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The map label for this gene is ccmA

Identifier: 110679783

GI number: 110679783

Start: 2436278

End: 2436898

Strand: Direct

Name: ccmA

Synonym: RD1_2547

Alternate gene names: 110679783

Gene position: 2436278-2436898 (Clockwise)

Preceding gene: 110679782

Following gene: 110679784

Centisome position: 58.95

GC content: 63.12

Gene sequence:

>621_bases
ATGACTGTTTCTGTAGATGATCTTTGCGTGACCCGCGGCGGCGTCCCCATCCTTTCCGGTGTGAGCTTTGATCTGGCTGA
AGGGGCCGCACTGATCCTGCAGGGGCCAAATGGCTCGGGGAAAACCACCTTGCTGCGCACGCTCGCGGGATTACAGCCGC
CACTGGCCGGACAGATAAGCGGCACCGAGGATCGCATCGCCTATGCCGCCCATTCCGACGGGTTGAAATCCATGCTCTCT
GTGGCCGAAAACCTGCGGTTCTGGGCGGCGGTTTTTGGGCGTTCGGACATTGCCCCGGCCTTGCAGGCCTTTGATTTACA
TGACCTCGCGGACCGGCTTGCGGGGACGCTCTCGGCGGGGCAGAAACGGCGGCTCGGCCTTGCGCGCCTGCTGGTTACGG
GCCGCCCGGTCTGGATGCTGGATGAGCCGACCGTGTCACTGGACAAAAGGGCAGTAGAGATGTTCGCCGCCGCCGTAGAG
GCGCATTTGGCCACCGGTGGATCGGCCTTGATCGCCACGCATATTGATCTGGGTCTGCGTGATGCGCAGGTGTTGGATGT
GGGACCGTTGCGCGCCTCGCCAACCGCACTTGCGGGCGCAAGTGACGAGGCCTTCCTGTGA

Upstream 100 bases:

>100_bases
TCCTGCTGAGCGAAGGGCGGCGGATCGCGCTGGCCCTGATCCCGGTTACCGCGTGAAATCGTGCTTTTGTGCCGTGGCAC
AATAGGTTAACGATCTGGGC

Downstream 100 bases:

>100_bases
AGGCGCTGCTGGTGCGTGATCTGGCCCTTGCGCTGCGGGCAGGGGGCGGCTTCGGCCTCGGGCTGGCCTTTTTCCTTATT
GTCACCGTGCTTGTCCCGCT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTVSVDDLCVTRGGVPILSGVSFDLAEGAALILQGPNGSGKTTLLRTLAGLQPPLAGQISGTEDRIAYAAHSDGLKSMLS
VAENLRFWAAVFGRSDIAPALQAFDLHDLADRLAGTLSAGQKRRLGLARLLVTGRPVWMLDEPTVSLDKRAVEMFAAAVE
AHLATGGSALIATHIDLGLRDAQVLDVGPLRASPTALAGASDEAFL

Sequences:

>Translated_206_residues
MTVSVDDLCVTRGGVPILSGVSFDLAEGAALILQGPNGSGKTTLLRTLAGLQPPLAGQISGTEDRIAYAAHSDGLKSMLS
VAENLRFWAAVFGRSDIAPALQAFDLHDLADRLAGTLSAGQKRRLGLARLLVTGRPVWMLDEPTVSLDKRAVEMFAAAVE
AHLATGGSALIATHIDLGLRDAQVLDVGPLRASPTALAGASDEAFL
>Mature_205_residues
TVSVDDLCVTRGGVPILSGVSFDLAEGAALILQGPNGSGKTTLLRTLAGLQPPLAGQISGTEDRIAYAAHSDGLKSMLSV
AENLRFWAAVFGRSDIAPALQAFDLHDLADRLAGTLSAGQKRRLGLARLLVTGRPVWMLDEPTVSLDKRAVEMFAAAVEA
HLATGGSALIATHIDLGLRDAQVLDVGPLRASPTALAGASDEAFL

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI27436953, Length=177, Percent_Identity=32.2033898305085, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI27477115, Length=153, Percent_Identity=33.9869281045752, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI153792144, Length=155, Percent_Identity=32.9032258064516, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI116734710, Length=152, Percent_Identity=34.2105263157895, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI27262624, Length=154, Percent_Identity=33.1168831168831, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI27262626, Length=154, Percent_Identity=33.1168831168831, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4505771, Length=174, Percent_Identity=29.8850574712644, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI9961252, Length=174, Percent_Identity=29.8850574712644, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI6005701, Length=169, Percent_Identity=33.7278106508876, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592971, Length=179, Percent_Identity=30.7262569832402, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI46592964, Length=179, Percent_Identity=30.7262569832402, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI46592978, Length=179, Percent_Identity=30.7262569832402, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI9961250, Length=181, Percent_Identity=28.7292817679558, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI46592915, Length=179, Percent_Identity=30.7262569832402, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI46592898, Length=179, Percent_Identity=30.7262569832402, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI46592956, Length=179, Percent_Identity=30.7262569832402, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI42741659, Length=174, Percent_Identity=29.3103448275862, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI87082064, Length=189, Percent_Identity=32.2751322751323, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788761, Length=168, Percent_Identity=31.547619047619, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790467, Length=190, Percent_Identity=29.4736842105263, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI87081709, Length=162, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87081782, Length=172, Percent_Identity=30.2325581395349, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788165, Length=149, Percent_Identity=36.9127516778523, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082267, Length=179, Percent_Identity=29.608938547486, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788897, Length=187, Percent_Identity=33.1550802139037, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786563, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790739, Length=201, Percent_Identity=28.8557213930348, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI48994943, Length=172, Percent_Identity=27.906976744186, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787772, Length=165, Percent_Identity=32.1212121212121, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787792, Length=210, Percent_Identity=29.0476190476191, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789873, Length=183, Percent_Identity=30.0546448087432, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1786872, Length=167, Percent_Identity=29.3413173652695, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786253, Length=145, Percent_Identity=31.0344827586207, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=182, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17558664, Length=209, Percent_Identity=30.622009569378, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17510237, Length=186, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=173, Percent_Identity=30.0578034682081, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007184, Length=167, Percent_Identity=28.7425149700599, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221500365, Length=167, Percent_Identity=28.7425149700599, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24666092, Length=201, Percent_Identity=31.3432835820896, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24643674, Length=190, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076682, Length=184, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076684, Length=184, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581617, Length=184, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581615, Length=184, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_ROSDO (Q166I9)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682790.1
- ProteinModelPortal:   Q166I9
- SMR:   Q166I9
- STRING:   Q166I9
- GeneID:   4198881
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2547
- NMPDR:   fig|375451.6.peg.2368
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   VRRPIWL
- ProtClustDB:   PRK13539
- BioCyc:   RDEN375451:RD1_2547-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 21364; Mature: 21233

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSVDDLCVTRGGVPILSGVSFDLAEGAALILQGPNGSGKTTLLRTLAGLQPPLAGQIS
CCCCCHHHHHHCCCCCEECCCCEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCC
GTEDRIAYAAHSDGLKSMLSVAENLRFWAAVFGRSDIAPALQAFDLHDLADRLAGTLSAG
CCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QKRRLGLARLLVTGRPVWMLDEPTVSLDKRAVEMFAAAVEAHLATGGSALIATHIDLGLR
CHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
DAQVLDVGPLRASPTALAGASDEAFL
CCEEEECCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure 
TVSVDDLCVTRGGVPILSGVSFDLAEGAALILQGPNGSGKTTLLRTLAGLQPPLAGQIS
CCCCHHHHHHCCCCCEECCCCEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCC
GTEDRIAYAAHSDGLKSMLSVAENLRFWAAVFGRSDIAPALQAFDLHDLADRLAGTLSAG
CCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QKRRLGLARLLVTGRPVWMLDEPTVSLDKRAVEMFAAAVEAHLATGGSALIATHIDLGLR
CHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
DAQVLDVGPLRASPTALAGASDEAFL
CCEEEECCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA