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The map label for this gene is pepA [H]

Identifier: 110680305

GI number: 110680305

Start: 2993893

End: 2995398

Strand: Reverse

Name: pepA [H]

Synonym: RD1_3118

Alternate gene names: 110680305

Gene position: 2995398-2993893 (Counterclockwise)

Preceding gene: 110680312

Following gene: 110680304

Centisome position: 72.47

GC content: 62.35

Gene sequence:

>1506_bases
ATGGGCGTAATTCATGAAAAGAAGGCTAATGATATGACGACGCCCACCCCTGTGACCTTTCTTGAAACTGATATCGAGCG
TCTTGCCGATCATGTCGGGCGTGTTTGCATTGTTGTCGATGACGCCGGGCGGACGGATGTGGCCGGGCGCCGGGTCAATC
GCCTGACGAAAGGGGCGCTCAAACGCGCGCTGGAGGCAAAGGCCGAGGCCGGGCTGAAGGCAGGCAGTGTGTTCACGCTG
GCCTATCCTGCGGGCATGGCGGCGGAGGCCGTGGATGTGATCTGTGTTCCGCGTGCCACCACGGTGCACAAGGCGCGCGC
GGCCGGTGCGGCGCTGGGGCGCAACCGGGGTAAGGCTGACCTGTTGCTGGCGGTCGGAAATTCCAAGTGGGCGGCGCAGA
TCATGCTGGGCGCTGTGCTGCGGGATTACAAGTTTCAGGACCACAAGACGGGTGCGGATGCCAAGACCGGCAGCATCCAT
GTGATGTGCAATGACCCCGACGCGATCTCGGCCAAGGCGCAGCCGTTGCTGGCGATTGCGGAGGGGACCTTCTTTACCCG
CGATCTGGTGAGCGAGCCGGCCAATGTGCTGACCACGAAAGAATTTGCGGACCGGCTTGCAGCAATGGAAAGCATCGGCC
TCAAGGTCGAAGTGCTTGAAGAGGACGAGCTGGCGAAACTCGGCATGCGCACGCTGCTTGCCGTTGGCCAAGGCTCGGAC
AGTCCCTCCAAGGTCGTGGTCATGCAATGGAACGGCGGGGCCAAGGGCGAGGCCCCGCTGGCACTGGTCGGCAAGGGCGT
GGTGTTTGACACCGGTGGCATCAGCCTCAAGCCGGCGGCAGGCATGGAAGACATGACCATGGACATGGGCGGTGCGGGGA
CCGTGGCAGGTGTGATGCGCGCGCTGGCCCTGCGCAAGGCCAAGGCCAATGTCGTGGGCATCGTCGGTCTTGTAGAAAAC
ATGCCGTCGGGCAATGCGATCCGGCCGGGGGATGTCGTGACCTCGATGAAGGGCGATACCGTTGAAATCCTCAACACCGA
TGCCGAGGGGCGCTTGGTGCTGTGCGATGCGATCTGGTACACGCAGGAACGGTTTGAACCTGCCGCAGTGATTGATCTGG
CCACCCTGACCGGGGCCATCATCGTCGGGCTCGGTCACGAGAATGCGGGGGTCTTTTCCAATGACGACACCCTGTGCAAC
GCGTTCCTGAAATCCGCCGAGGCAGAGGGCGAGGGCGCTTGGCGCATGCCTTTGGGTCAGGCCTATGACGATATGTTGAA
ATCGCCCATTGCGGACATGAAAAACATCGGGGGCCGCGCGGCGGGGTCGGTAACAGCGGCGCAGTTCATCCAGCGGTTCG
TCAAAGACGGTGTGCCGTGGATTCACCTTGATATTGCCGGTGTCGCCTCCGTCAAATCCGAAACGGATTATGCGCCCAAA
GGGGCCACGGGCTGGGGCGTGCGCGCGCTCGACCGTCTGGTCGCGGATCGTTTCGAAGGAGAATAG

Upstream 100 bases:

>100_bases
TTCCCTCTTACGCCGTTTCTCATTCTTGCGGCCACGTTAGACCAAAGCGCGCTGTGGTAAAACTGCTATCTGGTCTTTGC
GCATCAGGCGCGCTACGTCC

Downstream 100 bases:

>100_bases
CGCCAATGGGCAAGGCCATGTTCTATCATTTGACGCGGCGTCCCATGGAAGACACGCTGATGATGCTGCTTGGCAAGGCG
ACGGGTGCAGGCTGGCGCGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MGVIHEKKANDMTTPTPVTFLETDIERLADHVGRVCIVVDDAGRTDVAGRRVNRLTKGALKRALEAKAEAGLKAGSVFTL
AYPAGMAAEAVDVICVPRATTVHKARAAGAALGRNRGKADLLLAVGNSKWAAQIMLGAVLRDYKFQDHKTGADAKTGSIH
VMCNDPDAISAKAQPLLAIAEGTFFTRDLVSEPANVLTTKEFADRLAAMESIGLKVEVLEEDELAKLGMRTLLAVGQGSD
SPSKVVVMQWNGGAKGEAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGTVAGVMRALALRKAKANVVGIVGLVEN
MPSGNAIRPGDVVTSMKGDTVEILNTDAEGRLVLCDAIWYTQERFEPAAVIDLATLTGAIIVGLGHENAGVFSNDDTLCN
AFLKSAEAEGEGAWRMPLGQAYDDMLKSPIADMKNIGGRAAGSVTAAQFIQRFVKDGVPWIHLDIAGVASVKSETDYAPK
GATGWGVRALDRLVADRFEGE

Sequences:

>Translated_501_residues
MGVIHEKKANDMTTPTPVTFLETDIERLADHVGRVCIVVDDAGRTDVAGRRVNRLTKGALKRALEAKAEAGLKAGSVFTL
AYPAGMAAEAVDVICVPRATTVHKARAAGAALGRNRGKADLLLAVGNSKWAAQIMLGAVLRDYKFQDHKTGADAKTGSIH
VMCNDPDAISAKAQPLLAIAEGTFFTRDLVSEPANVLTTKEFADRLAAMESIGLKVEVLEEDELAKLGMRTLLAVGQGSD
SPSKVVVMQWNGGAKGEAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGTVAGVMRALALRKAKANVVGIVGLVEN
MPSGNAIRPGDVVTSMKGDTVEILNTDAEGRLVLCDAIWYTQERFEPAAVIDLATLTGAIIVGLGHENAGVFSNDDTLCN
AFLKSAEAEGEGAWRMPLGQAYDDMLKSPIADMKNIGGRAAGSVTAAQFIQRFVKDGVPWIHLDIAGVASVKSETDYAPK
GATGWGVRALDRLVADRFEGE
>Mature_500_residues
GVIHEKKANDMTTPTPVTFLETDIERLADHVGRVCIVVDDAGRTDVAGRRVNRLTKGALKRALEAKAEAGLKAGSVFTLA
YPAGMAAEAVDVICVPRATTVHKARAAGAALGRNRGKADLLLAVGNSKWAAQIMLGAVLRDYKFQDHKTGADAKTGSIHV
MCNDPDAISAKAQPLLAIAEGTFFTRDLVSEPANVLTTKEFADRLAAMESIGLKVEVLEEDELAKLGMRTLLAVGQGSDS
PSKVVVMQWNGGAKGEAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGTVAGVMRALALRKAKANVVGIVGLVENM
PSGNAIRPGDVVTSMKGDTVEILNTDAEGRLVLCDAIWYTQERFEPAAVIDLATLTGAIIVGLGHENAGVFSNDDTLCNA
FLKSAEAEGEGAWRMPLGQAYDDMLKSPIADMKNIGGRAAGSVTAAQFIQRFVKDGVPWIHLDIAGVASVKSETDYAPKG
ATGWGVRALDRLVADRFEGE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=476, Percent_Identity=35.2941176470588, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI47155554, Length=369, Percent_Identity=31.4363143631436, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1790710, Length=320, Percent_Identity=47.1875, Blast_Score=279, Evalue=4e-76,
Organism=Escherichia coli, GI87082123, Length=341, Percent_Identity=35.7771260997067, Blast_Score=181, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=353, Percent_Identity=34.8441926345609, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=181, Percent_Identity=29.2817679558011, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24661038, Length=316, Percent_Identity=34.4936708860759, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355725, Length=316, Percent_Identity=33.8607594936709, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129969, Length=322, Percent_Identity=31.6770186335404, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161077148, Length=290, Percent_Identity=32.4137931034483, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI20130057, Length=290, Percent_Identity=32.4137931034483, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24662227, Length=290, Percent_Identity=31.0344827586207, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI20129963, Length=346, Percent_Identity=30.0578034682081, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355645, Length=347, Percent_Identity=29.1066282420749, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24662223, Length=347, Percent_Identity=29.1066282420749, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI19922386, Length=291, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221379063, Length=315, Percent_Identity=33.015873015873, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221379062, Length=315, Percent_Identity=33.015873015873, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21357381, Length=315, Percent_Identity=33.015873015873, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646701, Length=265, Percent_Identity=27.9245283018868, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24646703, Length=265, Percent_Identity=27.9245283018868, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358201, Length=265, Percent_Identity=27.9245283018868, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52595; Mature: 52464

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVIHEKKANDMTTPTPVTFLETDIERLADHVGRVCIVVDDAGRTDVAGRRVNRLTKGAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHH
KRALEAKAEAGLKAGSVFTLAYPAGMAAEAVDVICVPRATTVHKARAAGAALGRNRGKAD
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEE
LLLAVGNSKWAAQIMLGAVLRDYKFQDHKTGADAKTGSIHVMCNDPDAISAKAQPLLAIA
EEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEE
EGTFFTRDLVSEPANVLTTKEFADRLAAMESIGLKVEVLEEDELAKLGMRTLLAVGQGSD
CCCHHHHHHHHCCHHHEEHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCC
SPSKVVVMQWNGGAKGEAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGTVAGVMR
CCCEEEEEEECCCCCCCCCEEEEECCEEEECCCCEECCCCCCCHHEECCCCCHHHHHHHH
ALALRKAKANVVGIVGLVENMPSGNAIRPGDVVTSMKGDTVEILNTDAEGRLVLCDAIWY
HHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEEEHHH
TQERFEPAAVIDLATLTGAIIVGLGHENAGVFSNDDTLCNAFLKSAEAEGEGAWRMPLGQ
HHHHCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCHH
AYDDMLKSPIADMKNIGGRAAGSVTAAQFIQRFVKDGVPWIHLDIAGVASVKSETDYAPK
HHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCCCCCC
GATGWGVRALDRLVADRFEGE
CCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GVIHEKKANDMTTPTPVTFLETDIERLADHVGRVCIVVDDAGRTDVAGRRVNRLTKGAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHH
KRALEAKAEAGLKAGSVFTLAYPAGMAAEAVDVICVPRATTVHKARAAGAALGRNRGKAD
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEE
LLLAVGNSKWAAQIMLGAVLRDYKFQDHKTGADAKTGSIHVMCNDPDAISAKAQPLLAIA
EEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEE
EGTFFTRDLVSEPANVLTTKEFADRLAAMESIGLKVEVLEEDELAKLGMRTLLAVGQGSD
CCCHHHHHHHHCCHHHEEHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCC
SPSKVVVMQWNGGAKGEAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGTVAGVMR
CCCEEEEEEECCCCCCCCCEEEEECCEEEECCCCEECCCCCCCHHEECCCCCHHHHHHHH
ALALRKAKANVVGIVGLVENMPSGNAIRPGDVVTSMKGDTVEILNTDAEGRLVLCDAIWY
HHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEEEHHH
TQERFEPAAVIDLATLTGAIIVGLGHENAGVFSNDDTLCNAFLKSAEAEGEGAWRMPLGQ
HHHHCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCHH
AYDDMLKSPIADMKNIGGRAAGSVTAAQFIQRFVKDGVPWIHLDIAGVASVKSETDYAPK
HHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCCCCCC
GATGWGVRALDRLVADRFEGE
CCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA