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The map label for this gene is rnd [H]

Identifier: 110679520

GI number: 110679520

Start: 2157298

End: 2158461

Strand: Direct

Name: rnd [H]

Synonym: RD1_2254

Alternate gene names: 110679520

Gene position: 2157298-2158461 (Clockwise)

Preceding gene: 110679519

Following gene: 110679522

Centisome position: 52.2

GC content: 60.57

Gene sequence:

>1164_bases
ATGAAAACCATCACAACGACACAAGCGCTGGCCGAGTTCTGCACGCAGGCAGCCCAGTTCGATTATGTGACGGTCGACAC
GGAATTCCTCAGAGAGCGCACGTATTATTCCAAGCTGTGCCTTATCCAGCTTGCCATGCCGGGGGAGGATGACAGCACCG
GCTGTATCGTGGACCCGCTCGCGCCGGGGTTGTCGCTTGAACCGCTCTATGCGCTGTTTCGCGACACATCCGTGGTCAAG
GTGTTTCACGCCGCTCGGCAGGATCTCGAAATCTTTTACGTCGATGCCGAAGTCTTTCCCGAGCCGTTGTTTGACACGCA
GGTCGCAGCCATGGTCTGCGGCTTTGGCGAGCAGGTGGGCTATGAAACGCTGGTGCGCCGGATTGCCAAAAAGCCGCTGG
ACAAGACCTCACGCTTTACCGATTGGTCGCGCCGCCCGTTGACGGATGCGCAGATGAAATATGCCTTGGCCGATGTCACC
CATCTGCGGGAGGTCTATGAGTTTCTGGCAGAAAAGCTCGAAGAAACCGGGCGCAGCCGCTGGGTGCGTGAGGAGTTGAC
CGTTCTGACCAGCCCGGAAACCTATATCATTGCACCGATGGACGCGTGGCGGCGGGTGAAAACGCGCACCAATTCGCCCA
AGTTTCTCGCCGTGGTGCGGGAGTTGGCAGCTTTCCGCGAGACCTATGCGCAGGAGCGCAACGTCCCCCGTAACCGTGTG
TTCAAGGATGATGCGCTGATCGAACTGGCCTCCAACAAGCCAAAGACGCAGGAAGAACTGGGGCGCTCGCGGCTGCTGCT
GCGCGAGGGGCGGCGCGGCGATGTGGCGGATGGTATCTTACAGGCGGTCAAGCGCGGTGTGGAATGCCCGCAACAGGACA
TGCCCAAACCGGATAGATCACGCGACAAGCTGCAGGTGAACCCTGCGCTGGCGGATCTGTTGCGCGTCCTGCTCAAGGCC
AAGACGGAAAGCGCGGGTGTTGCGGCCAAGCTGATCGCTCCTGCAGCGGACCTTGATGCGATCGCCGCCGGCCTGCGCGA
TGTGCCGGCACTCAACGGATGGCGGCGCGAGGTGTTTGGCGAGGATGCGCTGCGGCTCTGTGAGGGAAAGATTGCCCTTG
CTGCGGAAGGGGCAAATGTGCGTATCGTCAACCTTGACGCATGA

Upstream 100 bases:

>100_bases
CTCGACGGGTGATGGGTGGTGCTGCTGGTCAATGCCACCCGGCTCGTGTAACGTCCCGTTACGGGGTGGACGCAAACATC
AAAAACAAAGAATTGCCCGA

Downstream 100 bases:

>100_bases
CCATGCGCTCAGCGCCGCCGCTCCAATGCGTTTTGCAGACCTTCAACCCGGATCGTGCGCGTCCCTGACAGTTCCTGATC
GGTGAGCGTGCGCGCAACGA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKTITTTQALAEFCTQAAQFDYVTVDTEFLRERTYYSKLCLIQLAMPGEDDSTGCIVDPLAPGLSLEPLYALFRDTSVVK
VFHAARQDLEIFYVDAEVFPEPLFDTQVAAMVCGFGEQVGYETLVRRIAKKPLDKTSRFTDWSRRPLTDAQMKYALADVT
HLREVYEFLAEKLEETGRSRWVREELTVLTSPETYIIAPMDAWRRVKTRTNSPKFLAVVRELAAFRETYAQERNVPRNRV
FKDDALIELASNKPKTQEELGRSRLLLREGRRGDVADGILQAVKRGVECPQQDMPKPDRSRDKLQVNPALADLLRVLLKA
KTESAGVAAKLIAPAADLDAIAAGLRDVPALNGWRREVFGEDALRLCEGKIALAAEGANVRIVNLDA

Sequences:

>Translated_387_residues
MKTITTTQALAEFCTQAAQFDYVTVDTEFLRERTYYSKLCLIQLAMPGEDDSTGCIVDPLAPGLSLEPLYALFRDTSVVK
VFHAARQDLEIFYVDAEVFPEPLFDTQVAAMVCGFGEQVGYETLVRRIAKKPLDKTSRFTDWSRRPLTDAQMKYALADVT
HLREVYEFLAEKLEETGRSRWVREELTVLTSPETYIIAPMDAWRRVKTRTNSPKFLAVVRELAAFRETYAQERNVPRNRV
FKDDALIELASNKPKTQEELGRSRLLLREGRRGDVADGILQAVKRGVECPQQDMPKPDRSRDKLQVNPALADLLRVLLKA
KTESAGVAAKLIAPAADLDAIAAGLRDVPALNGWRREVFGEDALRLCEGKIALAAEGANVRIVNLDA
>Mature_387_residues
MKTITTTQALAEFCTQAAQFDYVTVDTEFLRERTYYSKLCLIQLAMPGEDDSTGCIVDPLAPGLSLEPLYALFRDTSVVK
VFHAARQDLEIFYVDAEVFPEPLFDTQVAAMVCGFGEQVGYETLVRRIAKKPLDKTSRFTDWSRRPLTDAQMKYALADVT
HLREVYEFLAEKLEETGRSRWVREELTVLTSPETYIIAPMDAWRRVKTRTNSPKFLAVVRELAAFRETYAQERNVPRNRV
FKDDALIELASNKPKTQEELGRSRLLLREGRRGDVADGILQAVKRGVECPQQDMPKPDRSRDKLQVNPALADLLRVLLKA
KTESAGVAAKLIAPAADLDAIAAGLRDVPALNGWRREVFGEDALRLCEGKIALAAEGANVRIVNLDA

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=310, Percent_Identity=21.9354838709677, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4505917, Length=310, Percent_Identity=21.9354838709677, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788105, Length=372, Percent_Identity=30.9139784946237, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17531757, Length=167, Percent_Identity=32.3353293413174, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=245, Percent_Identity=27.7551020408163, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43454; Mature: 43454

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTITTTQALAEFCTQAAQFDYVTVDTEFLRERTYYSKLCLIQLAMPGEDDSTGCIVDPL
CCCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHEEEEEEECCCCCCCCCEEECCC
APGLSLEPLYALFRDTSVVKVFHAARQDLEIFYVDAEVFPEPLFDTQVAAMVCGFGEQVG
CCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHCCCHHCC
YETLVRRIAKKPLDKTSRFTDWSRRPLTDAQMKYALADVTHLREVYEFLAEKLEETGRSR
HHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVREELTVLTSPETYIIAPMDAWRRVKTRTNSPKFLAVVRELAAFRETYAQERNVPRNRV
HHHHHHHEEECCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHC
FKDDALIELASNKPKTQEELGRSRLLLREGRRGDVADGILQAVKRGVECPQQDMPKPDRS
CCCCHHHEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCC
RDKLQVNPALADLLRVLLKAKTESAGVAAKLIAPAADLDAIAAGLRDVPALNGWRREVFG
CCCEEECHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHH
EDALRLCEGKIALAAEGANVRIVNLDA
HHHHHHHCCCEEEEECCCEEEEEEECC
>Mature Secondary Structure
MKTITTTQALAEFCTQAAQFDYVTVDTEFLRERTYYSKLCLIQLAMPGEDDSTGCIVDPL
CCCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHEEEEEEECCCCCCCCCEEECCC
APGLSLEPLYALFRDTSVVKVFHAARQDLEIFYVDAEVFPEPLFDTQVAAMVCGFGEQVG
CCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHCCCHHCC
YETLVRRIAKKPLDKTSRFTDWSRRPLTDAQMKYALADVTHLREVYEFLAEKLEETGRSR
HHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVREELTVLTSPETYIIAPMDAWRRVKTRTNSPKFLAVVRELAAFRETYAQERNVPRNRV
HHHHHHHEEECCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHC
FKDDALIELASNKPKTQEELGRSRLLLREGRRGDVADGILQAVKRGVECPQQDMPKPDRS
CCCCHHHEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCC
RDKLQVNPALADLLRVLLKAKTESAGVAAKLIAPAADLDAIAAGLRDVPALNGWRREVFG
CCCEEECHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHH
EDALRLCEGKIALAAEGANVRIVNLDA
HHHHHHHCCCEEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]