BacMap

Definition	Alcanivorax borkumensis SK2 chromosome, complete genome.
Accession	NC_008260
Length	3,120,143

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The map label for this gene is fabG2 [H]

Identifier: 110833517

GI number: 110833517

Start: 726506

End: 727276

Strand: Direct

Name: fabG2 [H]

Synonym: ABO_0656

Alternate gene names: 110833517

Gene position: 726506-727276 (Clockwise)

Preceding gene: 110833512

Following gene: 110833519

Centisome position: 23.28

GC content: 55.12

Gene sequence:

>771_bases
ATGAATATTACCGATAAAGTGGCCGTGATTACTGGTGGTGCTTCAGGCCTGGGCCAGGCGACAGCAGAAGCGATTATTGC
CAAGGGTGGCAAGGTCATGATTTTTGACCGTGACGACAAGCGCGGCCCGGAAGTCGCGGACCAGCTTGGTGATAATGCTG
CCTTTACCCAGACTGACGTGACAGACGAAGCTTCCGTGAAAGCTGCCGTGGATGCCACGATGGCTAAATTCGGTGCCATT
CATGTGTGCGTGAATTGCGCTGGTGTGGGCTCGGCCATGAAAGTTGTGGGCCGTGAGAACAAGCCCCATGACCTGGGTGT
GTTCAACATGGTGGTGCAGATCAACCTGGTCGGCACTTTCAACGTGGCCCGTCTCGCGGCAGCTGCTATGGCTGAGAATG
AGCCGGATGAAGACAATGAGCGCGGCCTGATTGTGAACACTGCGTCTGTGGCTGCATTCGATGGTCAGGTTGGCCAGGCC
GCTTATGCGGCAACCAAAGGTGGCGTGGTCGGCATGACGCTTCCCATCGCTCGTGATTTGGCTCCGCTGGGCATTCGTTG
TAACACTATCGCCCCAGGTATTTTTAATACCCCGTTGTTGAATGCGGCACCGGACAAGGTGAAACAGCCGCTGATCGAAA
TGACTCAGTTCCCGAAGCGCTTGGGACACCCTAAGGAATACGGTCAGCTAGTGTGTCACATGATCGAGAACACGTTCCTT
AACGGTGAAACCATCCGTATCGATGGTGCTATCCGTATGCAGCCGCGGTAA

Upstream 100 bases:

>100_bases
TGAGCGAAAGTAACAATGAGTCGCTTGGCAGGGCTGGGTATACTCCGGGTAATGTTTTATAGATCCGTTACCTTTCTACC
TTTCACAAGAAGGAGAGCAT

Downstream 100 bases:

>100_bases
CAAAAGACGCAACATGCGTCATGGTACCCGCAACACAAAAAAGCCCCGCTTTGCGGGGCTTTTTTGTGTCAATGTAGCCG
CTACCTGTTAGCTCACTAAC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MNITDKVAVITGGASGLGQATAEAIIAKGGKVMIFDRDDKRGPEVADQLGDNAAFTQTDVTDEASVKAAVDATMAKFGAI
HVCVNCAGVGSAMKVVGRENKPHDLGVFNMVVQINLVGTFNVARLAAAAMAENEPDEDNERGLIVNTASVAAFDGQVGQA
AYAATKGGVVGMTLPIARDLAPLGIRCNTIAPGIFNTPLLNAAPDKVKQPLIEMTQFPKRLGHPKEYGQLVCHMIENTFL
NGETIRIDGAIRMQPR

Sequences:

