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The map label for this gene is fadA [H]

Identifier: 110681105

GI number: 110681105

Start: 3829356

End: 3830567

Strand: Direct

Name: fadA [H]

Synonym: RD1_3972

Alternate gene names: 110681105

Gene position: 3829356-3830567 (Clockwise)

Preceding gene: 110681104

Following gene: 110681106

Centisome position: 92.65

GC content: 61.72

Gene sequence:

>1212_bases
ATGACCGACGCCTATATCTATGACGCGCTGCGCACCCCGCGTGGCAAGGGCCGCAAGGACGGCAGCCTGCACGAGGTGAC
ATCCCTGCGCCTGTCCGCGCTGACGCTGAACGCGCTGAAGGACCGCAACAACCTTGAGGGCCACGCTGTTGAGGATGTGA
TCTGGGGAAATGTGACACAGGTGATGGAACAGGGCGGCTGCCTTGCGCGCTCTGCCGTGTTGGCGTCCGATCTGGATGAA
CGCATCCCCGGTCTGGCGATTAACCGCTTTTGCGCCTCTGGCATGGAGGCGGTCAACCTCGCCGCCAATCAGGTGCGCGG
TGGTGCCGGTCAGGCCTACATCGCGGGCGGGGTCGAGATGATGGGCCGTGTGGCCATGGGCAGTGACGGGGCGGCCATCG
CGGTTGATCCGACGCTCGCAATGGAAAAACACTTCGTCCCCCAAGGCATCAGCGCGGATATCATCGCGACCGAATATGGC
TTTAGCCGCGATGATGCGGACACGCTGGCGGTCGAATCCCAGCGTCGCGCAAAACAGGCATGGGATGAGGGGCGTTTTGA
CAAATCGGTCATCGAGGTGCGCGACCAGAACGGGCTGAAGATTCTGGATCACGACGAATACATGCGCCCGCAAACCGACA
TGCAAAGCCTTGGCGCGCTGAACCCCGCCTTTCAGGCGATGGGAGAGGTCATGCCCGGCTTCGACAAGGTCGCGCTGATG
AAATACCCGCATCTTGAGCGGATCAACCATATCCACCACGCGGGCAACTCATCGGGTATCGTCGATGGGGCGGCAGCCGT
TCTGATCGGCAACAAAGAGTTCGGCGAAGAGCACGGACTGAAGCCGCGCGCCCGCATCCGCGCCACGGCGAAAATCGGCA
CCGACCCCACGATCATGCTGACCGGTCCTGTGCCGGTGACCGAAAAAATCCTCGCCGACAGTGGGATGGACATCAAGGAC
ATTGATCTTTTTGAGGTGAACGAGGCCTTTGCCGCCGTGGTGCTGCGGTTTTTGCAGGCGTTTGATGTCGATGATGCGAA
GGTGAACGTCAACGGCGGCTCGATCGCCATGGGCCATCCGCTTGGCGCGACCGGGGCCATCATCATCGGCACGCTGCTGG
ATGAGTTGGAGCGCGACGACAAAGAGGTCGGTCTGGCTACGCTCTGCATCGCCTCCGGCATGGGTGCCGCGACCATCATC
GAGCGCGTTTAA

Upstream 100 bases:

>100_bases
GTCCCGGGGTGGAAATCCCCCTATGATCTGATGCCCGGCTCGCCCGCTGATCGCACATAAACCAATCGGGACCGATGGCT
GGCCCCAAAAGGAGACGACG

Downstream 100 bases:

>100_bases
CCGCCGAAACCCCGGAAAAAGGGAAACGAGACATGACTGATTTTACAATGGACACCGATGGACAAGGCATCGCGACGATC
ACATGGGATGTGAAAGACAA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTDAYIYDALRTPRGKGRKDGSLHEVTSLRLSALTLNALKDRNNLEGHAVEDVIWGNVTQVMEQGGCLARSAVLASDLDE
RIPGLAINRFCASGMEAVNLAANQVRGGAGQAYIAGGVEMMGRVAMGSDGAAIAVDPTLAMEKHFVPQGISADIIATEYG
FSRDDADTLAVESQRRAKQAWDEGRFDKSVIEVRDQNGLKILDHDEYMRPQTDMQSLGALNPAFQAMGEVMPGFDKVALM
KYPHLERINHIHHAGNSSGIVDGAAAVLIGNKEFGEEHGLKPRARIRATAKIGTDPTIMLTGPVPVTEKILADSGMDIKD
IDLFEVNEAFAAVVLRFLQAFDVDDAKVNVNGGSIAMGHPLGATGAIIIGTLLDELERDDKEVGLATLCIASGMGAATII
ERV

Sequences:

>Translated_403_residues
MTDAYIYDALRTPRGKGRKDGSLHEVTSLRLSALTLNALKDRNNLEGHAVEDVIWGNVTQVMEQGGCLARSAVLASDLDE
RIPGLAINRFCASGMEAVNLAANQVRGGAGQAYIAGGVEMMGRVAMGSDGAAIAVDPTLAMEKHFVPQGISADIIATEYG
FSRDDADTLAVESQRRAKQAWDEGRFDKSVIEVRDQNGLKILDHDEYMRPQTDMQSLGALNPAFQAMGEVMPGFDKVALM
KYPHLERINHIHHAGNSSGIVDGAAAVLIGNKEFGEEHGLKPRARIRATAKIGTDPTIMLTGPVPVTEKILADSGMDIKD
IDLFEVNEAFAAVVLRFLQAFDVDDAKVNVNGGSIAMGHPLGATGAIIIGTLLDELERDDKEVGLATLCIASGMGAATII
ERV
>Mature_402_residues
TDAYIYDALRTPRGKGRKDGSLHEVTSLRLSALTLNALKDRNNLEGHAVEDVIWGNVTQVMEQGGCLARSAVLASDLDER
IPGLAINRFCASGMEAVNLAANQVRGGAGQAYIAGGVEMMGRVAMGSDGAAIAVDPTLAMEKHFVPQGISADIIATEYGF
SRDDADTLAVESQRRAKQAWDEGRFDKSVIEVRDQNGLKILDHDEYMRPQTDMQSLGALNPAFQAMGEVMPGFDKVALMK
YPHLERINHIHHAGNSSGIVDGAAAVLIGNKEFGEEHGLKPRARIRATAKIGTDPTIMLTGPVPVTEKILADSGMDIKDI
DLFEVNEAFAAVVLRFLQAFDVDDAKVNVNGGSIAMGHPLGATGAIIIGTLLDELERDDKEVGLATLCIASGMGAATIIE
RV

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=411, Percent_Identity=33.5766423357664, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4501853, Length=405, Percent_Identity=35.5555555555556, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI148539872, Length=404, Percent_Identity=32.6732673267327, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4557237, Length=417, Percent_Identity=29.4964028776978, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=28.0269058295964, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI194353979, Length=127, Percent_Identity=36.2204724409449, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI48994986, Length=410, Percent_Identity=39.5121951219512, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1787663, Length=425, Percent_Identity=36.2352941176471, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1788554, Length=418, Percent_Identity=37.5598086124402, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI87082165, Length=418, Percent_Identity=35.6459330143541, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1788683, Length=428, Percent_Identity=28.0373831775701, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=415, Percent_Identity=33.0120481927711, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=412, Percent_Identity=29.8543689320388, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17535921, Length=414, Percent_Identity=26.8115942028986, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17551802, Length=451, Percent_Identity=26.8292682926829, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17535917, Length=406, Percent_Identity=28.0788177339901, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322031, Length=406, Percent_Identity=33.0049261083744, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6325229, Length=421, Percent_Identity=29.2161520190024, Blast_Score=159, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24655093, Length=418, Percent_Identity=36.1244019138756, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17648125, Length=414, Percent_Identity=33.5748792270531, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24640423, Length=420, Percent_Identity=30.2380952380952, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI17137578, Length=447, Percent_Identity=27.2930648769575, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 43047; Mature: 42915

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAYIYDALRTPRGKGRKDGSLHEVTSLRLSALTLNALKDRNNLEGHAVEDVIWGNVTQ
CCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHH
VMEQGGCLARSAVLASDLDERIPGLAINRFCASGMEAVNLAANQVRGGAGQAYIAGGVEM
HHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHH
MGRVAMGSDGAAIAVDPTLAMEKHFVPQGISADIIATEYGFSRDDADTLAVESQRRAKQA
HHHHEECCCCCEEEECCHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
WDEGRFDKSVIEVRDQNGLKILDHDEYMRPQTDMQSLGALNPAFQAMGEVMPGFDKVALM
HHCCCCCCHHHEEECCCCCEEECCCHHCCCCHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
KYPHLERINHIHHAGNSSGIVDGAAAVLIGNKEFGEEHGLKPRARIRATAKIGTDPTIML
CCCCHHHHHHHHHCCCCCCCCCCEEEEEECCHHHCHHHCCCCHHHEEEEEECCCCCEEEE
TGPVPVTEKILADSGMDIKDIDLFEVNEAFAAVVLRFLQAFDVDDAKVNVNGGSIAMGHP
ECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCC
LGATGAIIIGTLLDELERDDKEVGLATLCIASGMGAATIIERV
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure 
TDAYIYDALRTPRGKGRKDGSLHEVTSLRLSALTLNALKDRNNLEGHAVEDVIWGNVTQ
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHH
VMEQGGCLARSAVLASDLDERIPGLAINRFCASGMEAVNLAANQVRGGAGQAYIAGGVEM
HHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHH
MGRVAMGSDGAAIAVDPTLAMEKHFVPQGISADIIATEYGFSRDDADTLAVESQRRAKQA
HHHHEECCCCCEEEECCHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
WDEGRFDKSVIEVRDQNGLKILDHDEYMRPQTDMQSLGALNPAFQAMGEVMPGFDKVALM
HHCCCCCCHHHEEECCCCCEEECCCHHCCCCHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
KYPHLERINHIHHAGNSSGIVDGAAAVLIGNKEFGEEHGLKPRARIRATAKIGTDPTIML
CCCCHHHHHHHHHCCCCCCCCCCEEEEEECCHHHCHHHCCCCHHHEEEEEECCCCCEEEE
TGPVPVTEKILADSGMDIKDIDLFEVNEAFAAVVLRFLQAFDVDDAKVNVNGGSIAMGHP
ECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCC
LGATGAIIIGTLLDELERDDKEVGLATLCIASGMGAATIIERV
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]