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The map label for this gene is adk

Identifier: 110833701

GI number: 110833701

Start: 934160

End: 934816

Strand: Direct

Name: adk

Synonym: ABO_0840

Alternate gene names: 110833701

Gene position: 934160-934816 (Clockwise)

Preceding gene: 110833700

Following gene: 110833702

Centisome position: 29.94

GC content: 53.12

Gene sequence:

>657_bases
ATGCGTGTCATCCTGCTTGGTGCCCCCGGTGCGGGCAAGGGCACCCAGGCGCAGTTCATCAAGGAACAGTTCAATATTCC
TCAGATTTCCACCGGTGACATGCTGCGCGCTGCGGTAAAAGCAGGCACTCCCTTGGGCCTGGAAGCTAAAAAAGTGATGG
ATGCGGGTGGTCTCGTTTCCGACGATATTATCCTTGGTCTAGTGAAAGAACGTATTACGGAAAATGATTGTGCCAACGGG
TTCCTGTTCGATGGCTTCCCACGCACTATCCCACAGGCGCAATCGCTAGTTGAGCAGGGCGTTGATATCGATTTTGTAGT
GGAGATCGATGTCGATGATGAAGAAATTATTGAACGTTTGAGCGGGCGTCGTGTTCACCCGGCCTCCGGTCGTGTGTATC
ACACCAAGTACAATCCGCCAAAAGTTGAAGGCAAAGACGATGAAACCGGTGATGAGCTGGTTCAGCGCGATGACGATCAA
GAAGAGACGGTGCGTAAGCGGCTAGAGGTTTACCAAGCGCAGACACGTCCTCTGGTGGACTTCTACCAGGATCTGGCTAC
ACAGGGAGAATCTAACGCCCCACGTTATGTGCGTGTTGCCGGCGTTGGCTCCGTGGACGATATCCGCGATCGAGTACTGT
CTGCTCTTAAAGGCTGA

Upstream 100 bases:

>100_bases
GAGTCGCTTCTGGGCTGGAACACATAGGGCCGCAGCGGTGAAGGTGAACAAATCAGAGGCACTTTTTACCTCTTCTGACG
ATAGAAAGATGGAGAATCCT

Downstream 100 bases:

>100_bases
TTACTGCTTTGCCGGTACCTGAATAGCAAAAAAAGAATGGGAAGCTGAGGCTTCCCGTTTTTTTGCCTATTACCACCACA
GTTACATAATGGCGTATTCT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRVILLGAPGAGKGTQAQFIKEQFNIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGGLVSDDIILGLVKERITENDCANG
FLFDGFPRTIPQAQSLVEQGVDIDFVVEIDVDDEEIIERLSGRRVHPASGRVYHTKYNPPKVEGKDDETGDELVQRDDDQ
EETVRKRLEVYQAQTRPLVDFYQDLATQGESNAPRYVRVAGVGSVDDIRDRVLSALKG

Sequences:

>Translated_218_residues
MRVILLGAPGAGKGTQAQFIKEQFNIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGGLVSDDIILGLVKERITENDCANG
FLFDGFPRTIPQAQSLVEQGVDIDFVVEIDVDDEEIIERLSGRRVHPASGRVYHTKYNPPKVEGKDDETGDELVQRDDDQ
EETVRKRLEVYQAQTRPLVDFYQDLATQGESNAPRYVRVAGVGSVDDIRDRVLSALKG
>Mature_218_residues
MRVILLGAPGAGKGTQAQFIKEQFNIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGGLVSDDIILGLVKERITENDCANG
FLFDGFPRTIPQAQSLVEQGVDIDFVVEIDVDDEEIIERLSGRRVHPASGRVYHTKYNPPKVEGKDDETGDELVQRDDDQ
EETVRKRLEVYQAQTRPLVDFYQDLATQGESNAPRYVRVAGVGSVDDIRDRVLSALKG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=187, Percent_Identity=46.524064171123, Blast_Score=187, Evalue=4e-48,
Organism=Homo sapiens, GI4502013, Length=187, Percent_Identity=46.524064171123, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI19923437, Length=183, Percent_Identity=44.8087431693989, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=40.2173913043478, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=40.2173913043478, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=40.2173913043478, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=40.2173913043478, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=28.8372093023256, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=29.1208791208791, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=28.7671232876712, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=25.7142857142857, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI1786680, Length=209, Percent_Identity=61.7224880382775, Blast_Score=272, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17552384, Length=187, Percent_Identity=45.9893048128342, Blast_Score=180, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=208, Percent_Identity=36.5384615384615, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=32.093023255814, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=199, Percent_Identity=28.1407035175879, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=28.8372093023256, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=188, Percent_Identity=55.3191489361702, Blast_Score=224, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6321018, Length=185, Percent_Identity=43.2432432432432, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=218, Percent_Identity=28.8990825688073, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI22026816, Length=186, Percent_Identity=49.4623655913978, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17737899, Length=183, Percent_Identity=42.0765027322404, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645822, Length=183, Percent_Identity=42.0765027322404, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17647141, Length=215, Percent_Identity=28.8372093023256, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24663208, Length=215, Percent_Identity=28.8372093023256, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=25.9459459459459, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=25.9459459459459, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ALCBS (Q0VRB0)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692560.1
- ProteinModelPortal:   Q0VRB0
- SMR:   Q0VRB0
- STRING:   Q0VRB0
- GeneID:   4211286
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0840
- NMPDR:   fig|393595.12.peg.842
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   Q0VRB0
- ProtClustDB:   PRK00279
- BioCyc:   ABOR393595:ABO_0840-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23968; Mature: 23968

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVILLGAPGAGKGTQAQFIKEQFNIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGGLVS
CEEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCH
DDIILGLVKERITENDCANGFLFDGFPRTIPQAQSLVEQGVDIDFVVEIDVDDEEIIERL
HHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHCCCCEEEEEEEECCHHHHHHHH
SGRRVHPASGRVYHTKYNPPKVEGKDDETGDELVQRDDDQEETVRKRLEVYQAQTRPLVD
HCCEECCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHH
FYQDLATQGESNAPRYVRVAGVGSVDDIRDRVLSALKG
HHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVILLGAPGAGKGTQAQFIKEQFNIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGGLVS
CEEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCH
DDIILGLVKERITENDCANGFLFDGFPRTIPQAQSLVEQGVDIDFVVEIDVDDEEIIERL
HHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHCCCCEEEEEEEECCHHHHHHHH
SGRRVHPASGRVYHTKYNPPKVEGKDDETGDELVQRDDDQEETVRKRLEVYQAQTRPLVD
HCCEECCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHH
FYQDLATQGESNAPRYVRVAGVGSVDDIRDRVLSALKG
HHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA