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The map label for this gene is livM [H]

Identifier: 110680756

GI number: 110680756

Start: 3464279

End: 3465412

Strand: Direct

Name: livM [H]

Synonym: RD1_3599

Alternate gene names: 110680756

Gene position: 3464279-3465412 (Clockwise)

Preceding gene: 110680755

Following gene: 110680757

Centisome position: 83.82

GC content: 58.47

Gene sequence:

>1134_bases
ATGAGTGCCTCTTCCAACCGTCTCTTCTCCCTGCAGGATATCATCGGGTTCGCCATCCTCGCTGCTGTCATCTTCATCCT
GCTGCCGCTGGCACTCGACACCTTCCGGCTGAACCTGTTTGGCAAATACCTCACATATGCCTTTGTCGCCGTTGGTCTGG
TGCTGTGCTGGGGCGCTGGTGGGATCCTCAGCCTTGGACAGGGTGTTTTCTTCGGACTTGGCGGGTACTGCATGGCGATG
TTCCTCAAGCTTGAGGCCTCAACGCCCGAAAATACCGCGATCCAGTCCACCCCGGGGATTCCGGACTTCATGGACTGGAA
CCAGCTCACCGCCCTGCCCTGGTGGTGGGAACCGTTCAACAACCTTGCCTTTGCGCTTTTTGCGGTGGTCGCGGTGCCGG
TGATCTTTGCGTTCATCATCGGGGTTGCGATGTTCCGCCGCCGGGTGGGCGGGGTTTATTTCGCAATCATCACGCAGGCT
TTCGCGGCAATCCTGACCATTCTGATCATTGGCCAGCAAGGGTTCACCGGGGGCGTCAATGGCATCACCGACTTGCGCAC
CCTGAACGGATGGGACATCCGCACCGATGAGGCCAAGGAGTTGCTCTATTTTGTGAACGGCATCCTGCTGTTTGCCTGTC
TGTTCATTGCGCAATTCGTTCGCAAGTCAAAACTCGGGCGCTTGCTGATCGCCATGCGCGATCAGGAGGACCGTGTGCGG
TTTTCGGGCTATGACGTGGCGAGTTTCAAGATTTTCATCTTCTGCCTCGGCGCTGCCTTCGCCGGCATCGGTGGAGCCAT
GTTCACCCTGCAGGTCGGGTTCATGTCACCGACCCTCGTGGGCATCGTCCCGTCGATCGAGATGGTGATCTTCTGCGCGG
TTGGCGGTCGCTTGTCCATCATCGGGGCGGTTTACGGCGCGCTTCTGGTCAACTGGGCCAAGACCTCCCTGTCAGAGACA
TTCCCCGAACTTTGGCTCTTGGGTCTGGGCGGGTTGTTCATTGCGGTTGTCATGCTGTTCCCGAACGGCTTGGCCGGCGT
CTATGCGGAACATGTCGCACCCCGCATCGCCAGGCTGTTCTCAAAGACCAGCACCACGGAAGCCAAGCAATCAAAACAAT
CGCCCGCTGAATAG

Upstream 100 bases:

>100_bases
CATGGCCAAGGTGCTGACCCTGCTGGTGGTGGTCGGCATCCTCATGGTCCGCCCGCAGGGTCTCTTTTCCCTCAAACTGC
GCAAGTAAGGAGCCCAAAAG

Downstream 100 bases:

>100_bases
GAGGCCCGGATATGCGCGACACACCCCCCCATCCCAGCTTTGTGCTATCGGTCGAAGGGCTGACAGTCTCCTTTGACGGT
TTCAAAGCGGTGGATGACCT

Product: branched-chain amino acid ABC transporter, permease protein, putative

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSASSNRLFSLQDIIGFAILAAVIFILLPLALDTFRLNLFGKYLTYAFVAVGLVLCWGAGGILSLGQGVFFGLGGYCMAM
FLKLEASTPENTAIQSTPGIPDFMDWNQLTALPWWWEPFNNLAFALFAVVAVPVIFAFIIGVAMFRRRVGGVYFAIITQA
FAAILTILIIGQQGFTGGVNGITDLRTLNGWDIRTDEAKELLYFVNGILLFACLFIAQFVRKSKLGRLLIAMRDQEDRVR
FSGYDVASFKIFIFCLGAAFAGIGGAMFTLQVGFMSPTLVGIVPSIEMVIFCAVGGRLSIIGAVYGALLVNWAKTSLSET
FPELWLLGLGGLFIAVVMLFPNGLAGVYAEHVAPRIARLFSKTSTTEAKQSKQSPAE

Sequences:

>Translated_377_residues
MSASSNRLFSLQDIIGFAILAAVIFILLPLALDTFRLNLFGKYLTYAFVAVGLVLCWGAGGILSLGQGVFFGLGGYCMAM
FLKLEASTPENTAIQSTPGIPDFMDWNQLTALPWWWEPFNNLAFALFAVVAVPVIFAFIIGVAMFRRRVGGVYFAIITQA
FAAILTILIIGQQGFTGGVNGITDLRTLNGWDIRTDEAKELLYFVNGILLFACLFIAQFVRKSKLGRLLIAMRDQEDRVR
FSGYDVASFKIFIFCLGAAFAGIGGAMFTLQVGFMSPTLVGIVPSIEMVIFCAVGGRLSIIGAVYGALLVNWAKTSLSET
FPELWLLGLGGLFIAVVMLFPNGLAGVYAEHVAPRIARLFSKTSTTEAKQSKQSPAE
>Mature_376_residues
SASSNRLFSLQDIIGFAILAAVIFILLPLALDTFRLNLFGKYLTYAFVAVGLVLCWGAGGILSLGQGVFFGLGGYCMAMF
LKLEASTPENTAIQSTPGIPDFMDWNQLTALPWWWEPFNNLAFALFAVVAVPVIFAFIIGVAMFRRRVGGVYFAIITQAF
AAILTILIIGQQGFTGGVNGITDLRTLNGWDIRTDEAKELLYFVNGILLFACLFIAQFVRKSKLGRLLIAMRDQEDRVRF
SGYDVASFKIFIFCLGAAFAGIGGAMFTLQVGFMSPTLVGIVPSIEMVIFCAVGGRLSIIGAVYGALLVNWAKTSLSETF
PELWLLGLGGLFIAVVMLFPNGLAGVYAEHVAPRIARLFSKTSTTEAKQSKQSPAE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=324, Percent_Identity=27.1604938271605, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 40924; Mature: 40793

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSNRLFSLQDIIGFAILAAVIFILLPLALDTFRLNLFGKYLTYAFVAVGLVLCWGAG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GILSLGQGVFFGLGGYCMAMFLKLEASTPENTAIQSTPGIPDFMDWNQLTALPWWWEPFN
CHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHH
NLAFALFAVVAVPVIFAFIIGVAMFRRRVGGVYFAIITQAFAAILTILIIGQQGFTGGVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GITDLRTLNGWDIRTDEAKELLYFVNGILLFACLFIAQFVRKSKLGRLLIAMRDQEDRVR
CHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEECCCCCCEE
FSGYDVASFKIFIFCLGAAFAGIGGAMFTLQVGFMSPTLVGIVPSIEMVIFCAVGGRLSI
ECCCCHHHHHHHHHHHHHHHHHCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHH
IGAVYGALLVNWAKTSLSETFPELWLLGLGGLFIAVVMLFPNGLAGVYAEHVAPRIARLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SKTSTTEAKQSKQSPAE
HHCCCHHHHHCCCCCCC
>Mature Secondary Structure 
SASSNRLFSLQDIIGFAILAAVIFILLPLALDTFRLNLFGKYLTYAFVAVGLVLCWGAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GILSLGQGVFFGLGGYCMAMFLKLEASTPENTAIQSTPGIPDFMDWNQLTALPWWWEPFN
CHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHH
NLAFALFAVVAVPVIFAFIIGVAMFRRRVGGVYFAIITQAFAAILTILIIGQQGFTGGVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GITDLRTLNGWDIRTDEAKELLYFVNGILLFACLFIAQFVRKSKLGRLLIAMRDQEDRVR
CHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEECCCCCCEE
FSGYDVASFKIFIFCLGAAFAGIGGAMFTLQVGFMSPTLVGIVPSIEMVIFCAVGGRLSI
ECCCCHHHHHHHHHHHHHHHHHCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHH
IGAVYGALLVNWAKTSLSETFPELWLLGLGGLFIAVVMLFPNGLAGVYAEHVAPRIARLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SKTSTTEAKQSKQSPAE
HHCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]