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The map label for this gene is accC [H]

Identifier: 110680056

GI number: 110680056

Start: 2721708

End: 2723060

Strand: Direct

Name: accC [H]

Synonym: RD1_2851

Alternate gene names: 110680056

Gene position: 2721708-2723060 (Clockwise)

Preceding gene: 110680055

Following gene: 110680057

Centisome position: 65.85

GC content: 59.35

Gene sequence:

>1353_bases
ATGTTCAACAAGATTTTGATTGCCAACCGGGGCGAGATCGCGCTGCGCGTTGTGCGGGCCGCGCGCGAGATGGGCATTGC
CTCAGTTGCGGTACACTCGACTGCGGACAGCGACGCGATGCATGTGCGCATGGCCGATGAAAGCATCTGCATCGGTCCAC
CGGCGAGCCAGCAAAGCTATCTGTCCTTTCCCGCCATCATTTCTGCCTGCGAAATTACCGGCGCAGAGGCGATACATCCG
GGATACGGGTTCTTGTCCGAAAACGCGGGCTTCGTGCAGATCGTCGAAGATCACGGGATCAGCTTTATCGGGCCGACCGC
CGAGCATATTCGCATCATGGGCGATAAGATCACCGCCAAGGAGACGATGAAAAACCTCGGCGTGCCCTGCGTGCCCGGCT
CTGACGGCGGCGTTGCAACGCTGGAGGAAGCGCAGCGCATCGGTGCGGAAATCGGCTATCCCGTCATCATCAAGGCAACC
GCGGGCGGGGGTGGGCGCGGCATGAAAGTTGCCCAGAACGCGGAAGAGATGGAAAAAGCCTTTCTGACCGCGCGCGCCGA
GGGCAAATCGAATTTCGGCAATGATGAGGTCTATATCGAGAAATACCTCACCACACCCCGCCACATCGAGATACAGGTGT
TTGGCGATGGCAAGGGCCGCGCGGTGCATCTGGGCGAGCGGGATTGTTCATTGCAGCGCCGCCACCAGAAAGTCTTTGAA
GAGGCTCCTGGCCCATCCATTTCTGCCGAAGAGCGCATGGCCATCGGCAAGGTCTGCGCGGATGCGGTGGCGCGGATCAA
CTACATCGGCGCGGGCACGATCGAATTTCTCTACGAAAACGGTGAGTTCTACTTCATCGAGATGAACACGCGGCTGCAGG
TTGAGCATCCGGTGACCGAAGCGATTTTCGGCGTAGACCTTGTGCGCGAACAGATTCGCGTGGCCAGCGGTATGGAGATG
TCCTTCCGGCAGGAAGACCTGACAATCAACGGACATGCCATCGAAGTGCGCATCAATGCGGAGAAACTGCCGAATTTCTC
ACCCTGCCCCGGCCGCATCACGCAGTATCACGCGCCCGGCGGTCTTGGCGTGCGGATGGATTCCGCGCTTTATGACGGCT
ATTCGATCCCGCCTTACTACGACAGCCTGATCGGCAAGCTGATCGTGCATGGCCGTGATCGACCCGAGGCGCTCGCACGG
CTGCATCGCGCGCTGGGGGAGTTGATCGTTGATGGCGTTGATACGACGGTGCCGCTCTTTCATGCCCTGCTGGAAGAAGA
AGCCGTTCTGTCGGGTGGCTACAACATTCACTGGCTGGAGCAGTGGCTGGACGCAAACCTCAGCGCAACTTAA

Upstream 100 bases:

>100_bases
CGTCCCCAAGATCCGGCATCGTAAAACGCATTGTCGTCGAAGATGGCGCCGCAGTCGAATTCGGCACCCCGCTCGTTATC
CTCGAATAGGAGCGACCAGC

Downstream 100 bases:

>100_bases
GGGTTTGTCGTCATGCGATTGACCCCGGATGTGCTGATGCAGGCCTATGCCACGGGCATTTTCCCGATGGCAGAGCATCG
CGATGATCCGGACATTTTCT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFNKILIANRGEIALRVVRAAREMGIASVAVHSTADSDAMHVRMADESICIGPPASQQSYLSFPAIISACEITGAEAIHP
GYGFLSENAGFVQIVEDHGISFIGPTAEHIRIMGDKITAKETMKNLGVPCVPGSDGGVATLEEAQRIGAEIGYPVIIKAT
AGGGGRGMKVAQNAEEMEKAFLTARAEGKSNFGNDEVYIEKYLTTPRHIEIQVFGDGKGRAVHLGERDCSLQRRHQKVFE
EAPGPSISAEERMAIGKVCADAVARINYIGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAIFGVDLVREQIRVASGMEM
SFRQEDLTINGHAIEVRINAEKLPNFSPCPGRITQYHAPGGLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDRPEALAR
LHRALGELIVDGVDTTVPLFHALLEEEAVLSGGYNIHWLEQWLDANLSAT

Sequences:

>Translated_450_residues
MFNKILIANRGEIALRVVRAAREMGIASVAVHSTADSDAMHVRMADESICIGPPASQQSYLSFPAIISACEITGAEAIHP
GYGFLSENAGFVQIVEDHGISFIGPTAEHIRIMGDKITAKETMKNLGVPCVPGSDGGVATLEEAQRIGAEIGYPVIIKAT
AGGGGRGMKVAQNAEEMEKAFLTARAEGKSNFGNDEVYIEKYLTTPRHIEIQVFGDGKGRAVHLGERDCSLQRRHQKVFE
EAPGPSISAEERMAIGKVCADAVARINYIGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAIFGVDLVREQIRVASGMEM
SFRQEDLTINGHAIEVRINAEKLPNFSPCPGRITQYHAPGGLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDRPEALAR
LHRALGELIVDGVDTTVPLFHALLEEEAVLSGGYNIHWLEQWLDANLSAT
>Mature_450_residues
MFNKILIANRGEIALRVVRAAREMGIASVAVHSTADSDAMHVRMADESICIGPPASQQSYLSFPAIISACEITGAEAIHP
GYGFLSENAGFVQIVEDHGISFIGPTAEHIRIMGDKITAKETMKNLGVPCVPGSDGGVATLEEAQRIGAEIGYPVIIKAT
AGGGGRGMKVAQNAEEMEKAFLTARAEGKSNFGNDEVYIEKYLTTPRHIEIQVFGDGKGRAVHLGERDCSLQRRHQKVFE
EAPGPSISAEERMAIGKVCADAVARINYIGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAIFGVDLVREQIRVASGMEM
SFRQEDLTINGHAIEVRINAEKLPNFSPCPGRITQYHAPGGLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDRPEALAR
LHRALGELIVDGVDTTVPLFHALLEEEAVLSGGYNIHWLEQWLDANLSAT

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.7584650112867, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.7584650112867, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.7584650112867, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI116805327, Length=425, Percent_Identity=46.5882352941176, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=43.9461883408072, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=43.9461883408072, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=43.9461883408072, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI38679971, Length=517, Percent_Identity=28.6266924564797, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI38679977, Length=517, Percent_Identity=28.6266924564797, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI38679967, Length=517, Percent_Identity=28.6266924564797, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI38679960, Length=517, Percent_Identity=28.6266924564797, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI38679974, Length=517, Percent_Identity=28.6266924564797, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=29.4695481335953, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=59.9099099099099, Blast_Score=534, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=45.4751131221719, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=424, Percent_Identity=47.1698113207547, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17562816, Length=452, Percent_Identity=42.4778761061947, Blast_Score=338, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=30.3462321792261, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=26.1811023622047, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=26.1811023622047, Blast_Score=177, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6319685, Length=430, Percent_Identity=42.7906976744186, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=41.3870246085011, Blast_Score=314, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=41.834451901566, Blast_Score=307, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6324343, Length=526, Percent_Identity=28.8973384030418, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6323863, Length=485, Percent_Identity=29.0721649484536, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=46.6367713004484, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651757, Length=421, Percent_Identity=45.3681710213777, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651759, Length=383, Percent_Identity=44.3864229765013, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=28.5148514851485, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=28.5148514851485, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=28.5148514851485, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=28.5148514851485, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48977; Mature: 48977

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILIANRGEIALRVVRAAREMGIASVAVHSTADSDAMHVRMADESICIGPPASQQSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCCCH
LSFPAIISACEITGAEAIHPGYGFLSENAGFVQIVEDHGISFIGPTAEHIRIMGDKITAK
HHHHHHHHHHHCCCCCEECCCCCEECCCCCEEEEEECCCCEEECCCHHHEEEECCCCCHH
ETMKNLGVPCVPGSDGGVATLEEAQRIGAEIGYPVIIKATAGGGGRGMKVAQNAEEMEKA
HHHHHCCCCCCCCCCCCEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCHHHHHHH
FLTARAEGKSNFGNDEVYIEKYLTTPRHIEIQVFGDGKGRAVHLGERDCSLQRRHQKVFE
HHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPGPSISAEERMAIGKVCADAVARINYIGAGTIEFLYENGEFYFIEMNTRLQVEHPVTE
HCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AIFGVDLVREQIRVASGMEMSFRQEDLTINGHAIEVRINAEKLPNFSPCPGRITQYHAPG
HHHHHHHHHHHHHHHCCCCCEECCCCEEECCEEEEEEEEHHHCCCCCCCCCCCEEEECCC
GLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDRPEALARLHRALGELIVDGVDTTVPLF
CCCEEECHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
HALLEEEAVLSGGYNIHWLEQWLDANLSAT
HHHHHHHHHHCCCCEEEHHHHHHCCCCCCC
>Mature Secondary Structure
MFNKILIANRGEIALRVVRAAREMGIASVAVHSTADSDAMHVRMADESICIGPPASQQSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCCCH
LSFPAIISACEITGAEAIHPGYGFLSENAGFVQIVEDHGISFIGPTAEHIRIMGDKITAK
HHHHHHHHHHHCCCCCEECCCCCEECCCCCEEEEEECCCCEEECCCHHHEEEECCCCCHH
ETMKNLGVPCVPGSDGGVATLEEAQRIGAEIGYPVIIKATAGGGGRGMKVAQNAEEMEKA
HHHHHCCCCCCCCCCCCEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCHHHHHHH
FLTARAEGKSNFGNDEVYIEKYLTTPRHIEIQVFGDGKGRAVHLGERDCSLQRRHQKVFE
HHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPGPSISAEERMAIGKVCADAVARINYIGAGTIEFLYENGEFYFIEMNTRLQVEHPVTE
HCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AIFGVDLVREQIRVASGMEMSFRQEDLTINGHAIEVRINAEKLPNFSPCPGRITQYHAPG
HHHHHHHHHHHHHHHCCCCCEECCCCEEECCEEEEEEEEHHHCCCCCCCCCCCEEEECCC
GLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDRPEALARLHRALGELIVDGVDTTVPLF
CCCEEECHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
HALLEEEAVLSGGYNIHWLEQWLDANLSAT
HHHHHHHHHHCCCCEEEHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]