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The map label for this gene is uxuB [H]

Identifier: 110680134

GI number: 110680134

Start: 2811765

End: 2813216

Strand: Reverse

Name: uxuB [H]

Synonym: RD1_2933

Alternate gene names: 110680134

Gene position: 2813216-2811765 (Counterclockwise)

Preceding gene: 110680135

Following gene: 110680130

Centisome position: 68.07

GC content: 62.12

Gene sequence:

>1452_bases
ATGACCATGCCACCCCGCTTGCAACGCCAGAACAAAGCGCCAGGGATCGGCATGGTCCACCTTGGCCCGGGTGCGTTCTT
CCGCGCGTTTAACGCCGTCTATACGGATGAGGCGATGGCCCTCAACGGGGGCGATTGGGGGATCCTTGCCGTCAGCCTGC
AAAGCGCGCGCGCGCGGGAGGAACTTGCGCCGCAAGGCTGCGTTTACACATCCGTCTCGATGGGGCCGGAAGGGGAGGAA
ACGCGCCTTGTTAACGCGATTTCAGACGTGATGGTCGCCCCTCAAAATCCCGATGCTGTGCTGCGCGCCATGGCGCGGGC
AGATGTCAAAATCGTCTCGCTCACCATCACGGAAAAAGGGTATTGTCGTGATCCCTCGACCGGCGGGCTGGATGTGCAAC
ATCCGGACGTGCAGCATGATCTGAGCACCCCGGCCATGCCCAAAACCGCACCCGGCCTGATCGTTAAGGCGCTCGCACGG
CGCAGGGCAGTCGATGAAAGACCCTTTAGCGTGCTGAGTTGTGACAACCTGCCAGACAACGGGGCCACAACACGGCGCAT
CATTCTGGAGTTTGCCCGCAAGCGCGACCCGGAACTGGCCGCATGGATCGCGCAGCAGGCCCGTTTTCCATCCACCATGG
TGGATCGCATCACGCCTGCCACGACACCGGCGGATATCGACGCGCTGGCCCAGCGCAGCGGCTATCATGATGCGGCCCTC
GTGCGTCATGAAGCGTTTCGCCAATGGGTGATCGAAGATGACTTTGTCGATGGTCTGCGACCGGCCTGGGACAAGGTGGG
TGCGCAATTCGTCACTTCCGTTACCGCGCATGAAAAGATGAAGCTGCGATGCCTCAATGGCACCCATTCAACGCTGGCCT
ATCTCGGCTATCTCGCGGGCTACGAAACGATTGCCGAAACCGTGGCGGATGCCTCCTTTGCGGCGCTGTGTACCACGCTT
TGGCATCGTGAAATCCTGCCGACCATTCCTGCGCCAGAAGGTGAGGATCTACAGGCCTATGTGGCCGCCTTGCTGGCGCG
GTATCAAAACCCGGCCATTCGGCATCTGACATGGCAGATCGCGATGGATGGGTCGCAAAAACTGCCGCAGCGTATTCTGG
GCACAATTGCCGATGGGTATGCGGCCGGGCGCGCACCGGACGGTCTCTGCCTCGCGGTGGCGGGATGGATGCGCTACGTG
GGAGGCGTGGATGAAAACGGTGCGGCGATAGATGTGCGCGACCCGCTGGCGGCAAGGCTCAGGGCGGCCTCGGACAGTGC
GCAGAGTGCTGCGGGCAAGGTCGATGCGCTTTTGGACATCCGTGACGTTTTTGACGAAGCGCTCGCGTCCAATCCGGATT
TCAGGCGGGCGGTGCACGGTGCTTACGAAACGCTGGTATCCAAGGGGGCAGGGGGCGCCGTGGCGGATTACGTGGCGCGC
GGCTCAGCTTGA

Upstream 100 bases:

>100_bases
ATCTGGCGACGCTGGTCAGGACGGGTCGGCTGACAGAGGCCGAAGCCTTGGATCTGGCCTATGATCTGACCTACCGTCTG
GCAAAGGAGGCCTATCGGTT

Downstream 100 bases:

>100_bases
GACACGCGGGACCAGCGCGCGGACGAGTTCTTTCATGTCCAGAATGCCGACGGGCACATCGTCCTGCATCACGCGGTAGG
TAAGGGTCGTATCCCCCCCG

Product: D-mannonate oxidoreductase, putative

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTMPPRLQRQNKAPGIGMVHLGPGAFFRAFNAVYTDEAMALNGGDWGILAVSLQSARAREELAPQGCVYTSVSMGPEGEE
TRLVNAISDVMVAPQNPDAVLRAMARADVKIVSLTITEKGYCRDPSTGGLDVQHPDVQHDLSTPAMPKTAPGLIVKALAR
RRAVDERPFSVLSCDNLPDNGATTRRIILEFARKRDPELAAWIAQQARFPSTMVDRITPATTPADIDALAQRSGYHDAAL
VRHEAFRQWVIEDDFVDGLRPAWDKVGAQFVTSVTAHEKMKLRCLNGTHSTLAYLGYLAGYETIAETVADASFAALCTTL
WHREILPTIPAPEGEDLQAYVAALLARYQNPAIRHLTWQIAMDGSQKLPQRILGTIADGYAAGRAPDGLCLAVAGWMRYV
GGVDENGAAIDVRDPLAARLRAASDSAQSAAGKVDALLDIRDVFDEALASNPDFRRAVHGAYETLVSKGAGGAVADYVAR
GSA

Sequences:

>Translated_483_residues
MTMPPRLQRQNKAPGIGMVHLGPGAFFRAFNAVYTDEAMALNGGDWGILAVSLQSARAREELAPQGCVYTSVSMGPEGEE
TRLVNAISDVMVAPQNPDAVLRAMARADVKIVSLTITEKGYCRDPSTGGLDVQHPDVQHDLSTPAMPKTAPGLIVKALAR
RRAVDERPFSVLSCDNLPDNGATTRRIILEFARKRDPELAAWIAQQARFPSTMVDRITPATTPADIDALAQRSGYHDAAL
VRHEAFRQWVIEDDFVDGLRPAWDKVGAQFVTSVTAHEKMKLRCLNGTHSTLAYLGYLAGYETIAETVADASFAALCTTL
WHREILPTIPAPEGEDLQAYVAALLARYQNPAIRHLTWQIAMDGSQKLPQRILGTIADGYAAGRAPDGLCLAVAGWMRYV
GGVDENGAAIDVRDPLAARLRAASDSAQSAAGKVDALLDIRDVFDEALASNPDFRRAVHGAYETLVSKGAGGAVADYVAR
GSA
>Mature_482_residues
TMPPRLQRQNKAPGIGMVHLGPGAFFRAFNAVYTDEAMALNGGDWGILAVSLQSARAREELAPQGCVYTSVSMGPEGEET
RLVNAISDVMVAPQNPDAVLRAMARADVKIVSLTITEKGYCRDPSTGGLDVQHPDVQHDLSTPAMPKTAPGLIVKALARR
RAVDERPFSVLSCDNLPDNGATTRRIILEFARKRDPELAAWIAQQARFPSTMVDRITPATTPADIDALAQRSGYHDAALV
RHEAFRQWVIEDDFVDGLRPAWDKVGAQFVTSVTAHEKMKLRCLNGTHSTLAYLGYLAGYETIAETVADASFAALCTTLW
HREILPTIPAPEGEDLQAYVAALLARYQNPAIRHLTWQIAMDGSQKLPQRILGTIADGYAAGRAPDGLCLAVAGWMRYVG
GVDENGAAIDVRDPLAARLRAASDSAQSAAGKVDALLDIRDVFDEALASNPDFRRAVHGAYETLVSKGAGGAVADYVARG
SA

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=463, Percent_Identity=47.5161987041037, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1788497, Length=476, Percent_Identity=46.4285714285714, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1787823, Length=478, Percent_Identity=45.1882845188285, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI48994885, Length=407, Percent_Identity=25.0614250614251, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1790028, Length=281, Percent_Identity=24.5551601423488, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=468, Percent_Identity=39.3162393162393, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6320765, Length=468, Percent_Identity=39.3162393162393, Blast_Score=328, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 51983; Mature: 51852

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPPRLQRQNKAPGIGMVHLGPGAFFRAFNAVYTDEAMALNGGDWGILAVSLQSARARE
CCCCCCCHHCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEECCCCEEEEEEEHHHHHHHH
ELAPQGCVYTSVSMGPEGEETRLVNAISDVMVAPQNPDAVLRAMARADVKIVSLTITEKG
HCCCCCCEEEEECCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHCCEEEEEEEEECCC
YCRDPSTGGLDVQHPDVQHDLSTPAMPKTAPGLIVKALARRRAVDERPFSVLSCDNLPDN
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
GATTRRIILEFARKRDPELAAWIAQQARFPSTMVDRITPATTPADIDALAQRSGYHDAAL
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHCCCCHHHH
VRHEAFRQWVIEDDFVDGLRPAWDKVGAQFVTSVTAHEKMKLRCLNGTHSTLAYLGYLAG
HHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHH
YETIAETVADASFAALCTTLWHREILPTIPAPEGEDLQAYVAALLARYQNPAIRHLTWQI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHEEEEEE
AMDGSQKLPQRILGTIADGYAAGRAPDGLCLAVAGWMRYVGGVDENGAAIDVRDPLAARL
EECCHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHH
RAASDSAQSAAGKVDALLDIRDVFDEALASNPDFRRAVHGAYETLVSKGAGGAVADYVAR
HHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GSA
CCC
>Mature Secondary Structure 
TMPPRLQRQNKAPGIGMVHLGPGAFFRAFNAVYTDEAMALNGGDWGILAVSLQSARARE
CCCCCCHHCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEECCCCEEEEEEEHHHHHHHH
ELAPQGCVYTSVSMGPEGEETRLVNAISDVMVAPQNPDAVLRAMARADVKIVSLTITEKG
HCCCCCCEEEEECCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHCCEEEEEEEEECCC
YCRDPSTGGLDVQHPDVQHDLSTPAMPKTAPGLIVKALARRRAVDERPFSVLSCDNLPDN
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
GATTRRIILEFARKRDPELAAWIAQQARFPSTMVDRITPATTPADIDALAQRSGYHDAAL
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHCCCCHHHH
VRHEAFRQWVIEDDFVDGLRPAWDKVGAQFVTSVTAHEKMKLRCLNGTHSTLAYLGYLAG
HHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHH
YETIAETVADASFAALCTTLWHREILPTIPAPEGEDLQAYVAALLARYQNPAIRHLTWQI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHEEEEEE
AMDGSQKLPQRILGTIADGYAAGRAPDGLCLAVAGWMRYVGGVDENGAAIDVRDPLAARL
EECCHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHH
RAASDSAQSAAGKVDALLDIRDVFDEALASNPDFRRAVHGAYETLVSKGAGGAVADYVAR
HHHCCHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GSA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]