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The map label for this gene is lysC [H]

Identifier: 110679431

GI number: 110679431

Start: 2052577

End: 2053815

Strand: Direct

Name: lysC [H]

Synonym: RD1_2157

Alternate gene names: 110679431

Gene position: 2052577-2053815 (Clockwise)

Preceding gene: 110679430

Following gene: 110679432

Centisome position: 49.66

GC content: 56.66

Gene sequence:

>1239_bases
ATGCCTGTTCTGGTAATGAAATTCGGGGGGACATCGGTCGCGACGCTGGACCGTATCCGGCGCGTGGCAAAACGGGTCGG
GGTCGAAGTGGCCAAGGGCTATGATGTCATTGTGATTGTCTCGGCGATGTCGGGTAAAACCAATGAATTGGTCGGCTGGG
TCAATGAAATTTCGCCCCTTCATGATGCGCGCGAATATGATGCTGTTGTCTCCTCCGGTGAGAATGTGACGGCGGGCCTC
ATGGCTCTGACCTTGCAGGAAATGGACGTGCCTGCGCGCAGTTGGCAAGGCTGGCAGGTGCCGGTCCGAACCACCAATGC
GCATTCCTCCGCCCGGATCGAAGAGATTCCAACCGAAAATATACGTGCAAAATTCGCCGAAGGGATGCGGGTCGCTGTTG
TCGCGGGGTTTCAAGGCCTCAGCCCGGAAGGGCGCATCACAACGCTGGGGCGCGGCGGGTCGGACACCACGGCCGTCGCC
TTTGCCGCTGCTTTTGAGGCAGAGCGCTGCGATATCTATACCGATGTCGATGGGGTCTATACAACCGATCCTCGCGTCAG
CGCCAAGGCGCGCAAGCTTGACAAGATCGCCTTTGAAGAGATGCTTGAATTGGCATCATTGGGGGCAAAGGTTCTGCAGA
CCCGCTCGGTCGAGCTGGCAATGCGCTACAAAGTGAAACTGCGCGTGTTGAGCAGTTTCGAAGAACAATCTGACACAGCG
GGAACGCTGGTGTGTGATGAGGAGGAAATCATGGAAAGCAATGTAGTCGCCGGTGTCGCCTTCAGCCGCGATGAGGCCAA
AATGACCCTTCTCAGCGTCGCCGACCGACCCGGAATCGCAGCGAACATCTTCACCGCGCTCAGCGATGCGGGTGTCAACG
TGGATATGATCGTGCAGAATATTGCCGAAGAAGGGCGCACCGACATGACGTGGTCCTGCCCCACCGATCATGTGGCCCGC
GCCCAGAAAGCGGTGGAAAATGCGAAATCCGAAGGGGTTATCAACTACCACGAGGTCATCGCGGATCTTGATGTGGCCAA
AGTGTCGGTGGTTGGAATCGGTATGCGCAGCCATACGGGTGTCGCTGCCAAGATGTTTCAGGTACTCAGTGCCGAAGGCA
TCAACATCAAGGTCATAACGACCTCGGAAATCAAGATTTCTGTCCTCATTGACCGGAAATACATGGAACTTGCCGTGCAG
GCCCTGCATGATGCCTTCGAATTGGAAAAGGCCGCCTGA

Upstream 100 bases:

>100_bases
TCCGGGGATCGGGATGCAGATGCTTTGGGCGTTTGCAAAGTACTTGTGTGTCATGGGCGTTGCGCGTAAACCCGCCGCGA
CTGATGCAAGGGACGCACAA

Downstream 100 bases:

>100_bases
CCGTCACACGCAAAATGGCGTCGCGCATATGGGAAGGAAGCATACGTGGCTGAACGTCTCGAGAGTGAATCGCGCAAACT
GCTGGGGCGATTGCGCGATG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MPVLVMKFGGTSVATLDRIRRVAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVNEISPLHDAREYDAVVSSGENVTAGL
MALTLQEMDVPARSWQGWQVPVRTTNAHSSARIEEIPTENIRAKFAEGMRVAVVAGFQGLSPEGRITTLGRGGSDTTAVA
FAAAFEAERCDIYTDVDGVYTTDPRVSAKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDTA
GTLVCDEEEIMESNVVAGVAFSRDEAKMTLLSVADRPGIAANIFTALSDAGVNVDMIVQNIAEEGRTDMTWSCPTDHVAR
AQKAVENAKSEGVINYHEVIADLDVAKVSVVGIGMRSHTGVAAKMFQVLSAEGINIKVITTSEIKISVLIDRKYMELAVQ
ALHDAFELEKAA

Sequences:

>Translated_412_residues
MPVLVMKFGGTSVATLDRIRRVAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVNEISPLHDAREYDAVVSSGENVTAGL
MALTLQEMDVPARSWQGWQVPVRTTNAHSSARIEEIPTENIRAKFAEGMRVAVVAGFQGLSPEGRITTLGRGGSDTTAVA
FAAAFEAERCDIYTDVDGVYTTDPRVSAKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDTA
GTLVCDEEEIMESNVVAGVAFSRDEAKMTLLSVADRPGIAANIFTALSDAGVNVDMIVQNIAEEGRTDMTWSCPTDHVAR
AQKAVENAKSEGVINYHEVIADLDVAKVSVVGIGMRSHTGVAAKMFQVLSAEGINIKVITTSEIKISVLIDRKYMELAVQ
ALHDAFELEKAA
>Mature_411_residues
PVLVMKFGGTSVATLDRIRRVAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVNEISPLHDAREYDAVVSSGENVTAGLM
ALTLQEMDVPARSWQGWQVPVRTTNAHSSARIEEIPTENIRAKFAEGMRVAVVAGFQGLSPEGRITTLGRGGSDTTAVAF
AAAFEAERCDIYTDVDGVYTTDPRVSAKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDTAG
TLVCDEEEIMESNVVAGVAFSRDEAKMTLLSVADRPGIAANIFTALSDAGVNVDMIVQNIAEEGRTDMTWSCPTDHVARA
QKAVENAKSEGVINYHEVIADLDVAKVSVVGIGMRSHTGVAAKMFQVLSAEGINIKVITTSEIKISVLIDRKYMELAVQA
LHDAFELEKAA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=288, Percent_Identity=32.6388888888889, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790455, Length=462, Percent_Identity=29.2207792207792, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790376, Length=466, Percent_Identity=24.0343347639485, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=313, Percent_Identity=28.1150159744409, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44515; Mature: 44384

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVLVMKFGGTSVATLDRIRRVAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVNEISPL
CCEEEEEECCCCHHHHHHHHHHHHHHCCEEECCCEEEEEEEECCCCCHHHHHHHHHHCHH
HDAREYDAVVSSGENVTAGLMALTLQEMDVPARSWQGWQVPVRTTNAHSSARIEEIPTEN
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCHH
IRAKFAEGMRVAVVAGFQGLSPEGRITTLGRGGSDTTAVAFAAAFEAERCDIYTDVDGVY
HHHHHHCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEE
TTDPRVSAKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDTA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCC
GTLVCDEEEIMESNVVAGVAFSRDEAKMTLLSVADRPGIAANIFTALSDAGVNVDMIVQN
CEEEECHHHHHHCCCEEEEEECCCCHHEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHH
IAEEGRTDMTWSCPTDHVARAQKAVENAKSEGVINYHEVIADLDVAKVSVVGIGMRSHTG
HHHCCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCHHEEEEEEECCCCCCC
VAAKMFQVLSAEGINIKVITTSEIKISVLIDRKYMELAVQALHDAFELEKAA
HHHHHHHHHCCCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVLVMKFGGTSVATLDRIRRVAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVNEISPL
CEEEEEECCCCHHHHHHHHHHHHHHCCEEECCCEEEEEEEECCCCCHHHHHHHHHHCHH
HDAREYDAVVSSGENVTAGLMALTLQEMDVPARSWQGWQVPVRTTNAHSSARIEEIPTEN
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCHH
IRAKFAEGMRVAVVAGFQGLSPEGRITTLGRGGSDTTAVAFAAAFEAERCDIYTDVDGVY
HHHHHHCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEE
TTDPRVSAKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDTA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCC
GTLVCDEEEIMESNVVAGVAFSRDEAKMTLLSVADRPGIAANIFTALSDAGVNVDMIVQN
CEEEECHHHHHHCCCEEEEEECCCCHHEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHH
IAEEGRTDMTWSCPTDHVARAQKAVENAKSEGVINYHEVIADLDVAKVSVVGIGMRSHTG
HHHCCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCHHEEEEEEECCCCCCC
VAAKMFQVLSAEGINIKVITTSEIKISVLIDRKYMELAVQALHDAFELEKAA
HHHHHHHHHCCCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]