>Translated_256_residues
MNITDKVAVITGGASGLGQATAEAIIAKGGKVMIFDRDDKRGPEVADQLGDNAAFTQTDVTDEASVKAAVDATMAKFGAI
HVCVNCAGVGSAMKVVGRENKPHDLGVFNMVVQINLVGTFNVARLAAAAMAENEPDEDNERGLIVNTASVAAFDGQVGQA
AYAATKGGVVGMTLPIARDLAPLGIRCNTIAPGIFNTPLLNAAPDKVKQPLIEMTQFPKRLGHPKEYGQLVCHMIENTFL
NGETIRIDGAIRMQPR
>Mature_256_residues
MNITDKVAVITGGASGLGQATAEAIIAKGGKVMIFDRDDKRGPEVADQLGDNAAFTQTDVTDEASVKAAVDATMAKFGAI
HVCVNCAGVGSAMKVVGRENKPHDLGVFNMVVQINLVGTFNVARLAAAAMAENEPDEDNERGLIVNTASVAAFDGQVGQA
AYAATKGGVVGMTLPIARDLAPLGIRCNTIAPGIFNTPLLNAAPDKVKQPLIEMTQFPKRLGHPKEYGQLVCHMIENTFL
NGETIRIDGAIRMQPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=56.4, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI83715985, Length=250, Percent_Identity=53.6, Blast_Score=257, Evalue=6e-69,
Organism=Homo sapiens, GI15277342, Length=266, Percent_Identity=30.0751879699248, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=28.1746031746032, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI31542939, Length=266, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI59889578, Length=238, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=27.7566539923954, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=30.1960784313725, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI224922801, Length=195, Percent_Identity=30.2564102564103, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=27.7992277992278, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4504505, Length=207, Percent_Identity=28.9855072463768, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI5031737, Length=255, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=29.6875, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=32.2097378277154, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87082160, Length=203, Percent_Identity=29.5566502463054, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=26.4591439688716, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789057, Length=265, Percent_Identity=25.6603773584906, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787820, Length=190, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=27.6, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=27.734375, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=29.2490118577075, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790717, Length=262, Percent_Identity=25.9541984732824, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786812, Length=211, Percent_Identity=27.4881516587678, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=23.6, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=25.8823529411765, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=248, Percent_Identity=51.2096774193548, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=29.5275590551181, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=256, Percent_Identity=30.078125, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=26.1363636363636, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=29.0697674418605, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17560332, Length=202, Percent_Identity=30.1980198019802, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=262, Percent_Identity=26.3358778625954, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=265, Percent_Identity=26.4150943396226, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=264, Percent_Identity=26.1363636363636, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=28.1481481481481, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=25.1908396946565, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=25.8555133079848, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=24.4360902255639, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=24.5353159851301, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=202, Percent_Identity=29.7029702970297, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=24.3346007604563, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=276, Percent_Identity=27.1739130434783, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=198, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=248, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=204, Percent_Identity=28.921568627451, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=25.5639097744361, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=24.4274809160305, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=201, Percent_Identity=27.8606965174129, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=236, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=206, Percent_Identity=31.0679611650485, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=258, Percent_Identity=29.4573643410853, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320089, Length=181, Percent_Identity=29.2817679558011, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=55.1181102362205, Blast_Score=275, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=34.6456692913386, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28571526, Length=267, Percent_Identity=28.8389513108614, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21357041, Length=264, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=26.4227642276423, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI23397609, Length=198, Percent_Identity=30.3030303030303, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644339, Length=268, Percent_Identity=26.865671641791, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24665264, Length=230, Percent_Identity=28.695652173913, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26884; Mature: 26884

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITDKVAVITGGASGLGQATAEAIIAKGGKVMIFDRDDKRGPEVADQLGDNAAFTQTDV
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCCCCEEECCC
TDEASVKAAVDATMAKFGAIHVCVNCAGVGSAMKVVGRENKPHDLGVFNMVVQINLVGTF
CCCHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEEEEEEEECC
NVARLAAAAMAENEPDEDNERGLIVNTASVAAFDGQVGQAAYAATKGGVVGMTLPIARDL
HHHHHHHHHHHCCCCCCCCCCEEEEEECEEEEECCCCCCHHHHHCCCCEEEEECHHHHCC
APLGIRCNTIAPGIFNTPLLNAAPDKVKQPLIEMTQFPKRLGHPKEYGQLVCHMIENTFL
CCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
NGETIRIDGAIRMQPR
CCCEEEECCEEEECCC
>Mature Secondary Structure
MNITDKVAVITGGASGLGQATAEAIIAKGGKVMIFDRDDKRGPEVADQLGDNAAFTQTDV
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCCCCEEECCC
TDEASVKAAVDATMAKFGAIHVCVNCAGVGSAMKVVGRENKPHDLGVFNMVVQINLVGTF
CCCHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEEEEEEEECC
NVARLAAAAMAENEPDEDNERGLIVNTASVAAFDGQVGQAAYAATKGGVVGMTLPIARDL
HHHHHHHHHHHCCCCCCCCCCEEEEEECEEEEECCCCCCHHHHHCCCCEEEEECHHHHCC
APLGIRCNTIAPGIFNTPLLNAAPDKVKQPLIEMTQFPKRLGHPKEYGQLVCHMIENTFL
CCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
NGETIRIDGAIRMQPR
CCCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]