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The map label for this gene is cysK [H]

Identifier: 110680142

GI number: 110680142

Start: 2820572

End: 2821651

Strand: Direct

Name: cysK [H]

Synonym: RD1_2941

Alternate gene names: 110680142

Gene position: 2820572-2821651 (Clockwise)

Preceding gene: 110680133

Following gene: 110680146

Centisome position: 68.24

GC content: 59.44

Gene sequence:

>1080_bases
ATGTCAGCAGATCACATCCGACAGACGAAAGGCCGGGGCAGGCTTTATGACAGCGTCCTTGACACGATCGGGAACACGCC
GGCCATCCGGATCAATCACCTCGCCCCCGATCACGTGACGATTTATGTGAAGGCCGAGTTTTTCAACCCCGCCGGCTCCG
TCAAGGATCGTCTGGCGGTGAACATCATAGAAGCGGCAGAGCGTGCAGGCACATTGAAACCGGGACAGACCGTGGTGGAG
GCCACAAGTGGCAACACCGGCATCGGCCTTGCCATGGTCTGTGCGCAAAAGGGCTATCCGCTGGTTGTGACCATGGCGGA
GAGCTTTTCGGTGGAACGGCGGCGGCTGATGCGGATGCTCGGGGCCAAGGTCATCCTGACCCCCAAAGCGGAAAAAGGTT
TTGGGATGTATCGAAAAGCGGTGGAGCTTGCAGAACAAAACGGCTGGTTTCTGGCGCATCAGTTTGAAACGGGCGCCAAT
GCGGCGATCCATGAAAACACGACAGGGCCTGAAATCGTGGCGGATTTCGCGGGTGAGCGGCTGGATTACATCGTCACGGG
CTATGGCACCGGGGGCACGGTGTCCGGCCTTGGGCGCGTGATCCGCAAGGAGCGGCCAGAGACAAAAATCATCCTGACCG
AACCAAGTAACGCGCAGCTTCTGGGCAGTGGCCATGCGCAGGAGCGCAACGCAGACCACTCGCCAGCCGTCAGCCACCCC
GCGTTTGAGCCGCACCCCATTCAGGGCTGGACACCGGATTTCATCCCGGCCGTTCTGCAGGAGGCTGTGGATGGTGCCTA
TTATGACGAACTGCTGCCCATCGCCGGTGCGGATGGTGTCAAATGCGCGCGGCTTCTGGCGCAGAAAGAGGGTATTTTCA
CCGGCATTTCGGGCGGGTCGACCTTTTCGGTGTCACTGGAAATCGCCAAAACTGCACCACCCGGCTCGGTGATCCTGTGC
ATGCTGCCCGATACCGGCGAGCGGTATCTTTCGACCCCGCTGTTTGAAGGCATCGTTGAGGATATGGACGCCGAAGAGCA
AGCAATCTCACGCTCCACACCCGGGTATCAAATGGGATAA

Upstream 100 bases:

>100_bases
CCTGTGGCATAGTAACACGGCGTCGCAAAGTCACCACCAGAGCAATCTTGTCTGAACACGCGCCGCTTGGCTGGACGCAT
ATCATGGGAGAACACGTAAA

Downstream 100 bases:

>100_bases
GGGGGGCTGCGCACAGGGATGTTTGCGGGAAGGCTATTGTATCATCGCATCCACCCATTCGGCCAGAAACCCCTTGCTTT
TCAGGGCGTCGAGATAGGTC

Product: O-acetylserine sulfhydrylase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSADHIRQTKGRGRLYDSVLDTIGNTPAIRINHLAPDHVTIYVKAEFFNPAGSVKDRLAVNIIEAAERAGTLKPGQTVVE
ATSGNTGIGLAMVCAQKGYPLVVTMAESFSVERRRLMRMLGAKVILTPKAEKGFGMYRKAVELAEQNGWFLAHQFETGAN
AAIHENTTGPEIVADFAGERLDYIVTGYGTGGTVSGLGRVIRKERPETKIILTEPSNAQLLGSGHAQERNADHSPAVSHP
AFEPHPIQGWTPDFIPAVLQEAVDGAYYDELLPIAGADGVKCARLLAQKEGIFTGISGGSTFSVSLEIAKTAPPGSVILC
MLPDTGERYLSTPLFEGIVEDMDAEEQAISRSTPGYQMG

Sequences:

