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The map label for this gene is mepA [H]

Identifier: 110679714

GI number: 110679714

Start: 2354458

End: 2355795

Strand: Direct

Name: mepA [H]

Synonym: RD1_2470

Alternate gene names: 110679714

Gene position: 2354458-2355795 (Clockwise)

Preceding gene: 110679711

Following gene: 110679716

Centisome position: 56.97

GC content: 59.94

Gene sequence:

>1338_bases
ATGGCATCCAGAGAATTGACAAGCGGGCCGGTGTGGCGCGCTTTGATCGCTGTATCTGCACCGATGACCTTTGGCATTCT
GGCGGTGCTCAGCGTTGGACTGGTCGATGCGTTCTTCCTCGGCCAGTTGGGAAACGCGCCGCTGGCGGCCGTCGGTTTCA
TTTACCCGCTGACAACCGCGCTGACGTCGCTGTCGATTGGTATGTCAGCAGGCGCCAATGCCGCCATATCGCAGGCCGTG
GGTCGCGGCGGATCTGACGATCATCCGCAGCGCCTTGCAATACACGCAGTGGCTGTTGGGCTATTGCTGTCTGTCGCTGT
TGCGTTGGGCTTTCTATTTTCCGCGCCGCTGTTGTTTTCGTGGATGGGTGCATCCGATCAGCCGTTGACGGAGGCGGTGT
CCTATGTGCCTTTCTGGTCATTATCGTTCCCCTTCCTCGTTGTGATGATGGTGGTGAACGCGATTTTTCGCGCCTATGGC
GATGGGGGGACATCGTCATTGATCATGATTGGGTCTGCACTGGTCAACATCGCGCTTACCCCTTTGTTTATTTTTGGCTG
GGGTCCTGTGGCCGGAATGGGAACCGAAGGCGCAGCACTTGCTACGGCAATCGGGCGGGGATTGGGGTGCACGGCCGCGA
TTTACTGGGCGTGGCGCACGGGAGTTCTGGCGATCTGCGGCGATATGCTCAAGGGCATCGCCTTTTCCCTGCAGGAGATA
TTCAAGGTCGGTTTGCCCGCCGCATTCTCAAACGCTATCAATCCCGCCGGTATCGCGTTGGTGACGGCTGCCGTGGCGAC
CCTGGGCGATGAGGCCGTCGCAGGTTTTGGGGCCGCCACGCGCATCCAGTCGGTTGCGGTCGTCGTTCTTCTGGCGCTTT
CGGCGGGGATCGGTCCCGTCGTCGGTCAGAATTGGGGGGCAGACAAGCAAGAAAGAGCGCAAGCGGCTATGCGTATCGCA
TGGATGGCCTGCGTTGCCTATGGGCTCTGCCTGGGCGTTGTCATGGCCCTGTTTGCCGATCAGCTCGCGGGTCTTTTCGC
GCAAGGGGACGCCGCAGCCTATGCTGCGCAATATCTGCGGATTGTCGGGTGGAGCCTGTTCGGTTACGGGATCGTGATTA
CCACGAATGCCGCAATGAACGCGCGGTCCAAGGCGGGATATTCCATGGGTCTGAGCATCGGGCGCATTTTTTTCGTCTAC
GTGCCCGCGGCGTGGGTGGGTGCGCTCTTTCTGGGGTTCACGGGGGTATTGTTTGCGGCGGTAGCGGCGAACCTGCTGGC
CGTTGGGGCCGCGTATTTCTGTGCCCGGAAAACAAAGATCGTGACTGCACTGATCTGA

Upstream 100 bases:

>100_bases
CCATGATGGAAGATGTGGAACAAACCCTATCGTTCAGAGTTCCTGACCGTCGGTGGCGTTGTGGTGCCACCGTGAAATGA
ACAACAGTTTGGAATTTTTC

Downstream 100 bases:

>100_bases
GGGTCGAAAACGAACAACGCCGCCCCCTTGTATCAGGGGCGGCGTTGGGATTGTGCGCTCAGTAGCCGCTTAATCCCTGG
TGTCGGGTGCGTCCTTGGCG

Product: MatE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MASRELTSGPVWRALIAVSAPMTFGILAVLSVGLVDAFFLGQLGNAPLAAVGFIYPLTTALTSLSIGMSAGANAAISQAV
GRGGSDDHPQRLAIHAVAVGLLLSVAVALGFLFSAPLLFSWMGASDQPLTEAVSYVPFWSLSFPFLVVMMVVNAIFRAYG
DGGTSSLIMIGSALVNIALTPLFIFGWGPVAGMGTEGAALATAIGRGLGCTAAIYWAWRTGVLAICGDMLKGIAFSLQEI
FKVGLPAAFSNAINPAGIALVTAAVATLGDEAVAGFGAATRIQSVAVVVLLALSAGIGPVVGQNWGADKQERAQAAMRIA
WMACVAYGLCLGVVMALFADQLAGLFAQGDAAAYAAQYLRIVGWSLFGYGIVITTNAAMNARSKAGYSMGLSIGRIFFVY
VPAAWVGALFLGFTGVLFAAVAANLLAVGAAYFCARKTKIVTALI

Sequences:

>Translated_445_residues
MASRELTSGPVWRALIAVSAPMTFGILAVLSVGLVDAFFLGQLGNAPLAAVGFIYPLTTALTSLSIGMSAGANAAISQAV
GRGGSDDHPQRLAIHAVAVGLLLSVAVALGFLFSAPLLFSWMGASDQPLTEAVSYVPFWSLSFPFLVVMMVVNAIFRAYG
DGGTSSLIMIGSALVNIALTPLFIFGWGPVAGMGTEGAALATAIGRGLGCTAAIYWAWRTGVLAICGDMLKGIAFSLQEI
FKVGLPAAFSNAINPAGIALVTAAVATLGDEAVAGFGAATRIQSVAVVVLLALSAGIGPVVGQNWGADKQERAQAAMRIA
WMACVAYGLCLGVVMALFADQLAGLFAQGDAAAYAAQYLRIVGWSLFGYGIVITTNAAMNARSKAGYSMGLSIGRIFFVY
VPAAWVGALFLGFTGVLFAAVAANLLAVGAAYFCARKTKIVTALI
>Mature_444_residues
ASRELTSGPVWRALIAVSAPMTFGILAVLSVGLVDAFFLGQLGNAPLAAVGFIYPLTTALTSLSIGMSAGANAAISQAVG
RGGSDDHPQRLAIHAVAVGLLLSVAVALGFLFSAPLLFSWMGASDQPLTEAVSYVPFWSLSFPFLVVMMVVNAIFRAYGD
GGTSSLIMIGSALVNIALTPLFIFGWGPVAGMGTEGAALATAIGRGLGCTAAIYWAWRTGVLAICGDMLKGIAFSLQEIF
KVGLPAAFSNAINPAGIALVTAAVATLGDEAVAGFGAATRIQSVAVVVLLALSAGIGPVVGQNWGADKQERAQAAMRIAW
MACVAYGLCLGVVMALFADQLAGLFAQGDAAAYAAQYLRIVGWSLFGYGIVITTNAAMNARSKAGYSMGLSIGRIFFVYV
PAAWVGALFLGFTGVLFAAVAANLLAVGAAYFCARKTKIVTALI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 45559; Mature: 45428

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRELTSGPVWRALIAVSAPMTFGILAVLSVGLVDAFFLGQLGNAPLAAVGFIYPLTTA
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LTSLSIGMSAGANAAISQAVGRGGSDDHPQRLAIHAVAVGLLLSVAVALGFLFSAPLLFS
HHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WMGASDQPLTEAVSYVPFWSLSFPFLVVMMVVNAIFRAYGDGGTSSLIMIGSALVNIALT
HCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
PLFIFGWGPVAGMGTEGAALATAIGRGLGCTAAIYWAWRTGVLAICGDMLKGIAFSLQEI
HHHEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKVGLPAAFSNAINPAGIALVTAAVATLGDEAVAGFGAATRIQSVAVVVLLALSAGIGPV
HHHCCCHHHHCCCCHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
VGQNWGADKQERAQAAMRIAWMACVAYGLCLGVVMALFADQLAGLFAQGDAAAYAAQYLR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IVGWSLFGYGIVITTNAAMNARSKAGYSMGLSIGRIFFVYVPAAWVGALFLGFTGVLFAA
HHHHHHHHCEEEEEECCHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAANLLAVGAAYFCARKTKIVTALI
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASRELTSGPVWRALIAVSAPMTFGILAVLSVGLVDAFFLGQLGNAPLAAVGFIYPLTTA
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LTSLSIGMSAGANAAISQAVGRGGSDDHPQRLAIHAVAVGLLLSVAVALGFLFSAPLLFS
HHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WMGASDQPLTEAVSYVPFWSLSFPFLVVMMVVNAIFRAYGDGGTSSLIMIGSALVNIALT
HCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
PLFIFGWGPVAGMGTEGAALATAIGRGLGCTAAIYWAWRTGVLAICGDMLKGIAFSLQEI
HHHEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKVGLPAAFSNAINPAGIALVTAAVATLGDEAVAGFGAATRIQSVAVVVLLALSAGIGPV
HHHCCCHHHHCCCCHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
VGQNWGADKQERAQAAMRIAWMACVAYGLCLGVVMALFADQLAGLFAQGDAAAYAAQYLR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IVGWSLFGYGIVITTNAAMNARSKAGYSMGLSIGRIFFVYVPAAWVGALFLGFTGVLFAA
HHHHHHHHCEEEEEECCHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAANLLAVGAAYFCARKTKIVTALI
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA