGCC
TGATGGTGTAGGAGAACAGC

Downstream 100 bases:

>100_bases
GCACAATAGAGCGATCAACAAAAAGCGCGGCTAAGCCGCGCTTTTTGTTTTTAAGGCAGGGCAGTAGACTCTCCCTTTGT
CTTTAACAAGGTCTTTGGGC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MINLELPEKLKQTQQMAQQLASGVFRPISRKYDAIEHCETPEELKPVAQMMAAMPRGGGKKGGSSESIKNGINMMGILGV
EAMCWGDVGLMLSIPGSGLGNAAIMAVGTPEQKEKYGKLYCAMAITEPGAGSDSAAVATTAVAEGDEWVLNGEKIYCTAG
QRCDAIVVWATLDKSLGKAAIKSFIVPRDNPGVELVRVEDKMGLRVSDTAALAFNNCRIPKDHILGSAEVGDTEEARKKS
FGGVMQTFDNTRPQVAAMALGVARAALEITCDILEKEGVAADYSKQPYNSTARELEVYRLEADLEAARLMTLKAAWMADN
GQPNSREASMCKAKAGRMGNDVTLKCVALCGELGYSERTLLEKLARDSKIIDIFEGTQQIQQLIVARHLLGLSSKELK

Sequences:

>Translated_398_residues
MINLELPEKLKQTQQMAQQLASGVFRPISRKYDAIEHCETPEELKPVAQMMAAMPRGGGKKGGSSESIKNGINMMGILGV
EAMCWGDVGLMLSIPGSGLGNAAIMAVGTPEQKEKYGKLYCAMAITEPGAGSDSAAVATTAVAEGDEWVLNGEKIYCTAG
QRCDAIVVWATLDKSLGKAAIKSFIVPRDNPGVELVRVEDKMGLRVSDTAALAFNNCRIPKDHILGSAEVGDTEEARKKS
FGGVMQTFDNTRPQVAAMALGVARAALEITCDILEKEGVAADYSKQPYNSTARELEVYRLEADLEAARLMTLKAAWMADN
GQPNSREASMCKAKAGRMGNDVTLKCVALCGELGYSERTLLEKLARDSKIIDIFEGTQQIQQLIVARHLLGLSSKELK
>Mature_398_residues
MINLELPEKLKQTQQMAQQLASGVFRPISRKYDAIEHCETPEELKPVAQMMAAMPRGGGKKGGSSESIKNGINMMGILGV
EAMCWGDVGLMLSIPGSGLGNAAIMAVGTPEQKEKYGKLYCAMAITEPGAGSDSAAVATTAVAEGDEWVLNGEKIYCTAG
QRCDAIVVWATLDKSLGKAAIKSFIVPRDNPGVELVRVEDKMGLRVSDTAALAFNNCRIPKDHILGSAEVGDTEEARKKS
FGGVMQTFDNTRPQVAAMALGVARAALEITCDILEKEGVAADYSKQPYNSTARELEVYRLEADLEAARLMTLKAAWMADN
GQPNSREASMCKAKAGRMGNDVTLKCVALCGELGYSERTLLEKLARDSKIIDIFEGTQQIQQLIVARHLLGLSSKELK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=411, Percent_Identity=33.3333333333333, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4557231, Length=402, Percent_Identity=33.5820895522388, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI187960098, Length=402, Percent_Identity=33.5820895522388, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4501859, Length=296, Percent_Identity=34.1216216216216, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI21361497, Length=342, Percent_Identity=30.1169590643275, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI76496475, Length=322, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4557235, Length=322, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4501857, Length=409, Percent_Identity=25.1833740831296, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI226958414, Length=288, Percent_Identity=27.4305555555556, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI226958412, Length=288, Percent_Identity=27.4305555555556, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI7656849, Length=402, Percent_Identity=25.1243781094527, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4503943, Length=306, Percent_Identity=23.8562091503268, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI7669494, Length=173, Percent_Identity=27.7456647398844, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38505218, Length=317, Percent_Identity=24.6056782334385, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786223, Length=314, Percent_Identity=26.4331210191083, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87081958, Length=291, Percent_Identity=25.4295532646048, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=404, Percent_Identity=34.1584158415842, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17534899, Length=406, Percent_Identity=34.2364532019704, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=32.2751322751323, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=289, Percent_Identity=32.8719723183391, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17506239, Length=336, Percent_Identity=30.6547619047619, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71990804, Length=251, Percent_Identity=32.2709163346614, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17538396, Length=300, Percent_Identity=29, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71985184, Length=302, Percent_Identity=28.476821192053, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17505929, Length=307, Percent_Identity=27.3615635179153, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17533517, Length=277, Percent_Identity=27.0758122743682, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17551932, Length=298, Percent_Identity=26.510067114094, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32563615, Length=225, Percent_Identity=31.5555555555556, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71985192, Length=187, Percent_Identity=33.1550802139037, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=207, Percent_Identity=29.951690821256, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=299, Percent_Identity=23.4113712374582, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24660351, Length=324, Percent_Identity=36.7283950617284, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24646207, Length=397, Percent_Identity=29.2191435768262, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI21356377, Length=308, Percent_Identity=34.0909090909091, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24666513, Length=391, Percent_Identity=30.4347826086957, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI281363737, Length=315, Percent_Identity=29.8412698412698, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355753, Length=297, Percent_Identity=29.6296296296296, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19920834, Length=313, Percent_Identity=27.4760383386581, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 42796; Mature: 42796

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINLELPEKLKQTQQMAQQLASGVFRPISRKYDAIEHCETPEELKPVAQMMAAMPRGGGK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
KGGSSESIKNGINMMGILGVEAMCWGDVGLMLSIPGSGLGNAAIMAVGTPEQKEKYGKLY
CCCCHHHHHCCCCEEEHHCCHHEEECCCCEEEECCCCCCCCEEEEEECCCHHHHHHCCEE
CAMAITEPGAGSDSAAVATTAVAEGDEWVLNGEKIYCTAGQRCDAIVVWATLDKSLGKAA
EEEEEECCCCCCCCCCEEEEEEECCCCEEEECCEEEEECCCCCCEEEEEEECCHHHHHHH
IKSFIVPRDNPGVELVRVEDKMGLRVSDTAALAFNNCRIPKDHILGSAEVGDTEEARKKS
HHHHCCCCCCCCEEEEEEECCCCCEEECCEEEEECCCCCCHHHCCCCCCCCCCHHHHHHH
FGGVMQTFDNTRPQVAAMALGVARAALEITCDILEKEGVAADYSKQPYNSTARELEVYRL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEE
EADLEAARLMTLKAAWMADNGQPNSREASMCKAKAGRMGNDVTLKCVALCGELGYSERTL
CCCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHH
LEKLARDSKIIDIFEGTQQIQQLIVARHLLGLSSKELK
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MINLELPEKLKQTQQMAQQLASGVFRPISRKYDAIEHCETPEELKPVAQMMAAMPRGGGK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
KGGSSESIKNGINMMGILGVEAMCWGDVGLMLSIPGSGLGNAAIMAVGTPEQKEKYGKLY
CCCCHHHHHCCCCEEEHHCCHHEEECCCCEEEECCCCCCCCEEEEEECCCHHHHHHCCEE
CAMAITEPGAGSDSAAVATTAVAEGDEWVLNGEKIYCTAGQRCDAIVVWATLDKSLGKAA
EEEEEECCCCCCCCCCEEEEEEECCCCEEEECCEEEEECCCCCCEEEEEEECCHHHHHHH
IKSFIVPRDNPGVELVRVEDKMGLRVSDTAALAFNNCRIPKDHILGSAEVGDTEEARKKS
HHHHCCCCCCCCEEEEEEECCCCCEEECCEEEEECCCCCCHHHCCCCCCCCCCHHHHHHH
FGGVMQTFDNTRPQVAAMALGVARAALEITCDILEKEGVAADYSKQPYNSTARELEVYRL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEE
EADLEAARLMTLKAAWMADNGQPNSREASMCKAKAGRMGNDVTLKCVALCGELGYSERTL
CCCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHH
LEKLARDSKIIDIFEGTQQIQQLIVARHLLGLSSKELK
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]