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The map label for this gene is fabF [H]

Identifier: 110833932

GI number: 110833932

Start: 1213045

End: 1214247

Strand: Direct

Name: fabF [H]

Synonym: ABO_1071

Alternate gene names: 110833932

Gene position: 1213045-1214247 (Clockwise)

Preceding gene: 110833931

Following gene: 110833933

Centisome position: 38.88

GC content: 55.28

Gene sequence:

>1203_bases
ATGCTCACGCCGCTTGGAGTCGATGTGGCTTCTACTTGGGAAGGCATCAAGGCGGGTAAAAGTGGCATTCGCAATATCGA
GCACTTTGATACGGAGCGCTTTGCTACCCGTTTTGCTGGCCTGGTGCCTGACTTTGATATTTCCGAATACTTGTCCCCCA
AAGATGCCCGCAAGATGGACATTTTTGTTCAGTACGGTTTGGTGGCGGCTATTCAGGCTGTGCGTGATGCGGGCTTGGAC
ATGGAAAAGGAAGACGCCGAACGCGTTGGTGCCGCTATTGGCTCGGGCATTGGAGGCCTCACCTATATCGAAGAAAACCA
TCGTAAACTGCTCGATTCCGGTCCGCGTAAGCTGTCGCCCTTCTTTGTGCCCGGCACCATTATTAATATGATCGCAGGTA
ATCTGGCGATCATGTACGGGATGAAAGGGCCGAACTTTGCCACGGTAACAGCGTGCACCACAGGCACCCACAATATAGGG
TTTGCCGCCCAGCAGATTATTCTGGGGCAGGCGGATGTGATGGTTGCTGGCGGGGCAGAGAAAGGATCTTCACCATTGGG
AGTAGGTGGTTTTGCCGCTGCACGTGCATTATCTACTCGTAACGATGACCCACAAGCAGCTAGTCGCCCCTGGGACAAAG
ATCGCGATGGCTTTGTGCTGGCTGATGGCGCTGGTGCGGTTGTGCTAGAAGAGTACGAGCACGCCAAGGCCCGTGGTGCC
ACCATCTATGCGGAGCTGGTAGGTTTTGGCATGAGTGATGATGCATACCACATCACTTCTCCGGCAGCGGGCGGCGACGG
AGCCATGCGTGCCATGCGCAACGCCCTGCGCAATGCCGGGGTTGAGCCGGATCAGGTGGATTACATCAATGCCCACGGCA
CCTCCACGCAAATGGGTGATGTGGCCGAAGCGATGGCGGTGAAAACCCTGTTTGGTGATCATGCCTACAAATTGGCGGTG
AGCTCCACCAAGTCCATGGTCGGGCATTTGCTGGGTGCGGCGGGGGCCGTGGAAGCGATTTTCTCCATTTTGGCCATGCG
TGATTCGGTGGCTCCGCCTACCATCAATCTGGATAACCCGGATGAAGGGTGTGACCTGAACTTCGTGGCAAATCAGGCTC
AGGAACGCACCATCAACTACGCGCTGTCCAATTCCTTTGGTTTTGGTGGTACTAACGGCACCTTGCTGTTCAAGAAGGTG
TAA

Upstream 100 bases:

>100_bases
TAGTAGTCTTGTTGCATTAAGGCCTTTAAATGGCGCCAAAAAACATGGATTTGGGAGGTATTGGGTGACGTCACGTCGAG
TCGTTATTACAGGGTTGGGA

Downstream 100 bases:

>100_bases
TGCCACTAGACCCCCGTGATCGCGGCCTCGCTTACGGAGATGGTGTGTTTGAAACCGTGCGAGTGACCGCCTCCGGCAAG
TCGCCATTGTGGGCTCGCCA

Product: 3-oxoacyl-[acyl-carrier-protein] synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLTPLGVDVASTWEGIKAGKSGIRNIEHFDTERFATRFAGLVPDFDISEYLSPKDARKMDIFVQYGLVAAIQAVRDAGLD
MEKEDAERVGAAIGSGIGGLTYIEENHRKLLDSGPRKLSPFFVPGTIINMIAGNLAIMYGMKGPNFATVTACTTGTHNIG
FAAQQIILGQADVMVAGGAEKGSSPLGVGGFAAARALSTRNDDPQAASRPWDKDRDGFVLADGAGAVVLEEYEHAKARGA
TIYAELVGFGMSDDAYHITSPAAGGDGAMRAMRNALRNAGVEPDQVDYINAHGTSTQMGDVAEAMAVKTLFGDHAYKLAV
SSTKSMVGHLLGAAGAVEAIFSILAMRDSVAPPTINLDNPDEGCDLNFVANQAQERTINYALSNSFGFGGTNGTLLFKKV

Sequences:

>Translated_400_residues
MLTPLGVDVASTWEGIKAGKSGIRNIEHFDTERFATRFAGLVPDFDISEYLSPKDARKMDIFVQYGLVAAIQAVRDAGLD
MEKEDAERVGAAIGSGIGGLTYIEENHRKLLDSGPRKLSPFFVPGTIINMIAGNLAIMYGMKGPNFATVTACTTGTHNIG
FAAQQIILGQADVMVAGGAEKGSSPLGVGGFAAARALSTRNDDPQAASRPWDKDRDGFVLADGAGAVVLEEYEHAKARGA
TIYAELVGFGMSDDAYHITSPAAGGDGAMRAMRNALRNAGVEPDQVDYINAHGTSTQMGDVAEAMAVKTLFGDHAYKLAV
SSTKSMVGHLLGAAGAVEAIFSILAMRDSVAPPTINLDNPDEGCDLNFVANQAQERTINYALSNSFGFGGTNGTLLFKKV
>Mature_400_residues
MLTPLGVDVASTWEGIKAGKSGIRNIEHFDTERFATRFAGLVPDFDISEYLSPKDARKMDIFVQYGLVAAIQAVRDAGLD
MEKEDAERVGAAIGSGIGGLTYIEENHRKLLDSGPRKLSPFFVPGTIINMIAGNLAIMYGMKGPNFATVTACTTGTHNIG
FAAQQIILGQADVMVAGGAEKGSSPLGVGGFAAARALSTRNDDPQAASRPWDKDRDGFVLADGAGAVVLEEYEHAKARGA
TIYAELVGFGMSDDAYHITSPAAGGDGAMRAMRNALRNAGVEPDQVDYINAHGTSTQMGDVAEAMAVKTLFGDHAYKLAV
SSTKSMVGHLLGAAGAVEAIFSILAMRDSVAPPTINLDNPDEGCDLNFVANQAQERTINYALSNSFGFGGTNGTLLFKKV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=407, Percent_Identity=47.4201474201474, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI223972627, Length=171, Percent_Identity=53.2163742690059, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI41872631, Length=394, Percent_Identity=26.1421319796954, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1787337, Length=401, Percent_Identity=67.5810473815461, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=38.423645320197, Blast_Score=238, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=403, Percent_Identity=38.9578163771712, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=44.6969696969697, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=24.8603351955307, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=350, Percent_Identity=25.1428571428571, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=435, Percent_Identity=38.6206896551724, Blast_Score=279, Evalue=7e-76,
Organism=Drosophila melanogaster, GI24644341, Length=407, Percent_Identity=41.2776412776413, Blast_Score=301, Evalue=4e-82,
Organism=Drosophila melanogaster, GI221330659, Length=410, Percent_Identity=24.8780487804878, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19920632, Length=410, Percent_Identity=24.8780487804878, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581345, Length=407, Percent_Identity=23.8329238329238, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42091; Mature: 42091

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTPLGVDVASTWEGIKAGKSGIRNIEHFDTERFATRFAGLVPDFDISEYLSPKDARKMD
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCEE
IFVQYGLVAAIQAVRDAGLDMEKEDAERVGAAIGSGIGGLTYIEENHRKLLDSGPRKLSP
EHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCC
FFVPGTIINMIAGNLAIMYGMKGPNFATVTACTTGTHNIGFAAQQIILGQADVMVAGGAE
EECCHHHHHHHHCCEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHCCCCCEEEECCCC
KGSSPLGVGGFAAARALSTRNDDPQAASRPWDKDRDGFVLADGAGAVVLEEYEHAKARGA
CCCCCCCCCHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEEECCCCEEEEHHHHHHHHCCC
TIYAELVGFGMSDDAYHITSPAAGGDGAMRAMRNALRNAGVEPDQVDYINAHGTSTQMGD
EEEEHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
VAEAMAVKTLFGDHAYKLAVSSTKSMVGHLLGAAGAVEAIFSILAMRDSVAPPTINLDNP
HHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCC
DEGCDLNFVANQAQERTINYALSNSFGFGGTNGTLLFKKV
CCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MLTPLGVDVASTWEGIKAGKSGIRNIEHFDTERFATRFAGLVPDFDISEYLSPKDARKMD
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCEE
IFVQYGLVAAIQAVRDAGLDMEKEDAERVGAAIGSGIGGLTYIEENHRKLLDSGPRKLSP
EHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCC
FFVPGTIINMIAGNLAIMYGMKGPNFATVTACTTGTHNIGFAAQQIILGQADVMVAGGAE
EECCHHHHHHHHCCEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHCCCCCEEEECCCC
KGSSPLGVGGFAAARALSTRNDDPQAASRPWDKDRDGFVLADGAGAVVLEEYEHAKARGA
CCCCCCCCCHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEEECCCCEEEEHHHHHHHHCCC
TIYAELVGFGMSDDAYHITSPAAGGDGAMRAMRNALRNAGVEPDQVDYINAHGTSTQMGD
EEEEHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
VAEAMAVKTLFGDHAYKLAVSSTKSMVGHLLGAAGAVEAIFSILAMRDSVAPPTINLDNP
HHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCC
DEGCDLNFVANQAQERTINYALSNSFGFGGTNGTLLFKKV
CCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]