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The map label for this gene is murB

Identifier: 110833920

GI number: 110833920

Start: 1200216

End: 1201259

Strand: Direct

Name: murB

Synonym: ABO_1059

Alternate gene names: 110833920

Gene position: 1200216-1201259 (Clockwise)

Preceding gene: 110833919

Following gene: 110833922

Centisome position: 38.47

GC content: 54.12

Gene sequence:

>1044_bases
GTGAGCGAGTCGGTACCACCAACCCACACTTTCACACAGATTGATGATGCGGATTTGACGGGGCTGAACACCCTAGGCCT
GCCGGCCCGGGCTCAACGTTTAGCTCGTCCGACTACTTTGGATGCGTTGTCTCAGGTCTTGGCAGAGCGAAATCCCGCTG
AGCCGCTTTTTGTGATCGGCGAAGGCAGTAATTTGGTGATTTGCTCTGATCTGCCGGGCTTGACGTTAAGCTTAGCAATC
GATGGCATGTCCCTGGTTAAGCAAGATAATACGCATGTGTGGGTCGCTGCGGGCGCGGGTGTGCATTGGGATGATTTGGT
GGCCTGGACCGTGGAGCAGGGTTGGCAGGGGTTGGAAAACTTATCTCTGATTCCCGGCACGGTAGGGGCTGCGCCTTTTC
AGAATATTGGCGCCTATGGTGTAGAGCTGTCACAGTTGCTTGAGCAGGTGACGGTGATGGATGTGGTTACCGCTCAAGTA
ACGCACTTTGCTGGCAATGAATGTGAATTTGCTTATCGCGATAGCCGTTTCAAAAGCCGAGACCGTGGCCGTTATATCAT
TACCGGCATTGAGCTGCGTCTGAATAAAATGCCGCAGTGTAATGTGAGTTACGGGCCGCTTAAGGCCCGCTTTGGGCACT
TGTCGCAAGCAGATATTCTCCCCGCCGCGGTTCGCGAGCATGTGATTGCGGTGCGCCAGAGTAAGCTGCCGGCTCCTGAT
GTGTTGGCTAACGCAGGGAGTTTTTTTAAAAACCCGGTGGTAACAAAAGAGCGGGGGGATGCGTTAAAGAGGCGCTTTGC
GGATTTGGTGGCGTATACGCAACCGGATGGTGTGAAGCTGGCAGCAGGATGGTTAATCGAGCAGGCCGGCTGGAAGGGAA
AACGGTTGGGACCAGTTGGTATGCATAGCGAGCAAGCGCTGGTGTTGGTCAATCACGGTAATGCTACCAGTGCGGATGTC
ATTGCGTTGGCAGAGGCTGTGTGTGCTGATGTGCAGGAGAAATTTGGTGTTGCGCTAGAACAGGAGCCAGTGTTGTTGCC
ATAG

Upstream 100 bases:

>100_bases
TGCCCGATCCTTATTATGGCGGCGAAGACGGTTTCGACACGGTGTTGGACTTGATTGAAGAGGGTGCCGATGGATTGTTG
CGCCGTGTGCGGGAGCAGCT

Downstream 100 bases:

>100_bases
AGGCATGGCGGTGGTTAATTCCAGCATATTATAGCTGGAGCAAAGAATGGACCCACAAAAAAGCCCGCTATAAAGCGGGC
TTTTTTGTGGGTGGGATTTC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSESVPPTHTFTQIDDADLTGLNTLGLPARAQRLARPTTLDALSQVLAERNPAEPLFVIGEGSNLVICSDLPGLTLSLAI
DGMSLVKQDNTHVWVAAGAGVHWDDLVAWTVEQGWQGLENLSLIPGTVGAAPFQNIGAYGVELSQLLEQVTVMDVVTAQV
THFAGNECEFAYRDSRFKSRDRGRYIITGIELRLNKMPQCNVSYGPLKARFGHLSQADILPAAVREHVIAVRQSKLPAPD
VLANAGSFFKNPVVTKERGDALKRRFADLVAYTQPDGVKLAAGWLIEQAGWKGKRLGPVGMHSEQALVLVNHGNATSADV
IALAEAVCADVQEKFGVALEQEPVLLP

Sequences:

>Translated_347_residues
MSESVPPTHTFTQIDDADLTGLNTLGLPARAQRLARPTTLDALSQVLAERNPAEPLFVIGEGSNLVICSDLPGLTLSLAI
DGMSLVKQDNTHVWVAAGAGVHWDDLVAWTVEQGWQGLENLSLIPGTVGAAPFQNIGAYGVELSQLLEQVTVMDVVTAQV
THFAGNECEFAYRDSRFKSRDRGRYIITGIELRLNKMPQCNVSYGPLKARFGHLSQADILPAAVREHVIAVRQSKLPAPD
VLANAGSFFKNPVVTKERGDALKRRFADLVAYTQPDGVKLAAGWLIEQAGWKGKRLGPVGMHSEQALVLVNHGNATSADV
IALAEAVCADVQEKFGVALEQEPVLLP
>Mature_346_residues
SESVPPTHTFTQIDDADLTGLNTLGLPARAQRLARPTTLDALSQVLAERNPAEPLFVIGEGSNLVICSDLPGLTLSLAID
GMSLVKQDNTHVWVAAGAGVHWDDLVAWTVEQGWQGLENLSLIPGTVGAAPFQNIGAYGVELSQLLEQVTVMDVVTAQVT
HFAGNECEFAYRDSRFKSRDRGRYIITGIELRLNKMPQCNVSYGPLKARFGHLSQADILPAAVREHVIAVRQSKLPAPDV
LANAGSFFKNPVVTKERGDALKRRFADLVAYTQPDGVKLAAGWLIEQAGWKGKRLGPVGMHSEQALVLVNHGNATSADVI
ALAEAVCADVQEKFGVALEQEPVLLP

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=333, Percent_Identity=41.4414414414414, Blast_Score=227, Evalue=8e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_ALCBS (Q0VQP1)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692779.1
- ProteinModelPortal:   Q0VQP1
- SMR:   Q0VQP1
- STRING:   Q0VQP1
- GeneID:   4211240
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1059
- NMPDR:   fig|393595.12.peg.1067
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- PhylomeDB:   Q0VQP1
- BioCyc:   ABOR393595:ABO_1059-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 37370; Mature: 37239

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 173-173 ACT_SITE 247-247 ACT_SITE 342-342

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVPPTHTFTQIDDADLTGLNTLGLPARAQRLARPTTLDALSQVLAERNPAEPLFVIG
CCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEE
EGSNLVICSDLPGLTLSLAIDGMSLVKQDNTHVWVAAGAGVHWDDLVAWTVEQGWQGLEN
CCCCEEEECCCCCCEEEEEECCHHHHCCCCCEEEEEECCCCCHHHHHEEEHHHHCCCCCC
LSLIPGTVGAAPFQNIGAYGVELSQLLEQVTVMDVVTAQVTHFAGNECEFAYRDSRFKSR
CEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
DRGRYIITGIELRLNKMPQCNVSYGPLKARFGHLSQADILPAAVREHVIAVRQSKLPAPD
CCCCEEEEEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
VLANAGSFFKNPVVTKERGDALKRRFADLVAYTQPDGVKLAAGWLIEQAGWKGKRLGPVG
HHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCCCCCCCCCCC
MHSEQALVLVNHGNATSADVIALAEAVCADVQEKFGVALEQEPVLLP
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCCC
>Mature Secondary Structure 
SESVPPTHTFTQIDDADLTGLNTLGLPARAQRLARPTTLDALSQVLAERNPAEPLFVIG
CCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEE
EGSNLVICSDLPGLTLSLAIDGMSLVKQDNTHVWVAAGAGVHWDDLVAWTVEQGWQGLEN
CCCCEEEECCCCCCEEEEEECCHHHHCCCCCEEEEEECCCCCHHHHHEEEHHHHCCCCCC
LSLIPGTVGAAPFQNIGAYGVELSQLLEQVTVMDVVTAQVTHFAGNECEFAYRDSRFKSR
CEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
DRGRYIITGIELRLNKMPQCNVSYGPLKARFGHLSQADILPAAVREHVIAVRQSKLPAPD
CCCCEEEEEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
VLANAGSFFKNPVVTKERGDALKRRFADLVAYTQPDGVKLAAGWLIEQAGWKGKRLGPVG
HHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCCCCCCCCCCC
MHSEQALVLVNHGNATSADVIALAEAVCADVQEKFGVALEQEPVLLP
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA