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The map label for this gene is hemA [H]

Identifier: 110680034

GI number: 110680034

Start: 2698389

End: 2699612

Strand: Reverse

Name: hemA [H]

Synonym: RD1_2827

Alternate gene names: 110680034

Gene position: 2699612-2698389 (Counterclockwise)

Preceding gene: 110680037

Following gene: 110680033

Centisome position: 65.32

GC content: 59.31

Gene sequence:

>1224_bases
GTGGAGTATAACGATAAGCTGGACGAAGCGCTTGCGCGTCTGCACGACGAAGGCCGCTATCGCACGTTCATCGATATTGA
ACGGCGCAACGGCCAGTTCCCCCATGCGGTCTGGACGCAACCCGACGGGCAACAGCGTGACATCACGGTGTGGTGTGGCA
ATGACTACCTCGGCATGGGCCAGCACCCGGTCGTTCTGGACGCCATGCATGAGGCACTGGATGCAACCGGGGCAGGGTCG
GGCGGTACGCGCAACATCTCCGGCACAACGGTCTATCACAAGCGGCTGGAGGCGGAGCTTGCCGATCTGCATGGCAAGGA
AACGGCGCTGCTCTTTACCTCTGCCTATATTGCCAATGATGCGACGCTGTCCACTTTGCCGAAACTATTCCCCGGCCTCA
TTATCTATTCGGATGCGCTGAACCACGCGTCGATGATCGAGGGCGTGCGCCGGAATGGGGGCGCGAAACGCATTTTCCGC
CATAATGACGTGTCACATTTGCGCGAACTCCTGGCGGCGGATGATCCTGCGGCGCCGAAGTTGATTGCATTTGAGTCAAT
TTATTCGATGGACGGCGATTTCGGCCCGATCGAGGCGATTTGTGATCTCGCGGATGAATTCAACGCACTGACCTACATCG
ACGAAGTGCACGCCGTTGGCATGTACGGGCCTCGGGGTGCCGGTGTGGCCGAGCGGGACGGGTTGATGCACCGCATCGAC
ATCATCAACGGCACGCTGGCGAAAGCCTATGGCGTTTTGGGTGGCTATATCGCCGCATCCGAGAAAATGTGTGACGCCAT
AAGGTCTTACGCGCCGGGCTTCATCTTTACCACGTCCTTGCCGCCTGCCATTGCGGCGGGGGCTGCTGCCTCTGTTGCGT
TTCTCAAACGCAGCCCTGAATTGCGCGAGGCACATCAGTTGCAGGCGCGCATTCTGAAAATGCGGCTCAAGGGGTTGGGC
CTGCCCATCATAGATCATGGCAGCCATATCGTGCCCGTGATGGTCGGCGATCCGGTTCACACGAAGAAACTGAGCGACAT
GTTGCTGGCGGATCACGGGATTTATGTGCAGCCGATCAACTATCCAACCGTTCCGCGTGGAACAGAACGGCTGCGCTTCA
CGCCGTCGCCGGTGCATGGACCACGTGAGCTGGACGCGCTGGTGCGTGCGATGGACGGGCTGTGGTCACATTGTGCGCTA
AATCGCGCCGAGGCGGCAGGTTAA

Upstream 100 bases:

>100_bases
CGTCCTGCCATGCGTTATTGAAAAATTGTCACCTGTTCTATAGTGAACTCGGAACAGTTGCGTGCCAACTGACCAAGGGT
GAGCGATACAGGAGATGCGC

Downstream 100 bases:

>100_bases
CCTGAGGTCTGGTGAAATTCGAGTTGCCTTGTGTTAACCTAACCTAAACAACAAGTCAGATACGAATCGTGGGGACGATT
CTTTTTCACTGACGACGGCA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MEYNDKLDEALARLHDEGRYRTFIDIERRNGQFPHAVWTQPDGQQRDITVWCGNDYLGMGQHPVVLDAMHEALDATGAGS
GGTRNISGTTVYHKRLEAELADLHGKETALLFTSAYIANDATLSTLPKLFPGLIIYSDALNHASMIEGVRRNGGAKRIFR
HNDVSHLRELLAADDPAAPKLIAFESIYSMDGDFGPIEAICDLADEFNALTYIDEVHAVGMYGPRGAGVAERDGLMHRID
IINGTLAKAYGVLGGYIAASEKMCDAIRSYAPGFIFTTSLPPAIAAGAAASVAFLKRSPELREAHQLQARILKMRLKGLG
LPIIDHGSHIVPVMVGDPVHTKKLSDMLLADHGIYVQPINYPTVPRGTERLRFTPSPVHGPRELDALVRAMDGLWSHCAL
NRAEAAG

Sequences:

>Translated_407_residues
MEYNDKLDEALARLHDEGRYRTFIDIERRNGQFPHAVWTQPDGQQRDITVWCGNDYLGMGQHPVVLDAMHEALDATGAGS
GGTRNISGTTVYHKRLEAELADLHGKETALLFTSAYIANDATLSTLPKLFPGLIIYSDALNHASMIEGVRRNGGAKRIFR
HNDVSHLRELLAADDPAAPKLIAFESIYSMDGDFGPIEAICDLADEFNALTYIDEVHAVGMYGPRGAGVAERDGLMHRID
IINGTLAKAYGVLGGYIAASEKMCDAIRSYAPGFIFTTSLPPAIAAGAAASVAFLKRSPELREAHQLQARILKMRLKGLG
LPIIDHGSHIVPVMVGDPVHTKKLSDMLLADHGIYVQPINYPTVPRGTERLRFTPSPVHGPRELDALVRAMDGLWSHCAL
NRAEAAG
>Mature_407_residues
MEYNDKLDEALARLHDEGRYRTFIDIERRNGQFPHAVWTQPDGQQRDITVWCGNDYLGMGQHPVVLDAMHEALDATGAGS
GGTRNISGTTVYHKRLEAELADLHGKETALLFTSAYIANDATLSTLPKLFPGLIIYSDALNHASMIEGVRRNGGAKRIFR
HNDVSHLRELLAADDPAAPKLIAFESIYSMDGDFGPIEAICDLADEFNALTYIDEVHAVGMYGPRGAGVAERDGLMHRID
IINGTLAKAYGVLGGYIAASEKMCDAIRSYAPGFIFTTSLPPAIAAGAAASVAFLKRSPELREAHQLQARILKMRLKGLG
LPIIDHGSHIVPVMVGDPVHTKKLSDMLLADHGIYVQPINYPTVPRGTERLRFTPSPVHGPRELDALVRAMDGLWSHCAL
NRAEAAG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=50.6203473945409, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=50.6203473945409, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=50.6203473945409, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=49.6277915632754, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=49.6277915632754, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=35.2331606217617, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=36.5217391304348, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=29.5890410958904, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4758668, Length=357, Percent_Identity=29.6918767507003, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI5454084, Length=256, Percent_Identity=25.78125, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790046, Length=359, Percent_Identity=36.7688022284123, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1786993, Length=342, Percent_Identity=33.3333333333333, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=388, Percent_Identity=32.7319587628866, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=374, Percent_Identity=30.4812834224599, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17560914, Length=378, Percent_Identity=27.7777777777778, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=378, Percent_Identity=27.7777777777778, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=278, Percent_Identity=26.2589928057554, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982625, Length=278, Percent_Identity=26.2589928057554, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=427, Percent_Identity=47.0725995316159, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320267, Length=355, Percent_Identity=30.4225352112676, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=260, Percent_Identity=24.6153846153846, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17137420, Length=397, Percent_Identity=50.1259445843829, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24662918, Length=386, Percent_Identity=34.1968911917098, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI17136286, Length=344, Percent_Identity=28.7790697674419, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24653280, Length=308, Percent_Identity=25.6493506493506, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653276, Length=308, Percent_Identity=25.6493506493506, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653278, Length=308, Percent_Identity=25.6493506493506, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44363; Mature: 44363

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNDKLDEALARLHDEGRYRTFIDIERRNGQFPHAVWTQPDGQQRDITVWCGNDYLGMG
CCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCC
QHPVVLDAMHEALDATGAGSGGTRNISGTTVYHKRLEAELADLHGKETALLFTSAYIAND
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHHCCC
ATLSTLPKLFPGLIIYSDALNHASMIEGVRRNGGAKRIFRHNDVSHLRELLAADDPAAPK
CHHHHHHHHHCCEEEEHHHCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCCCCC
LIAFESIYSMDGDFGPIEAICDLADEFNALTYIDEVHAVGMYGPRGAGVAERDGLMHRID
EEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCEEEHH
IINGTLAKAYGVLGGYIAASEKMCDAIRSYAPGFIFTTSLPPAIAAGAAASVAFLKRSPE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCH
LREAHQLQARILKMRLKGLGLPIIDHGSHIVPVMVGDPVHTKKLSDMLLADHGIYVQPIN
HHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEECC
YPTVPRGTERLRFTPSPVHGPRELDALVRAMDGLWSHCALNRAEAAG
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MEYNDKLDEALARLHDEGRYRTFIDIERRNGQFPHAVWTQPDGQQRDITVWCGNDYLGMG
CCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCC
QHPVVLDAMHEALDATGAGSGGTRNISGTTVYHKRLEAELADLHGKETALLFTSAYIAND
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHHCCC
ATLSTLPKLFPGLIIYSDALNHASMIEGVRRNGGAKRIFRHNDVSHLRELLAADDPAAPK
CHHHHHHHHHCCEEEEHHHCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCCCCC
LIAFESIYSMDGDFGPIEAICDLADEFNALTYIDEVHAVGMYGPRGAGVAERDGLMHRID
EEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCEEEHH
IINGTLAKAYGVLGGYIAASEKMCDAIRSYAPGFIFTTSLPPAIAAGAAASVAFLKRSPE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCH
LREAHQLQARILKMRLKGLGLPIIDHGSHIVPVMVGDPVHTKKLSDMLLADHGIYVQPIN
HHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEECC
YPTVPRGTERLRFTPSPVHGPRELDALVRAMDGLWSHCALNRAEAAG
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2381418; 1904045 [H]