Click here to switch to the map view.

The map label for this gene is betC-1 [H]

Identifier: 110679304

GI number: 110679304

Start: 1928126

End: 1929634

Strand: Direct

Name: betC-1 [H]

Synonym: RD1_2022

Alternate gene names: 110679304

Gene position: 1928126-1929634 (Clockwise)

Preceding gene: 110679303

Following gene: 110679305

Centisome position: 46.65

GC content: 59.64

Gene sequence:

>1509_bases
ATGAGCAAGCCGAACATCCTGATCCTGATGGTCGACCAGTTGAACGGCACCCTTTTTCCCGATGGCCCAGCCGAGTGGCT
GCATGCGCCAAACCTGAAAAAGCTCGCCGCGCGCTCAACACGGTTCAAGAACGCCTATACCGCCAGCCCCCTGTGCGCGC
CGGGTCGTGCCGCGTTCATGTCGGGTCAATTGCCCTCGGCCACCGGCGTTTATGACAATGCCGCCGAATTCTGTTCCTCG
ATCCCGACCTATGCGCATCATCTGCGGCGGGCGGGGTATCAGACCTGCCTGTCGGGCAAGATGCATTTTGTCGGCCCCGA
TCAGTTGCACGGCTTCGAAGAGCGCCTGACCACCGATATCTACCCGGCGGATTTTGGCTGGACCCCGGATTATCGCAAAC
CGGGCGAGCGTATCGACTGGTGGTATCACAATATGGGCTCGGTCACGGGCGCGGGTGTGGCCGAGATTTCCAACCAGATG
GAATATGATGACGAGGTGGCCTTCAACGCGACCCGCAAACTCTACGATCTGTCACGCGGGGCAGATGCGCGCCCCTGGTG
TCTGACGGTCAGCTTCACCCATCCGCATGACCCTTACGTGGCGCGCAAGAAATACTGGGATCTCTACGAGGATTGTGCGC
ATCTTCAGCCTGAGGTCGCGGCCTTTGACTACGCCGATCAGGACCCGCACAGCCAGCGTATTTTCGATGCGAACGACTGG
CGCAGCTTTGACATCACGAAACGCGATATCGAACGGTCCAGACGCGCGTATTTTGCCAATATCAGTTACCTCGACGACAA
AATCGGTGACATCCTGCAAACGCTGGAAGACACGCGGCAGGAGGCGATCATCCTCTTTGTCTCGGATCATGGCGATATGT
TGGGCGAGCGTGGGTTATGGTTCAAGATGTCCTTTTTCGAGGGATCCTCGCGGGTGCCGCTGATGATCTCTGCGCCGCAA
ATGGAACCGGGGCTGCAGACAACGGCCGTGTCCAACATCGATGTCTGTCCGACGCTCTGTGACCTTGCGGGCGTGTCGAT
GGACGAGGTGATGGCATGGACAACCGGGGTGTCGCTGGTGCCCATGGGGCAGGGGGTCGAACGCACAGAACCCGTTGCGA
TGGAATATGCGGCGGAAGCCTCCTATGCCCCGATGGTGTCCCTGCGCTATGGCCCGTGGAAGTACAACAAATGCGTTCTC
GATCCGGAACAACTGTTTGATCTGGAAAACGACCCGCACGAATTGCACAACCTTGCCGGGCACCCGGATCACCAAGGCAC
CCTGTCGGCTTTGCGCAGCAAGGCGGAAGCGCGCTGGGATCTCGACGCCTTTGACGCCGATGTGCGCAAAAGTCAGGCGC
GCCGCTGGGTCGTCTACGAGGCCCTGCGCGAGGGCGGGTACTACCCATGGGACTATCAGCCCCTGCGCGCCGCATCCGAG
CAATACATGCGCAATCACATGGACCTCAACGTGCTCGAAGAGAGCAAACGGTTTCCGCGCGGTGAGTAA

Upstream 100 bases:

>100_bases
ATGGCCTTTATCTGCGCGCCGCCCTGTCGCGTTCAAAAAGTGCCGACGCCGCACGCGATACCGCCCTTGCCGCGTTGTCG
ACCTTGCTGGAGCGCCCCGC

Downstream 100 bases:

>100_bases
CCACGCCCCAAAACCCCTGCACCAAAGGCAATACAGCTGATGAGTTATCCAACCCAACCCACCGCCAGCCATTTCATCAA
CGGGCAATATGTCGAAGATA

Product: choline sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSKPNILILMVDQLNGTLFPDGPAEWLHAPNLKKLAARSTRFKNAYTASPLCAPGRAAFMSGQLPSATGVYDNAAEFCSS
IPTYAHHLRRAGYQTCLSGKMHFVGPDQLHGFEERLTTDIYPADFGWTPDYRKPGERIDWWYHNMGSVTGAGVAEISNQM
EYDDEVAFNATRKLYDLSRGADARPWCLTVSFTHPHDPYVARKKYWDLYEDCAHLQPEVAAFDYADQDPHSQRIFDANDW
RSFDITKRDIERSRRAYFANISYLDDKIGDILQTLEDTRQEAIILFVSDHGDMLGERGLWFKMSFFEGSSRVPLMISAPQ
MEPGLQTTAVSNIDVCPTLCDLAGVSMDEVMAWTTGVSLVPMGQGVERTEPVAMEYAAEASYAPMVSLRYGPWKYNKCVL
DPEQLFDLENDPHELHNLAGHPDHQGTLSALRSKAEARWDLDAFDADVRKSQARRWVVYEALREGGYYPWDYQPLRAASE
QYMRNHMDLNVLEESKRFPRGE

Sequences:

>Translated_502_residues
MSKPNILILMVDQLNGTLFPDGPAEWLHAPNLKKLAARSTRFKNAYTASPLCAPGRAAFMSGQLPSATGVYDNAAEFCSS
IPTYAHHLRRAGYQTCLSGKMHFVGPDQLHGFEERLTTDIYPADFGWTPDYRKPGERIDWWYHNMGSVTGAGVAEISNQM
EYDDEVAFNATRKLYDLSRGADARPWCLTVSFTHPHDPYVARKKYWDLYEDCAHLQPEVAAFDYADQDPHSQRIFDANDW
RSFDITKRDIERSRRAYFANISYLDDKIGDILQTLEDTRQEAIILFVSDHGDMLGERGLWFKMSFFEGSSRVPLMISAPQ
MEPGLQTTAVSNIDVCPTLCDLAGVSMDEVMAWTTGVSLVPMGQGVERTEPVAMEYAAEASYAPMVSLRYGPWKYNKCVL
DPEQLFDLENDPHELHNLAGHPDHQGTLSALRSKAEARWDLDAFDADVRKSQARRWVVYEALREGGYYPWDYQPLRAASE
QYMRNHMDLNVLEESKRFPRGE
>Mature_501_residues
SKPNILILMVDQLNGTLFPDGPAEWLHAPNLKKLAARSTRFKNAYTASPLCAPGRAAFMSGQLPSATGVYDNAAEFCSSI
PTYAHHLRRAGYQTCLSGKMHFVGPDQLHGFEERLTTDIYPADFGWTPDYRKPGERIDWWYHNMGSVTGAGVAEISNQME
YDDEVAFNATRKLYDLSRGADARPWCLTVSFTHPHDPYVARKKYWDLYEDCAHLQPEVAAFDYADQDPHSQRIFDANDWR
SFDITKRDIERSRRAYFANISYLDDKIGDILQTLEDTRQEAIILFVSDHGDMLGERGLWFKMSFFEGSSRVPLMISAPQM
EPGLQTTAVSNIDVCPTLCDLAGVSMDEVMAWTTGVSLVPMGQGVERTEPVAMEYAAEASYAPMVSLRYGPWKYNKCVLD
PEQLFDLENDPHELHNLAGHPDHQGTLSALRSKAEARWDLDAFDADVRKSQARRWVVYEALREGGYYPWDYQPLRAASEQ
YMRNHMDLNVLEESKRFPRGE

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4557659, Length=401, Percent_Identity=28.1795511221945, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI39930577, Length=191, Percent_Identity=32.4607329842932, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI5360208, Length=322, Percent_Identity=27.639751552795, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI262118210, Length=341, Percent_Identity=26.9794721407625, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790112, Length=430, Percent_Identity=27.4418604651163, Blast_Score=153, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24656835, Length=373, Percent_Identity=25.7372654155496, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 57063; Mature: 56932

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPNILILMVDQLNGTLFPDGPAEWLHAPNLKKLAARSTRFKNAYTASPLCAPGRAAFM
CCCCCEEEEEEECCCCEECCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHC
SGQLPSATGVYDNAAEFCSSIPTYAHHLRRAGYQTCLSGKMHFVGPDQLHGFEERLTTDI
CCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCHHHHCCHHHHHHCCC
YPADFGWTPDYRKPGERIDWWYHNMGSVTGAGVAEISNQMEYDDEVAFNATRKLYDLSRG
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCC
ADARPWCLTVSFTHPHDPYVARKKYWDLYEDCAHLQPEVAAFDYADQDPHSQRIFDANDW
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCC
RSFDITKRDIERSRRAYFANISYLDDKIGDILQTLEDTRQEAIILFVSDHGDMLGERGLW
CCCCCCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCE
FKMSFFEGSSRVPLMISAPQMEPGLQTTAVSNIDVCPTLCDLAGVSMDEVMAWTTGVSLV
EEEEEECCCCCCCEEEECCCCCCCCCHHCCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEE
PMGQGVERTEPVAMEYAAEASYAPMVSLRYGPWKYNKCVLDPEQLFDLENDPHELHNLAG
ECCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCEEEECHHHHHCCCCCHHHHHHCCC
HPDHQGTLSALRSKAEARWDLDAFDADVRKSQARRWVVYEALREGGYYPWDYQPLRAASE
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
QYMRNHMDLNVLEESKRFPRGE
HHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
SKPNILILMVDQLNGTLFPDGPAEWLHAPNLKKLAARSTRFKNAYTASPLCAPGRAAFM
CCCCEEEEEEECCCCEECCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHC
SGQLPSATGVYDNAAEFCSSIPTYAHHLRRAGYQTCLSGKMHFVGPDQLHGFEERLTTDI
CCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCHHHHCCHHHHHHCCC
YPADFGWTPDYRKPGERIDWWYHNMGSVTGAGVAEISNQMEYDDEVAFNATRKLYDLSRG
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCC
ADARPWCLTVSFTHPHDPYVARKKYWDLYEDCAHLQPEVAAFDYADQDPHSQRIFDANDW
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCC
RSFDITKRDIERSRRAYFANISYLDDKIGDILQTLEDTRQEAIILFVSDHGDMLGERGLW
CCCCCCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCE
FKMSFFEGSSRVPLMISAPQMEPGLQTTAVSNIDVCPTLCDLAGVSMDEVMAWTTGVSLV
EEEEEECCCCCCCEEEECCCCCCCCCHHCCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEE
PMGQGVERTEPVAMEYAAEASYAPMVSLRYGPWKYNKCVLDPEQLFDLENDPHELHNLAG
ECCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCEEEECHHHHHCCCCCHHHHHHCCC
HPDHQGTLSALRSKAEARWDLDAFDADVRKSQARRWVVYEALREGGYYPWDYQPLRAASE
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
QYMRNHMDLNVLEESKRFPRGE
HHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]