Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 110833383

GI number: 110833383

Start: 573722

End: 574978

Strand: Direct

Name: hemA

Synonym: ABO_0522

Alternate gene names: 110833383

Gene position: 573722-574978 (Clockwise)

Preceding gene: 110833375

Following gene: 110833384

Centisome position: 18.39

GC content: 58.07

Gene sequence:

>1257_bases
ATGAATCTAGTCGCTGTCGGCGTAAATCACACCACCGCGGATGTGGAACTACGCGAACGTCTGGCGTTTTCAACGCAGCA
GGCGGAGGTGGCGTTGGCCAGCTTGCGTGAGATGCCCGGGGTGCGGGAAGCTGCATTGCTGTCTACCTGTAACCGCACCG
AACTGTATTGCCTCACTGACGACGTCACTCCAAATTTTGCTCAATGGCTGGCCTCTAGCCGCAATCTGTCCGTCGAACGA
CTCTCCACGGTGCTGTATCAGCATACCGGTGAGCAGGCGCTGGAGCATATGATGCGGGTAGCTGGCGGTCTGGATTCGCT
GGTACTGGGCGAGCCACAAATTCTTGGTCAGATGCGTGAAGCCTATGCTCGAGCCCATGAGGCTGGCTTGCTCAACGGCG
AGTTGTCGCGTTTGTTTCAGGAAGTCTTTTCGGTAGCCAAGCGGATCCGTACGGAAACCGGTATCGGTGCTAACCCGGTG
TCTGTGGCCTATGCGGCAGTTTCGTTTGCGCGTCACATTTTTGCTGACCTGAAAAAAAGCCGGGCGCTGCTGATTGGTGC
CGGTGAAATGATTGAGCTGGTGGCGCGACATTTGAGTGAGCAGCAGGTGCAGGAAATTACCATTGCCAATCGCACTCAGG
AGCGAGCCTCGGAGTTGGCCGCCGCCGTGGGGGGGCGTGGTATCAGCCTAGAAGAATTGCCGGTGGCGCTGGAGCGTGCG
GATATCCTGATCTCATGCACCGCTGCGCCGTTGCCGATTATGGGCAAGGGTATGGTGGAGCGGGCGCTGAAAAAACGCCG
TCACCGACCCATGTTTATGGTGGATATTGCCGTGCCACGGGATATCGAACCGGAAGTGGGCGAACTGGGTGATGTCTACC
TGTATACGGTGGACCATCTGCAAGAAGCGATTCAGGAAAATGTCCGTTCTCGTCAGCAGGCGGCCCAGGAGGCCTCAGAG
CTGATTCGAGATGCCATTGTGCGCCACCGTCGTCAGCGCCGTGAACAGGATGCCGTTAAGGTGCTGCGTGATTATCGTGA
GCAGCGCAAGGCTATGGCGGAAAGCGAACTGGAAAAAGCGTTGCAGCAGTTGCGCAATGGTGGCGATGCGGAGCAGGTGC
TGCGCAGGTTTCAGCATTCGCTGGTGAACAAGTGGCTGCATTCCCCCAGCGTGACCTTGCGCAAAATGGCCGCGGATGGC
CGCGCCGAAGCCCTGTTGCTGGCTCGTGAGTTGCTGCTCGACGACGACCAGTCGTAG

Upstream 100 bases:

>100_bases
GCGCTTTCGCGCAAAATGCCACACCCTTGCGCCCCGGCTTTCCGGGGCTCCGGGCTGGCCGGGTACGATCGCCCGCTGTC
ATTGTCGGGCACAGGAAACT

Downstream 100 bases:

>100_bases
CGCAAAGAACTCTCTCGATGTATCGAATTTTTGCGTGCGCCCGCCGGGCGGCGTATTTGCGTGAAGCGTGGAAGCGAATT
TATGAAAGCGTCATTGCAAG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MNLVAVGVNHTTADVELRERLAFSTQQAEVALASLREMPGVREAALLSTCNRTELYCLTDDVTPNFAQWLASSRNLSVER
LSTVLYQHTGEQALEHMMRVAGGLDSLVLGEPQILGQMREAYARAHEAGLLNGELSRLFQEVFSVAKRIRTETGIGANPV
SVAYAAVSFARHIFADLKKSRALLIGAGEMIELVARHLSEQQVQEITIANRTQERASELAAAVGGRGISLEELPVALERA
DILISCTAAPLPIMGKGMVERALKKRRHRPMFMVDIAVPRDIEPEVGELGDVYLYTVDHLQEAIQENVRSRQQAAQEASE
LIRDAIVRHRRQRREQDAVKVLRDYREQRKAMAESELEKALQQLRNGGDAEQVLRRFQHSLVNKWLHSPSVTLRKMAADG
RAEALLLARELLLDDDQS

Sequences:

>Translated_418_residues
MNLVAVGVNHTTADVELRERLAFSTQQAEVALASLREMPGVREAALLSTCNRTELYCLTDDVTPNFAQWLASSRNLSVER
LSTVLYQHTGEQALEHMMRVAGGLDSLVLGEPQILGQMREAYARAHEAGLLNGELSRLFQEVFSVAKRIRTETGIGANPV
SVAYAAVSFARHIFADLKKSRALLIGAGEMIELVARHLSEQQVQEITIANRTQERASELAAAVGGRGISLEELPVALERA
DILISCTAAPLPIMGKGMVERALKKRRHRPMFMVDIAVPRDIEPEVGELGDVYLYTVDHLQEAIQENVRSRQQAAQEASE
LIRDAIVRHRRQRREQDAVKVLRDYREQRKAMAESELEKALQQLRNGGDAEQVLRRFQHSLVNKWLHSPSVTLRKMAADG
RAEALLLARELLLDDDQS
>Mature_418_residues
MNLVAVGVNHTTADVELRERLAFSTQQAEVALASLREMPGVREAALLSTCNRTELYCLTDDVTPNFAQWLASSRNLSVER
LSTVLYQHTGEQALEHMMRVAGGLDSLVLGEPQILGQMREAYARAHEAGLLNGELSRLFQEVFSVAKRIRTETGIGANPV
SVAYAAVSFARHIFADLKKSRALLIGAGEMIELVARHLSEQQVQEITIANRTQERASELAAAVGGRGISLEELPVALERA
DILISCTAAPLPIMGKGMVERALKKRRHRPMFMVDIAVPRDIEPEVGELGDVYLYTVDHLQEAIQENVRSRQQAAQEASE
LIRDAIVRHRRQRREQDAVKVLRDYREQRKAMAESELEKALQQLRNGGDAEQVLRRFQHSLVNKWLHSPSVTLRKMAADG
RAEALLLARELLLDDDQS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=415, Percent_Identity=49.3975903614458, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_ALCBS (Q0VS78)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692242.1
- ProteinModelPortal:   Q0VS78
- SMR:   Q0VS78
- STRING:   Q0VS78
- GeneID:   4212665
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0522
- NMPDR:   fig|393595.12.peg.518
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q0VS78
- BioCyc:   ABOR393595:ABO_0522-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46631; Mature: 46631

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 106-106 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVAVGVNHTTADVELRERLAFSTQQAEVALASLREMPGVREAALLSTCNRTELYCLTD
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEC
DVTPNFAQWLASSRNLSVERLSTVLYQHTGEQALEHMMRVAGGLDSLVLGEPQILGQMRE
CCCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
AYARAHEAGLLNGELSRLFQEVFSVAKRIRTETGIGANPVSVAYAAVSFARHIFADLKKS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
RALLIGAGEMIELVARHLSEQQVQEITIANRTQERASELAAAVGGRGISLEELPVALERA
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
DILISCTAAPLPIMGKGMVERALKKRRHRPMFMVDIAVPRDIEPEVGELGDVYLYTVDHL
CEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEHHHH
QEAIQENVRSRQQAAQEASELIRDAIVRHRRQRREQDAVKVLRDYREQRKAMAESELEKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQQLRNGGDAEQVLRRFQHSLVNKWLHSPSVTLRKMAADGRAEALLLARELLLDDDQS
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLVAVGVNHTTADVELRERLAFSTQQAEVALASLREMPGVREAALLSTCNRTELYCLTD
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEC
DVTPNFAQWLASSRNLSVERLSTVLYQHTGEQALEHMMRVAGGLDSLVLGEPQILGQMRE
CCCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
AYARAHEAGLLNGELSRLFQEVFSVAKRIRTETGIGANPVSVAYAAVSFARHIFADLKKS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
RALLIGAGEMIELVARHLSEQQVQEITIANRTQERASELAAAVGGRGISLEELPVALERA
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
DILISCTAAPLPIMGKGMVERALKKRRHRPMFMVDIAVPRDIEPEVGELGDVYLYTVDHL
CEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEHHHH
QEAIQENVRSRQQAAQEASELIRDAIVRHRRQRREQDAVKVLRDYREQRKAMAESELEKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQQLRNGGDAEQVLRRFQHSLVNKWLHSPSVTLRKMAADGRAEALLLARELLLDDDQS
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA