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The map label for this gene is gor [H]

Identifier: 110679208

GI number: 110679208

Start: 1831174

End: 1832628

Strand: Direct

Name: gor [H]

Synonym: RD1_1919

Alternate gene names: 110679208

Gene position: 1831174-1832628 (Clockwise)

Preceding gene: 110679207

Following gene: 110679209

Centisome position: 44.31

GC content: 59.45

Gene sequence:

>1455_bases
ATGACTGACTTTGACTATGATCTTTTCGTAATCGGCGGCGGCTCTGGGGGCGTCAGGGCGGCGCGTGTTGCGGCCAGCGA
AGCAGGCGCGAAGGTGGCTCTGGCGGAAGAAGACAGATACGGCGGCACCTGCGTGATCCGGGGCTGTGTGCCCAAAAAGC
TGATGGTATTCGCCTCGGAATATGCGGGCATGCCGGATGAGGCGCAGGCCTATGGCTGGGACATGCAGAGAGGCGGCTTT
GATTGGCCGGCTTTCAAAACCAAGCTGAACGCCGAACTGGACCGTCTTGAGCAGGTCTACCGCAGGCTGCTGTCGGAATC
AGGTGTCGAGACCTTTGATGCACGCGCCACGGTGTCCGGCCAGCATGAGGTGACGCTGTCCGACGGGCAAACCAAATCGG
CCAAACATATCCTCGTGGCAACCGGCGGCCACCCGGTCAGGCCCGACTTGCCCAATGCCCATCTTGGCATTGTGTCCGAT
GACATTTTCCATCTGGAAAACCTGCCCAAATCGGTTCTGATCGTAGGCGGGGGTTACATCGCCTGCGAATTCGCCGGTAT
TCTGAACGGGTTGGGGGTCAAGGTTACACAATACTATCGGGGGGCGCAGATTTTGCGTGGCTTTGATGACGAGGCGCGGG
GCCTTGTGGCCGAACAGATGCGCGAGCGCGGCATTGATCTGAAAGTCGGCACCAACATTCTGGAGATGGCCCCGGCCAAG
GAGCACGACAGCACGTCCGAAGGCGGTGCCATGGGCGGCACAGCGCAGGATCGCGCCGATCTTGCACAAATGCATGAAAG
CGCTGCGACAAAAGGCCCGGTCTGGGTGAAATCCACCAGCGGCACCGAAGGAGTTTTTGACGTGGTCCTCTTCGCGACCG
GGCGGGACCCGAACAGCAAAGACATGGGGCTTGAAGCGCAGGGCGTGAAACTGGGCCGGCGTGGCCAGATCGAGGTTGAC
GCCTACAGTCAGACCGCCGTGCCCTCCATCTATGCGATCGGCGATGTCACCGACCGCGTCAACCTGACGCCGGTTGCGAT
CCGCGAGGGCATGGCCTTTGTCGAAACCGTGTTCAAGGGCAATCCGACTGCCGTGGATCACGACCTGATCCCAAGCGCGA
TTTTCACCCAGCCCGAGATGGGCACGGTCGGTCTGGGCGAAGAAGCGGCCCGCGAACAGGAACCGGTTGAAATTTATTGC
ACTTCGTTTCGCCCCATGCGGACGGCTTTTGCCGAAAAACCGGACCGCGTGTTGATGAAACTTATTGTTTCCATAAAGAC
GCGAAAGGTCCTTGGATGCCATATTGTGGCCCCGAATGCGGGTGAAATGATCCAACTGGCGGGTGTTGCAATCAAGATGG
GCGCAACCAAGGAAGACTTTGACCGAACGGTTGCGGTCCACCCCACAATGTCGGAAGAGATCGTGACGATGCGTTCTCCC
ATGCGCACGGCTTGA

Upstream 100 bases:

>100_bases
ATTGATCGGAGCTATGCCTGTCTGACCGGTGTGACGCAGGAACAGGCAAACCTCTTGGCCCCGCTGCGGGTCAGCAGATT
AATACAGAAAGGCCCTTCCC

Downstream 100 bases:

>100_bases
ATTCCGGGCAGGGCAACGTACCTATGACTTGGTTTGATCGTGACGTTATGCGGTTTAGAAGGGAAAGAACTTAATGGCTG
GCAACAATGGCGGCCCCTGG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTDFDYDLFVIGGGSGGVRAARVAASEAGAKVALAEEDRYGGTCVIRGCVPKKLMVFASEYAGMPDEAQAYGWDMQRGGF
DWPAFKTKLNAELDRLEQVYRRLLSESGVETFDARATVSGQHEVTLSDGQTKSAKHILVATGGHPVRPDLPNAHLGIVSD
DIFHLENLPKSVLIVGGGYIACEFAGILNGLGVKVTQYYRGAQILRGFDDEARGLVAEQMRERGIDLKVGTNILEMAPAK
EHDSTSEGGAMGGTAQDRADLAQMHESAATKGPVWVKSTSGTEGVFDVVLFATGRDPNSKDMGLEAQGVKLGRRGQIEVD
AYSQTAVPSIYAIGDVTDRVNLTPVAIREGMAFVETVFKGNPTAVDHDLIPSAIFTQPEMGTVGLGEEAAREQEPVEIYC
TSFRPMRTAFAEKPDRVLMKLIVSIKTRKVLGCHIVAPNAGEMIQLAGVAIKMGATKEDFDRTVAVHPTMSEEIVTMRSP
MRTA

Sequences:

>Translated_484_residues
MTDFDYDLFVIGGGSGGVRAARVAASEAGAKVALAEEDRYGGTCVIRGCVPKKLMVFASEYAGMPDEAQAYGWDMQRGGF
DWPAFKTKLNAELDRLEQVYRRLLSESGVETFDARATVSGQHEVTLSDGQTKSAKHILVATGGHPVRPDLPNAHLGIVSD
DIFHLENLPKSVLIVGGGYIACEFAGILNGLGVKVTQYYRGAQILRGFDDEARGLVAEQMRERGIDLKVGTNILEMAPAK
EHDSTSEGGAMGGTAQDRADLAQMHESAATKGPVWVKSTSGTEGVFDVVLFATGRDPNSKDMGLEAQGVKLGRRGQIEVD
AYSQTAVPSIYAIGDVTDRVNLTPVAIREGMAFVETVFKGNPTAVDHDLIPSAIFTQPEMGTVGLGEEAAREQEPVEIYC
TSFRPMRTAFAEKPDRVLMKLIVSIKTRKVLGCHIVAPNAGEMIQLAGVAIKMGATKEDFDRTVAVHPTMSEEIVTMRSP
MRTA
>Mature_483_residues
TDFDYDLFVIGGGSGGVRAARVAASEAGAKVALAEEDRYGGTCVIRGCVPKKLMVFASEYAGMPDEAQAYGWDMQRGGFD
WPAFKTKLNAELDRLEQVYRRLLSESGVETFDARATVSGQHEVTLSDGQTKSAKHILVATGGHPVRPDLPNAHLGIVSDD
IFHLENLPKSVLIVGGGYIACEFAGILNGLGVKVTQYYRGAQILRGFDDEARGLVAEQMRERGIDLKVGTNILEMAPAKE
HDSTSEGGAMGGTAQDRADLAQMHESAATKGPVWVKSTSGTEGVFDVVLFATGRDPNSKDMGLEAQGVKLGRRGQIEVDA
YSQTAVPSIYAIGDVTDRVNLTPVAIREGMAFVETVFKGNPTAVDHDLIPSAIFTQPEMGTVGLGEEAAREQEPVEIYCT
SFRPMRTAFAEKPDRVLMKLIVSIKTRKVLGCHIVAPNAGEMIQLAGVAIKMGATKEDFDRTVAVHPTMSEEIVTMRSPM
RTA

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=482, Percent_Identity=38.5892116182573, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=36.1655773420479, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=33.4792122538293, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=33.4792122538293, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=33.4792122538293, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=33.4792122538293, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI148277071, Length=457, Percent_Identity=33.4792122538293, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI291045266, Length=453, Percent_Identity=32.4503311258278, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI291045268, Length=450, Percent_Identity=30, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI91199540, Length=487, Percent_Identity=29.3634496919918, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1789915, Length=465, Percent_Identity=37.8494623655914, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87082354, Length=485, Percent_Identity=27.8350515463918, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1786307, Length=481, Percent_Identity=25.3638253638254, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87081717, Length=484, Percent_Identity=24.5867768595041, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=458, Percent_Identity=36.0262008733624, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71983429, Length=462, Percent_Identity=35.7142857142857, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17557007, Length=504, Percent_Identity=31.7460317460317, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71982272, Length=500, Percent_Identity=31.8, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI32565766, Length=479, Percent_Identity=29.4363256784969, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=490, Percent_Identity=37.9591836734694, Blast_Score=280, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6321091, Length=485, Percent_Identity=28.2474226804124, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=495, Percent_Identity=26.4646464646465, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI17737741, Length=503, Percent_Identity=33.9960238568588, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24640551, Length=501, Percent_Identity=33.1337325349301, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24640549, Length=501, Percent_Identity=33.1337325349301, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24640553, Length=501, Percent_Identity=33.1337325349301, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21358499, Length=486, Percent_Identity=28.8065843621399, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 52059; Mature: 51928

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFDYDLFVIGGGSGGVRAARVAASEAGAKVALAEEDRYGGTCVIRGCVPKKLMVFASE
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHH
YAGMPDEAQAYGWDMQRGGFDWPAFKTKLNAELDRLEQVYRRLLSESGVETFDARATVSG
HCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECC
QHEVTLSDGQTKSAKHILVATGGHPVRPDLPNAHLGIVSDDIFHLENLPKSVLIVGGGYI
CEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCHHHHHCCCCEEEEEECCEE
ACEFAGILNGLGVKVTQYYRGAQILRGFDDEARGLVAEQMRERGIDLKVGTNILEMAPAK
EEEHHHHHCCCCEEEEHHHCCHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHCCCC
EHDSTSEGGAMGGTAQDRADLAQMHESAATKGPVWVKSTSGTEGVFDVVLFATGRDPNSK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEECCCCCCC
DMGLEAQGVKLGRRGQIEVDAYSQTAVPSIYAIGDVTDRVNLTPVAIREGMAFVETVFKG
CCCCEECCCEECCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
NPTAVDHDLIPSAIFTQPEMGTVGLGEEAAREQEPVEIYCTSFRPMRTAFAEKPDRVLMK
CCCEECCCCCCHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECCCHHHHHHHCCHHHHHHH
LIVSIKTRKVLGCHIVAPNAGEMIQLAGVAIKMGATKEDFDRTVAVHPTMSEEIVTMRSP
HHHHHHCCEEEEEEEECCCCCCEEEEECEEEEECCCHHHHCCEEEECCCCCHHHHHHCCC
MRTA
CCCC
>Mature Secondary Structure 
TDFDYDLFVIGGGSGGVRAARVAASEAGAKVALAEEDRYGGTCVIRGCVPKKLMVFASE
CCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHH
YAGMPDEAQAYGWDMQRGGFDWPAFKTKLNAELDRLEQVYRRLLSESGVETFDARATVSG
HCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECC
QHEVTLSDGQTKSAKHILVATGGHPVRPDLPNAHLGIVSDDIFHLENLPKSVLIVGGGYI
CEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCHHHHHCCCCEEEEEECCEE
ACEFAGILNGLGVKVTQYYRGAQILRGFDDEARGLVAEQMRERGIDLKVGTNILEMAPAK
EEEHHHHHCCCCEEEEHHHCCHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHCCCC
EHDSTSEGGAMGGTAQDRADLAQMHESAATKGPVWVKSTSGTEGVFDVVLFATGRDPNSK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEECCCCCCC
DMGLEAQGVKLGRRGQIEVDAYSQTAVPSIYAIGDVTDRVNLTPVAIREGMAFVETVFKG
CCCCEECCCEECCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
NPTAVDHDLIPSAIFTQPEMGTVGLGEEAAREQEPVEIYCTSFRPMRTAFAEKPDRVLMK
CCCEECCCCCCHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECCCHHHHHHHCCHHHHHHH
LIVSIKTRKVLGCHIVAPNAGEMIQLAGVAIKMGATKEDFDRTVAVHPTMSEEIVTMRSP
HHHHHHCCEEEEEEEECCCCCCEEEEECEEEEECCCHHHHCCEEEECCCCCHHHHHHCCC
MRTA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]