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The map label for this gene is pyrH

Identifier: 110834006

GI number: 110834006

Start: 1302561

End: 1303319

Strand: Direct

Name: pyrH

Synonym: ABO_1145

Alternate gene names: 110834006

Gene position: 1302561-1303319 (Clockwise)

Preceding gene: 110834005

Following gene: 110834007

Centisome position: 41.75

GC content: 52.31

Gene sequence:

>759_bases
ATGAGTGGTGGAGAGAAAGAGATGCCGACGAACAAGGAGCGCTCACCGCGCTATAACCGAATCCTGCTCAAGCTGAGCGG
GGAAGCACTGGCGGGTGAAGAGGGCTTTGGCATTGATCCGAAGGTTCTGGATGCGATTTCCTTGGAAATTGGTCAGTTGG
TTGGGATTGGTGTTCAGGTTGGGCTGGTCGTTGGTGGTGGTAATCTGTTTCGGGGTGCGGCTCTGCAAAGCGCAGGCTTG
GACCGGGTAGCCGGCGACCATATGGGTATGCTGGCAACAGTGATGAATGGCCTGGCTCTGCGTGATGCGCTGGAACGTTC
TAATATCCGTACGCGTCTCATGTCTGCGATCCCCATGAGTGGGGTGGTTGAGCACTATGATCATCGCAATGCTAATCGTC
ACCTAAAAAACGGAGAGGTGGTGATTTTTTGCGCAGGAACAGGCAACCCGTTCTTTACTACAGACTCTGCCGCGTGTCTG
CGTGGAATCGAGATCAGTGCTGATGTAGTGCTAAAGGCCACCAAGGTGGATGGCGTTTATAATGACGATCCGGTGAAGAA
CCCGGATGCGGTTAAATATGACGCGTTGACCTATGATGAAGTGTTGGAAAAAAAGCTGGGCGTGATGGATCTGACGGCTA
TTTGTTTGTGCCGGGATCATTCCATGCCACTGCGTGTTTTTGATATGAACAAGAAGGGTGCCTTGCTTAATCTGATGCTG
GGCGGTAAGGAAGGCACTCTGGTAGAGGCCGCACAATAA

Upstream 100 bases:

>100_bases
TGCTATGCAGCATAGGCTCGTGCGTTTGAATGAAGTGGAAGGCCGGTTTGAGCCGGTGTAAGTGATGAGGATGGCAGGTT
TTCATGGGTGGCGGTTTCGT

Downstream 100 bases:

>100_bases
GTGCAGCTGATACGCTGAATAGAAGCGAGGAAAAACGGTGATTGACGATATTCGCAGTGATGCGCAAAGCCGCATGAAAA
AGAGTCTTGAAGCGCTGGAT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSGGEKEMPTNKERSPRYNRILLKLSGEALAGEEGFGIDPKVLDAISLEIGQLVGIGVQVGLVVGGGNLFRGAALQSAGL
DRVAGDHMGMLATVMNGLALRDALERSNIRTRLMSAIPMSGVVEHYDHRNANRHLKNGEVVIFCAGTGNPFFTTDSAACL
RGIEISADVVLKATKVDGVYNDDPVKNPDAVKYDALTYDEVLEKKLGVMDLTAICLCRDHSMPLRVFDMNKKGALLNLML
GGKEGTLVEAAQ

Sequences:

>Translated_252_residues
MSGGEKEMPTNKERSPRYNRILLKLSGEALAGEEGFGIDPKVLDAISLEIGQLVGIGVQVGLVVGGGNLFRGAALQSAGL
DRVAGDHMGMLATVMNGLALRDALERSNIRTRLMSAIPMSGVVEHYDHRNANRHLKNGEVVIFCAGTGNPFFTTDSAACL
RGIEISADVVLKATKVDGVYNDDPVKNPDAVKYDALTYDEVLEKKLGVMDLTAICLCRDHSMPLRVFDMNKKGALLNLML
GGKEGTLVEAAQ
>Mature_251_residues
SGGEKEMPTNKERSPRYNRILLKLSGEALAGEEGFGIDPKVLDAISLEIGQLVGIGVQVGLVVGGGNLFRGAALQSAGLD
RVAGDHMGMLATVMNGLALRDALERSNIRTRLMSAIPMSGVVEHYDHRNANRHLKNGEVVIFCAGTGNPFFTTDSAACLR
GIEISADVVLKATKVDGVYNDDPVKNPDAVKYDALTYDEVLEKKLGVMDLTAICLCRDHSMPLRVFDMNKKGALLNLMLG
GKEGTLVEAAQ

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=241, Percent_Identity=65.5601659751037, Blast_Score=320, Evalue=6e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_ALCBS (Q0VQF5)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692865.1
- ProteinModelPortal:   Q0VQF5
- SMR:   Q0VQF5
- STRING:   Q0VQF5
- GeneID:   4211643
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1145
- NMPDR:   fig|393595.12.peg.1156
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q0VQF5
- ProtClustDB:   PRK00358
- BioCyc:   ABOR393595:ABO_1145-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26985; Mature: 26853

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: BINDING 66-66 BINDING 67-67 BINDING 71-71 BINDING 86-86 BINDING 174-174 BINDING 180-180 BINDING 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGGEKEMPTNKERSPRYNRILLKLSGEALAGEEGFGIDPKVLDAISLEIGQLVGIGVQV
CCCCCCCCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHEECCEEE
GLVVGGGNLFRGAALQSAGLDRVAGDHMGMLATVMNGLALRDALERSNIRTRLMSAIPMS
EEEEECCCHHHCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
GVVEHYDHRNANRHLKNGEVVIFCAGTGNPFFTTDSAACLRGIEISADVVLKATKVDGVY
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEECCHHHHHCCCEECCEEEEEEEEECCCC
NDDPVKNPDAVKYDALTYDEVLEKKLGVMDLTAICLCRDHSMPLRVFDMNKKGALLNLML
CCCCCCCCCCEEECCCCHHHHHHHHCCHHHHHHEEEECCCCCCEEEEECCCCCCEEEEEE
GGKEGTLVEAAQ
CCCCCCEEECCC
>Mature Secondary Structure 
SGGEKEMPTNKERSPRYNRILLKLSGEALAGEEGFGIDPKVLDAISLEIGQLVGIGVQV
CCCCCCCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHEECCEEE
GLVVGGGNLFRGAALQSAGLDRVAGDHMGMLATVMNGLALRDALERSNIRTRLMSAIPMS
EEEEECCCHHHCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
GVVEHYDHRNANRHLKNGEVVIFCAGTGNPFFTTDSAACLRGIEISADVVLKATKVDGVY
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEECCHHHHHCCCEECCEEEEEEEEECCCC
NDDPVKNPDAVKYDALTYDEVLEKKLGVMDLTAICLCRDHSMPLRVFDMNKKGALLNLML
CCCCCCCCCCEEECCCCHHHHHHHHCCHHHHHHEEEECCCCCCEEEEECCCCCCEEEEEE
GGKEGTLVEAAQ
CCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA