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The map label for this gene is mscS [H]

Identifier: 110679698

GI number: 110679698

Start: 2341132

End: 2342139

Strand: Direct

Name: mscS [H]

Synonym: RD1_2453

Alternate gene names: 110679698

Gene position: 2341132-2342139 (Clockwise)

Preceding gene: 110679697

Following gene: 110679699

Centisome position: 56.64

GC content: 56.94

Gene sequence:

>1008_bases
TTGAACGCGTGTCGGATAAAACCGCCCAAGGGTCTGAACGCAACCGGTGAAGGCGCTTGTGCAGCGGGAACAAAGCACCG
ATCACCGCGTTCCCCCTCAAACAAGAGGAAGTTTCATATGTCTTGGGAAGAAATGCTGCGCACTGTCGAGCAACGCGTAT
TGGCCTATTGGGATGGGTTGATCGCGGCTGTGCCGAAACTTGGGGCTGCGATCATAGTGCTGCTCGTCACATGGGTGGTT
GTTGCCCTTGTCCGCGCCTTCATTGCGAAGGTTGGAAGCAAGACGCGGATGCGGCAGAACCTGATTGACGTGTTGTCCAT
GCTGGCAAGCACGGGTCTTTGGCTGATGGGCATGCTGGTGGCGCTTGCCATCGTTTTTCCAACCATCACCCCGGGCAAAG
CCCTGACCACCTTAGGTCTCGGCTCGGTGGCGATCGGTTTTGCATTCAAGGACACATTCGAGAACTTTCTGGCCGGAATC
CTGATCCTGCTGCGCGAACCCTTTGCGATCAACGATTATGTTGAATGCGGGGACATCGAAGGCCAGATTGAGGAAATTAC
AATCCGCGACACGCATGTCCGCCAGACGGATGGTCAACTGGTCGTGGTGCCCAACCACATGCTTTTTCAAAACCCTGTCA
CTGTTCTGACGAACCGGGATTTCCGCCGCACCACCATCATCTGTGGCGTTGCCTATGGTGAGAACGTCGATGATGCGCGC
AAGGTGATCGAAACCGCGGTGCGACGCGTTGATACGGTTCGCGATGACGTCCGCGACGTGCAGGTTTTTGCGCAGGAATT
CGGGGCGTCCTCGATCAACTTTGAGGTGACATGGTGGACGGGGTCCAAACCCCTCGACATCCGCACCTCGCGGGACCAGG
TCGTCGCAGGTGTGAAAGCGGCGCTCGACGAAGCTGGCATCGAAATTCCCTTTCCCTATCGCACGCTCACTTTCAATGAG
CCGTTGCCCGTGCGCGAACAAGGCAGCAAACTGGAGGAGGCCGCGTAA

Upstream 100 bases:

>100_bases
GGCACCGGCGTGATCGGAATCGCCTGTGGGCTTGGGTATTTTGCGCAGGCGTTCGCCGTGTCGTTCCTCTTTTTCGCCGT
GCTGAACATATATGATGCAG

Downstream 100 bases:

>100_bases
CGGCGGCTCTCACACAGGAGGTTTCTCGCGGCACGTGGACGCAAAACGGAGGATCCGACGGGTACTTCGTGGAACGCCGT
CCTTGCGCATCAATGGCGCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNACRIKPPKGLNATGEGACAAGTKHRSPRSPSNKRKFHMSWEEMLRTVEQRVLAYWDGLIAAVPKLGAAIIVLLVTWVV
VALVRAFIAKVGSKTRMRQNLIDVLSMLASTGLWLMGMLVALAIVFPTITPGKALTTLGLGSVAIGFAFKDTFENFLAGI
LILLREPFAINDYVECGDIEGQIEEITIRDTHVRQTDGQLVVVPNHMLFQNPVTVLTNRDFRRTTIICGVAYGENVDDAR
KVIETAVRRVDTVRDDVRDVQVFAQEFGASSINFEVTWWTGSKPLDIRTSRDQVVAGVKAALDEAGIEIPFPYRTLTFNE
PLPVREQGSKLEEAA

Sequences:

>Translated_335_residues
MNACRIKPPKGLNATGEGACAAGTKHRSPRSPSNKRKFHMSWEEMLRTVEQRVLAYWDGLIAAVPKLGAAIIVLLVTWVV
VALVRAFIAKVGSKTRMRQNLIDVLSMLASTGLWLMGMLVALAIVFPTITPGKALTTLGLGSVAIGFAFKDTFENFLAGI
LILLREPFAINDYVECGDIEGQIEEITIRDTHVRQTDGQLVVVPNHMLFQNPVTVLTNRDFRRTTIICGVAYGENVDDAR
KVIETAVRRVDTVRDDVRDVQVFAQEFGASSINFEVTWWTGSKPLDIRTSRDQVVAGVKAALDEAGIEIPFPYRTLTFNE
PLPVREQGSKLEEAA
>Mature_335_residues
MNACRIKPPKGLNATGEGACAAGTKHRSPRSPSNKRKFHMSWEEMLRTVEQRVLAYWDGLIAAVPKLGAAIIVLLVTWVV
VALVRAFIAKVGSKTRMRQNLIDVLSMLASTGLWLMGMLVALAIVFPTITPGKALTTLGLGSVAIGFAFKDTFENFLAGI
LILLREPFAINDYVECGDIEGQIEEITIRDTHVRQTDGQLVVVPNHMLFQNPVTVLTNRDFRRTTIICGVAYGENVDDAR
KVIETAVRRVDTVRDDVRDVQVFAQEFGASSINFEVTWWTGSKPLDIRTSRDQVVAGVKAALDEAGIEIPFPYRTLTFNE
PLPVREQGSKLEEAA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=259, Percent_Identity=26.2548262548263, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787591, Length=206, Percent_Identity=31.0679611650485, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786670, Length=136, Percent_Identity=32.3529411764706, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI2367355, Length=262, Percent_Identity=23.6641221374046, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 36966; Mature: 36966

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNACRIKPPKGLNATGEGACAAGTKHRSPRSPSNKRKFHMSWEEMLRTVEQRVLAYWDGL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
IAAVPKLGAAIIVLLVTWVVVALVRAFIAKVGSKTRMRQNLIDVLSMLASTGLWLMGMLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
ALAIVFPTITPGKALTTLGLGSVAIGFAFKDTFENFLAGILILLREPFAINDYVECGDIE
HHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GQIEEITIRDTHVRQTDGQLVVVPNHMLFQNPVTVLTNRDFRRTTIICGVAYGENVDDAR
CCEEEEEEECCEEEECCCCEEEECCCHHHCCCCCEEECCCCEEEEEEEEECCCCCHHHHH
KVIETAVRRVDTVRDDVRDVQVFAQEFGASSINFEVTWWTGSKPLDIRTSRDQVVAGVKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCHHHHHHHHHH
ALDEAGIEIPFPYRTLTFNEPLPVREQGSKLEEAA
HHHHCCCCCCCCCEEEEECCCCCCHHCCCHHHCCC
>Mature Secondary Structure
MNACRIKPPKGLNATGEGACAAGTKHRSPRSPSNKRKFHMSWEEMLRTVEQRVLAYWDGL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
IAAVPKLGAAIIVLLVTWVVVALVRAFIAKVGSKTRMRQNLIDVLSMLASTGLWLMGMLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
ALAIVFPTITPGKALTTLGLGSVAIGFAFKDTFENFLAGILILLREPFAINDYVECGDIE
HHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GQIEEITIRDTHVRQTDGQLVVVPNHMLFQNPVTVLTNRDFRRTTIICGVAYGENVDDAR
CCEEEEEEECCEEEECCCCEEEECCCHHHCCCCCEEECCCCEEEEEEEEECCCCCHHHHH
KVIETAVRRVDTVRDDVRDVQVFAQEFGASSINFEVTWWTGSKPLDIRTSRDQVVAGVKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCHHHHHHHHHH
ALDEAGIEIPFPYRTLTFNEPLPVREQGSKLEEAA
HHHHCCCCCCCCCEEEEECCCCCCHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]