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The map label for this gene is pyr [H]

Identifier: 110680599

GI number: 110680599

Start: 3293626

End: 3294906

Strand: Direct

Name: pyr [H]

Synonym: RD1_3429

Alternate gene names: 110680599

Gene position: 3293626-3294906 (Clockwise)

Preceding gene: 110680598

Following gene: 110680600

Centisome position: 79.69

GC content: 63.39

Gene sequence:

>1281_bases
ATGATGAAACCGCTCAACCTCGTGAATGCGCGGCTGGTTGATTCTGAAACCGGCAGCATTTCCATCGGTGGTCTGCGCAT
CGAAAATGGCAGGATCTCACAGCGGCTCGACAGGGACGAGCGGCCGGGCGGCGAAACGGTGGATTGCAACCTCAAACATC
TCGCTCCGGGGATTGTCGATATCGGCGTCAAGGTCTGTGAACCCGGTGAACGGCATAAGGAAAGCTACCGCTCCGCCGGG
CTGGCGGCGGCGGCAGGCGGTGTGACGACGATGGTCACGCGACCCGACACGACACCGGCCATTGACAGCCCTGAGGCGCT
TGAATTCGTCACCCGGCGGGCCAATCAGGCCGCCGCCGTGAACGTCCTGCCCATGGCCGCCCTGACAAAAGGGCGTGCGG
GCCGCGAAATGACCGAAATCGGTTTTCTGATGGACGCAGGCGCGGTCGCCTTTACCGATTGCGACCGTGTGGTCACTGAT
ACCAAAGTTCTGTCGCGCGCGCTCAGCTATGCGCGCTCGCTTGGCGCTCTGGTCATTGCACACCCGCAGGATCCGGGCCT
GAGTGCGGGCGCTGCGGCGACCTCCGGGAAATTTGCCTCTCTCAGGGGGTTGCCGGCGGTATCTCCCATGGCCGAACGCA
TGGCGCTCGACCGGGACATCGCCCTGGTCGAGATGACGGGCGCGCGATACCATGCGGATCAGATCACCTGCGCGCGCGCG
CTTCCCGCGTTGGAGCGGGCCAAGCAGAACGGCCATGACGTGACCGCTGGCACCTCGATCCACCATTTGACGCTGAACGC
GCTGGATGTGGCGGATTACCGGACGTTCTTCAAACTGAAACCGCCACTGCGCGATGAAACCGATCGCCTCGCCGTGGCTG
ATGCCGTGCGCAGCGGGTTGATTGACGTGATCTCCTCGATGCACACCCCGCAGGATGAGGAAAGCAAGCGCCTGCCCTTT
GAAGAAGCCGCGTCAGGGGCGGTGGCCCTTGAAACGCTCTTGCCTGCGGCGATGCGGCTTTATCATGCGGATCTGATTGA
CCTGCCGACGCTCTGGCGCGCCATGTCGCTCAACCCCGCAAAACGGCTGGGCCTCGACAGCGGGCGTCTGGCAGCAGGCG
CACCTGCGGACCTTGTGCTGTTTGACCCCGACGCACCGTTCTTGATGGACCGCACGACGCTACGGTCAAAATCCCGCAAC
ACACCATTTGACGGCGCGCGCATGCAGGGCCGCGTGCTTGCGACCTATGTCGCGGGACAGCGCGTCTATGAAAGAAGCTG
A

Upstream 100 bases:

>100_bases
AGAAACGCCCCTCCGATGCGGCCATGTCCGGCAGGATTGCAACCCTCGCGCTGCTGGTCGCCTTTGGCGTGGTCGGCTTG
ATGCTCTGGGTGGGAAGCTG

Downstream 100 bases:

>100_bases
TGCCGTTGATTGAAAGCACCCTGCCCGCGCTCGCTCTTTGGGGCGTTATCGGTTATCTTTTGGGGTCGATCCCGTTTGGC
ATGGTACTGGCCAAGGTCAT

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MMKPLNLVNARLVDSETGSISIGGLRIENGRISQRLDRDERPGGETVDCNLKHLAPGIVDIGVKVCEPGERHKESYRSAG
LAAAAGGVTTMVTRPDTTPAIDSPEALEFVTRRANQAAAVNVLPMAALTKGRAGREMTEIGFLMDAGAVAFTDCDRVVTD
TKVLSRALSYARSLGALVIAHPQDPGLSAGAAATSGKFASLRGLPAVSPMAERMALDRDIALVEMTGARYHADQITCARA
LPALERAKQNGHDVTAGTSIHHLTLNALDVADYRTFFKLKPPLRDETDRLAVADAVRSGLIDVISSMHTPQDEESKRLPF
EEAASGAVALETLLPAAMRLYHADLIDLPTLWRAMSLNPAKRLGLDSGRLAAGAPADLVLFDPDAPFLMDRTTLRSKSRN
TPFDGARMQGRVLATYVAGQRVYERS

Sequences:

>Translated_426_residues
MMKPLNLVNARLVDSETGSISIGGLRIENGRISQRLDRDERPGGETVDCNLKHLAPGIVDIGVKVCEPGERHKESYRSAG
LAAAAGGVTTMVTRPDTTPAIDSPEALEFVTRRANQAAAVNVLPMAALTKGRAGREMTEIGFLMDAGAVAFTDCDRVVTD
TKVLSRALSYARSLGALVIAHPQDPGLSAGAAATSGKFASLRGLPAVSPMAERMALDRDIALVEMTGARYHADQITCARA
LPALERAKQNGHDVTAGTSIHHLTLNALDVADYRTFFKLKPPLRDETDRLAVADAVRSGLIDVISSMHTPQDEESKRLPF
EEAASGAVALETLLPAAMRLYHADLIDLPTLWRAMSLNPAKRLGLDSGRLAAGAPADLVLFDPDAPFLMDRTTLRSKSRN
TPFDGARMQGRVLATYVAGQRVYERS
>Mature_426_residues
MMKPLNLVNARLVDSETGSISIGGLRIENGRISQRLDRDERPGGETVDCNLKHLAPGIVDIGVKVCEPGERHKESYRSAG
LAAAAGGVTTMVTRPDTTPAIDSPEALEFVTRRANQAAAVNVLPMAALTKGRAGREMTEIGFLMDAGAVAFTDCDRVVTD
TKVLSRALSYARSLGALVIAHPQDPGLSAGAAATSGKFASLRGLPAVSPMAERMALDRDIALVEMTGARYHADQITCARA
LPALERAKQNGHDVTAGTSIHHLTLNALDVADYRTFFKLKPPLRDETDRLAVADAVRSGLIDVISSMHTPQDEESKRLPF
EEAASGAVALETLLPAAMRLYHADLIDLPTLWRAMSLNPAKRLGLDSGRLAAGAPADLVLFDPDAPFLMDRTTLRSKSRN
TPFDGARMQGRVLATYVAGQRVYERS

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786722, Length=414, Percent_Identity=24.1545893719807, Blast_Score=126, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322218, Length=389, Percent_Identity=25.9640102827763, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18859883, Length=408, Percent_Identity=28.921568627451, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45641; Mature: 45641

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKPLNLVNARLVDSETGSISIGGLRIENGRISQRLDRDERPGGETVDCNLKHLAPGIVD
CCCCCCHHHEEEEECCCCEEEECCEEEECCCHHHHHCCCCCCCCCEEECCHHHHCCCHHC
IGVKVCEPGERHKESYRSAGLAAAAGGVTTMVTRPDTTPAIDSPEALEFVTRRANQAAAV
CCCEECCCCHHHHHHHHHCCHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHEE
NVLPMAALTKGRAGREMTEIGFLMDAGAVAFTDCDRVVTDTKVLSRALSYARSLGALVIA
EEHHHHHHHCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEE
HPQDPGLSAGAAATSGKFASLRGLPAVSPMAERMALDRDIALVEMTGARYHADQITCARA
CCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCEECCHHHHHHHH
LPALERAKQNGHDVTAGTSIHHLTLNALDVADYRTFFKLKPPLRDETDRLAVADAVRSGL
HHHHHHHHHCCCEEECCCEEEEEEEEHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
IDVISSMHTPQDEESKRLPFEEAASGAVALETLLPAAMRLYHADLIDLPTLWRAMSLNPA
HHHHHHCCCCCCCHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KRLGLDSGRLAAGAPADLVLFDPDAPFLMDRTTLRSKSRNTPFDGARMQGRVLATYVAGQ
HHCCCCCCCCCCCCCCEEEEECCCCCCEECHHHHHHCCCCCCCCCCCCCCEEEEEEHHCC
RVYERS
HHHCCC
>Mature Secondary Structure
MMKPLNLVNARLVDSETGSISIGGLRIENGRISQRLDRDERPGGETVDCNLKHLAPGIVD
CCCCCCHHHEEEEECCCCEEEECCEEEECCCHHHHHCCCCCCCCCEEECCHHHHCCCHHC
IGVKVCEPGERHKESYRSAGLAAAAGGVTTMVTRPDTTPAIDSPEALEFVTRRANQAAAV
CCCEECCCCHHHHHHHHHCCHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHEE
NVLPMAALTKGRAGREMTEIGFLMDAGAVAFTDCDRVVTDTKVLSRALSYARSLGALVIA
EEHHHHHHHCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEE
HPQDPGLSAGAAATSGKFASLRGLPAVSPMAERMALDRDIALVEMTGARYHADQITCARA
CCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCEECCHHHHHHHH
LPALERAKQNGHDVTAGTSIHHLTLNALDVADYRTFFKLKPPLRDETDRLAVADAVRSGL
HHHHHHHHHCCCEEECCCEEEEEEEEHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
IDVISSMHTPQDEESKRLPFEEAASGAVALETLLPAAMRLYHADLIDLPTLWRAMSLNPA
HHHHHHCCCCCCCHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KRLGLDSGRLAAGAPADLVLFDPDAPFLMDRTTLRSKSRNTPFDGARMQGRVLATYVAGQ
HHCCCCCCCCCCCCCCEEEEECCCCCCEECHHHHHHCCCCCCCCCCCCCCEEEEEEHHCC
RVYERS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA