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The map label for this gene is ykoW [H]

Identifier: 110679489

GI number: 110679489

Start: 2119485

End: 2121842

Strand: Reverse

Name: ykoW [H]

Synonym: RD1_2218

Alternate gene names: 110679489

Gene position: 2121842-2119485 (Counterclockwise)

Preceding gene: 110679491

Following gene: 110679487

Centisome position: 51.34

GC content: 54.66

Gene sequence:

>2358_bases
ATGCGCTGGAGCAGAGGGGAAACGCATGAGCTCACAGATCAGCACGGCACATCGCATAGTGTTCCCGGTGATTTTTCCGG
CAAGGCGTACTGCCTGCATTCTGGCGGCATGGAGGCATTGCGCATGACACAACAGAACACTGTCCCGATCCACCGCGACC
CCGATCAATCACTTCATCTCGCAAATGTGTCGGCGCTGCAGCGGTTTCGCATTCTCGACAGCGCACCCGAAGCAGCCTTC
GATCATATTGTTGAAATTGCCTCGCGTGTTTTTTCGGTTCCTATTGTTCTCGTCTCCTTGATCGATCTCAACCGACAGTG
GTTCAAGGCCAAGGTTGGCTTGGAATTATGCGAGACAAACCTTGATGTCTCCTTTTGCACCTACGCCGTGCGCCAGAACG
ATGTGATGGTCATTCCTGATGCGACCAAGGACGCCCGCTTTGCAAATAACGAACTTGTCAGGGGACCAGACGGCATTCGT
TTTTATGCGGGTGCGCCACTGCGCACCGCCGACGGTTTTGTTGTGGGGACATTATGTCTGGTTGATGGGGTTCCACATCT
GGACTTTGGGTCCGAAGACCGCGCACTCCTTGCGAAACTGGCGGTTCTTGTTGTCGACCTGATGGAAGGGCGCGCCAGCC
ATCAGGCGAGTTTGGAGGCGAAAAGCAAACTGGAGGATTTCACAACCGCATCACTCGATATTTTCTGGGAAACAGATGTC
GAGCATCGGTTTACCCGTTTGTCTTCCGAAACAATGCCCGGCATGTCGGCCAGCGCCAACCCCTGGGACTCAGGGCTGGA
AAGCATGGTGGGCCATAAAAGATGGGACATCCTGAAGGTGGATACGACGCGCGAGCCCTGGCGTTCTCACCTGAAACTTC
TGGAAGCTCGCAAGCCCTTTCGAGATTTGCGCTATGCCAAGGAGTTTGACGGCAAACTCATGTATTTTTCGGTAAGCGGA
CGACCGGTTTTCGACAAGGACGGTGCATTTCTTGGCTACCGAGGCGCGACGCAGAATGTCACCGAACAAGAGCAATCGAG
ACTTGAGGCGGAAAGGTTGGCCAATTCGGACCCGCTGACGGGCCTTGCCAACCGCCGCTGTTGGAACGCGGCCCTGCGCG
AGCGTCTCAACGCGGATGAGATACCCCCGACGGGCATTTTGCTGTTCGACGTGGATCGGTTCAAGGACATAAATGACGCG
CTCGGGCATGCCGTCGGTGATCGCCTGCTGATCGAAATCGCCAAGCGTATTGTGAATTGTTCGCTGAAAACATCGCTCGC
CGCGCGCCTTGGCGGGGATGAGTTCGCTTTGATGATAGAAGGCAAGAACAAAGATACGGTGCGTTCAGCCGATTGCATCT
TGCAGGCGATGAAACAGCCTTTCGAAATTGACGGGCACAATCTGCATGTCGAGCTTTCGATCGGGATAAAACTGGTTGGA
ACGCGCGAATTTGAATGCGACAGGATCATGGTCGACGCGGACCTCGCATTGCGAACGGCCAAGATGCAAGGCCGCAGTCG
GCATGTCGTTTATGAACCGAGCATGCGCAAAGAGAATGACAGCCGCATAACGCTCACCGCACAATTCGAGCGCGCATTGC
AGAATAACGAATTCGAGCTGCATTTTCAGCCGCAGATACGTCTTTCAAACGATACTGTCGTCGGTGTCGAGAGCCTGCTG
CGGTGGAACCATCCGGAACGCGGGTTATTGTTTCCCAATCAGTTTCTGAACGCACTTGAAACATCTGCATATGACATTCC
CGCAGGCCAGCAAGTGATCGACCTTGCCTGCAAACAAGCGCGGATCTGGCAGGATTTGGGCACGCCAGTGCGGGTCGGGA
TCAATGTATCGGCCAGCCAGCTTTACGGGGACAACCTGCCGAAGGTCCTGAATGACGCAATGACCCGGCATGGCACAGCA
CCCGCTTTGATCGAGGTTGAGGTCACCGAGCGCGTCGCGCTTGGCAACGTGGAGAAAATCACCTCAGTGCTTGAAGCCAT
ACGCGACTTGGGCGTTACGATTGCCTTTGATGACTTCGGAACCGGCTTTGCATCTCTGAGTTCTTTGATGCAATTCCCGC
TGGACCGGGTCAAAGTCGACCAGCGGTTCATTACCGATCTTCACAAGAATCCGGCCAACACGCGGCTGACAAGCGGTCTG
ATACGCCTGTGCCATAGCCTCGGTTTTGAAGTCATCGCCGAGGGTGTGGAAAAGCACGCGCATGAAACCTTTCTGCGCAA
ACAGAATTGCGACGAGGTACAGGGGTATCTGTACAGCAAACCGGTAAGTGCGCAGAAAACGACAGATTTCCTGATCAAAG
GAAAACATGCGCAAACACGAAGGAAGCAGGCAGGCTGA

Upstream 100 bases:

>100_bases
ACCCGCGCTCAAATGCGACCGATTTGATGTAAATGCGCAAAATCCAATGCATTGTTGCAAAAGGAATTTCAGAAAAAATT
AGAGCTTTGATGGGCACCTT

Downstream 100 bases:

>100_bases
CGGGTGGGTCGGTTTTCCTGCTCGCTGGTCAAAAACCGCAGAACTTGCTGCCGGGGTCCATGCGCGGGTTGGCATACCTG
CCAAATGCGTGCCATCAATG

Product: sensory box/GGDEF family protein, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MRWSRGETHELTDQHGTSHSVPGDFSGKAYCLHSGGMEALRMTQQNTVPIHRDPDQSLHLANVSALQRFRILDSAPEAAF
DHIVEIASRVFSVPIVLVSLIDLNRQWFKAKVGLELCETNLDVSFCTYAVRQNDVMVIPDATKDARFANNELVRGPDGIR
FYAGAPLRTADGFVVGTLCLVDGVPHLDFGSEDRALLAKLAVLVVDLMEGRASHQASLEAKSKLEDFTTASLDIFWETDV
EHRFTRLSSETMPGMSASANPWDSGLESMVGHKRWDILKVDTTREPWRSHLKLLEARKPFRDLRYAKEFDGKLMYFSVSG
RPVFDKDGAFLGYRGATQNVTEQEQSRLEAERLANSDPLTGLANRRCWNAALRERLNADEIPPTGILLFDVDRFKDINDA
LGHAVGDRLLIEIAKRIVNCSLKTSLAARLGGDEFALMIEGKNKDTVRSADCILQAMKQPFEIDGHNLHVELSIGIKLVG
TREFECDRIMVDADLALRTAKMQGRSRHVVYEPSMRKENDSRITLTAQFERALQNNEFELHFQPQIRLSNDTVVGVESLL
RWNHPERGLLFPNQFLNALETSAYDIPAGQQVIDLACKQARIWQDLGTPVRVGINVSASQLYGDNLPKVLNDAMTRHGTA
PALIEVEVTERVALGNVEKITSVLEAIRDLGVTIAFDDFGTGFASLSSLMQFPLDRVKVDQRFITDLHKNPANTRLTSGL
IRLCHSLGFEVIAEGVEKHAHETFLRKQNCDEVQGYLYSKPVSAQKTTDFLIKGKHAQTRRKQAG

Sequences:

>Translated_785_residues
MRWSRGETHELTDQHGTSHSVPGDFSGKAYCLHSGGMEALRMTQQNTVPIHRDPDQSLHLANVSALQRFRILDSAPEAAF
DHIVEIASRVFSVPIVLVSLIDLNRQWFKAKVGLELCETNLDVSFCTYAVRQNDVMVIPDATKDARFANNELVRGPDGIR
FYAGAPLRTADGFVVGTLCLVDGVPHLDFGSEDRALLAKLAVLVVDLMEGRASHQASLEAKSKLEDFTTASLDIFWETDV
EHRFTRLSSETMPGMSASANPWDSGLESMVGHKRWDILKVDTTREPWRSHLKLLEARKPFRDLRYAKEFDGKLMYFSVSG
RPVFDKDGAFLGYRGATQNVTEQEQSRLEAERLANSDPLTGLANRRCWNAALRERLNADEIPPTGILLFDVDRFKDINDA
LGHAVGDRLLIEIAKRIVNCSLKTSLAARLGGDEFALMIEGKNKDTVRSADCILQAMKQPFEIDGHNLHVELSIGIKLVG
TREFECDRIMVDADLALRTAKMQGRSRHVVYEPSMRKENDSRITLTAQFERALQNNEFELHFQPQIRLSNDTVVGVESLL
RWNHPERGLLFPNQFLNALETSAYDIPAGQQVIDLACKQARIWQDLGTPVRVGINVSASQLYGDNLPKVLNDAMTRHGTA
PALIEVEVTERVALGNVEKITSVLEAIRDLGVTIAFDDFGTGFASLSSLMQFPLDRVKVDQRFITDLHKNPANTRLTSGL
IRLCHSLGFEVIAEGVEKHAHETFLRKQNCDEVQGYLYSKPVSAQKTTDFLIKGKHAQTRRKQAG
>Mature_785_residues
MRWSRGETHELTDQHGTSHSVPGDFSGKAYCLHSGGMEALRMTQQNTVPIHRDPDQSLHLANVSALQRFRILDSAPEAAF
DHIVEIASRVFSVPIVLVSLIDLNRQWFKAKVGLELCETNLDVSFCTYAVRQNDVMVIPDATKDARFANNELVRGPDGIR
FYAGAPLRTADGFVVGTLCLVDGVPHLDFGSEDRALLAKLAVLVVDLMEGRASHQASLEAKSKLEDFTTASLDIFWETDV
EHRFTRLSSETMPGMSASANPWDSGLESMVGHKRWDILKVDTTREPWRSHLKLLEARKPFRDLRYAKEFDGKLMYFSVSG
RPVFDKDGAFLGYRGATQNVTEQEQSRLEAERLANSDPLTGLANRRCWNAALRERLNADEIPPTGILLFDVDRFKDINDA
LGHAVGDRLLIEIAKRIVNCSLKTSLAARLGGDEFALMIEGKNKDTVRSADCILQAMKQPFEIDGHNLHVELSIGIKLVG
TREFECDRIMVDADLALRTAKMQGRSRHVVYEPSMRKENDSRITLTAQFERALQNNEFELHFQPQIRLSNDTVVGVESLL
RWNHPERGLLFPNQFLNALETSAYDIPAGQQVIDLACKQARIWQDLGTPVRVGINVSASQLYGDNLPKVLNDAMTRHGTA
PALIEVEVTERVALGNVEKITSVLEAIRDLGVTIAFDDFGTGFASLSSLMQFPLDRVKVDQRFITDLHKNPANTRLTSGL
IRLCHSLGFEVIAEGVEKHAHETFLRKQNCDEVQGYLYSKPVSAQKTTDFLIKGKHAQTRRKQAG

Specific function: Probable signaling protein whose physiological role is not yet known [H]

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=440, Percent_Identity=34.0909090909091, Blast_Score=269, Evalue=5e-73,
Organism=Escherichia coli, GI87081921, Length=434, Percent_Identity=30.184331797235, Blast_Score=206, Evalue=7e-54,
Organism=Escherichia coli, GI226510982, Length=439, Percent_Identity=24.373576309795, Blast_Score=161, Evalue=2e-40,
Organism=Escherichia coli, GI1790496, Length=244, Percent_Identity=30.7377049180328, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1786507, Length=264, Percent_Identity=28.4090909090909, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI87081845, Length=237, Percent_Identity=32.4894514767932, Blast_Score=120, Evalue=4e-28,
Organism=Escherichia coli, GI87081980, Length=259, Percent_Identity=30.5019305019305, Blast_Score=120, Evalue=5e-28,
Organism=Escherichia coli, GI87081743, Length=251, Percent_Identity=28.6852589641434, Blast_Score=119, Evalue=1e-27,
Organism=Escherichia coli, GI1788502, Length=248, Percent_Identity=29.0322580645161, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1787055, Length=271, Percent_Identity=28.4132841328413, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1788381, Length=435, Percent_Identity=25.7471264367816, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788956, Length=171, Percent_Identity=38.0116959064327, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788849, Length=441, Percent_Identity=24.7165532879819, Blast_Score=90, Evalue=7e-19,
Organism=Escherichia coli, GI87082096, Length=254, Percent_Identity=23.6220472440945, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1786584, Length=180, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI145693134, Length=164, Percent_Identity=31.7073170731707, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787410, Length=137, Percent_Identity=29.9270072992701, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87081881, Length=173, Percent_Identity=32.3699421965318, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1787802, Length=165, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1787816, Length=161, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1787262, Length=172, Percent_Identity=30.8139534883721, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 87797; Mature: 87797

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50113 PAC ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWSRGETHELTDQHGTSHSVPGDFSGKAYCLHSGGMEALRMTQQNTVPIHRDPDQSLHL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEE
ANVSALQRFRILDSAPEAAFDHIVEIASRVFSVPIVLVSLIDLNRQWFKAKVGLELCETN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
LDVSFCTYAVRQNDVMVIPDATKDARFANNELVRGPDGIRFYAGAPLRTADGFVVGTLCL
CCHHHHEEEECCCCEEEECCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHH
VDGVPHLDFGSEDRALLAKLAVLVVDLMEGRASHQASLEAKSKLEDFTTASLDIFWETDV
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCH
EHRFTRLSSETMPGMSASANPWDSGLESMVGHKRWDILKVDTTREPWRSHLKLLEARKPF
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCH
RDLRYAKEFDGKLMYFSVSGRPVFDKDGAFLGYRGATQNVTEQEQSRLEAERLANSDPLT
HHHHHHHHCCCEEEEEEECCCEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
GLANRRCWNAALRERLNADEIPPTGILLFDVDRFKDINDALGHAVGDRLLIEIAKRIVNC
CHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
SLKTSLAARLGGDEFALMIEGKNKDTVRSADCILQAMKQPFEIDGHNLHVELSIGIKLVG
HHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEECCCEEEEEEEEEEEEEE
TREFECDRIMVDADLALRTAKMQGRSRHVVYEPSMRKENDSRITLTAQFERALQNNEFEL
CCCCCCCEEEEECHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEHHHHHHHCCCCEEE
HFQPQIRLSNDTVVGVESLLRWNHPERGLLFPNQFLNALETSAYDIPAGQQVIDLACKQA
EECCEEEECCCCEECHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
RIWQDLGTPVRVGINVSASQLYGDNLPKVLNDAMTRHGTAPALIEVEVTERVALGNVEKI
HHHHHCCCCEEEEEECCHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEEHHHHHCCCHHHH
TSVLEAIRDLGVTIAFDDFGTGFASLSSLMQFPLDRVKVDQRFITDLHKNPANTRLTSGL
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
IRLCHSLGFEVIAEGVEKHAHETFLRKQNCDEVQGYLYSKPVSAQKTTDFLIKGKHAQTR
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHEEECCCHHHH
RKQAG
HHCCC
>Mature Secondary Structure
MRWSRGETHELTDQHGTSHSVPGDFSGKAYCLHSGGMEALRMTQQNTVPIHRDPDQSLHL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEE
ANVSALQRFRILDSAPEAAFDHIVEIASRVFSVPIVLVSLIDLNRQWFKAKVGLELCETN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
LDVSFCTYAVRQNDVMVIPDATKDARFANNELVRGPDGIRFYAGAPLRTADGFVVGTLCL
CCHHHHEEEECCCCEEEECCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHH
VDGVPHLDFGSEDRALLAKLAVLVVDLMEGRASHQASLEAKSKLEDFTTASLDIFWETDV
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCH
EHRFTRLSSETMPGMSASANPWDSGLESMVGHKRWDILKVDTTREPWRSHLKLLEARKPF
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCH
RDLRYAKEFDGKLMYFSVSGRPVFDKDGAFLGYRGATQNVTEQEQSRLEAERLANSDPLT
HHHHHHHHCCCEEEEEEECCCEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
GLANRRCWNAALRERLNADEIPPTGILLFDVDRFKDINDALGHAVGDRLLIEIAKRIVNC
CHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
SLKTSLAARLGGDEFALMIEGKNKDTVRSADCILQAMKQPFEIDGHNLHVELSIGIKLVG
HHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEECCCEEEEEEEEEEEEEE
TREFECDRIMVDADLALRTAKMQGRSRHVVYEPSMRKENDSRITLTAQFERALQNNEFEL
CCCCCCCEEEEECHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEHHHHHHHCCCCEEE
HFQPQIRLSNDTVVGVESLLRWNHPERGLLFPNQFLNALETSAYDIPAGQQVIDLACKQA
EECCEEEECCCCEECHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
RIWQDLGTPVRVGINVSASQLYGDNLPKVLNDAMTRHGTAPALIEVEVTERVALGNVEKI
HHHHHCCCCEEEEEECCHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEEHHHHHCCCHHHH
TSVLEAIRDLGVTIAFDDFGTGFASLSSLMQFPLDRVKVDQRFITDLHKNPANTRLTSGL
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
IRLCHSLGFEVIAEGVEKHAHETFLRKQNCDEVQGYLYSKPVSAQKTTDFLIKGKHAQTR
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHEEECCCHHHH
RKQAG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 11728710 [H]