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The map label for this gene is ffh [H]

Identifier: 110833658

GI number: 110833658

Start: 890658

End: 892079

Strand: Direct

Name: ffh [H]

Synonym: ABO_0797

Alternate gene names: 110833658

Gene position: 890658-892079 (Clockwise)

Preceding gene: 110833655

Following gene: 110833659

Centisome position: 28.55

GC content: 56.33

Gene sequence:

>1422_bases
ATGTTCGAGAATCTCACCGATCGGTTGGGATCGTCGCTTAAAAGCCTGGCAGGTCAGGGTTCCCTGACCGAAGACAATAT
CCGCGACACCCTGCGCGAAGTGCGCAAGGCACTGCTGGAGGCCGACGTGGCCTTGCCGGTGGTGAAAGAGTTTGTCGAGC
AGGTAAAAGAAAAAGCCTTGGGGCAGGAGGTGTTGCAGAGCCTGAACCCTGGCCAAGCGTTCGTAAAGATCGTCAACGAC
GAGCTTGTCCATACCATGGGCGACGCCAATGATGGTCTGGATTTGGCTACTAAGCCTCCAGCCATTATTTTGATGGCGGG
TTTGCAGGGGGCAGGTAAAACCACGTCCGTAGCCAAGCTTGCGCGCTTCCTGCAAGAGCGGGAGAAGAAGAAGGTCATGG
TGGTGTCTGCGGATATTTACCGCCCGGCGGCTATTGAGCAGCTGAAAACCTTGGCTGGTGAGGTGGAGACTCACTTCTTC
CCGTCTTCCAGCGATCAGGATCCGGTGGATATTGCCAATGCGGCGCTGGATGAAGCCCGTCGTCGCTATATGGACGTGCT
GATCGTTGATACCGCTGGTCGTCTCCATGTCGATGAAGACATGATGAGCGAAATTAAGCGTCTACACGGCGCTATTAGCC
CGGTGGAAACCCTGTTCGTGGTCGATGCCATGACGGGTCAAGATGCGGCGAATACCGCCCAGGCTTTCAATGAGGCTTTG
CCTCTCACCGGTGTGATCCTTACCAAGGCCGATGGTGACTCCCGCGGTGGTGCTGCGCTGTCCGTACGCCAGCTTACTGG
TAAGCCCATCAAGTTTATCGGCATGGGTGAGAAAACCGATGCCTTGGAGCCGTTTCACCCGGATCGTATTGCCAGCCGGA
TCCTCGGCATGGGCGATGTGTTGTCCTTGGTGGAAGAAGCCGAGCGCAAGCTGGACAAAAAGAAAGCCGAAAAAATCGCC
AAGAAGTTCAAGAAAGGCAAGGCGATGGACTTCGAGGATCTGAAGGACCAGTTCCAACAGATGCGTAATATGGGCGGTAT
GGCCGGCCTGCTCGACAAGCTGCCGGGCATGGGCGGGATGATGGAAGCAGCCCAAGATCCGGCAGCCATGAAGCAAATGA
AGCACATGGAAGCGTTGATCGATTCCATGACGCCGAAAGAGCGTCGCAACCCGGAATTGCTCAAAGGGTCACGTAAGAAA
CGCATTGTCGCCGGTGCCGGCCTGGAAATTCAGGACCTGAATCGTCTCATCAAGCAGCAAAAAATGATGGCCAAGATGAT
GAAGAAGATGCGTACCAAGGGTGGCATGAAGAACATGATGCGGGGTATGGAAGGTATGATGGGAGGGGGAGGCCAAGGCG
GCCCCGGTGGCGGCATGCCGCCAGGGGGCATGGGTGGCCCAGGTGGCATGCCGCCGATGTAG

Upstream 100 bases:

>100_bases
GTGCCCCATGACGTTGATGCCCAAGGAGGGCTATAATTGCGCCCCTGTCACTGCGGCAGGCATGCCTGGCCGCAGACATG
GTGCATTTGGAGGTAGACCC

Downstream 100 bases:

>100_bases
GAACAGCGTCAAGGCGCAAGCTGTAGAGCGCGGGCAGAGCGGGCGGCAAGGTCTACCCCTCTGCCCGCGTTGCGTTTGGG
GTGCGAGGTAGTCTAAACGC

Product: signal recognition particle protein Ffh

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MFENLTDRLGSSLKSLAGQGSLTEDNIRDTLREVRKALLEADVALPVVKEFVEQVKEKALGQEVLQSLNPGQAFVKIVND
ELVHTMGDANDGLDLATKPPAIILMAGLQGAGKTTSVAKLARFLQEREKKKVMVVSADIYRPAAIEQLKTLAGEVETHFF
PSSSDQDPVDIANAALDEARRRYMDVLIVDTAGRLHVDEDMMSEIKRLHGAISPVETLFVVDAMTGQDAANTAQAFNEAL
PLTGVILTKADGDSRGGAALSVRQLTGKPIKFIGMGEKTDALEPFHPDRIASRILGMGDVLSLVEEAERKLDKKKAEKIA
KKFKKGKAMDFEDLKDQFQQMRNMGGMAGLLDKLPGMGGMMEAAQDPAAMKQMKHMEALIDSMTPKERRNPELLKGSRKK
RIVAGAGLEIQDLNRLIKQQKMMAKMMKKMRTKGGMKNMMRGMEGMMGGGGQGGPGGGMPPGGMGGPGGMPPM

Sequences:

>Translated_473_residues
MFENLTDRLGSSLKSLAGQGSLTEDNIRDTLREVRKALLEADVALPVVKEFVEQVKEKALGQEVLQSLNPGQAFVKIVND
ELVHTMGDANDGLDLATKPPAIILMAGLQGAGKTTSVAKLARFLQEREKKKVMVVSADIYRPAAIEQLKTLAGEVETHFF
PSSSDQDPVDIANAALDEARRRYMDVLIVDTAGRLHVDEDMMSEIKRLHGAISPVETLFVVDAMTGQDAANTAQAFNEAL
PLTGVILTKADGDSRGGAALSVRQLTGKPIKFIGMGEKTDALEPFHPDRIASRILGMGDVLSLVEEAERKLDKKKAEKIA
KKFKKGKAMDFEDLKDQFQQMRNMGGMAGLLDKLPGMGGMMEAAQDPAAMKQMKHMEALIDSMTPKERRNPELLKGSRKK
RIVAGAGLEIQDLNRLIKQQKMMAKMMKKMRTKGGMKNMMRGMEGMMGGGGQGGPGGGMPPGGMGGPGGMPPM
>Mature_473_residues
MFENLTDRLGSSLKSLAGQGSLTEDNIRDTLREVRKALLEADVALPVVKEFVEQVKEKALGQEVLQSLNPGQAFVKIVND
ELVHTMGDANDGLDLATKPPAIILMAGLQGAGKTTSVAKLARFLQEREKKKVMVVSADIYRPAAIEQLKTLAGEVETHFF
PSSSDQDPVDIANAALDEARRRYMDVLIVDTAGRLHVDEDMMSEIKRLHGAISPVETLFVVDAMTGQDAANTAQAFNEAL
PLTGVILTKADGDSRGGAALSVRQLTGKPIKFIGMGEKTDALEPFHPDRIASRILGMGDVLSLVEEAERKLDKKKAEKIA
KKFKKGKAMDFEDLKDQFQQMRNMGGMAGLLDKLPGMGGMMEAAQDPAAMKQMKHMEALIDSMTPKERRNPELLKGSRKK
RIVAGAGLEIQDLNRLIKQQKMMAKMMKKMRTKGGMKNMMRGMEGMMGGGGQGGPGGGMPPGGMGGPGGMPPM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=446, Percent_Identity=33.1838565022422, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI226371618, Length=348, Percent_Identity=34.4827586206897, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI23308697, Length=315, Percent_Identity=27.6190476190476, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI295424842, Length=315, Percent_Identity=27.6190476190476, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI89061728, Length=166, Percent_Identity=37.3493975903614, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI1788963, Length=453, Percent_Identity=66.2251655629139, Blast_Score=586, Evalue=1e-168,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.2075471698113, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=448, Percent_Identity=29.4642857142857, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=311, Percent_Identity=28.9389067524116, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=433, Percent_Identity=32.7944572748268, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320498, Length=315, Percent_Identity=25.0793650793651, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647949, Length=452, Percent_Identity=32.7433628318584, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24641198, Length=330, Percent_Identity=25.4545454545455, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 51173; Mature: 51173

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.6 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.6 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLGSSLKSLAGQGSLTEDNIRDTLREVRKALLEADVALPVVKEFVEQVKEKAL
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLQSLNPGQAFVKIVNDELVHTMGDANDGLDLATKPPAIILMAGLQGAGKTTSVAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHH
ARFLQEREKKKVMVVSADIYRPAAIEQLKTLAGEVETHFFPSSSDQDPVDIANAALDEAR
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
RRYMDVLIVDTAGRLHVDEDMMSEIKRLHGAISPVETLFVVDAMTGQDAANTAQAFNEAL
HHHHHEEEEECCCCEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHCC
PLTGVILTKADGDSRGGAALSVRQLTGKPIKFIGMGEKTDALEPFHPDRIASRILGMGDV
CCCEEEEEECCCCCCCCCEEEHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLVEEAERKLDKKKAEKIAKKFKKGKAMDFEDLKDQFQQMRNMGGMAGLLDKLPGMGGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCH
MEAAQDPAAMKQMKHMEALIDSMTPKERRNPELLKGSRKKRIVAGAGLEIQDLNRLIKQQ
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHHH
KMMAKMMKKMRTKGGMKNMMRGMEGMMGGGGQGGPGGGMPPGGMGGPGGMPPM
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLGSSLKSLAGQGSLTEDNIRDTLREVRKALLEADVALPVVKEFVEQVKEKAL
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLQSLNPGQAFVKIVNDELVHTMGDANDGLDLATKPPAIILMAGLQGAGKTTSVAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHH
ARFLQEREKKKVMVVSADIYRPAAIEQLKTLAGEVETHFFPSSSDQDPVDIANAALDEAR
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
RRYMDVLIVDTAGRLHVDEDMMSEIKRLHGAISPVETLFVVDAMTGQDAANTAQAFNEAL
HHHHHEEEEECCCCEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHCC
PLTGVILTKADGDSRGGAALSVRQLTGKPIKFIGMGEKTDALEPFHPDRIASRILGMGDV
CCCEEEEEECCCCCCCCCEEEHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLVEEAERKLDKKKAEKIAKKFKKGKAMDFEDLKDQFQQMRNMGGMAGLLDKLPGMGGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCH
MEAAQDPAAMKQMKHMEALIDSMTPKERRNPELLKGSRKKRIVAGAGLEIQDLNRLIKQQ
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHHH
KMMAKMMKKMRTKGGMKNMMRGMEGMMGGGGQGGPGGGMPPGGMGGPGGMPPM
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]