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The map label for this gene is hpt [H]

Identifier: 110679981

GI number: 110679981

Start: 2642466

End: 2643011

Strand: Direct

Name: hpt [H]

Synonym: RD1_2771

Alternate gene names: 110679981

Gene position: 2642466-2643011 (Clockwise)

Preceding gene: 110679979

Following gene: 110679986

Centisome position: 63.93

GC content: 54.21

Gene sequence:

>546_bases
ATGGTAGCGCGTCCTTATGTCATAGACGAGATGATCTCGGCAAAATCCATTGCGGCGCGCATTGAAGAACTCTGCAAGGA
AATTCAAAGCGAGTTTTCCGAAACGAACAAGTTGGTGGTGGTTGGTCTGCTGCGCGGCAGTTTCGTCTTCATCGCTGATC
TGGTGCGCGAGCTTGATCTGCCCATCGAAGTCGATTTCCTTGAGGCGTCCAGCTATGGCGATGGCATGGAAAGCAGCCGT
GAAGTGCGCATTCTCAAGGACTTGCGCGGCGCAATCGAAGGTCGCGATGTGCTGGTTGTCGAAGACATCGTCGACACAGG
CCACACGCTGAACCATGTGACGGGCCTGCTCAAAAGCCGCCTGCCAGCACGTCTGAAATCCATCGCTTTGCTCGACAAAC
CAAGCCAACGCGAAGTCGATTTCAAAGCGGACTGGACCGGATTCGAGATCCCGGATGAATTCGTCGTCGGCTATGGTATC
GATTTCGCGCAGCGTAACCGCAACCTGCCGTTCATCGGAAAAGTTCGCTTTACCGAGCCTGAGTAA

Upstream 100 bases:

>100_bases
GGTAGAGTACGTGTTTCAGAGTGCGTTGGCATTGCTTTGTCAGGCTCGTGCGGTTAGCCCTCATGTCCTATGTCCACCCG
ATTAATTCAAGGTAAAACCC

Downstream 100 bases:

>100_bases
GGTACCGGTGCCCGTACAGTTTTTCGACTGTACTCATACAACACACCGCCGCGTGATGATCCAGTTACGAACCGATCCCC
GCGCCCAAGCCCATGTCACC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MVARPYVIDEMISAKSIAARIEELCKEIQSEFSETNKLVVVGLLRGSFVFIADLVRELDLPIEVDFLEASSYGDGMESSR
EVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVTGLLKSRLPARLKSIALLDKPSQREVDFKADWTGFEIPDEFVVGYGI
DFAQRNRNLPFIGKVRFTEPE

Sequences:

>Translated_181_residues
MVARPYVIDEMISAKSIAARIEELCKEIQSEFSETNKLVVVGLLRGSFVFIADLVRELDLPIEVDFLEASSYGDGMESSR
EVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVTGLLKSRLPARLKSIALLDKPSQREVDFKADWTGFEIPDEFVVGYGI
DFAQRNRNLPFIGKVRFTEPE
>Mature_181_residues
MVARPYVIDEMISAKSIAARIEELCKEIQSEFSETNKLVVVGLLRGSFVFIADLVRELDLPIEVDFLEASSYGDGMESSR
EVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVTGLLKSRLPARLKSIALLDKPSQREVDFKADWTGFEIPDEFVVGYGI
DFAQRNRNLPFIGKVRFTEPE

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=166, Percent_Identity=33.7349397590361, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI9910262, Length=172, Percent_Identity=33.7209302325581, Blast_Score=91, Evalue=7e-19,
Organism=Escherichia coli, GI87081689, Length=171, Percent_Identity=54.3859649122807, Blast_Score=186, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17510817, Length=161, Percent_Identity=36.0248447204969, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20370; Mature: 20370

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVARPYVIDEMISAKSIAARIEELCKEIQSEFSETNKLVVVGLLRGSFVFIADLVRELDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
PIEVDFLEASSYGDGMESSREVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVTGLLKSR
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHH
LPARLKSIALLDKPSQREVDFKADWTGFEIPDEFVVGYGIDFAQRNRNLPFIGKVRFTEP
HHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHEEECCCHHHHHCCCCCEEEEEEECCC
E
C
>Mature Secondary Structure
MVARPYVIDEMISAKSIAARIEELCKEIQSEFSETNKLVVVGLLRGSFVFIADLVRELDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
PIEVDFLEASSYGDGMESSREVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVTGLLKSR
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHH
LPARLKSIALLDKPSQREVDFKADWTGFEIPDEFVVGYGIDFAQRNRNLPFIGKVRFTEP
HHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHEEECCCHHHHHCCCCCEEEEEEECCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756169 [H]