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The map label for this gene is pccB [H]

Identifier: 110679310

GI number: 110679310

Start: 1936990

End: 1938522

Strand: Direct

Name: pccB [H]

Synonym: RD1_2028

Alternate gene names: 110679310

Gene position: 1936990-1938522 (Clockwise)

Preceding gene: 110679307

Following gene: 110679311

Centisome position: 46.87

GC content: 56.82

Gene sequence:

>1533_bases
ATGAAAGACATCCTTGAGCAACTCGAAGATCGCCGGGCAGCTGCCCGATTGGGTGGCGGGCAAAAGCGGATCGATGCACA
GCACGGTCGTGGCAAGTTGACGGCGCGTGAACGTGTGGACCTTTTGCTTGATGAGGGCAGCTTTGAAGAGTTCGACATGT
TCGTCACGCACCGCTGCACCGATTTCAACATGCAAGATCAAAAGCCTGCGGGCGATGGTGTTGTTACGGGCTGGGGGACG
ATCAACGGACGGGTTGTCTATGTCTTCAGTCAGGACTTCACCGTGCTTGGCGGTTCGGTGTCCGAAACCCATTCCAAGAA
AATCTGCAAGATCATGGATATGGCGATGCAGAACGGGGCCCCGGTGATTGGGATAAACGACTCGGGCGGCGCGCGCATTC
AGGAGGGTGTTGATTCCCTTGCGGGTTATGGCGAGGTTTTCCAGCGCAACATCATGGCGTCGGGCGTTGTGCCGCAGATC
AGCATGATCATGGGGCCTTGTGCGGGCGGTGCGGTTTATTCTCCGGCGATGACTGACTTCATCTTCATGGTCAAAGACAG
CTCTTATATGTTTGTGACCGGACCCGACGTGGTCAAGACCGTTACAAATGAACAGGTCTCTGCGGAAGAGTTGGGGGGCG
CCACGACGCATACCCGCAAGTCATCGGTGGCCGATGCCGCTTTTGAAAACGATGTGGAAGCCTTGGCCGAAGTGCGTCGA
CTGGTCGATTTCCTGCCTCTGAACAACCGCGAAAAGCCGCCGGTACGACCGTTTTTTGATGATCCGGACCGGATCGAGCC
CTCGCTGGACACGCTTGTTCCGGACAATCCGAATACGCCTTACGATATGAAGGAGCTGATCCATAAGCTGGCGGATGAGG
GTGACTTTTACGAAATACAGGAAGAGTTCGCAAAAAACATCATCACAGGCTTCATCCGTCTTGAGGGGCGCACGGTGGGT
GTTGTCGCCAACCAACCCCTTGTTCTGGCGGGATGTCTGGACATTGACAGCTCGCGCAAAGCGGCGCGTTTCGTGCGCTT
TTGTGACGCCTTCGAAATCCCGCTGCTCACCTTGATTGACGTGCCCGGCTTCCTGCCCGGCACCAGCCAGGAGTACGGAG
GTGTGATCAAACACGGTGCCAAGCTGCTTTACGCCTATGGTGAAGCAACGGTGCCGATGGTGACGGTCATCACACGCAAA
GCCTATGGCGGTGCCTATGTCGTGATGTCATCCAAGCACCTGCGCGCTGATTTCAACTACGCCTGGCCAACCGCCGAAGT
CGCGGTGATGGGGGCGAAGGGGGCCACTGAGATCATTCACCGCGGTGATCTGGGTGACCCTGAGAAAATCGCGCAACATA
CGGCTGACTACGAAGAGCGTTTTGCCAACCCCTTTGTCGCCTCCGAGCGCGGGTTTGTGGATGAGGTGATTCAGCCGCGC
AGCACCCGAAAGCGTGTGGCGCGGGCCTTTGCCTCCTTGCGCAACAAGTCGGTACAGATGCCGTGGAAAAAGCACGATAA
CATCCCACTGTAA

Upstream 100 bases:

>100_bases
GCAAATATTACCGTGAATAAAGTTTGCAAATTTGCTTCTTTGTCCTTCGATTCCGATCCTTGTTTCGGTAAAAGTCCGAA
AACCAAAAATGGGGTTCAGA

Downstream 100 bases:

>100_bases
GGTGTTGTAAGGTATGATTTTCCATAAATCTCCCGATACCCCGGAACATGTGCCGCCGTTTGACTGCGTCACGAGGGTTG
ATGGCGGGTCGGCGGTGCCG

Product: propionyl-CoA carboxylase, beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKDILEQLEDRRAAARLGGGQKRIDAQHGRGKLTARERVDLLLDEGSFEEFDMFVTHRCTDFNMQDQKPAGDGVVTGWGT
INGRVVYVFSQDFTVLGGSVSETHSKKICKIMDMAMQNGAPVIGINDSGGARIQEGVDSLAGYGEVFQRNIMASGVVPQI
SMIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPDVVKTVTNEQVSAEELGGATTHTRKSSVADAAFENDVEALAEVRR
LVDFLPLNNREKPPVRPFFDDPDRIEPSLDTLVPDNPNTPYDMKELIHKLADEGDFYEIQEEFAKNIITGFIRLEGRTVG
VVANQPLVLAGCLDIDSSRKAARFVRFCDAFEIPLLTLIDVPGFLPGTSQEYGGVIKHGAKLLYAYGEATVPMVTVITRK
AYGGAYVVMSSKHLRADFNYAWPTAEVAVMGAKGATEIIHRGDLGDPEKIAQHTADYEERFANPFVASERGFVDEVIQPR
STRKRVARAFASLRNKSVQMPWKKHDNIPL

Sequences:

>Translated_510_residues
MKDILEQLEDRRAAARLGGGQKRIDAQHGRGKLTARERVDLLLDEGSFEEFDMFVTHRCTDFNMQDQKPAGDGVVTGWGT
INGRVVYVFSQDFTVLGGSVSETHSKKICKIMDMAMQNGAPVIGINDSGGARIQEGVDSLAGYGEVFQRNIMASGVVPQI
SMIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPDVVKTVTNEQVSAEELGGATTHTRKSSVADAAFENDVEALAEVRR
LVDFLPLNNREKPPVRPFFDDPDRIEPSLDTLVPDNPNTPYDMKELIHKLADEGDFYEIQEEFAKNIITGFIRLEGRTVG
VVANQPLVLAGCLDIDSSRKAARFVRFCDAFEIPLLTLIDVPGFLPGTSQEYGGVIKHGAKLLYAYGEATVPMVTVITRK
AYGGAYVVMSSKHLRADFNYAWPTAEVAVMGAKGATEIIHRGDLGDPEKIAQHTADYEERFANPFVASERGFVDEVIQPR
STRKRVARAFASLRNKSVQMPWKKHDNIPL
>Mature_510_residues
MKDILEQLEDRRAAARLGGGQKRIDAQHGRGKLTARERVDLLLDEGSFEEFDMFVTHRCTDFNMQDQKPAGDGVVTGWGT
INGRVVYVFSQDFTVLGGSVSETHSKKICKIMDMAMQNGAPVIGINDSGGARIQEGVDSLAGYGEVFQRNIMASGVVPQI
SMIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPDVVKTVTNEQVSAEELGGATTHTRKSSVADAAFENDVEALAEVRR
LVDFLPLNNREKPPVRPFFDDPDRIEPSLDTLVPDNPNTPYDMKELIHKLADEGDFYEIQEEFAKNIITGFIRLEGRTVG
VVANQPLVLAGCLDIDSSRKAARFVRFCDAFEIPLLTLIDVPGFLPGTSQEYGGVIKHGAKLLYAYGEATVPMVTVITRK
AYGGAYVVMSSKHLRADFNYAWPTAEVAVMGAKGATEIIHRGDLGDPEKIAQHTADYEERFANPFVASERGFVDEVIQPR
STRKRVARAFASLRNKSVQMPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=66.2721893491124, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=63.7571157495256, Blast_Score=686, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=516, Percent_Identity=33.1395348837209, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI134142062, Length=360, Percent_Identity=23.6111111111111, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI38679960, Length=463, Percent_Identity=25.2699784017279, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI38679974, Length=463, Percent_Identity=25.2699784017279, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI38679971, Length=463, Percent_Identity=25.2699784017279, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI38679977, Length=463, Percent_Identity=25.2699784017279, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI38679967, Length=463, Percent_Identity=25.2699784017279, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1788655, Length=194, Percent_Identity=26.8041237113402, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=64.8915187376726, Blast_Score=700, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=64.8915187376726, Blast_Score=699, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=518, Percent_Identity=33.2046332046332, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI71997163, Length=322, Percent_Identity=27.639751552795, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24586065, Length=534, Percent_Identity=31.4606741573034, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56100; Mature: 56100

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDILEQLEDRRAAARLGGGQKRIDAQHGRGKLTARERVDLLLDEGSFEEFDMFVTHRCT
CHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHEEECCCCCHHHHHHHHEECC
DFNMQDQKPAGDGVVTGWGTINGRVVYVFSQDFTVLGGSVSETHSKKICKIMDMAMQNGA
CCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCCC
PVIGINDSGGARIQEGVDSLAGYGEVFQRNIMASGVVPQISMIMGPCAGGAVYSPAMTDF
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHEE
IFMVKDSSYMFVTGPDVVKTVTNEQVSAEELGGATTHTRKSSVADAAFENDVEALAEVRR
EEEEECCCEEEEECCHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVDFLPLNNREKPPVRPFFDDPDRIEPSLDTLVPDNPNTPYDMKELIHKLADEGDFYEIQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHH
EEFAKNIITGFIRLEGRTVGVVANQPLVLAGCLDIDSSRKAARFVRFCDAFEIPLLTLID
HHHHHHHHEEEEEECCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHEEC
VPGFLPGTSQEYGGVIKHGAKLLYAYGEATVPMVTVITRKAYGGAYVVMSSKHLRADFNY
CCCCCCCCCHHHCHHHHHCCEEEEEECCCCCCCEEEEEHHCCCCEEEEEECCCCCCCCCC
AWPTAEVAVMGAKGATEIIHRGDLGDPEKIAQHTADYEERFANPFVASERGFVDEVIQPR
CCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHCCC
STRKRVARAFASLRNKSVQMPWKKHDNIPL
HHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKDILEQLEDRRAAARLGGGQKRIDAQHGRGKLTARERVDLLLDEGSFEEFDMFVTHRCT
CHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHEEECCCCCHHHHHHHHEECC
DFNMQDQKPAGDGVVTGWGTINGRVVYVFSQDFTVLGGSVSETHSKKICKIMDMAMQNGA
CCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCCC
PVIGINDSGGARIQEGVDSLAGYGEVFQRNIMASGVVPQISMIMGPCAGGAVYSPAMTDF
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHEE
IFMVKDSSYMFVTGPDVVKTVTNEQVSAEELGGATTHTRKSSVADAAFENDVEALAEVRR
EEEEECCCEEEEECCHHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVDFLPLNNREKPPVRPFFDDPDRIEPSLDTLVPDNPNTPYDMKELIHKLADEGDFYEIQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHH
EEFAKNIITGFIRLEGRTVGVVANQPLVLAGCLDIDSSRKAARFVRFCDAFEIPLLTLID
HHHHHHHHEEEEEECCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHEEC
VPGFLPGTSQEYGGVIKHGAKLLYAYGEATVPMVTVITRKAYGGAYVVMSSKHLRADFNY
CCCCCCCCCHHHCHHHHHCCEEEEEECCCCCCCEEEEEHHCCCCEEEEEECCCCCCCCCC
AWPTAEVAVMGAKGATEIIHRGDLGDPEKIAQHTADYEERFANPFVASERGFVDEVIQPR
CCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHCCC
STRKRVARAFASLRNKSVQMPWKKHDNIPL
HHHHHHHHHHHHHHCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]