>Translated_359_residues
MSADHIRQTKGRGRLYDSVLDTIGNTPAIRINHLAPDHVTIYVKAEFFNPAGSVKDRLAVNIIEAAERAGTLKPGQTVVE
ATSGNTGIGLAMVCAQKGYPLVVTMAESFSVERRRLMRMLGAKVILTPKAEKGFGMYRKAVELAEQNGWFLAHQFETGAN
AAIHENTTGPEIVADFAGERLDYIVTGYGTGGTVSGLGRVIRKERPETKIILTEPSNAQLLGSGHAQERNADHSPAVSHP
AFEPHPIQGWTPDFIPAVLQEAVDGAYYDELLPIAGADGVKCARLLAQKEGIFTGISGGSTFSVSLEIAKTAPPGSVILC
MLPDTGERYLSTPLFEGIVEDMDAEEQAISRSTPGYQMG
>Mature_358_residues
SADHIRQTKGRGRLYDSVLDTIGNTPAIRINHLAPDHVTIYVKAEFFNPAGSVKDRLAVNIIEAAERAGTLKPGQTVVEA
TSGNTGIGLAMVCAQKGYPLVVTMAESFSVERRRLMRMLGAKVILTPKAEKGFGMYRKAVELAEQNGWFLAHQFETGANA
AIHENTTGPEIVADFAGERLDYIVTGYGTGGTVSGLGRVIRKERPETKIILTEPSNAQLLGSGHAQERNADHSPAVSHPA
FEPHPIQGWTPDFIPAVLQEAVDGAYYDELLPIAGADGVKCARLLAQKEGIFTGISGGSTFSVSLEIAKTAPPGSVILCM
LPDTGERYLSTPLFEGIVEDMDAEEQAISRSTPGYQMG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=328, Percent_Identity=33.5365853658537, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI295821200, Length=328, Percent_Identity=33.5365853658537, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4557415, Length=328, Percent_Identity=33.5365853658537, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI2367138, Length=315, Percent_Identity=36.8253968253968, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1788754, Length=338, Percent_Identity=38.1656804733728, Blast_Score=187, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17535051, Length=320, Percent_Identity=37.8125, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17562970, Length=327, Percent_Identity=36.697247706422, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI32566674, Length=315, Percent_Identity=37.7777777777778, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI115535073, Length=333, Percent_Identity=38.1381381381381, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17561720, Length=338, Percent_Identity=34.3195266272189, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17534315, Length=334, Percent_Identity=32.9341317365269, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI25147552, Length=336, Percent_Identity=32.4404761904762, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32566672, Length=241, Percent_Identity=33.195020746888, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17539800, Length=208, Percent_Identity=26.4423076923077, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=332, Percent_Identity=32.2289156626506, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321449, Length=363, Percent_Identity=31.404958677686, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24643623, Length=343, Percent_Identity=31.7784256559767, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129101, Length=343, Percent_Identity=31.7784256559767, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38478; Mature: 38347

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADHIRQTKGRGRLYDSVLDTIGNTPAIRINHLAPDHVTIYVKAEFFNPAGSVKDRLAV
CCCHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEEEEECCCCCHHHHHHH
NIIEAAERAGTLKPGQTVVEATSGNTGIGLAMVCAQKGYPLVVTMAESFSVERRRLMRML
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHH
GAKVILTPKAEKGFGMYRKAVELAEQNGWFLAHQFETGANAAIHENTTGPEIVADFAGER
CCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCHHHHHHHCCCC
LDYIVTGYGTGGTVSGLGRVIRKERPETKIILTEPSNAQLLGSGHAQERNADHSPAVSHP
EEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCC
AFEPHPIQGWTPDFIPAVLQEAVDGAYYDELLPIAGADGVKCARLLAQKEGIFTGISGGS
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCC
TFSVSLEIAKTAPPGSVILCMLPDTGERYLSTPLFEGIVEDMDAEEQAISRSTPGYQMG
EEEEEEEEECCCCCCCEEEEECCCCCCHHHHCHHHHHHHHHCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SADHIRQTKGRGRLYDSVLDTIGNTPAIRINHLAPDHVTIYVKAEFFNPAGSVKDRLAV
CCHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEEEEECCCCCHHHHHHH
NIIEAAERAGTLKPGQTVVEATSGNTGIGLAMVCAQKGYPLVVTMAESFSVERRRLMRML
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHH
GAKVILTPKAEKGFGMYRKAVELAEQNGWFLAHQFETGANAAIHENTTGPEIVADFAGER
CCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCHHHHHHHCCCC
LDYIVTGYGTGGTVSGLGRVIRKERPETKIILTEPSNAQLLGSGHAQERNADHSPAVSHP
EEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCC
AFEPHPIQGWTPDFIPAVLQEAVDGAYYDELLPIAGADGVKCARLLAQKEGIFTGISGGS
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCC
TFSVSLEIAKTAPPGSVILCMLPDTGERYLSTPLFEGIVEDMDAEEQAISRSTPGYQMG
EEEEEEEEECCCCCCCEEEEECCCCCCHHHHCHHHHHHHHHCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA