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The map label for this gene is tmk [H]

Identifier: 110680630

GI number: 110680630

Start: 3336480

End: 3337118

Strand: Direct

Name: tmk [H]

Synonym: RD1_3466

Alternate gene names: 110680630

Gene position: 3336480-3337118 (Clockwise)

Preceding gene: 110680629

Following gene: 110680631

Centisome position: 80.73

GC content: 62.28

Gene sequence:

>639_bases
GTGATATCGCGCACCCGCGACACCGGGTTTTTCATCACCTTTGAGGGCATTGACGGGTCGGGCAAATCCACCCAATCCAA
AAGGCTTGCCGCCCATTTGCGCGCAAGCGGCCACGAGGTCGTCGAAACCCGCGAACCGGGTGGCTCTCCGGGGGCGGAGG
AAATCCGCGCGCTTGTCTTGCAGGGTGATCCCGACCGCTGGTCCGCCGAGACGGAGATCCTTTTGTTTACAGCCGCGCGG
CGCGACCATATGGAGCGGTTGATCCTCCCTGCCCTGGCGGATGGGAAAATCGTCATATGTGACCGGTTTGCCGATAGCAC
GCGCATGTATCAGGGCCTGTCGCGCGGCGATCTGCGACAGGTCGTGGACACGCTGCATGAGCTGATGATTGGCCGCGAAC
CCGACCTCACCGTGCTGATTGATATGGACCCGGCCATCGGGCTGTCCCGGGCGCTGTCGCGACAAACCGCTGACGAGCGT
TTTGAAGCCTTTGGCGAGGATTTGCAGACGAGGATGCGCGCCGGTTTTCTGGCACTGGCGCAGGAGTTCAAAGCCCGCTT
TCGCCTTGTGGATGGCGGGCGGGATGCCGACAGTGTCGCAGCGGAGGTGATCAAGATCGTCGATCAGGCGCTGGCATGA

Upstream 100 bases:

>100_bases
TGGCGGATCAAGACGTGCCGAGTGGCGGTTTTGTCACCCGCATGATGACGGCAGCCATGGTTCTGGTCACGACGCTGATA
CAGGGGCCAGAGGAACAGTC

Downstream 100 bases:

>100_bases
CGGCCCCCGATCAAATTGAAGGCGCGCCGCACCCGCGCGACACGCCGCAGGTTTTTGGTCAAGCCACTGCCGAACAGGGG
TTTCTGGACGCATATGCAAC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MISRTRDTGFFITFEGIDGSGKSTQSKRLAAHLRASGHEVVETREPGGSPGAEEIRALVLQGDPDRWSAETEILLFTAAR
RDHMERLILPALADGKIVICDRFADSTRMYQGLSRGDLRQVVDTLHELMIGREPDLTVLIDMDPAIGLSRALSRQTADER
FEAFGEDLQTRMRAGFLALAQEFKARFRLVDGGRDADSVAAEVIKIVDQALA

Sequences:

>Translated_212_residues
MISRTRDTGFFITFEGIDGSGKSTQSKRLAAHLRASGHEVVETREPGGSPGAEEIRALVLQGDPDRWSAETEILLFTAAR
RDHMERLILPALADGKIVICDRFADSTRMYQGLSRGDLRQVVDTLHELMIGREPDLTVLIDMDPAIGLSRALSRQTADER
FEAFGEDLQTRMRAGFLALAQEFKARFRLVDGGRDADSVAAEVIKIVDQALA
>Mature_212_residues
MISRTRDTGFFITFEGIDGSGKSTQSKRLAAHLRASGHEVVETREPGGSPGAEEIRALVLQGDPDRWSAETEILLFTAAR
RDHMERLILPALADGKIVICDRFADSTRMYQGLSRGDLRQVVDTLHELMIGREPDLTVLIDMDPAIGLSRALSRQTADER
FEAFGEDLQTRMRAGFLALAQEFKARFRLVDGGRDADSVAAEVIKIVDQALA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=181, Percent_Identity=40.3314917127072, Blast_Score=105, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23414; Mature: 23414

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRTRDTGFFITFEGIDGSGKSTQSKRLAAHLRASGHEVVETREPGGSPGAEEIRALVL
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHEEHC
QGDPDRWSAETEILLFTAARRDHMERLILPALADGKIVICDRFADSTRMYQGLSRGDLRQ
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCHHHH
VVDTLHELMIGREPDLTVLIDMDPAIGLSRALSRQTADERFEAFGEDLQTRMRAGFLALA
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEFKARFRLVDGGRDADSVAAEVIKIVDQALA
HHHHHHEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISRTRDTGFFITFEGIDGSGKSTQSKRLAAHLRASGHEVVETREPGGSPGAEEIRALVL
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHEEHC
QGDPDRWSAETEILLFTAARRDHMERLILPALADGKIVICDRFADSTRMYQGLSRGDLRQ
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCHHHH
VVDTLHELMIGREPDLTVLIDMDPAIGLSRALSRQTADERFEAFGEDLQTRMRAGFLALA
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEFKARFRLVDGGRDADSVAAEVIKIVDQALA
HHHHHHEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA