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The map label for this gene is folD

Identifier: 110679383

GI number: 110679383

Start: 2008627

End: 2009529

Strand: Direct

Name: folD

Synonym: RD1_2105

Alternate gene names: 110679383

Gene position: 2008627-2009529 (Clockwise)

Preceding gene: 110679382

Following gene: 110679388

Centisome position: 48.6

GC content: 60.47

Gene sequence:

>903_bases
ATGTCAGCTACGCTCATTGATGGCAAAGCCTTTGCCGCGCGCGTGCGCGCGCAGGTCGCAGAGCATGTAACGCGGCTCAA
GGCCGACCACGGGATCACACCGGGCCTGGCGGTTGTGCTTGTTGGGCAAGACCCGGCAAGTCAGGTCTACGTGCGTTCCA
AGGGCAAACAGACCACCGAGGTGGGGATGAAATCGGTTGAGCATAAGCTGGATGCCGACACCTCGGAAACGGATTTGCTG
GCGGTTGTGGATCAATTGAACAAGGATCCTGACATCCACGGCATTCTGGTGCAACTGCCCTTGCCGGGGCACCTGGACGA
GGATCTCGTGATCAATTCGATTGCGCCGGAAAAGGACGTCGATGGCTTTCACATCTCGAACGTGGGGCTGTTGGGCACGG
GACAGAAAAGCATGGTGCCCTGCACGCCGCTGGGCTGTCTGATGATGCTGCGGGATTATCATGGTTCCCTCTTGGGGATG
GATGCGGTCGTCGTGGGACGTTCGAATATTGTCGGCAAACCGATGGCGCAGCTTTTGCTGGGTGATAGTTGCACCGTGAC
CATTGCCCATAGCCGCACCAAGGACCTTGCGGATGTCGTGCGCCGCGCCGACATTGTCGTGGCGGCGGTGGGGCGGCCCG
AAATGGTGCCGGGGGATTGGATCAAACCCGGCGCGACGGTGATAGATGTGGGCATCAACCGTCTGGATGCGCCGGAAAAG
GGCGAAGGCAAAACGCGCCTCGTGGGCGATGTGGATTTTGACAGCTGTGCGGCAGTTGCCGGGGCCATCACGCCTGTGCC
CGGCGGTGTAGGGCCGATGACCATCGCCTGCCTGCTGGCCAATACGGTCACTGCCTGTTGTCGTGCAAACGGTCTTGAGG
AACCCGAAGGGCTGACGGCTTAA

Upstream 100 bases:

>100_bases
ACGATCTTTTACAGTTGCTGGCCTTTGATGAGTTGATCATCAGTGACGGTCAAAACTGGGCCCACCGGGTCGATTTCATC
AGATGACGGAAGGGTCAGAT

Downstream 100 bases:

>100_bases
GCCGGATGCTTTGAGGTTGCGGGAACGGGCACCATCGTGCCCTGCAAGGCGGCGACGTGGCGTTCCTGTGCACCGTTCAT
CGCATAGACATCCGCGGCGA

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSATLIDGKAFAARVRAQVAEHVTRLKADHGITPGLAVVLVGQDPASQVYVRSKGKQTTEVGMKSVEHKLDADTSETDLL
AVVDQLNKDPDIHGILVQLPLPGHLDEDLVINSIAPEKDVDGFHISNVGLLGTGQKSMVPCTPLGCLMMLRDYHGSLLGM
DAVVVGRSNIVGKPMAQLLLGDSCTVTIAHSRTKDLADVVRRADIVVAAVGRPEMVPGDWIKPGATVIDVGINRLDAPEK
GEGKTRLVGDVDFDSCAAVAGAITPVPGGVGPMTIACLLANTVTACCRANGLEEPEGLTA

Sequences:

>Translated_300_residues
MSATLIDGKAFAARVRAQVAEHVTRLKADHGITPGLAVVLVGQDPASQVYVRSKGKQTTEVGMKSVEHKLDADTSETDLL
AVVDQLNKDPDIHGILVQLPLPGHLDEDLVINSIAPEKDVDGFHISNVGLLGTGQKSMVPCTPLGCLMMLRDYHGSLLGM
DAVVVGRSNIVGKPMAQLLLGDSCTVTIAHSRTKDLADVVRRADIVVAAVGRPEMVPGDWIKPGATVIDVGINRLDAPEK
GEGKTRLVGDVDFDSCAAVAGAITPVPGGVGPMTIACLLANTVTACCRANGLEEPEGLTA
>Mature_299_residues
SATLIDGKAFAARVRAQVAEHVTRLKADHGITPGLAVVLVGQDPASQVYVRSKGKQTTEVGMKSVEHKLDADTSETDLLA
VVDQLNKDPDIHGILVQLPLPGHLDEDLVINSIAPEKDVDGFHISNVGLLGTGQKSMVPCTPLGCLMMLRDYHGSLLGMD
AVVVGRSNIVGKPMAQLLLGDSCTVTIAHSRTKDLADVVRRADIVVAAVGRPEMVPGDWIKPGATVIDVGINRLDAPEKG
EGKTRLVGDVDFDSCAAVAGAITPVPGGVGPMTIACLLANTVTACCRANGLEEPEGLTA

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=291, Percent_Identity=45.7044673539519, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI222418558, Length=297, Percent_Identity=44.4444444444444, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI94721354, Length=309, Percent_Identity=43.3656957928803, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI36796743, Length=201, Percent_Identity=27.363184079602, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786741, Length=286, Percent_Identity=52.0979020979021, Blast_Score=272, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17568735, Length=296, Percent_Identity=41.8918918918919, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=45.6445993031359, Blast_Score=254, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6321643, Length=299, Percent_Identity=44.4816053511706, Blast_Score=249, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6322933, Length=318, Percent_Identity=25.4716981132075, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136816, Length=293, Percent_Identity=47.098976109215, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI17136818, Length=293, Percent_Identity=47.098976109215, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI62472483, Length=290, Percent_Identity=45.1724137931035, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI45551871, Length=290, Percent_Identity=45.1724137931035, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24645718, Length=290, Percent_Identity=45.1724137931035, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI17137370, Length=290, Percent_Identity=45.1724137931035, Blast_Score=237, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD1_ROSDO (Q167Y9)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682390.1
- ProteinModelPortal:   Q167Y9
- SMR:   Q167Y9
- STRING:   Q167Y9
- GeneID:   4196651
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2105
- NMPDR:   fig|375451.6.peg.1965
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   CLMMLRD
- PhylomeDB:   Q167Y9
- ProtClustDB:   PRK14188
- BioCyc:   RDEN375451:RD1_2105-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 31314; Mature: 31182

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATLIDGKAFAARVRAQVAEHVTRLKADHGITPGLAVVLVGQDPASQVYVRSKGKQTTE
CCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCHHH
VGMKSVEHKLDADTSETDLLAVVDQLNKDPDIHGILVQLPLPGHLDEDLVINSIAPEKDV
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCC
DGFHISNVGLLGTGQKSMVPCTPLGCLMMLRDYHGSLLGMDAVVVGRSNIVGKPMAQLLL
CCEEECCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEECCEEEEECCCCCCCCHHHHHHC
GDSCTVTIAHSRTKDLADVVRRADIVVAAVGRPEMVPGDWIKPGATVIDVGINRLDAPEK
CCCEEEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
GEGKTRLVGDVDFDSCAAVAGAITPVPGGVGPMTIACLLANTVTACCRANGLEEPEGLTA
CCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SATLIDGKAFAARVRAQVAEHVTRLKADHGITPGLAVVLVGQDPASQVYVRSKGKQTTE
CCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCHHH
VGMKSVEHKLDADTSETDLLAVVDQLNKDPDIHGILVQLPLPGHLDEDLVINSIAPEKDV
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCC
DGFHISNVGLLGTGQKSMVPCTPLGCLMMLRDYHGSLLGMDAVVVGRSNIVGKPMAQLLL
CCEEECCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEECCEEEEECCCCCCCCHHHHHHC
GDSCTVTIAHSRTKDLADVVRRADIVVAAVGRPEMVPGDWIKPGATVIDVGINRLDAPEK
CCCEEEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
GEGKTRLVGDVDFDSCAAVAGAITPVPGGVGPMTIACLLANTVTACCRANGLEEPEGLTA
CCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA