Click here to switch to the map view.

The map label for this gene is adhE [H]

Identifier: 110680121

GI number: 110680121

Start: 2794691

End: 2796094

Strand: Reverse

Name: adhE [H]

Synonym: RD1_2918

Alternate gene names: 110680121

Gene position: 2796094-2794691 (Counterclockwise)

Preceding gene: 110680122

Following gene: 110680120

Centisome position: 67.65

GC content: 60.54

Gene sequence:

>1404_bases
ATGAATGCGCAGGACGACATGGGCGAGGTCGAAACAACGGTGGCGCGCGCGCGCGCAGCCCAACAGGAATATGAGGCGCA
GGGCTCGCAAGCGCGTTATGACCTTGCAGCGCAAGCCGCCGCCTGGGCCATTATGGAGCCTGCGCGCAACCGCCACCTTG
CTGAACTCTCCGTCAAAACCACGGGCCTTGGGAATGTGGCCGACAAGATCACCAAGAACCACCGCAAAACGCTCGGCCTG
ATGCGCGACATCGCGGGCGTAAAGACGTTCGGTGCCATCACCCATACCCCCGAAACAGGAATCACCGAAATCGCCCGTCC
GATTGGCGTTATCGGGGCCGTCGTGCCATCCACCAACCCGGCGGCGACACCGGCCAACAACATCATCAATGCGCTGAAAT
GCGGCAACGCGATTGTCCTGTCCCCATCGCCCAAAGGCGTGCCCGCCTGCGAAACACTGCTGGAATATGTCCATGCGGAA
TTCGCAAAAATCGGTGAAAACCCGGATCTGGTGCAAATGGTTCCGGCACCGGGATCCAAGGAAAAAACCCAACGGTTGCT
GGAAATCAGCGACATGATCGTGGTGACGGGATCGCAAAACAATGTCCGGCGCGCGTATACCAGCGGCACACCCGCCCTGG
CCGTGGGGGCGGGAAATGTGCCCGTGATCGTGGATGAAACCGCGGATTTGGCAGCGGCGGCACGCAAGATCGCGGCATCC
AAGACCTTTGACAACGCCACCTCCTGCAGTTCTGAAAACGCATTGGTGGTCGTTGATGCGATTTATGACGCCTTCATGGA
TGAACTCGCACAGATCGGCGGCGCGCTCATCCGCGATGAGAACCGCATCGTGCAGGCGCTTTGGCCGGAGGGGCATCTCA
ACCGCGCTGTGATTGCGCAGGATGCCGCAGAGACCATCGCCGCCCTTGGCCTTGAAGGGGACGTGCCAGCCGAGACGCAA
TTCATTCTGGTCGAAACCACAGGCATCGGCCCCCAGCATCCGCTGTCCGGCGAAAAGCTGTCGCGCGTTGCCGCAGTTTA
CCGGGCGGATGATTTCGCCTCTGCCGGTGAGATCACGGCGCGCATTCTGGCGCATCAGGGGGCAGGGCATTCGGTTGGGC
TGCATTCCACGCAGGATGCGCGTGCGGTTGAACTGGCGACTTGCCTGCCGACCTGTCGGGTCATCGTCAATCAGGCGCAT
TGTTTCGCGACCGGAGGGGCCTTCAACAACGGGATGCCGTTTTCCCTTTCGATGGGCTGTGGGTCGTGGGGCGGCAATTC
CATTGATGACAACCTGCACTGGAAACACTTCATGCAGAGGGCAAAGGTGATCCGCGAAATCCCCGCGCGTGAACCCAGCG
TGGAAGAGATTTTCGGCGATTACTGGAAAGCTGCTGGCGCATGA

Upstream 100 bases:

>100_bases
CGGCAGGAAACCCTGACGGATTTGCTCGCCGGGCTTTGATAACCAACGTCCGCGCCCCAGGGCTGAGGCGCGGACCCTCC
ACTTTTGCAGGATGGCGACG

Downstream 100 bases:

>100_bases
CGGGGGATATCGCAGCGCCACCGACCGGCACGGTGCGCGACTGGCTTGATCAGCGTGCCGCAGGTACTGCAACAGCATAT
CTGTTCCCGCAGGAGGGCAC

Product: aldehyde-alcohol dehydrogenase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNAQDDMGEVETTVARARAAQQEYEAQGSQARYDLAAQAAAWAIMEPARNRHLAELSVKTTGLGNVADKITKNHRKTLGL
MRDIAGVKTFGAITHTPETGITEIARPIGVIGAVVPSTNPAATPANNIINALKCGNAIVLSPSPKGVPACETLLEYVHAE
FAKIGENPDLVQMVPAPGSKEKTQRLLEISDMIVVTGSQNNVRRAYTSGTPALAVGAGNVPVIVDETADLAAAARKIAAS
KTFDNATSCSSENALVVVDAIYDAFMDELAQIGGALIRDENRIVQALWPEGHLNRAVIAQDAAETIAALGLEGDVPAETQ
FILVETTGIGPQHPLSGEKLSRVAAVYRADDFASAGEITARILAHQGAGHSVGLHSTQDARAVELATCLPTCRVIVNQAH
CFATGGAFNNGMPFSLSMGCGSWGGNSIDDNLHWKHFMQRAKVIREIPAREPSVEEIFGDYWKAAGA

Sequences:

>Translated_467_residues
MNAQDDMGEVETTVARARAAQQEYEAQGSQARYDLAAQAAAWAIMEPARNRHLAELSVKTTGLGNVADKITKNHRKTLGL
MRDIAGVKTFGAITHTPETGITEIARPIGVIGAVVPSTNPAATPANNIINALKCGNAIVLSPSPKGVPACETLLEYVHAE
FAKIGENPDLVQMVPAPGSKEKTQRLLEISDMIVVTGSQNNVRRAYTSGTPALAVGAGNVPVIVDETADLAAAARKIAAS
KTFDNATSCSSENALVVVDAIYDAFMDELAQIGGALIRDENRIVQALWPEGHLNRAVIAQDAAETIAALGLEGDVPAETQ
FILVETTGIGPQHPLSGEKLSRVAAVYRADDFASAGEITARILAHQGAGHSVGLHSTQDARAVELATCLPTCRVIVNQAH
CFATGGAFNNGMPFSLSMGCGSWGGNSIDDNLHWKHFMQRAKVIREIPAREPSVEEIFGDYWKAAGA
>Mature_467_residues
MNAQDDMGEVETTVARARAAQQEYEAQGSQARYDLAAQAAAWAIMEPARNRHLAELSVKTTGLGNVADKITKNHRKTLGL
MRDIAGVKTFGAITHTPETGITEIARPIGVIGAVVPSTNPAATPANNIINALKCGNAIVLSPSPKGVPACETLLEYVHAE
FAKIGENPDLVQMVPAPGSKEKTQRLLEISDMIVVTGSQNNVRRAYTSGTPALAVGAGNVPVIVDETADLAAAARKIAAS
KTFDNATSCSSENALVVVDAIYDAFMDELAQIGGALIRDENRIVQALWPEGHLNRAVIAQDAAETIAALGLEGDVPAETQ
FILVETTGIGPQHPLSGEKLSRVAAVYRADDFASAGEITARILAHQGAGHSVGLHSTQDARAVELATCLPTCRVIVNQAH
CFATGGAFNNGMPFSLSMGCGSWGGNSIDDNLHWKHFMQRAKVIREIPAREPSVEEIFGDYWKAAGA

Specific function: Catalyzes the reduction of succinate semialdehyde to succinyl-CoA. The enzyme is specific for succinate semialdehyde and succinyl-CoA, and only shows low activity with palmitoyl-CoA. There is no activity with NAD(+) as cosubstrate [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787493, Length=448, Percent_Identity=35.9375, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1788797, Length=371, Percent_Identity=32.8840970350404, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.76 [H]

Molecular weight: Translated: 49327; Mature: 49327

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQDDMGEVETTVARARAAQQEYEAQGSQARYDLAAQAAAWAIMEPARNRHLAELSVKT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
TGLGNVADKITKNHRKTLGLMRDIAGVKTFGAITHTPETGITEIARPIGVIGAVVPSTNP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHCCCCCC
AATPANNIINALKCGNAIVLSPSPKGVPACETLLEYVHAEFAKIGENPDLVQMVPAPGSK
CCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH
EKTQRLLEISDMIVVTGSQNNVRRAYTSGTPALAVGAGNVPVIVDETADLAAAARKIAAS
HHHHHHHHHCCEEEEECCCCCCEEHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHH
KTFDNATSCSSENALVVVDAIYDAFMDELAQIGGALIRDENRIVQALWPEGHLNRAVIAQ
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCHHHHHH
DAAETIAALGLEGDVPAETQFILVETTGIGPQHPLSGEKLSRVAAVYRADDFASAGEITA
HHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RILAHQGAGHSVGLHSTQDARAVELATCLPTCRVIVNQAHCFATGGAFNNGMPFSLSMGC
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCC
GSWGGNSIDDNLHWKHFMQRAKVIREIPAREPSVEEIFGDYWKAAGA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNAQDDMGEVETTVARARAAQQEYEAQGSQARYDLAAQAAAWAIMEPARNRHLAELSVKT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
TGLGNVADKITKNHRKTLGLMRDIAGVKTFGAITHTPETGITEIARPIGVIGAVVPSTNP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHCCCCCC
AATPANNIINALKCGNAIVLSPSPKGVPACETLLEYVHAEFAKIGENPDLVQMVPAPGSK
CCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH
EKTQRLLEISDMIVVTGSQNNVRRAYTSGTPALAVGAGNVPVIVDETADLAAAARKIAAS
HHHHHHHHHCCEEEEECCCCCCEEHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHH
KTFDNATSCSSENALVVVDAIYDAFMDELAQIGGALIRDENRIVQALWPEGHLNRAVIAQ
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCHHHHHH
DAAETIAALGLEGDVPAETQFILVETTGIGPQHPLSGEKLSRVAAVYRADDFASAGEITA
HHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RILAHQGAGHSVGLHSTQDARAVELATCLPTCRVIVNQAHCFATGGAFNNGMPFSLSMGC
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCC
GSWGGNSIDDNLHWKHFMQRAKVIREIPAREPSVEEIFGDYWKAAGA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]