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The map label for this gene is mco [H]

Identifier: 110679565

GI number: 110679565

Start: 2201862

End: 2203250

Strand: Direct

Name: mco [H]

Synonym: RD1_2306

Alternate gene names: 110679565

Gene position: 2201862-2203250 (Clockwise)

Preceding gene: 110679564

Following gene: 110679566

Centisome position: 53.27

GC content: 65.08

Gene sequence:

>1389_bases
ATGACAGGGTTCACCCGCAGGCAGTTTCATCAATCGGTTCTCAGTGCCGCAGCGGCAGCAGCACTGCCGAGCGTCGCAGG
GGCTCAGACGGCGCCCGTGCTTCATGCGCGGACGGGCAGCGCGCGGCTTGCGCCGGCACAATACCCGGAAACGCGGATTT
GGGGGTATGACGGCACCGTGCCGGGGCCGATCCTGCGCGCCCAACAGGGACAGCGCATCGGCAGGGTCTTTCAAAATGAC
CTGCCGCAGGCGTCATCCGTGCACTGGCACGGCATTCGGATCGAAAACGCCATGGATGGGGTGCCGGGCATGACGCAAGC
GGCGGTGGAACCGGGCGCGGCGTTTCTGTATGATTTCGTGCTGCCGGACGCGGGCACCTATTGGTATCACCCGCATAACC
GCACCTATGAGCAGATGGCGCGTGGCCTTTATGGCGCGCTGATCGTGGATGAGGCGACAGGCGCGCCCGAGGTCGATCTG
GACGAGGTGTTGCTGCTGGATGATTGGCGTCTGAATGATGACGCCCAGATCGCCGAAGGGTTTGGCAACATGCGTGACTG
GTCCCATGCGGGCCGGATCGGCAACTGGATCACGGTGAACGGCGATGGCGGCTGGTCGCGCGCGGTGCCGCGTCTTGCCC
GGATGCGGCTGCGCCTTGTGAACACGGCCAATGCGCGGATTTTCACGCTGGCGGCGCGCGGTCTTGAGGGCTGGGTGGTC
GCTCTGGACGGGATGCCGCTTGCGGCTCCGCAGCCGCTGGCTGAACTGACACTTGCCCCGGCACAGCGCGCTGACCTGAT
CGTCGATGTGGTGGCTGGTGAGGGGGAAGAAGCCTTTCTCGTCAGCTATGAGCGCGACGGCGGCTATGCCGTTGCGGCTT
TCCCGGTCACCCGTTCGGCGCGGGAAATGCGCATGACCGCACCTGTTGCCTTACCCCCAAACCCGGTGCCTGCACTCGGC
CCGCTGGAGAGCGCGCGGCGCGCTGATCTGCTGATGGAGGGCGGGGCCATGGGCGCCATGGCGGGCGCGATGATGGGCGG
TCAAAGGATGGAAATGCGCGAGATGGTCGCTGCCGGAAAGGTCTGGGCGTTCAACGGCATGGCCGATATGGCTGACACCC
CCCTCATCGAGGCAAACCGTGGCGAGACCGTGCGGATCGCGATGACCAACGACACCCGCTGGCAGCATGGGATGCATCTG
CATGGGCATCATTTCAGGCAGATTGGGCGCGATGGCGCTTTGGGTCCGCTGCGGGACACGCTGCTGATGAACCGGGGCGA
GACGGCTGAGATCGCCTTTGTCGCGGATAATCCGGGCGATTGGCTGCTGCATTGCCATATGCTGGAGCATTCCGCGGGCG
GGATGATGACCTGGTTGCGCGTCCTGTAA

Upstream 100 bases:

>100_bases
TCATCACCGTGACACCCCTGCCGGGCAAAGGCCCCGGCGCATCGACACCACTTATGTTGCCACCCATCGGGGCGGCAGGG
CACACATCAGGAGACGCGGC

Downstream 100 bases:

>100_bases
CGCGCCATCTGACGAACACACGTAACAGGAGATACAAAATGAACCGCAGACGCTTTATCTTTAACAGCCTCGCCTCCGGC
CTTGGGGCCGGGATGCTCGC

Product: multicopper oxidase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTGFTRRQFHQSVLSAAAAAALPSVAGAQTAPVLHARTGSARLAPAQYPETRIWGYDGTVPGPILRAQQGQRIGRVFQND
LPQASSVHWHGIRIENAMDGVPGMTQAAVEPGAAFLYDFVLPDAGTYWYHPHNRTYEQMARGLYGALIVDEATGAPEVDL
DEVLLLDDWRLNDDAQIAEGFGNMRDWSHAGRIGNWITVNGDGGWSRAVPRLARMRLRLVNTANARIFTLAARGLEGWVV
ALDGMPLAAPQPLAELTLAPAQRADLIVDVVAGEGEEAFLVSYERDGGYAVAAFPVTRSAREMRMTAPVALPPNPVPALG
PLESARRADLLMEGGAMGAMAGAMMGGQRMEMREMVAAGKVWAFNGMADMADTPLIEANRGETVRIAMTNDTRWQHGMHL
HGHHFRQIGRDGALGPLRDTLLMNRGETAEIAFVADNPGDWLLHCHMLEHSAGGMMTWLRVL

Sequences:

>Translated_462_residues
MTGFTRRQFHQSVLSAAAAAALPSVAGAQTAPVLHARTGSARLAPAQYPETRIWGYDGTVPGPILRAQQGQRIGRVFQND
LPQASSVHWHGIRIENAMDGVPGMTQAAVEPGAAFLYDFVLPDAGTYWYHPHNRTYEQMARGLYGALIVDEATGAPEVDL
DEVLLLDDWRLNDDAQIAEGFGNMRDWSHAGRIGNWITVNGDGGWSRAVPRLARMRLRLVNTANARIFTLAARGLEGWVV
ALDGMPLAAPQPLAELTLAPAQRADLIVDVVAGEGEEAFLVSYERDGGYAVAAFPVTRSAREMRMTAPVALPPNPVPALG
PLESARRADLLMEGGAMGAMAGAMMGGQRMEMREMVAAGKVWAFNGMADMADTPLIEANRGETVRIAMTNDTRWQHGMHL
HGHHFRQIGRDGALGPLRDTLLMNRGETAEIAFVADNPGDWLLHCHMLEHSAGGMMTWLRVL
>Mature_461_residues
TGFTRRQFHQSVLSAAAAAALPSVAGAQTAPVLHARTGSARLAPAQYPETRIWGYDGTVPGPILRAQQGQRIGRVFQNDL
PQASSVHWHGIRIENAMDGVPGMTQAAVEPGAAFLYDFVLPDAGTYWYHPHNRTYEQMARGLYGALIVDEATGAPEVDLD
EVLLLDDWRLNDDAQIAEGFGNMRDWSHAGRIGNWITVNGDGGWSRAVPRLARMRLRLVNTANARIFTLAARGLEGWVVA
LDGMPLAAPQPLAELTLAPAQRADLIVDVVAGEGEEAFLVSYERDGGYAVAAFPVTRSAREMRMTAPVALPPNPVPALGP
LESARRADLLMEGGAMGAMAGAMMGGQRMEMREMVAAGKVWAFNGMADMADTPLIEANRGETVRIAMTNDTRWQHGMHLH
GHHFRQIGRDGALGPLRDTLLMNRGETAEIAFVADNPGDWLLHCHMLEHSAGGMMTWLRVL

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=524, Percent_Identity=28.0534351145038, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1789394, Length=340, Percent_Identity=27.3529411764706, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=446, Percent_Identity=24.6636771300448, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321067, Length=514, Percent_Identity=21.7898832684825, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI18859919, Length=245, Percent_Identity=27.7551020408163, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574104, Length=163, Percent_Identity=31.2883435582822, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 50131; Mature: 50000

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFTRRQFHQSVLSAAAAAALPSVAGAQTAPVLHARTGSARLAPAQYPETRIWGYDGTV
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCC
PGPILRAQQGQRIGRVFQNDLPQASSVHWHGIRIENAMDGVPGMTQAAVEPGAAFLYDFV
CCCHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCHHEEEEEC
LPDAGTYWYHPHNRTYEQMARGLYGALIVDEATGAPEVDLDEVLLLDDWRLNDDAQIAEG
CCCCCCEEECCCCCCHHHHHCCHHEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHH
FGNMRDWSHAGRIGNWITVNGDGGWSRAVPRLARMRLRLVNTANARIFTLAARGLEGWVV
CCCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCEEEE
ALDGMPLAAPQPLAELTLAPAQRADLIVDVVAGEGEEAFLVSYERDGGYAVAAFPVTRSA
EECCCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCCH
REMRMTAPVALPPNPVPALGPLESARRADLLMEGGAMGAMAGAMMGGQRMEMREMVAAGK
HHHEEECCEECCCCCCCCCCCHHHHHHHHHEECCCCHHHHHHHHHCCCHHHHHHHHHCCC
VWAFNGMADMADTPLIEANRGETVRIAMTNDTRWQHGMHLHGHHFRQIGRDGALGPLRDT
EEEECCCHHHCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCHHHHH
LLMNRGETAEIAFVADNPGDWLLHCHMLEHSAGGMMTWLRVL
HHHCCCCCEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHC
>Mature Secondary Structure 
TGFTRRQFHQSVLSAAAAAALPSVAGAQTAPVLHARTGSARLAPAQYPETRIWGYDGTV
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCC
PGPILRAQQGQRIGRVFQNDLPQASSVHWHGIRIENAMDGVPGMTQAAVEPGAAFLYDFV
CCCHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCHHEEEEEC
LPDAGTYWYHPHNRTYEQMARGLYGALIVDEATGAPEVDLDEVLLLDDWRLNDDAQIAEG
CCCCCCEEECCCCCCHHHHHCCHHEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHH
FGNMRDWSHAGRIGNWITVNGDGGWSRAVPRLARMRLRLVNTANARIFTLAARGLEGWVV
CCCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCEEEE
ALDGMPLAAPQPLAELTLAPAQRADLIVDVVAGEGEEAFLVSYERDGGYAVAAFPVTRSA
EECCCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCCH
REMRMTAPVALPPNPVPALGPLESARRADLLMEGGAMGAMAGAMMGGQRMEMREMVAAGK
HHHEEECCEECCCCCCCCCCCHHHHHHHHHEECCCCHHHHHHHHHCCCHHHHHHHHHCCC
VWAFNGMADMADTPLIEANRGETVRIAMTNDTRWQHGMHLHGHHFRQIGRDGALGPLRDT
EEEECCCHHHCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCHHHHH
LLMNRGETAEIAFVADNPGDWLLHCHMLEHSAGGMMTWLRVL
HHHCCCCCEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]