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The map label for this gene is dapA

Identifier: 110833637

GI number: 110833637

Start: 869915

End: 870799

Strand: Direct

Name: dapA

Synonym: ABO_0776

Alternate gene names: 110833637

Gene position: 869915-870799 (Clockwise)

Preceding gene: 110833634

Following gene: 110833638

Centisome position: 27.88

GC content: 55.82

Gene sequence:

>885_bases
ATGATTCGCGGCAGCATAGTGGCGCTGGTGACCCCCATGCGTGCAGATGGGTCCGTAGACTGGGAGCGATTGCGCTCGCT
GGTTAATTGGCATGTAGAACAAGGCACCCATGCCATCGTAGCTGTGGGGACGACCGGTGAATCCGCTACCCTTGGGTTTG
AAGAGCACGATAGCGTGATCCGTGAAGTGGTGGCGCTGGCTAAGGGCCGCCTTCCGGTTATTGCCGGTACTGGTGCCAAC
AACACAGAAGAAGCCATTCGCCTGACTCGAGATGCCAAACGAGATGGCGCAGACGCTTGCCTGTTGGTGACGCCTTATTA
CAACAAGCCGCCCCAGGAAGGTCTGTATCAACACTTCTTGGCGATAGCTCGTGCGGTAGATATTCCGCAAATACTGTATA
ACGTGCCCGGTCGAACATCTTGCGATTTACTGCCGGAAACCGTGGAGCGCTTGAGTAAAGTGCCGAACATCGTGGGCATA
AAGGAAGCCACCGGTAATTTGGAGCGGGCTCGCGAAATCCGTGAGCGCTGTTCTGATGATTTCATGCTTTATTCTGGCGA
TGACGCCACCGCCATGGACTTTATTTTGGCTGGCGGACATGGCGATATTTCGGTGACCGCTAACGTGGCCCCGGCGAAGA
TGGCCGCCATGTGTGAGGCGGCTCTGGCTGGTGATGCGGATACCGCTCGGGCACTGAATGCGGAACTCGAACCCCTGCAT
CGTGATCTGTTTATTGAAGCGAATCCGATCCCGGTGAAATGGGCACTGTTTGAAATGGGCCTAATTGACGCGGGTATCAG
GCTACCGTTGGTGCCGATGTCAGAAGCGGCTCAGCCGCGGTTACGTGAAACCATGCGCCAATGCGGCCTGTTGGAGGTTA
AATGA

Upstream 100 bases:

>100_bases
TACCATAGCGCCCTTCACCCGACGATAGGGCTCGCTAGTTGGGAGGCATCGTTGAGCGCATTGAGTGGCGCAACGGGTTT
GCGCACAATAGGAGACAGGC

Downstream 100 bases:

>100_bases
AGAAAGCGGCGTTGCTGGCACCACTCATGCTCGCTTTGATGGTGGCTGGTTGTAGCTGGTTGCCAGACAGCAGTTTGGAA
TACCGTAAAGCGGCCGTGAC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MIRGSIVALVTPMRADGSVDWERLRSLVNWHVEQGTHAIVAVGTTGESATLGFEEHDSVIREVVALAKGRLPVIAGTGAN
NTEEAIRLTRDAKRDGADACLLVTPYYNKPPQEGLYQHFLAIARAVDIPQILYNVPGRTSCDLLPETVERLSKVPNIVGI
KEATGNLERAREIRERCSDDFMLYSGDDATAMDFILAGGHGDISVTANVAPAKMAAMCEAALAGDADTARALNAELEPLH
RDLFIEANPIPVKWALFEMGLIDAGIRLPLVPMSEAAQPRLRETMRQCGLLEVK

Sequences:

>Translated_294_residues
MIRGSIVALVTPMRADGSVDWERLRSLVNWHVEQGTHAIVAVGTTGESATLGFEEHDSVIREVVALAKGRLPVIAGTGAN
NTEEAIRLTRDAKRDGADACLLVTPYYNKPPQEGLYQHFLAIARAVDIPQILYNVPGRTSCDLLPETVERLSKVPNIVGI
KEATGNLERAREIRERCSDDFMLYSGDDATAMDFILAGGHGDISVTANVAPAKMAAMCEAALAGDADTARALNAELEPLH
RDLFIEANPIPVKWALFEMGLIDAGIRLPLVPMSEAAQPRLRETMRQCGLLEVK
>Mature_294_residues
MIRGSIVALVTPMRADGSVDWERLRSLVNWHVEQGTHAIVAVGTTGESATLGFEEHDSVIREVVALAKGRLPVIAGTGAN
NTEEAIRLTRDAKRDGADACLLVTPYYNKPPQEGLYQHFLAIARAVDIPQILYNVPGRTSCDLLPETVERLSKVPNIVGI
KEATGNLERAREIRERCSDDFMLYSGDDATAMDFILAGGHGDISVTANVAPAKMAAMCEAALAGDADTARALNAELEPLH
RDLFIEANPIPVKWALFEMGLIDAGIRLPLVPMSEAAQPRLRETMRQCGLLEVK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=301, Percent_Identity=29.9003322259136, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI13540533, Length=242, Percent_Identity=28.099173553719, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=58.5616438356164, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI87082415, Length=298, Percent_Identity=30.5369127516779, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1789620, Length=289, Percent_Identity=30.7958477508651, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786463, Length=240, Percent_Identity=30.4166666666667, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_ALCBS (Q0VRH4)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692496.1
- ProteinModelPortal:   Q0VRH4
- SMR:   Q0VRH4
- STRING:   Q0VRH4
- GeneID:   4213286
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0776
- NMPDR:   fig|393595.12.peg.780
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   Q0VRH4
- BioCyc:   ABOR393595:ABO_0776-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31906; Mature: 31906

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRGSIVALVTPMRADGSVDWERLRSLVNWHVEQGTHAIVAVGTTGESATLGFEEHDSVI
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHH
REVVALAKGRLPVIAGTGANNTEEAIRLTRDAKRDGADACLLVTPYYNKPPQEGLYQHFL
HHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHH
AIARAVDIPQILYNVPGRTSCDLLPETVERLSKVPNIVGIKEATGNLERAREIRERCSDD
HHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHCCCHHHHHHHHHHCCCC
FMLYSGDDATAMDFILAGGHGDISVTANVAPAKMAAMCEAALAGDADTARALNAELEPLH
EEEEECCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHCCHHCCCC
RDLFIEANPIPVKWALFEMGLIDAGIRLPLVPMSEAAQPRLRETMRQCGLLEVK
CEEEEECCCCCEEHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHCCCEECC
>Mature Secondary Structure
MIRGSIVALVTPMRADGSVDWERLRSLVNWHVEQGTHAIVAVGTTGESATLGFEEHDSVI
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHH
REVVALAKGRLPVIAGTGANNTEEAIRLTRDAKRDGADACLLVTPYYNKPPQEGLYQHFL
HHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHH
AIARAVDIPQILYNVPGRTSCDLLPETVERLSKVPNIVGIKEATGNLERAREIRERCSDD
HHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHCCCHHHHHHHHHHCCCC
FMLYSGDDATAMDFILAGGHGDISVTANVAPAKMAAMCEAALAGDADTARALNAELEPLH
EEEEECCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHCCHHCCCC
RDLFIEANPIPVKWALFEMGLIDAGIRLPLVPMSEAAQPRLRETMRQCGLLEVK
CEEEEECCCCCEEHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA