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The map label for this gene is allD [C]

Identifier: 110679330

GI number: 110679330

Start: 1958004

End: 1958999

Strand: Direct

Name: allD [C]

Synonym: RD1_2049

Alternate gene names: 110679330

Gene position: 1958004-1958999 (Clockwise)

Preceding gene: 110679329

Following gene: 110679332

Centisome position: 47.37

GC content: 62.55

Gene sequence:

>996_bases
ATGCCATACCACAGCTTGGAAGACATAGAAGCGCTGACCAAACAGGCACTCATGGCCTATGGCGCGACCCCGTTTGTGGC
CGCCGAAGTTGCCCGCGCCGTGCGCGTGGCCGAGGGCTATGGCAACAAGATCTGCGGGTTGTACTATGTCGAAAGTTATT
GTTTGCAGCTCGAAACGGGTCGGGTCGACGGGCATGCGGTGCCCGATGTGACCAACCCCCGTCCCGCGGCGATCCATGTG
AACGCCAATTATGGATTTGCCCAGCCTGCCTTTGCGCAGGGTCTGGTGCCTGCGCTGGACGCGGCCAAGACGCTGGGAAC
CGCGACGCTTGCCGTGGGGCATGCACACACCTGCACGTCGCTGGGGTATTTTACCGAACAGATCGCTCAAAGTGGGTGTA
TCGGGATCGGGTTCACCAATGCCTCGCCCATCGTTGCCGCACCCGGTGGTAAAACGCGGGTGATCGGCACAAACCCGATC
GCGTTTTCGGTGCCTGACGGGGCTGGCGGCGTCGCGATGCAGTTTGATCAGTCAACCACCACCGTGGCCTTGGGCAAGAT
CACGATGGCCAAGGCCCTGGGCCAGCAGATTCCGTTGGGCTGGGCGCTGGATGCGCAGGGAAAGCCCACCACCGATCCGC
AGGCCGCTCTCGAAGGTTCGCTGGTGTCGGTTGGCGGGCATAAGGGCTGGGGCTTTGGCCTGATGGCTGAAATCCTCGCA
GCCGGCATGACGGGCTCGGTCCTGTCGGGCAGCGTCAAACCGCTCAAGGCCCCGCAGGGACCGCCGCATGATCTGGGGCA
GTTTTACATCCTCATCGATCCACAAAGCGGGGAGGCCTTTGCCGAGCGGCTCGCCGCGCTGTCTCAGGCTGCTACCAAGG
ATGAAGGGGCGCGCATGCCGGGCCAGTCACGCCAGATCATGCAGGAAGTCGAAGTGGTGGATCAGGTCTGGAACAGATTG
CAGGAACTGGCGCAGGGGCCTAAACCTTCTGGGTGA

Upstream 100 bases:

>100_bases
GCCCGTATGGACCGGCAAATCCGTTTGGACGCAGGGCAGCTGTCTGACGTATAATATCAAGGCCTTACGCAGGCTAGCGG
GCGAACCGGAAGGAACAGTG

Downstream 100 bases:

>100_bases
TGAACACGCCGGTTGCCATGACCGCTATCCCGAGGGCGCGGGTTGCGCTGATCGGGCTGACGCGTGCGCCAAACAGGCCA
AAGTGATCGATGACAGCGGC

Product: malate/L-lactate dehydrogenase, putative

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MPYHSLEDIEALTKQALMAYGATPFVAAEVARAVRVAEGYGNKICGLYYVESYCLQLETGRVDGHAVPDVTNPRPAAIHV
NANYGFAQPAFAQGLVPALDAAKTLGTATLAVGHAHTCTSLGYFTEQIAQSGCIGIGFTNASPIVAAPGGKTRVIGTNPI
AFSVPDGAGGVAMQFDQSTTTVALGKITMAKALGQQIPLGWALDAQGKPTTDPQAALEGSLVSVGGHKGWGFGLMAEILA
AGMTGSVLSGSVKPLKAPQGPPHDLGQFYILIDPQSGEAFAERLAALSQAATKDEGARMPGQSRQIMQEVEVVDQVWNRL
QELAQGPKPSG

Sequences:

>Translated_331_residues
MPYHSLEDIEALTKQALMAYGATPFVAAEVARAVRVAEGYGNKICGLYYVESYCLQLETGRVDGHAVPDVTNPRPAAIHV
NANYGFAQPAFAQGLVPALDAAKTLGTATLAVGHAHTCTSLGYFTEQIAQSGCIGIGFTNASPIVAAPGGKTRVIGTNPI
AFSVPDGAGGVAMQFDQSTTTVALGKITMAKALGQQIPLGWALDAQGKPTTDPQAALEGSLVSVGGHKGWGFGLMAEILA
AGMTGSVLSGSVKPLKAPQGPPHDLGQFYILIDPQSGEAFAERLAALSQAATKDEGARMPGQSRQIMQEVEVVDQVWNRL
QELAQGPKPSG
>Mature_330_residues
PYHSLEDIEALTKQALMAYGATPFVAAEVARAVRVAEGYGNKICGLYYVESYCLQLETGRVDGHAVPDVTNPRPAAIHVN
ANYGFAQPAFAQGLVPALDAAKTLGTATLAVGHAHTCTSLGYFTEQIAQSGCIGIGFTNASPIVAAPGGKTRVIGTNPIA
FSVPDGAGGVAMQFDQSTTTVALGKITMAKALGQQIPLGWALDAQGKPTTDPQAALEGSLVSVGGHKGWGFGLMAEILAA
GMTGSVLSGSVKPLKAPQGPPHDLGQFYILIDPQSGEAFAERLAALSQAATKDEGARMPGQSRQIMQEVEVVDQVWNRLQ
ELAQGPKPSG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=331, Percent_Identity=29.3051359516616, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787020, Length=244, Percent_Identity=26.2295081967213, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790000, Length=335, Percent_Identity=21.7910447761194, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17507179, Length=289, Percent_Identity=25.9515570934256, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17536633, Length=293, Percent_Identity=26.6211604095563, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667908, Length=253, Percent_Identity=30.0395256916996, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45553211, Length=253, Percent_Identity=30.0395256916996, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667912, Length=253, Percent_Identity=30.0395256916996, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667904, Length=261, Percent_Identity=29.8850574712644, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24658010, Length=319, Percent_Identity=27.8996865203762, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24648360, Length=306, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 34297; Mature: 34166

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYHSLEDIEALTKQALMAYGATPFVAAEVARAVRVAEGYGNKICGLYYVESYCLQLETG
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEHHHEEEECC
RVDGHAVPDVTNPRPAAIHVNANYGFAQPAFAQGLVPALDAAKTLGTATLAVGHAHTCTS
CCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHEEECCCHHHHH
LGYFTEQIAQSGCIGIGFTNASPIVAAPGGKTRVIGTNPIAFSVPDGAGGVAMQFDQSTT
HHHHHHHHHHCCCEEEEECCCCCEEECCCCCEEEEECCCEEEECCCCCCCEEEEECCCCC
TVALGKITMAKALGQQIPLGWALDAQGKPTTDPQAALEGSLVSVGGHKGWGFGLMAEILA
EEEEHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHH
AGMTGSVLSGSVKPLKAPQGPPHDLGQFYILIDPQSGEAFAERLAALSQAATKDEGARMP
CCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
GQSRQIMQEVEVVDQVWNRLQELAQGPKPSG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PYHSLEDIEALTKQALMAYGATPFVAAEVARAVRVAEGYGNKICGLYYVESYCLQLETG
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEHHHEEEECC
RVDGHAVPDVTNPRPAAIHVNANYGFAQPAFAQGLVPALDAAKTLGTATLAVGHAHTCTS
CCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHEEECCCHHHHH
LGYFTEQIAQSGCIGIGFTNASPIVAAPGGKTRVIGTNPIAFSVPDGAGGVAMQFDQSTT
HHHHHHHHHHCCCEEEEECCCCCEEECCCCCEEEEECCCEEEECCCCCCCEEEEECCCCC
TVALGKITMAKALGQQIPLGWALDAQGKPTTDPQAALEGSLVSVGGHKGWGFGLMAEILA
EEEEHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHH
AGMTGSVLSGSVKPLKAPQGPPHDLGQFYILIDPQSGEAFAERLAALSQAATKDEGARMP
CCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
GQSRQIMQEVEVVDQVWNRLQELAQGPKPSG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]