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The map label for this gene is hydA [H]

Identifier: 110680289

GI number: 110680289

Start: 2976403

End: 2977857

Strand: Reverse

Name: hydA [H]

Synonym: RD1_3100

Alternate gene names: 110680289

Gene position: 2977857-2976403 (Counterclockwise)

Preceding gene: 110680290

Following gene: 110680288

Centisome position: 72.05

GC content: 59.66

Gene sequence:

>1455_bases
ATGTCTACTGTGATCAAAAACGGCACCGTGGTGACGCATGATCTGACTTACAAGGCCGATGTGTTGGTCGACGCGGGCAC
CATCATCGAGATTGGCCCGAACCTTAGTGGGGATCAGAAACTGGATGCAACCGGGTGCTATGTCATGCCGGGCGGTATTG
ATCCGCACACGCATCTGGAAATGCCCTTTATGGGCACCTATTCCTCGGATGATTTCGAAAGCGGGACGCGTGCGGCTTTG
GCGGGCGGCACCACGATGGTCATTGATTTCGCGCTGCCATCGCCGGGGCAGGGGCTGCATGATGCGCTCAAGATGTGGGA
CAATAAATCGACACGCGCCAATTGCGACTATTCCTTCCACATGGCGGTCACGTGGTGGGGGGAGCAGGTTTTTGACGAGA
TGAAATCCGTCATCGAGGATCGCGGCATCAACACCTTCAAGCACTTCCTCGCCTATAAGGGCGCGCTCATGGTCAATGAT
GATGAGCTTTATGCCTCCTTCAACCGCTTGGCTGAACTGGGCGGCATCGCCATGGTGCATGCGGAAAACGGCGATGTAGT
CGCGGAACTCTCAGCCAAATTGCTGGCCGAGGGCAACACCGGCCCCGAGGCGCATGCCTATTCCCGACCGCCGCAGGTCG
AGGGGGAGGCGACAAACCGTGCCATCATGATCGCCGATATGGCGGGCGTGCCGCTCTATGTGGTGCACACCTCCTGCGAG
GAGGCACATGAAGCCATCCGTCGCGCGCGCCAGCAGGGCAAACGCGTCTGGGGCGAGCCGCTGATCCAGCACCTGACGCT
GGATGAAAGCGAGTATTTCAACAAGGACTGGGACCACGCCGCGCGTCGTGTGATGTCGCCGCCCTTCCGCAACAAACAGC
ATCAGGACAGCCTCTGGGCCGGGTTGCAGGCCGGGTCCCTGTCTGTCGTGGCGACCGATCACTGTGCCTTTACAACGGAG
CAGAAACGCTTTGGCGTGGGTGATTTCACCAAGATCCCCAATGGCACCGGAGGTCTGGAAGACCGCATGCCCATGCTCTG
GACACATGGGGTCGCGACGGGACGGCTGACGCCGAATGAGTTTGTGGCAGTCACATCGACCAACATTGCCAAAATCCTGA
ATTGTTATCCCAAAAAGGGCGCCGTCCTTGTCGGGGCAGATGCGGATCTGGTCGTGTGGGATCCGCAGAAGGAAAAGACG
ATTGCAGCGAGCACCCAGCAGTCTGCCATTGATTACAACGTCTTCGAGGGTCAAACGGTCAAGGGTCTGCCGCGCTTTAC
CCTGACGCGGGGGCATGTCGCTGTGCATGACGGCGAAATCCGCACGCAGGAAGGACATGGCAAATTCGTCAAGCGCGCCG
GCAACGGCGTGACCAACAAGGCGTTGTCGACGTGGAAAGAACTGACCGCCCCGCGCCCGGTTGAGCGCAGCGGCATCCCC
GCCACCGGCGTCTGA

Upstream 100 bases:

>100_bases
ACGCCCGAATGGGCCGCTGCGGGCACGGATGTGCTGCTGCATGCGGTCTTGGAAACGGCCGAAGTGGTATCATGATCCCA
CCCTTTCAAGGAGTTCACTT

Downstream 100 bases:

>100_bases
TCCATGATTCAGAAAGCCCGAGCGTGACCCAAGACATGACGATCCATGCGCAGGGTCTTGATCTGACCTTTGACACCAAT
GATGGCCCGGTCCATGCGCT

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSTVIKNGTVVTHDLTYKADVLVDAGTIIEIGPNLSGDQKLDATGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAAL
AGGTTMVIDFALPSPGQGLHDALKMWDNKSTRANCDYSFHMAVTWWGEQVFDEMKSVIEDRGINTFKHFLAYKGALMVND
DELYASFNRLAELGGIAMVHAENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAIMIADMAGVPLYVVHTSCE
EAHEAIRRARQQGKRVWGEPLIQHLTLDESEYFNKDWDHAARRVMSPPFRNKQHQDSLWAGLQAGSLSVVATDHCAFTTE
QKRFGVGDFTKIPNGTGGLEDRMPMLWTHGVATGRLTPNEFVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPQKEKT
IAASTQQSAIDYNVFEGQTVKGLPRFTLTRGHVAVHDGEIRTQEGHGKFVKRAGNGVTNKALSTWKELTAPRPVERSGIP
ATGV

Sequences:

>Translated_484_residues
MSTVIKNGTVVTHDLTYKADVLVDAGTIIEIGPNLSGDQKLDATGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAAL
AGGTTMVIDFALPSPGQGLHDALKMWDNKSTRANCDYSFHMAVTWWGEQVFDEMKSVIEDRGINTFKHFLAYKGALMVND
DELYASFNRLAELGGIAMVHAENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAIMIADMAGVPLYVVHTSCE
EAHEAIRRARQQGKRVWGEPLIQHLTLDESEYFNKDWDHAARRVMSPPFRNKQHQDSLWAGLQAGSLSVVATDHCAFTTE
QKRFGVGDFTKIPNGTGGLEDRMPMLWTHGVATGRLTPNEFVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPQKEKT
IAASTQQSAIDYNVFEGQTVKGLPRFTLTRGHVAVHDGEIRTQEGHGKFVKRAGNGVTNKALSTWKELTAPRPVERSGIP
ATGV
>Mature_483_residues
STVIKNGTVVTHDLTYKADVLVDAGTIIEIGPNLSGDQKLDATGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAALA
GGTTMVIDFALPSPGQGLHDALKMWDNKSTRANCDYSFHMAVTWWGEQVFDEMKSVIEDRGINTFKHFLAYKGALMVNDD
ELYASFNRLAELGGIAMVHAENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAIMIADMAGVPLYVVHTSCEE
AHEAIRRARQQGKRVWGEPLIQHLTLDESEYFNKDWDHAARRVMSPPFRNKQHQDSLWAGLQAGSLSVVATDHCAFTTEQ
KRFGVGDFTKIPNGTGGLEDRMPMLWTHGVATGRLTPNEFVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPQKEKTI
AASTQQSAIDYNVFEGQTVKGLPRFTLTRGHVAVHDGEIRTQEGHGKFVKRAGNGVTNKALSTWKELTAPRPVERSGIPA
TGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=484, Percent_Identity=47.7272727272727, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI4503379, Length=455, Percent_Identity=43.7362637362637, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI190194363, Length=454, Percent_Identity=44.4933920704846, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI4503377, Length=454, Percent_Identity=42.7312775330396, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI4503051, Length=454, Percent_Identity=42.7312775330396, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI62422571, Length=454, Percent_Identity=42.7312775330396, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI19923821, Length=480, Percent_Identity=42.9166666666667, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI18105007, Length=458, Percent_Identity=24.8908296943231, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87082175, Length=459, Percent_Identity=39.8692810457516, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1786722, Length=448, Percent_Identity=29.2410714285714, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17539558, Length=483, Percent_Identity=46.9979296066253, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71989490, Length=482, Percent_Identity=43.7759336099585, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI86575075, Length=457, Percent_Identity=31.7286652078775, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI193204318, Length=431, Percent_Identity=25.0580046403712, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322218, Length=403, Percent_Identity=26.5508684863524, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=45.0549450549451, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI17137462, Length=453, Percent_Identity=44.1501103752759, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24644287, Length=294, Percent_Identity=43.8775510204082, Blast_Score=261, Evalue=9e-70,
Organism=Drosophila melanogaster, GI24644289, Length=252, Percent_Identity=44.4444444444444, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24642586, Length=419, Percent_Identity=26.7303102625298, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859883, Length=425, Percent_Identity=24, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52766; Mature: 52635

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVIKNGTVVTHDLTYKADVLVDAGTIIEIGPNLSGDQKLDATGCYVMPGGIDPHTHLE
CCCEECCCEEEEEECEEEEEEEEECCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCEEC
MPFMGTYSSDDFESGTRAALAGGTTMVIDFALPSPGQGLHDALKMWDNKSTRANCDYSFH
CCEECCCCCCCCCCCCCEEECCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEE
MAVTWWGEQVFDEMKSVIEDRGINTFKHFLAYKGALMVNDDELYASFNRLAELGGIAMVH
EEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCEEEEE
AENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAIMIADMAGVPLYVVHTSCE
ECCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCHH
EAHEAIRRARQQGKRVWGEPLIQHLTLDESEYFNKDWDHAARRVMSPPFRNKQHQDSLWA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHH
GLQAGSLSVVATDHCAFTTEQKRFGVGDFTKIPNGTGGLEDRMPMLWTHGVATGRLTPNE
CCCCCCEEEEEECCEEEECCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEECCCCCCC
FVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPQKEKTIAASTQQSAIDYNVFEGQTV
EEEEECCCHHHHHHCCCCCCCEEEECCCCEEEECCCCCCEEECCCHHCCCEEEEECCCCC
KGLPRFTLTRGHVAVHDGEIRTQEGHGKFVKRAGNGVTNKALSTWKELTAPRPVERSGIP
CCCCCEEEECCEEEEECCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
ATGV
CCCC
>Mature Secondary Structure 
STVIKNGTVVTHDLTYKADVLVDAGTIIEIGPNLSGDQKLDATGCYVMPGGIDPHTHLE
CCEECCCEEEEEECEEEEEEEEECCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCEEC
MPFMGTYSSDDFESGTRAALAGGTTMVIDFALPSPGQGLHDALKMWDNKSTRANCDYSFH
CCEECCCCCCCCCCCCCEEECCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEE
MAVTWWGEQVFDEMKSVIEDRGINTFKHFLAYKGALMVNDDELYASFNRLAELGGIAMVH
EEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCEEEEE
AENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAIMIADMAGVPLYVVHTSCE
ECCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCHH
EAHEAIRRARQQGKRVWGEPLIQHLTLDESEYFNKDWDHAARRVMSPPFRNKQHQDSLWA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHH
GLQAGSLSVVATDHCAFTTEQKRFGVGDFTKIPNGTGGLEDRMPMLWTHGVATGRLTPNE
CCCCCCEEEEEECCEEEECCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEECCCCCCC
FVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPQKEKTIAASTQQSAIDYNVFEGQTV
EEEEECCCHHHHHHCCCCCCCEEEECCCCEEEECCCCCCEEECCCHHCCCEEEEECCCCC
KGLPRFTLTRGHVAVHDGEIRTQEGHGKFVKRAGNGVTNKALSTWKELTAPRPVERSGIP
CCCCCEEEECCEEEEECCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
ATGV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]