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The map label for this gene is alkK [H]

Identifier: 110681107

GI number: 110681107

Start: 3833041

End: 3834663

Strand: Direct

Name: alkK [H]

Synonym: RD1_3974

Alternate gene names: 110681107

Gene position: 3833041-3834663 (Clockwise)

Preceding gene: 110681106

Following gene: 110681108

Centisome position: 92.74

GC content: 59.52

Gene sequence:

>1623_bases
ATGGGATGGATGTCAAACGAAACGGGACTGGATAAATGTGCCGCAAACCATGTGCCGCTGACGCCCTTGTCCCATCTGAA
ACGCGCAGCCGTGGTTTTTGCCAACCACACCGCGATTGTCTACGGCGATGTGCGACGCAGCTACGGCGAACATGCAGCGC
GCGCAACGCGGCTGGCCTCGGCATTGGCGGCAAAGGGTGTCGCACCGGGTGATGTCGTTGCAACGCTGCTGCCCAATGTG
CCCGCACAGGTCGAAGCGCATTTTGGCGTGCCCGCCTGTGGGGCCGTGCTCAATACCATCAACACGCGGCTGGACGTGGA
TACTGTCGCCTACATCCTTGAACATGGCGAAGCCAGGATGGTACTGGTCGACTCCCAGTTTCTGGATCTCGCCGAAGCGG
CCTGTGCCACGCTTGCATCCCCTCCCACGCTGATCGAGGTGCCGGACGCCGTTGCGGGTATCGAAGCGTCGGGCCGCCAT
CAGACCTACGAAGACCTCATCGCTGCCGGCACGACGGATTTCGACTGGATCATGCCGCAGGATGAATGGGAAAGCCTCGC
GTTGAATTATACCTCCGGCACGACCGGCAGGCCGAAAGGCGTGGTCTATCACCATCGCGGGGCCTATCTGATGACCATGG
GCACGGTGATCAGCTGGCGCATGACCCTGCACCCGACGTTTATGCAGATCGTTCCGCTGTTTCATTGCAACGGCTGGAAC
CACGCATGGATGATGCCGCTCATTGGCGGCACGCTGGTCTGTTGTCGCGATATCACCGCACCGGCGATCTTCAACGCCAT
CGCGGATGAAAAGGTGACGCATTTCGGCGGTGCGCCGATTGTTCTGAACATGCTGGTGAACGCCCCATCAGAAGAGCGCC
GCACGATTGAACACCCGGTTGAAATCTTTACCGCCGGCGCGCCCCCTGCCCCGGCAACCCTCGCCAAGGTCGAAGCACTG
GGTTTCAACGTAACACAGGTCTACGGGCTGACGGAAACCTACGGTCATGTGACCGAGTGCCTGTGGCGCAGCGAATGGGA
CGGGCATGAAGCGGAAGCCAAAGCGGCGATCAAATCGCGTCAGGGCGTTCCCTTTCCGATGATGGAAGACATCGTGGTGA
TGGATGCCGATATGACGCCTGTACCCACCGATGCCAGCACGCAGGGCGAGATCATGATCCGTGGCAATTCGGTGATGAAG
GGGTATTACAAGAACCCGCAGGCCACGTCAGAAGCCTTTGCGGGTGGCTATTTCCATTCCGGCGACATCGCGGTGCAGCA
TGACGACAGCTACATCCAGATCGCGGATCGCGCCAAGGACATCATCATCTCAGGCGGTGAAAACATCTCTTCGGTGGAGG
TCGAGGGCGTGTTGATGGCCCATGACGATGTGATGCTGGCCGCTGTGGTCGCCAAACCGGATGACAAATGGGGCGAGGTG
CCCTGCGCCTTTGTGGAGCTGAAACCGGAGGCCACGGTGGATGAGGCCGGGTTGATCGCTTTCTCGCGTGAAACGCTTGC
GGGGTTCAAAGCGCCCAAAAAGGTGGTGTTTCAGGAATTGCCCAAGACCTCGACCGGCAAGATACAGAAGTTCGAATTGC
GCAAGCTGGCCGCAGAAATCTAG

Upstream 100 bases:

>100_bases
CATCCCAATTGTCTGACATTCCGCTTTTCAATTGGAAGAAATACCATATCTTACGCGTCGCGGCGCGCAGACGCCACGAA
ACCAGAGTGGGGAGTGTTTC

Downstream 100 bases:

>100_bases
CGCCGCCCCGGCGTGTCAGGGCATAGAACCGCGACCTCGCCCATTGCCCGCTTGTGCGCGGCAATGCTAGACTGCGCCGA
GGCAAATCCGAGCAGAACAT

Product: AMP-binding domain-containing protein

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MGWMSNETGLDKCAANHVPLTPLSHLKRAAVVFANHTAIVYGDVRRSYGEHAARATRLASALAAKGVAPGDVVATLLPNV
PAQVEAHFGVPACGAVLNTINTRLDVDTVAYILEHGEARMVLVDSQFLDLAEAACATLASPPTLIEVPDAVAGIEASGRH
QTYEDLIAAGTTDFDWIMPQDEWESLALNYTSGTTGRPKGVVYHHRGAYLMTMGTVISWRMTLHPTFMQIVPLFHCNGWN
HAWMMPLIGGTLVCCRDITAPAIFNAIADEKVTHFGGAPIVLNMLVNAPSEERRTIEHPVEIFTAGAPPAPATLAKVEAL
GFNVTQVYGLTETYGHVTECLWRSEWDGHEAEAKAAIKSRQGVPFPMMEDIVVMDADMTPVPTDASTQGEIMIRGNSVMK
GYYKNPQATSEAFAGGYFHSGDIAVQHDDSYIQIADRAKDIIISGGENISSVEVEGVLMAHDDVMLAAVVAKPDDKWGEV
PCAFVELKPEATVDEAGLIAFSRETLAGFKAPKKVVFQELPKTSTGKIQKFELRKLAAEI

Sequences:

>Translated_540_residues
MGWMSNETGLDKCAANHVPLTPLSHLKRAAVVFANHTAIVYGDVRRSYGEHAARATRLASALAAKGVAPGDVVATLLPNV
PAQVEAHFGVPACGAVLNTINTRLDVDTVAYILEHGEARMVLVDSQFLDLAEAACATLASPPTLIEVPDAVAGIEASGRH
QTYEDLIAAGTTDFDWIMPQDEWESLALNYTSGTTGRPKGVVYHHRGAYLMTMGTVISWRMTLHPTFMQIVPLFHCNGWN
HAWMMPLIGGTLVCCRDITAPAIFNAIADEKVTHFGGAPIVLNMLVNAPSEERRTIEHPVEIFTAGAPPAPATLAKVEAL
GFNVTQVYGLTETYGHVTECLWRSEWDGHEAEAKAAIKSRQGVPFPMMEDIVVMDADMTPVPTDASTQGEIMIRGNSVMK
GYYKNPQATSEAFAGGYFHSGDIAVQHDDSYIQIADRAKDIIISGGENISSVEVEGVLMAHDDVMLAAVVAKPDDKWGEV
PCAFVELKPEATVDEAGLIAFSRETLAGFKAPKKVVFQELPKTSTGKIQKFELRKLAAEI
>Mature_539_residues
GWMSNETGLDKCAANHVPLTPLSHLKRAAVVFANHTAIVYGDVRRSYGEHAARATRLASALAAKGVAPGDVVATLLPNVP
AQVEAHFGVPACGAVLNTINTRLDVDTVAYILEHGEARMVLVDSQFLDLAEAACATLASPPTLIEVPDAVAGIEASGRHQ
TYEDLIAAGTTDFDWIMPQDEWESLALNYTSGTTGRPKGVVYHHRGAYLMTMGTVISWRMTLHPTFMQIVPLFHCNGWNH
AWMMPLIGGTLVCCRDITAPAIFNAIADEKVTHFGGAPIVLNMLVNAPSEERRTIEHPVEIFTAGAPPAPATLAKVEALG
FNVTQVYGLTETYGHVTECLWRSEWDGHEAEAKAAIKSRQGVPFPMMEDIVVMDADMTPVPTDASTQGEIMIRGNSVMKG
YYKNPQATSEAFAGGYFHSGDIAVQHDDSYIQIADRAKDIIISGGENISSVEVEGVLMAHDDVMLAAVVAKPDDKWGEVP
CAFVELKPEATVDEAGLIAFSRETLAGFKAPKKVVFQELPKTSTGKIQKFELRKLAAEI

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=539, Percent_Identity=29.3135435992579, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI187761345, Length=546, Percent_Identity=24.7252747252747, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI187761343, Length=546, Percent_Identity=24.7252747252747, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI42544132, Length=518, Percent_Identity=28.1853281853282, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI157311624, Length=516, Percent_Identity=25.968992248062, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI157311622, Length=516, Percent_Identity=25.968992248062, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI38505220, Length=511, Percent_Identity=26.027397260274, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI58082049, Length=532, Percent_Identity=25.5639097744361, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI122937307, Length=521, Percent_Identity=25.1439539347409, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI115511026, Length=526, Percent_Identity=23.9543726235741, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI28416953, Length=544, Percent_Identity=24.0808823529412, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI13325057, Length=369, Percent_Identity=26.0162601626016, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=504, Percent_Identity=30.1587301587302, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1788107, Length=548, Percent_Identity=26.6423357664234, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI221142682, Length=528, Percent_Identity=26.7045454545455, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786810, Length=535, Percent_Identity=28.785046728972, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1790505, Length=588, Percent_Identity=24.6598639455782, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788595, Length=504, Percent_Identity=23.8095238095238, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=532, Percent_Identity=28.9473684210526, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994694, Length=532, Percent_Identity=28.9473684210526, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994703, Length=532, Percent_Identity=28.9473684210526, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560308, Length=538, Percent_Identity=28.8104089219331, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17538037, Length=536, Percent_Identity=27.4253731343284, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17558820, Length=502, Percent_Identity=25.6972111553785, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=536, Percent_Identity=25, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=516, Percent_Identity=25, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=504, Percent_Identity=23.6111111111111, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17560140, Length=520, Percent_Identity=23.2692307692308, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17531443, Length=508, Percent_Identity=22.4409448818898, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71983001, Length=549, Percent_Identity=26.775956284153, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71982997, Length=549, Percent_Identity=26.775956284153, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=545, Percent_Identity=25.3211009174312, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI25147511, Length=487, Percent_Identity=23.4086242299795, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115534440, Length=519, Percent_Identity=22.5433526011561, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=356, Percent_Identity=29.4943820224719, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319264, Length=565, Percent_Identity=25.3097345132743, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323182, Length=550, Percent_Identity=24.3636363636364, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581924, Length=566, Percent_Identity=27.208480565371, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21355181, Length=502, Percent_Identity=25.6972111553785, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18859661, Length=523, Percent_Identity=28.1070745697897, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21356947, Length=516, Percent_Identity=22.2868217054264, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648260, Length=506, Percent_Identity=22.7272727272727, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653035, Length=503, Percent_Identity=22.2664015904573, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 58304; Mature: 58173

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWMSNETGLDKCAANHVPLTPLSHLKRAAVVFANHTAIVYGDVRRSYGEHAARATRLAS
CCCCCCCCCHHHHHCCCCCCCHHHHHHHEEEEEECCEEEEEEHHHHHHHHHHHHHHHHHH
ALAAKGVAPGDVVATLLPNVPAQVEAHFGVPACGAVLNTINTRLDVDTVAYILEHGEARM
HHHHCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEE
VLVDSQFLDLAEAACATLASPPTLIEVPDAVAGIEASGRHQTYEDLIAAGTTDFDWIMPQ
EEECCHHHHHHHHHHHHHCCCCCEEECCCHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCC
DEWESLALNYTSGTTGRPKGVVYHHRGAYLMTMGTVISWRMTLHPTFMQIVPLFHCNGWN
CCCCEEEEEECCCCCCCCCCEEEEECCEEEEEECCEEEEEEEECHHHHHHHHHEEECCCC
HAWMMPLIGGTLVCCRDITAPAIFNAIADEKVTHFGGAPIVLNMLVNAPSEERRTIEHPV
CEEEHHHHCCEEEEECCCCHHHHHHHHHHCHHHHCCCCCEEEHHHHCCCCHHHHHHHCCE
EIFTAGAPPAPATLAKVEALGFNVTQVYGLTETYGHVTECLWRSEWDGHEAEAKAAIKSR
EEEECCCCCCCHHHHHHHHCCCCEEHEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
QGVPFPMMEDIVVMDADMTPVPTDASTQGEIMIRGNSVMKGYYKNPQATSEAFAGGYFHS
CCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCHHHHCCCEEEC
GDIAVQHDDSYIQIADRAKDIIISGGENISSVEVEGVLMAHDDVMLAAVVAKPDDKWGEV
CCEEEEECCCEEEEECCCCEEEEECCCCCCEEEEEEEEEECCCEEEEEEEECCCCCCCCC
PCAFVELKPEATVDEAGLIAFSRETLAGFKAPKKVVFQELPKTSTGKIQKFELRKLAAEI
CEEEEEECCCCCCCCCCEEEEEHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
GWMSNETGLDKCAANHVPLTPLSHLKRAAVVFANHTAIVYGDVRRSYGEHAARATRLAS
CCCCCCCCHHHHHCCCCCCCHHHHHHHEEEEEECCEEEEEEHHHHHHHHHHHHHHHHHH
ALAAKGVAPGDVVATLLPNVPAQVEAHFGVPACGAVLNTINTRLDVDTVAYILEHGEARM
HHHHCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEE
VLVDSQFLDLAEAACATLASPPTLIEVPDAVAGIEASGRHQTYEDLIAAGTTDFDWIMPQ
EEECCHHHHHHHHHHHHHCCCCCEEECCCHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCC
DEWESLALNYTSGTTGRPKGVVYHHRGAYLMTMGTVISWRMTLHPTFMQIVPLFHCNGWN
CCCCEEEEEECCCCCCCCCCEEEEECCEEEEEECCEEEEEEEECHHHHHHHHHEEECCCC
HAWMMPLIGGTLVCCRDITAPAIFNAIADEKVTHFGGAPIVLNMLVNAPSEERRTIEHPV
CEEEHHHHCCEEEEECCCCHHHHHHHHHHCHHHHCCCCCEEEHHHHCCCCHHHHHHHCCE
EIFTAGAPPAPATLAKVEALGFNVTQVYGLTETYGHVTECLWRSEWDGHEAEAKAAIKSR
EEEECCCCCCCHHHHHHHHCCCCEEHEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
QGVPFPMMEDIVVMDADMTPVPTDASTQGEIMIRGNSVMKGYYKNPQATSEAFAGGYFHS
CCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCHHHHCCCEEEC
GDIAVQHDDSYIQIADRAKDIIISGGENISSVEVEGVLMAHDDVMLAAVVAKPDDKWGEV
CCEEEEECCCEEEEECCCCEEEEECCCCCCEEEEEEEEEECCCEEEEEEEECCCCCCCCC
PCAFVELKPEATVDEAGLIAFSRETLAGFKAPKKVVFQELPKTSTGKIQKFELRKLAAEI
CEEEEEECCCCCCCCCCEEEEEHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]