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The map label for this gene is betA [C]

Identifier: 110834035

GI number: 110834035

Start: 1334369

End: 1335934

Strand: Direct

Name: betA [C]

Synonym: ABO_1174

Alternate gene names: 110834035

Gene position: 1334369-1335934 (Clockwise)

Preceding gene: 110834034

Following gene: 110834036

Centisome position: 42.77

GC content: 52.94

Gene sequence:

>1566_bases
ATGAGTGAAACAATAACAGCAACAACAGCCAGCTCGGCGAAGTGGCAGGCAACAGGCCTTGCCGTACACCAAGCCAGTGA
TGTAACAGACAAAAACATCGAGATTCAGGCGGATGTTGTGATTGTGGGGTCTGGAGCCGGGGGAGCGGTTAGTGCTTATG
AGTTGGCACGGCGGGGCTTTAAGGTGGTGGTGTTGGAAGCGGGGGCTTATGTGCCCTCCAAGGACTTTACGGAACGTTTC
AGTGAGAGTCTGGGTACTCTTTATCAGGATCACGGAGCACAGACCAATAGCAGTGGTGATTTATTGGTGCTGCAGGGGGC
CTGCGTGGGTGGCTCCACAGTAGTTAATGGTTGCGTTTGTTTCCGTACCCCGGATTTCATTTTGCAGGACTGGCAGCGAG
ATTTTGGCCTTAGCGATCTGACCACCGCAGAACTCACTCCCTATTTTGAGGAAGTAGAAAAGAATCTGTCGGTGGACGAC
AACGGCGAACATGAGATTCCGAATCACAGCCGTCTAATTCGCGCTGGCGCTAACCGTCTTGGTTGGTCGGTGAAACCGTT
AAAACGCAATATTCGTCAATGCGGGCTTACCGGGCACTGCTTGTCTGGTTGTAAAACGGAACGCAAACAATCCATGTTAG
TGACCTATCTGCCTTGGGCAGCAGCCCATGGTGCGCAGATTTATGCGGATACTCGAGTGGATAAAATTCTTACTGAGAAT
GGTAAAGCCAGTGGAGTAAACGCGACGGTCACCCATCGTGATGGCACTGTGGCCGCGCGCATGACGGTAACGGCGCCGCG
GGTGGTTGTGGCGGCTGGCGCGGTACAAACCCCGTTGTTGATGCTAAAAAGTGCTCTGGGCAACCGTTCTGGCCAAGTGG
GTAAAAACTTTGCTTGTCACCCGTCATTGTATGTTCCGGCCCGCTATCCGGAGCCGGTGTATCCGTGGCGCGGTGCCCTG
CTTGGTGTCTATGTGGACGAATTCATGCCTCTGGATAAGGGTGGTTTCATACTTGAAGACGGAGGTTCTGGCCTGGTGGA
ACTCACCATGGGGGCGGAGCCGGGCACTGGCAAACCGTTTATGGCGTATATGGAAAAGGCTAAATATCTGGGTGGCTTGG
TTACTCTGATCCACGACCATAATGTAGGAACGGTAGAATGGGATGGGGAACGTAAAAAAATCGATTATCAGTTGAGTGAC
ATGGATTTTCCTTCCATGCAGCGAGCCTTGAAAGCGGCAGCACGCCTACATTTAGCGTCCGGTGCGGAAGAGGTTTATGT
GCCTGCTAGTGACCATCGAGTAATCCGTAGCGAAGCGGATATCGATACCATGGTCGACAGTCTGGAAAATCAGCCACAGC
ATTTGCGCATGGTCAGCTACCACCCTCAGGGTACCTGCAGGATGGGGGTGGACCCGGATAACAGTGTGGTAGGCAGTGAT
GGGCAGAGCCATGATGTGCCTGGCTTATACGTGGCAGATGCGAGCGTTTTGCCCACCTCTATTATCGTTAATCCGCAAAT
TACAGTGTATGCACTCGCCACCCGCATTGCCCGCCAAATGAGCTAA

Upstream 100 bases:

>100_bases
TCGATGGGCCGGTTAGCGACAAGTGGGGCCTGGCTTACCTTGGCAATGCGCCGCTGCCTGCAAACGATGTACTGCAGATT
AATCAGCCGGAGGGGCGGGC

Downstream 100 bases:

>100_bases
ACGGGGAGGGTAGGATTACTCTCATACCCATTAAGTCACCGTTTTTGACTATGCTGATTACGCCCCCGGTTATGCCGGGG
GTTTGGGTGTGTATAACGCT

Product: GMC oxidoreductase family protein

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MSETITATTASSAKWQATGLAVHQASDVTDKNIEIQADVVIVGSGAGGAVSAYELARRGFKVVVLEAGAYVPSKDFTERF
SESLGTLYQDHGAQTNSSGDLLVLQGACVGGSTVVNGCVCFRTPDFILQDWQRDFGLSDLTTAELTPYFEEVEKNLSVDD
NGEHEIPNHSRLIRAGANRLGWSVKPLKRNIRQCGLTGHCLSGCKTERKQSMLVTYLPWAAAHGAQIYADTRVDKILTEN
GKASGVNATVTHRDGTVAARMTVTAPRVVVAAGAVQTPLLMLKSALGNRSGQVGKNFACHPSLYVPARYPEPVYPWRGAL
LGVYVDEFMPLDKGGFILEDGGSGLVELTMGAEPGTGKPFMAYMEKAKYLGGLVTLIHDHNVGTVEWDGERKKIDYQLSD
MDFPSMQRALKAAARLHLASGAEEVYVPASDHRVIRSEADIDTMVDSLENQPQHLRMVSYHPQGTCRMGVDPDNSVVGSD
GQSHDVPGLYVADASVLPTSIIVNPQITVYALATRIARQMS

Sequences:

>Translated_521_residues
MSETITATTASSAKWQATGLAVHQASDVTDKNIEIQADVVIVGSGAGGAVSAYELARRGFKVVVLEAGAYVPSKDFTERF
SESLGTLYQDHGAQTNSSGDLLVLQGACVGGSTVVNGCVCFRTPDFILQDWQRDFGLSDLTTAELTPYFEEVEKNLSVDD
NGEHEIPNHSRLIRAGANRLGWSVKPLKRNIRQCGLTGHCLSGCKTERKQSMLVTYLPWAAAHGAQIYADTRVDKILTEN
GKASGVNATVTHRDGTVAARMTVTAPRVVVAAGAVQTPLLMLKSALGNRSGQVGKNFACHPSLYVPARYPEPVYPWRGAL
LGVYVDEFMPLDKGGFILEDGGSGLVELTMGAEPGTGKPFMAYMEKAKYLGGLVTLIHDHNVGTVEWDGERKKIDYQLSD
MDFPSMQRALKAAARLHLASGAEEVYVPASDHRVIRSEADIDTMVDSLENQPQHLRMVSYHPQGTCRMGVDPDNSVVGSD
GQSHDVPGLYVADASVLPTSIIVNPQITVYALATRIARQMS
>Mature_520_residues
SETITATTASSAKWQATGLAVHQASDVTDKNIEIQADVVIVGSGAGGAVSAYELARRGFKVVVLEAGAYVPSKDFTERFS
ESLGTLYQDHGAQTNSSGDLLVLQGACVGGSTVVNGCVCFRTPDFILQDWQRDFGLSDLTTAELTPYFEEVEKNLSVDDN
GEHEIPNHSRLIRAGANRLGWSVKPLKRNIRQCGLTGHCLSGCKTERKQSMLVTYLPWAAAHGAQIYADTRVDKILTENG
KASGVNATVTHRDGTVAARMTVTAPRVVVAAGAVQTPLLMLKSALGNRSGQVGKNFACHPSLYVPARYPEPVYPWRGALL
GVYVDEFMPLDKGGFILEDGGSGLVELTMGAEPGTGKPFMAYMEKAKYLGGLVTLIHDHNVGTVEWDGERKKIDYQLSDM
DFPSMQRALKAAARLHLASGAEEVYVPASDHRVIRSEADIDTMVDSLENQPQHLRMVSYHPQGTCRMGVDPDNSVVGSDG
QSHDVPGLYVADASVLPTSIIVNPQITVYALATRIARQMS

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 56141; Mature: 56010

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETITATTASSAKWQATGLAVHQASDVTDKNIEIQADVVIVGSGAGGAVSAYELARRGF
CCCEEEEEECCCCCEEEEEEEEEECCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHCCC
KVVVLEAGAYVPSKDFTERFSESLGTLYQDHGAQTNSSGDLLVLQGACVGGSTVVNGCVC
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHCCEEE
FRTPDFILQDWQRDFGLSDLTTAELTPYFEEVEKNLSVDDNGEHEIPNHSRLIRAGANRL
ECCCHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCHHHC
GWSVKPLKRNIRQCGLTGHCLSGCKTERKQSMLVTYLPWAAAHGAQIYADTRVDKILTEN
CCEEHHHHHHHHHCCCCHHHHHCCHHHHHHCEEEEEECCHHCCCCEEEECCHHHHHHHCC
GKASGVNATVTHRDGTVAARMTVTAPRVVVAAGAVQTPLLMLKSALGNRSGQVGKNFACH
CCCCCCEEEEEECCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEECC
PSLYVPARYPEPVYPWRGALLGVYVDEFMPLDKGGFILEDGGSGLVELTMGAEPGTGKPF
CCEEECCCCCCCCCCCCHHHHEEEHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCCCHH
MAYMEKAKYLGGLVTLIHDHNVGTVEWDGERKKIDYQLSDMDFPSMQRALKAAARLHLAS
HHHHHHHHHHCCEEEEEECCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCC
GAEEVYVPASDHRVIRSEADIDTMVDSLENQPQHLRMVSYHPQGTCRMGVDPDNSVVGSD
CCCEEEECCCCCEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCEECCC
GQSHDVPGLYVADASVLPTSIIVNPQITVYALATRIARQMS
CCCCCCCEEEEECCCCCCEEEEECCCEEEHHHHHHHHHHCC
>Mature Secondary Structure 
SETITATTASSAKWQATGLAVHQASDVTDKNIEIQADVVIVGSGAGGAVSAYELARRGF
CCEEEEEECCCCCEEEEEEEEEECCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHCCC
KVVVLEAGAYVPSKDFTERFSESLGTLYQDHGAQTNSSGDLLVLQGACVGGSTVVNGCVC
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHCCEEE
FRTPDFILQDWQRDFGLSDLTTAELTPYFEEVEKNLSVDDNGEHEIPNHSRLIRAGANRL
ECCCHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCHHHC
GWSVKPLKRNIRQCGLTGHCLSGCKTERKQSMLVTYLPWAAAHGAQIYADTRVDKILTEN
CCEEHHHHHHHHHCCCCHHHHHCCHHHHHHCEEEEEECCHHCCCCEEEECCHHHHHHHCC
GKASGVNATVTHRDGTVAARMTVTAPRVVVAAGAVQTPLLMLKSALGNRSGQVGKNFACH
CCCCCCEEEEEECCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEECC
PSLYVPARYPEPVYPWRGALLGVYVDEFMPLDKGGFILEDGGSGLVELTMGAEPGTGKPF
CCEEECCCCCCCCCCCCHHHHEEEHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCCCHH
MAYMEKAKYLGGLVTLIHDHNVGTVEWDGERKKIDYQLSDMDFPSMQRALKAAARLHLAS
HHHHHHHHHHCCEEEEEECCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCC
GAEEVYVPASDHRVIRSEADIDTMVDSLENQPQHLRMVSYHPQGTCRMGVDPDNSVVGSD
CCCEEEECCCCCEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCEECCC
GQSHDVPGLYVADASVLPTSIIVNPQITVYALATRIARQMS
CCCCCCCEEEEECCCCCCEEEEECCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]